Articles tagged with Receptor Complexes
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A team from Tokyo University of Science developed a novel trivalent platform for triple click chemistry, allowing for the efficient synthesis of complex compounds. The approach utilizes simple initial materials and promotes sustainable pharmaceutical synthesis.
Researchers at McGill University found that a protein produced in muscles helps manage the release of follicle-stimulating hormone (FSH), which promotes egg maturation. Lowering myostatin levels delayed puberty and reduced fertility, while restoring it boosted FSH levels.
Researchers discovered a novel platinum complex that targets androgen receptor signaling, inhibiting cell growth and survival in prostate cancer cells. The complex, 5-H-Y, showed stronger cytotoxic effects than cisplatin with minimal toxicity, offering a promising approach to treating advanced prostate cancer.
A new study finds that individuals with autism spectrum disorder have an increased dynamic range in their neuronal response, resulting in a more detailed but slower response to changes. This increase enables accurate encoding of details but comes at the expense of faster adaptation.
A new method to construct protein complex-based therapeutics has been discovered using a polymer cloak, which stabilizes the delivery of protein complexes and enables tumor-targeted immunomodulation. The study presents an IL-15 nanosuperagonist with enhanced efficacy and specificity, promising a safer therapy for cancer treatment.
A new study introduces a novel approach to mapping GPCR-RAMP interactions, expanding understanding of these interactions and their therapeutic potential. The technique allows researchers to parse out each RAMP's effect on every GPCR, supercharging drug development.
Researchers have discovered that the Z-isomer of doxepin has a higher affinity for the H1 receptor, which could lead to the development of more effective antihistamines. The study also sheds light on how the binding environment enhances selectivity for the Z-isomer.
A recent study discovered a critical brain signal mediated by dopamine and its 'D2' receptors that plays a crucial role in timing actions. The research team used novel imaging techniques to observe this activity before self-timed presses, finding a gradual increase in brain signals about half a second prior.
Researchers review cell-based therapies for comprehensive sepsis management, highlighting the potential of mesenchymal stem cells and innate immune cells like macrophages. The review also emphasizes the need for further studies on optimal dosage, administration routes, and storage methods to maximize efficacy and safety.
Researchers have developed PaCS-Toolkit to facilitate accessible parallel cascade selection MD (PaCS-MD) simulations. The software package automates the simulation process via a single configuration file, allowing users to explore different conformations and investigate molecular interactions more efficiently.
Researchers deciphered the molecular structure of bulevirtide in complex with HBV/HDV receptor NTCP, revealing a unique 'plug' that inhibits virus entry. The study also sheds light on evolutionary adaptation of HBVs to host species and provides insights for developing smaller, more effective active agents.
Researchers have made progress in understanding atherosclerosis, identifying potential new approaches for early detection and therapy. The study found that TREM2 regulates the activity of macrophages, playing an important role in forming unstable plaques that increase heart attack and stroke risk.
Researchers at the University of Helsinki have made a groundbreaking discovery about the Commander complex, a vital cellular machinery. The study reveals that mutations in this complex are associated with developmental disorders such as Ritscher-Schinzel syndrome and Alzheimer's Disease.
Researchers found that the SYNGAP1 gene has a dual function in regulating synapses and synaptic plasticity, which may lead to new treatments for children with SYNGAP1 mutations. The study suggests that targeting just one aspect of SynGAP's function is not enough to have a significant impact.
A new study found that the link between paternal age and rare congenital disorders is more complex than previously thought. Researchers discovered that while older fathers are more likely to have children with certain bone and heart malformations, some genetic mutations associated with these conditions do not increase with paternal age.
A study by University of Alabama at Birmingham researchers discovered that protons are the primary signals transmitting tactile sensations from Merkel cells to nerves. Protons bind to ASIC receptors on nerve endings, triggering an influx of sodium ions that propagate action potentials up the nerve towards the brain.
Researchers at ETH Zurich successfully simulated the protein complex JUNO-IZUMO1, which initiates fertilization. The simulations revealed a network of short-lived contacts between the proteins and showed how zinc ions destabilize the complex, preventing further sperm penetration.
Researchers at Ruhr University Bochum have identified molecules that block CO2 receptors in fruit flies, leading to potential insect repellents. The team's findings could also enable the development of a CO2 biosensor for detecting volatile substances.
A comprehensive review of targeted therapies for lupus nephritis discusses the challenges of current treatments and proposes strategies to overcome obstacles. Recent advancements in B-cell targeting and alternative approaches such as CAR-T cells are highlighted.
Researchers discovered cytoplasmic retinoic acid receptors, such as RARalpha, are essential for T cell linking sensing at the cell surface with downstream signaling cascades and gene expression programs. The study sheds new light on TCR signaling and its connection to cancer treatment.
Researchers developed a novel strategy to engineer root nodule symbiosis in legumes and cereals using nanobodies. This approach, tested in barley and Lotus plants, initiates nodulation by bringing receptors together, revealing the core complex involved in symbiotic signaling.
The UNC School of Medicine lab, led by Bryan L. Roth, MD, PhD, solved the high-resolution structures of drug-like compounds bound to designer brain cell receptors, paving the way for more effective therapeutics for neuropsychiatric illnesses.
A recent study led by Eliza Loo found that plant immune receptors and signaling components confer salt tolerance even in plants challenged by non-pathogenic microbes. This suggests that plants can sense and initiate adaptive responses to abiotic stresses upon detecting alterations in cues presented by plant-inhabiting microbes.
Researchers captured first image of antigen-bound T-cell receptor complex with bound antigen at atomic resolution. The study reveals no significant structural changes in the receptor after antigen binding, sparking further investigation into the signaling pathway activation mechanism.
A recent study at Tokyo Institute of Technology reveals that dopamine regulates insulin secretion through a complex of receptors, specifically D1 and D2. The discovery offers new insights into the mechanism behind this regulation and has potential therapeutic targets for preventing, treating, and managing diabetes.
A research team discovered that an excessive number of thromboxane A2 receptors in blood vessel cells hinders the formation of new blood vessels, leading to vascular and cardiovascular diseases. The finding offers a promising biomarker for treatment and potential therapeutic benefits from blocking the receptor's action.
Researchers used complex computer simulations to study the attachment of SARS-CoV-2 and its variants to human cells. They found that the virus has two main locations where it grabs onto the host cell receptor ACE2, with early strains having a slippery interaction at one region that becomes less slippery as variants evolve.
UT Southwestern researchers report the first structural confirmation that endogenous molecules can trigger innate immunity in mammals through the TLR4?MD-2 receptor complex. The discovery has wide-ranging implications for treating and preventing autoimmune diseases such as multiple sclerosis.
The study found that phospholipid PtdIns4P and cholesterol play a critical role in G-protein coupling and ligand recognition, stabilizing the receptor's basal activity. Water molecules also mimic polar functionalities of serotonin, sustaining basal activity.
Researchers have uncovered how plant immune receptors convert from inactive to active complexes that break down NAD+, initiating defense signaling. The study found that a tetramer composed of four receptor molecules creates a unique surface necessary for NAD+ cleavage, a critical step in plant immunity.
A new study shows that blocking the neonatal crystallizable fragment receptor (FcRn) can reduce levels of immunoglobulin G (IgG) and IgG immune complexes, potentially treating autoimmune diseases. The therapy, SYNT001, was well-tolerated in a Phase 1 clinical study.
Daily injections of patient autoantibodies in mice with injured paws led to increased pain sensitivity and microglial activation in brain regions. Blocking interleukin-1 receptors prevented or reversed these effects, suggesting an autoimmune contribution to CRPS development.
Researchers at Vanderbilt University have characterized a complex receptor type that activates hunger suppression when activated. The discovery provides a crucial milestone in developing small-molecule therapeutics to treat obesity.
Research reveals that estrogen hormones regulate gene expression through a multi-step process involving sequential recruitment of coactivators. The study, published in Molecular Cell, shows that the addition of specific coactivator CARM1 guides subsequent steps leading to gene activation.
A multidisciplinary team at VCU School of Medicine has developed a metric to determine the effectiveness of antipsychotic drugs and advance drug design. The study found that the connection between two brain receptors is critical to how these anti-psychotics work, particularly in signaling through this receptor complex.
Researchers at UC San Diego School of Medicine have uncovered a new signaling mechanism used to activate protein kinases involved in the body's inflammatory response. Smac mimic compounds may serve as prototypes for new anti-inflammatory therapy, potentially offering an alternative to expensive current treatments.
A Japanese research group identified the PKD1L3-PKD2L1 channel complex as a key player in the sour taste sensation. This 'off-response' mechanism allows humans to detect sour flavors even after the removal of acidic stimuli.
Researchers at Temple University's Sbarro Institute have made progress in understanding how ER-α is silenced in certain breast cancer cell lines. The findings could lead to new treatments for hormone-receptor positive breast cancers.
Scientists capture real-time video-clips of signal transmission in living cells using Quantum Dots, revealing new insights into cellular processes. The breakthrough is expected to speed up the development of new cancer-curing drugs.
Researchers deciphered the structure of a key protein complex in the human immune system, consisting of an antibody and its receptor. This discovery opens new avenues for therapies in allergies, autoimmune diseases, and transplantation medicine, enabling a better understanding of how pathogens are recognized and removed by immune cells.
The structure of E. coli intimin-receptor complex shows how the bacterium attaches to intestinal cells, using a protein-protein complex with rigid arms and attaching hands. This finding could lead to new drug designs to thwart infection.
Scientists have deciphered the molecular structure of neurotransmitter release machinery, revealing how proteins SNAREs propel neurotransmitters into synapses. This breakthrough may lead to improved treatments for brain disorders and shed light on processes like learning and memory.
Research by Dr Lanzavecchia reveals that dendritic cells need inflammation to effectively stimulate an immune response. The study also shows that chemical messengers guide immune cells to the target site, enabling the development of new anti-allergy drugs and improved vaccine delivery.
A team of researchers at Northwestern University and the Mayo Clinic have identified two new proteins, Cyp-40 and p23, that act as molecular chaperones to fold proteins into an intermediate state. This discovery expands our understanding of what molecular chaperones are and their role in enhancing hormone sensitivity in cells.