Researchers at NUS developed a new photodynamic therapy that selectively kills breast cancer cells without damaging surrounding tissues. The treatment uses a biocompatible silicone implant loaded with nanoparticles activated by near-infrared light, reducing the risk of toxicity and improving tumour control.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalACS Nano·TypeRandomized controlled/clinical trial·DateJul 19, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Research reveals NADPH's crucial role in accurate chromosome segregation and genomic integrity in aneuploid tumor cells. The study identifies potential targets for novel therapies by intervening in metabolic pathways, providing new biomarkers for selective inhibition of aneuploid tumors.
SourceUniversity of Science and Technology of China·JournalNature Metabolism·DateJul 15, 2023
A novel biomaterials-based approach enhances adoptive T cell therapy with cancer vaccine technology, providing strong and long-lasting effects against solid tumors. In mice carrying melanomas, SIVET enables fast tumor shrinking and long-term protection.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalNature Communications·TypeExperimental study·DateJul 13, 2023
Researchers at Tokyo Institute of Technology developed a novel boron agent that selectively accumulates in brain tumor cells, exhibits enhanced blood retention, and can be administered at low doses. The agent, PBC-IP, shows promising results in preclinical studies, highlighting its potential for radiotherapy in treating glioblastoma.
SourceTokyo Institute of Technology·JournalJournal of Controlled Release·TypeExperimental study·DateJul 13, 2023
Research suggests that glioblastoma cells possess large-scale coordination, allowing them to respond unison to therapies. Disrupting this organization may result in more powerful treatments for brain tumors.
SourceMichigan Medicine - University of Michigan·JournalScience Advances·TypeExperimental study·DateJun 28, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
The study investigates the effects of DPDT on human colon cancer HCT116 cells and non-tumorigenic MRC5 fibroblasts. The results show that DPDT preferentially targets HCT116 cells, inducing apoptosis and G2/M cell cycle arrest, likely through DNA topoisomerase I poisoning.
SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJun 26, 2023
Researchers at Aarhus University have discovered a new method to activate the complement system using bispecific single-domain antibodies, termed BiCEs. These molecules can specifically target cancer cells and activate the complement system, leading to the killing of targeted cancer cells.
SourceAarhus University·JournalThe Journal of Immunology·TypeExperimental study·DateJun 23, 2023
Researchers have developed a new approach to treating tumors using 'self-immolative' polyferrocenes that trigger a fatal cycle of oxidative stress in cancer cells. In experiments, these copolymers inhibited tumor growth with negligible side effects, offering potential for chemodynamic therapy.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateJun 21, 2023
Scientists from Institut Pasteur and Inserm discovered that CD4 T cells can remotely neutralize tumor cells by producing interferon gamma, offering new hopes for patients with incomplete responses to CAR T cell therapy. This study raises the possibility of personalized treatment approaches using larger quantities of CD4 CAR T cells.
SourceInstitut Pasteur·JournalNature Cancer·TypeImaging analysis·DateJun 12, 2023
GQ GMC-500Plus Geiger Counter
GQ GMC-500Plus Geiger Counter logs beta, gamma, and X-ray levels for environmental monitoring, training labs, and safety demonstrations.
A team of researchers found that a hydrogen sulfide donor adjuvant can disrupt mitochondrial respiration, suppressing heat shock protein production and making tumor cells more sensitive to photothermal therapy. This approach led to the eradication of tumors in laboratory mice with breast tumors within just a few days.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateMay 26, 2023
Researchers discovered that melanoma skin cancer cells adopt an efficient style of movement called rounded-amoeboid migration, which requires less energy than traditional cell movement. This process involves reshaping mitochondria to operate in a low-power mode, allowing cells to survive in stressful environments.
SourceQueen Mary University of London·JournalNature Communications·TypeExperimental study·DateMay 25, 2023
A research team at Göttingen University has discovered that mobile and stationary cells have different mechanical properties due to their cytoskeleton. The study found that intermediate filaments, which are crucial for cell stability, exhibit metal-like plasticity when stretched, similar to non-biological materials.
SourceUniversity of Göttingen·JournalMatter·TypeObservational study·DateMay 22, 2023
Researchers discovered that FDA-approved HDAC-inhibitors can impact energy metabolism in solid tumor cells, including glioblastoma. The combination of HDAC-inhibitors and imipridones may synergize to enhance killing of GBM cells by reversing cellular respiration.
SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateMay 19, 2023
Apple AirPods Pro (2nd Generation, USB-C)
Apple AirPods Pro (2nd Generation, USB-C) provide clear calls and strong noise reduction for interviews, conferences, and noisy field environments.
Researchers from China explore the mechanisms of action and clinical data of bispecific antibodies, which have shown promise in increasing cytotoxicity against cancerous cells and enhancing immune response towards tumor clearance. Several bsAbs are being evaluated in phase I-III clinical trials for lung cancer treatment.
SourceCactus Communications·JournalChinese Medical Journal·DateMay 16, 2023
Research reveals that brain tumor cells communicate with astrocytes through microtubes, transferring mitochondria to enhance growth. This connection increases treatment resistance and tumorigenicity in glioblastoma tumors.
SourceThe University of Bergen·JournalNature·DateMay 11, 2023
A team of researchers is exploring the potential of HDAC inhibitors to treat sickle cell disease by reactivating the fetal hemoglobin gene. Early evidence suggests that panobinostat, a specific inhibitor, can increase fetal hemoglobin levels in red blood cells and mouse models.
SourceMedical College of Georgia at Augusta University·DateMay 11, 2023
A clinical trial of 406 patients found that a fluorescent agent allowed surgeons to identify and remove residual tumor tissue with favorable results. The technique showed promising results in detecting tumor tissue missed by standard lumpectomy procedures, potentially avoiding second surgeries for positive margins.
SourceMass General Brigham·JournalNEJM Evidence·TypeRandomized controlled/clinical trial·DateMay 3, 2023
Celestron NexStar 8SE Computerized Telescope
Celestron NexStar 8SE Computerized Telescope combines portable Schmidt-Cassegrain optics with GoTo pointing for outreach nights and field campaigns.
Researchers developed glass filters to capture tumor cells from blood samples, enabling more efficient culture of these cells. The optimized filter design enhances the accuracy of cancer detection, allowing for earlier treatment and improved patient health.
SourceNagoya University·JournalScientific Reports·DateMay 2, 2023
A novel cell signaling pathway has been identified that could be targeted to treat aggressive pancreatic cancers. The High Mobility Group A1 (HMGA1) protein functions as a 'molecular switch' that activates genes required for tumor growth and invasion. Silencing HMGA1 or disrupting FGF19 signals in mouse models resulted in decreased tum...
SourceJohns Hopkins Medicine·JournalJournal of Clinical Investigation·DateApr 24, 2023
A study of 5,000 patients with breast cancer found that women from disadvantaged neighborhoods had shorter breast cancer-specific survival rates compared to those from advantaged areas. The findings suggest potential unaccounted mechanisms, including social determinants of health and access to care.
SourceJAMA Network·JournalJAMA Network Open·DateApr 21, 2023
DJI Air 3 (RC-N2)
DJI Air 3 (RC-N2) captures 4K mapping passes and environmental surveys with dual cameras, long flight time, and omnidirectional obstacle sensing.
Tumors with low PD-L1 levels use genetic strategies like MYC activation to avoid immune attack, but this can be predicted by monitoring for MYC status. The study's findings could lead to new clinical trials assessing MYC status as a marker for selecting patients for immunotherapy.
SourceJosep Carreras Leukaemia Research Institute·JournalCell Reports Medicine·TypeExperimental study·DateApr 14, 2023
Scientists discovered that deleting a protein called sphingosine kinase 2 (SphK2) reprograms the tumor microenvironment, decreasing S1P levels and increasing p53 tumor suppressor gene accumulation. This creates an inhospitable environment for aggressive breast tumors.
SourceVirginia Commonwealth University·JournalCancer Research·TypeExperimental study·DateApr 12, 2023
A new nuclear medicine therapy has been shown to cure human non-Hodgkin lymphoma in an animal model, achieving a median survival of over 221 days. The treatment, [177Lu]Lu-ofatumumab, was found to quickly eliminate tumor cells and showed favorable in vitro characteristics.
SourceSociety of Nuclear Medicine and Molecular Imaging·JournalJournal of Nuclear Medicine·DateApr 11, 2023
Apple iPad Pro 11-inch (M4)
Apple iPad Pro 11-inch (M4) runs demanding GIS, imaging, and annotation workflows on the go for surveys, briefings, and lab notebooks.
Researchers develop mechanical nanosurgery to destroy tumour cells from within, reducing GBM tumour size universally, including in TMZ-resistant cases. The treatment uses magnetically controlled carbon nanotubes to provide mechanical stimulation, damaging cellular structures and causing tumour cell death.
SourceThe Hospital for Sick Children·JournalScience Advances·DateApr 11, 2023
Researchers propose conjugating a cell-penetrating peptide to oxaliplatin to overcome chemotherapy resistance in colorectal cancer. The new approach reduces platinum accumulation in tumour microenvironment and healthy tissues.
SourceIMIM (Hospital del Mar Medical Research Institute)·JournalJournal of Medicinal Chemistry·DateMar 30, 2023
Researchers found that neutrophils activated by T cell-based immunotherapy can kill tumor cells that evade targeted therapies. This unexpected antitumor response could lead to new immunotherapies that harness this potent immune mechanism.
Rigol DP832 Triple-Output Bench Power Supply
Rigol DP832 Triple-Output Bench Power Supply powers sensors, microcontrollers, and test circuits with programmable rails and stable outputs.
Research at IRB Barcelona reveals CPEB4's essential role in T lymphocytes' adaptation to chronic cellular stress. By overcoming this stress, these cells can exert their antitumour function and halt tumour growth.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalThe EMBO Journal·TypeExperimental study·DateMar 28, 2023
A new technique combines machine learning with short-wave infrared fluorescence imaging to detect precise tumor boundaries with higher accuracy than traditional methods. The approach achieved a remarkable per-pixel classification accuracy of 97.5 percent and demonstrated robustness against changes in imaging conditions.
SourceSPIE--International Society for Optics and Photonics·JournalJournal of Biomedical Optics·TypeExperimental study·DateMar 27, 2023
Researchers created a three-dimensional structure that mimics bone and houses osteosarcoma cells beside immune cells, finding increased inflammation reduces chemotherapy effectiveness. The study highlights the importance of the tumor microenvironment in disease progression and treatment.
SourceRice University·JournalBiomaterials·TypeExperimental study·DateMar 20, 2023
A team of researchers has discovered a simple way to deliver cancer therapeutics to tumor cells by fluidizing the cell membrane using lipid nanoparticles containing EDTA. The mechanism is independent of metal chelation properties and involves changing the characteristics of the cell membrane to promote nanoparticle uptake.
SourceWiley·JournalAngewandte Chemie International Edition·TypeExperimental study·DateMar 16, 2023
A study found that Spp24 inhibits osteosarcoma tumor cell proliferation, invasiveness, and promotes apoptosis. It achieves this by neutralizing bone morphogenetic protein 2.
SourceWiley·JournalJournal of Orthopaedic Research®·DateMar 8, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Tumour cells exhibit an innate randomness in their ability to respond to chemotherapy, which can lead to resistance. Researchers identified a marker for resistance and propose combining chemotherapy with drugs targeting this 'noise' to improve treatment outcomes.
SourceGarvan Institute of Medical Research·JournalScience Advances·TypeExperimental study·DateMar 3, 2023
Researchers developed a new device that detects and analyzes cancer cells in blood samples, enabling doctors to avoid invasive biopsies and monitor treatment progress. The Static Droplet Microfluidic device uses metabolic signatures to differentiate tumour cells from normal blood cells.
SourceUniversity of Technology Sydney·JournalBiosensors and Bioelectronics·TypeExperimental study·DateFeb 27, 2023
Researchers at Karolinska Institutet have developed a new type of CAR T-cell therapy that effectively attacks and destroys ovarian cancer cells, significantly prolonging the lives of mice with the disease. The treatment has shown promising results in reducing tumor size and curing several mice.
SourceKarolinska Institutet·JournalJournal for ImmunoTherapy of Cancer·TypeRandomized controlled/clinical trial·DateFeb 6, 2023
Creality K1 Max 3D Printer
Creality K1 Max 3D Printer rapidly prototypes brackets, adapters, and fixtures for instruments and classroom demonstrations at large build volume.
Researchers have discovered that inhibiting conventional signalling pathway by disrupting LCK allows more efficient tumour cell killing, using FYN protein instead. This approach enhances T-cell function and reduces graft-versus-host disease, making CAR-T therapy more accessible to patients.
SourceNational University of Singapore, Yong Loo Lin School of Medicine·JournalCell Reports Medicine·TypeData/statistical analysis·DateFeb 2, 2023
Researchers developed a cancer-selective therapeutic agent that targets cancer cells' unique acidic pH microenvironment, inducing mitochondrial dysfunction and killing only cancer cells. The agent, Mito-SA, forms charge-shielded nano-assemblies that selectively disassemble in the tumoral environment.
SourceUlsan National Institute of Science and Technology(UNIST)·JournalAdvanced Functional Materials·DateJan 26, 2023
Researchers analyzed tumor microenvironment of pancreatic cancer, revealing two major defects that inhibit immune response. The study suggests a new approach using anti-CD137 agonist antibody treatment in combination with anti-PD-1 immunotherapy to activate T cells.
SourceJohns Hopkins Medicine·JournalCancer Cell·DateJan 26, 2023
Researchers discover that tumour tracks, formed by transformed blood vessels, trap immune cells and promote healing processes. The tension of extracellular matrix fibers plays a key role in tumour development, allowing cancer cells to grow undisturbed.
A new method utilizes an unnatural sugar to anchor cytokines to T cells, enhancing their functions without systemic side-effects. The approach has shown promise in stimulating the host immune system against tumor cells and inhibiting tumor growth in mice with melanoma.
SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 10, 2023
Sky-Watcher EQ6-R Pro Equatorial Mount
Sky-Watcher EQ6-R Pro Equatorial Mount provides precise tracking capacity for deep-sky imaging rigs during long astrophotography sessions.
Researchers at Brigham and Women's Hospital have developed a dual-action cell therapy approach to eliminate established tumors and induce long-term immunity. The vaccine, engineered using CRISPR-Cas9, is designed to kill tumor cells and stimulate the immune system to destroy primary tumors and prevent cancer recurrence.
SourceBrigham and Women's Hospital·JournalScience Translational Medicine·DateJan 4, 2023
Researchers tracked 392 patients with diffuse low-grade glioma over 20 years and found that aggressive surgical removal offered a distinct survival advantage. Smaller tumor sizes were associated with longer survival times, highlighting the importance of early intervention.
SourceUniversity of California - San Francisco·JournalJournal of Clinical Oncology·DateJan 4, 2023
Researchers have made a breakthrough in precision oncology for patients with metastatic urothelial carcinoma, identifying that certain cell surface molecules decrease or are absent in these patients, making them resistant to the new drug enfortumab vedotin.
SourceUniversitatsklinikum Bonn·JournalClinical Cancer Research·DateDec 30, 2022
Researchers at Tulane University discovered that breast cancer cells use complex immune-modulatory programs to evade immune clearance, leading to treatment resistance. They identified 16 immune checkpoint genes and found that chemotherapy triggers a program of immune checkpoints that shield cancer cells from different lines of attack.
SourceTulane University·JournalNature Cancer·DateDec 15, 2022
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
The TIL trial has demonstrated that cell therapy using patient's own immune cells is an extremely powerful immunotherapy for metastatic melanoma, with significant shrinkage of metastases in half of patients. Progression-free survival after six months was 53%, significantly better than standard immunotherapy with ipilimumab.
SourceNetherlands Cancer Institute·JournalNew England Journal of Medicine·TypeRandomized controlled/clinical trial·DateDec 7, 2022
Researchers found that tumor cells directly interact with blood vessel cells, altering their normal clockwise orientation to a counterclockwise position. This interaction may play a role in cancer metastasis and could be targeted for prevention and treatment.
SourceAmerican Institute of Physics·JournalAPL Bioengineering·DateDec 6, 2022
Comprehensive metabolic changes convert mature liver cells into immature progenitor cells that proliferate rapidly and develop tumors. The main causes of liver cancer are metabolic disorders and infections with hepatitis C virus and high alcohol consumption.
SourceUniversity of Basel·JournalMolecular Cell·DateNov 21, 2022
Kevin McHugh, a Rice bioengineer, has received the Distinguished Scientist Award from The Sontag Foundation for his work on gene editing to defeat glioblastoma multiforme. His approach involves delivering gene therapy agents directly to tumor cells, aiming to improve survival and reduce side effects.
A new study reveals that the protein fragile X mental retardation protein (FMRP) plays a crucial role in helping tumors evade immune destruction, leading to treatment resistance. FMRP regulates a network of genes and cells in the tumor microenvironment, contributing to its ability to hide from immune cells.
SourceEcole Polytechnique Fédérale de Lausanne·JournalScience·DateNov 17, 2022
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
Researchers at Goethe University Frankfurt found that dying colon cancer cells release ATP to neighboring tumor cells, activating a survival signaling pathway. Interrupting this communication can significantly increase the effectiveness of chemotherapy against resistant tumors.
SourceGoethe University Frankfurt·JournalNature·TypeExperimental study·DateNov 17, 2022
Neuroblastoma tumour cells adapt to mimic embryonic cells, making them resistant to chemotherapy. This understanding can lead to targeted treatments that better reach the entire tumour and avoid resistance development.
SourceLund University·JournalScience Advances·DateNov 11, 2022
Researchers have discovered that targeting a specific mutation in fibrolamellar tumors can reduce tumor growth in mice, offering a promising approach to treating this nearly incurable cancer. The findings highlight the potential for novel therapies against an intractable disease.
SourceRockefeller University·JournalClinical Cancer Research·DateNov 10, 2022
Researchers at IRB Barcelona have identified the tiny fraction of tumour cells that remain hidden after surgery, leading to metastatic recurrence. These 'High Relapse Cells' can be eliminated through genetic techniques, preventing metastases and opening the possibility for new therapeutic strategies.
SourceInstitute for Research in Biomedicine (IRB Barcelona)·JournalNature·DateNov 9, 2022
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers have discovered two novel drugs that can block the growth and shrink the size of schwannoma tumors, a type of nerve sheath tumor found in the nervous system. The treatment works by inhibiting the Hippo signaling pathway, which is dysregulated in multiple types of cancer.
SourceUniversity of Plymouth·JournalBrain·TypeExperimental study·DateNov 8, 2022
Researchers used DNA barcoding to track breast cancer cells over time, finding that some cells can suppress killer T-cells and reduce MHC1 expression to evade the immune system. This study suggests epigenetic mechanisms may play a role in cancer cell adaptation and provides potential targets for therapies.
SourceGarvan Institute of Medical Research·JournalNature Communications·TypeExperimental study·DateNov 7, 2022
Researchers at VCU Massey Cancer Center have found strong evidence for testing a novel drug in liver cancer treatment. MDA-9 inhibition may be an effective approach for hepatocellular carcinoma (HCC), with potential synergies with other therapeutics.
SourceVirginia Commonwealth University·JournalHepatology·DateNov 3, 2022
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
A new method of modifying our immune system has been demonstrated in a study published in Advanced Science, which could help treat skin cancer.
SourceUniversity of Bristol·JournalAdvanced Science·TypeExperimental study·DateOct 31, 2022
Researchers at the University of Seville have discovered a method to attack cancer cells using an origin-of-life molecule. The study found that inhibiting RNA production boosts the utility of radiation therapy in cancer cells, offering a promising approach to treating various types of cancer.
SourceUniversity of Seville·JournalNature Communications·TypeNews article·DateOct 28, 2022
Filopodia contribute to building a barrier surrounding breast tumours, blocking their escape. Cancer cells lacking Myosin-10 cannot maintain this barrier, making it easier for them to spread.
SourceUniversity of Turku·JournalDevelopmental Cell·DateOct 28, 2022
A new study suggests that chlorhexidine gluconate (CHG) is the most effective irrigation solution for killing bone tumor cells after surgery. CHG shows highest cytotoxicity against chondrosarcoma and giant cell tumors, potentially making it a useful chemical adjuvant during intralesional curettage.
SourceWolters Kluwer Health·JournalJournal of Bone and Joint Surgery·DateOct 28, 2022
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
Researchers at UNIGE have discovered a way to overcome resistance to chemotherapy in colorectal cancer, using an optimized combination of tyrosine kinase inhibitors. This breakthrough opens up new avenues for developing targeted therapies that can effectively treat patients with low five-year survival rates.
SourceUniversité de Genève·JournalCancers·TypeNews article·DateOct 27, 2022