Articles tagged with Synaptic Transmission
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Researchers developed a new tool to track changes in the synaptic proteome over time, correlating changes to synaptic dysregulation and synapse loss. The results suggest that toxic tau oligomers impact postsynaptic structures first, leading to a dynamic cascade of events that contribute to neurodegeneration.
Researchers found autophagy plays a major role in ensuring T stem cells undergo normal cell division. Boosting autophagy could enhance memory T cell generation and improve long-term immunity.
Research from Colorado State University sheds light on the regulation of chemical balance in the brain, focusing on GABA, a neurotransmitter that helps calm brain activity. The study provides insights into how neurons maintain effective communication with each other, even when GABA is produced far from synapses.
A team of researchers has captured the process of synaptic vesicle fusion with neurotransmitters, revealing a direct form of vesicle recruitment that enables neurons to send signals over longer periods. This breakthrough could lead to targeted therapies for synaptic disorders and improve our understanding of brain function.
Researchers discovered that pancreatic tumors form pseudosynapses, exploiting the body's nervous system to drive tumor growth. Calcium waves triggered by glutamate binding promote metastasis and cancer progression.
The Neuropixels Ultra probe overcomes technical challenges in recording individual cells across multiple brain regions. It detects twice as many brain cells and distinguishes specific subtypes, enabling scientists to decode and track brain cell performance related to visual stimuli.
A new photonic neural network developed in China achieves higher classification accuracy than digital models by using physical light transformations and multisynaptic optical paths. The system's design avoids errors introduced by translating software to hardware, marking a major step forward in optical AI hardware.
Researchers found that low-intensity rTMS can increase synaptic plasticity of cortical axons in mouse models of Alzheimer's disease, particularly in excitatory boutons. This suggests potential as a targeted treatment to improve quality of life for AD patients.
Scientists investigate whether living neurons can transport light through their axons, which would significantly change current models of the nervous system. If successful, it could have major implications for treating brain diseases and healing the brain.
Researchers at UMass Amherst have identified Hsc70 as a vital chaperone protein that ensures SNAP-25's proper functioning in neurotransmission. The study sheds new light on the underlying mechanics of neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers propose a new model for understanding how information is transmitted in the brain by describing a unique axon morphology that changes size and modulates action potential speed
The study found decreased NMDA receptors in synapses and increased extrasynaptic membranes in Alzheimer's patients, suggesting neuronal toxicity-related activity. The novel protocol allows for precise analysis of these receptors in human postmortem brains, paving the way for new therapeutic approaches.
A team of researchers discovered a class of materials that mimic the behavior of axons by spontaneously amplifying electrical pulses. These materials can harness internal instabilities to create spiking behavior and amplify signals, potentially leading to more efficient computing and artificial intelligence.
Researchers uncover the importance of kainate receptors in enabling synaptic plasticity and transmission in the cerebellum. The study's findings have significant implications for understanding neurological disorders and developing new treatments.
Researchers characterize thalamic and cortical neurons responding to ocular surface stimulation, showing diverse multimodal response profiles. The study provides insights into how sensory stimulus information is integrated from the peripheral nervous system into the brain's cortical networks.
Research suggests that altered lipid signaling in brain cells contributes to mental disorders, with specific inhibitors showing promise in rebalancing this mechanism. The study found similar changes in both human patients and healthy relatives, as well as mice with genetic disorders, opening up new treatment opportunities.
A Mayo Clinic study found that microglia shield neurons from the aftereffects of anesthesia, enhancing and boosting neuronal activity to awaken the brain. This discovery could lead to new treatments for post-anesthesia delirium and hyperactivity.
A study by University of Alabama at Birmingham researchers discovered that protons are the primary signals transmitting tactile sensations from Merkel cells to nerves. Protons bind to ASIC receptors on nerve endings, triggering an influx of sodium ions that propagate action potentials up the nerve towards the brain.
Researchers at Buck Institute for Research on Aging propose an alternate strategy for reversing memory problems in Alzheimer's disease by targeting the KIBRA protein. The findings suggest that KIBRA can rescue mechanisms that promote synapse resilience, potentially leading to improved memory function.
Researchers create biphasic gel iontronics that mimic neural networks, enabling diverse ionic signal transmission. The system is capable of regulating cardiac electrical activity and converting electronic signals into bioionic signals.
Researchers identify Noelin proteins as crucial for supporting synapse function in the brain and retina, providing insight into processes like learning and memory. The study also highlights the development of blinding conditions like glaucoma.
Researchers at Helmholtz-Zentrum Dresden-Rossendorf have discovered a potential therapeutic approach for curing neurodegenerative diseases using magnetic fields. In vitro trials showed that damaged motor neurons can be restored by exposure to magnetic fields, leading to axonal transport and regeneration of mitochondria.
A study by Mayo Clinic researchers found that brain transmission speeds continue to increase into early adulthood, reaching a plateau around age 30-40. This may help clinicians offer therapies to treat disorders such as anxiety and depression that emerge during late adolescence and early adulthood.
Researchers found that enhancing NMDAR function via increased serine racemase expression improved attention and cognitive flexibility in middle-aged rats. Upregulating serine racemase in the medial prefrontal cortex also increased glutamatergic synaptic transmission, including NMDAR activity.
Scientists have developed a system called PhAST, which uses light-emitting enzymes and ion channels to transmit information between neurons. This method has shown promising results in restoring communication in defective circuits and modifying animal behavior.
A new UC Davis study has identified 194 significantly different genes in the brains of people with autism, with many linked to brain connectivity, immune response, and inflammation. The research also found age-dependent differences in genes related to synaptic function and cell loss.
Researchers have discovered a unique, fast synapse in the inner ear that processes signals faster than any other in the human body. This breakthrough could lead to improved treatments for vertigo and balance disorders affecting millions of Americans over 40.
Researchers found that deleting a copy of the Arid1b gene in specific brain cells decreased inhibitory signaling, leading to changes in synaptic properties and connectivity. The study suggests that this gene may be a key target for therapeutics in treating autism spectrum disorder.
Scientists at OHSU have identified synaptotagmin-3 (SYT3) as a crucial protein for replenishing neurotransmitters between neurons. This discovery sheds new light on the underlying causes of neurological disorders such as epilepsy and autism, and may lead to the development of gene therapies or pharmaceutical approaches targeting SYT3.
Researchers at Buck Institute discover that blood-brain barrier cells influence neuron function and can cause problems rather than just being protective. This finding opens up new avenues for therapies targeting neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers have developed a groundbreaking 'toolbox' to study receptor mobility in the brain, revealing its critical role in certain types of memory. The study used high-resolution imaging and manipulation techniques to observe receptor dynamics in intact brain tissue, providing new insights into the mechanisms controlling memory.
Neuroscientists have uncovered the step-by-step process of how calcium channels accumulate at active zones in neurons, a critical component of synaptic transmission. The study reveals that alpha2delta plays a key role in regulating Cac levels, and its function has important clinical effects on conditions such as epilepsy and nerve pain.
A recent study published in eLife has revealed that high levels of soluble tau protein impair signaling between neurons, leading to cognitive decline. The research suggests that targeting the binding site of dynamin, a protein that binds to microtubules, may rescue synaptic transmission and prevent memory impairment.
A team at the University of Tokyo discovered that syntaxin protein plays a vital role in storing memory in the nervous system, influencing the migratory behavior of nematodes. The study found that altering syntaxin can lead to reversed behavior, allowing worms to choose whether to approach or avoid salt concentrations.
A new study suggests that supplementing a diet with Ascidiacea, also known as sea squirts, reverses some main signs of aging in animal models. The researchers found that plasmalogens, vital to body processes, decrease with age and contribute to neurodegenerative diseases like Alzheimer's and Parkinson's.
Researchers from LMU have identified two RNA-binding proteins that regulate synaptic transmission in distinct ways, controlling mRNA levels and translation. These findings provide insight into the mechanisms of neurological disorders such as epilepsy and autism.
Researchers at MIT's Picower Institute discovered that SAP102 regulates synaptic AMPAR function differently than PSD-95, with distinct effects on current decay timing. This finding may contribute to the greater cognitive capacity of mammals and other vertebrates.
Researchers discover how tau prevents synaptic transmission in nerve cells, even before forming tangles, which disrupts brain cell function. This mechanism may pave the way for a treatment to prevent death of nerve cells.
A recent study published in Nature Neuroscience has made significant progress in understanding the role of proteins in synaptic transmission. The researchers identified two variations of a protein called Unc13 that work separately to regulate synaptic function, paving the way for new diagnostic and therapeutic approaches.
Researchers have uncovered a mechanism that helps repair damaged synapses, enabling optimal neuronal communication. This discovery highlights the importance of microautophagy in breaking down cellular debris and may lead to new treatments for neurodegenerative diseases like Alzheimer's.
Researchers used optogenetics to record synaptic transmissions from light-sensitive neurons to interneurons in the mouse barrel cortex. The study revealed cell-type-specific synaptic connectivity and transmission patterns, shedding new light on brain function.
Researchers at IST Austria found loose coupling between calcium channels and sensors in a specific synapse, challenging the view that it's a developmental phenomenon. This discovery has implications for synaptic plasticity and the function of neurotransmission.
A new biologically accurate model of background noise in the nervous system has been developed to explain how noise induces delays in neuron responses. The researchers found that modulating two factors can help neurons encode information more accurately.
Researchers discovered SynCAM plays a major role in synaptic formation, crucial for brain function and neural network development. The study provides insights into the process of synaptic transmission and its importance in neurological diseases such as Alzheimer's and Parkinson's.
OHSU researchers have successfully recorded individual nerve cell transmissions for the first time, revealing how synapses enable cells to communicate. The study provides new insights into the mechanisms of neural communication and has potential implications for understanding neurological and mental diseases.
Researchers found that the brain enhances pain signals through silent synapses, which can lead to persistent pain. Blocking these pathways may lead to better treatments for chronic pain.
Researchers found that R-type channels control transmitter release in presynaptic terminals, contributing to fine-tuning synaptic activity. These high-voltage-activated channels are resistant to known blockers and have been identified through simultaneous recordings of Ca2+ influx and EPSC evoked by a single action potential.
Researchers have discovered that NSF, a universal protein involved in cellular fusion and secretion, controls the speed of neurotransmitter release. Inhibiting NSF function delays transmitter release, providing new insights into the molecular mechanisms governing synaptic communication.