Articles tagged with Gene Targeting
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at the University of Virginia Health System discovered that improper calcium signaling in mitochondria accelerates chronic inflammation, leading to age-related conditions. Increasing calcium uptake in macrophages may help prevent harmful inflammation and its effects on the brain.
Metalenses have been developed with differentiated design principles to eliminate chromatic aberration. By merging bright spots into a single focusing spot, researchers achieved an efficiency of up to 43% and demonstrated the versatility of their approach for various optical applications.
Researchers developed a tailored approach to weight loss and cardiometabolic risk factors, showing significant improvement in targeted areas like abnormal fullness and emotional eating. The study suggests the need for an actionable, phenotype-based classification of patients in obesity treatment, moving beyond reliance on scales or bod...
Researchers at MIT have developed a novel sensor that can detect immune molecule CXCL12, which plays a crucial role in several human diseases including cancer. The device uses receptor proteins found in cell membranes, making it a potential tool for early screening of hard-to-diagnose cancers.
Researchers have proposed an innovative solution to address limitations of lidar technology, enabling imaging in low SNR environments. The novel technique uses a high-scanning speed AOD and metasurface-enhanced scanning lidar, extending ambiguity range by up to 35 times.
The latest Alzheimer's drug, donanemab, has shown encouraging results in slowing cognitive decline by 35% compared to placebo in patients with low-to-intermediate levels of tau. However, its effectiveness is limited for those with more advanced disease, and risks include serious side effects such as amyloid-related imaging abnormalities.
A new study published in Circulation journal found that Black adults living in areas historically affected by discriminatory housing practices had a higher heart failure risk. The analysis included over 2.3 million adults from 2014-2019 and mapped historical redlining maps onto modern day maps of US zip codes.
Researchers have made groundbreaking progress in confining light to subnanometer scales using a novel waveguiding scheme. The approach generates an astonishingly efficient and confined optical field with applications in light-matter interactions, super-resolution nanoscopy, and ultrasensitive detection.
Researchers discover the key to modulating immune reactions by fine-tuning antibodies. The backbone of Y-shaped immunoglobulins plays a crucial role, with posttranslational modifications controlling the strength of the reaction.
Researchers have identified a new trichothecene, NX, produced by Fusarium graminearum, which contributes to the pathogen's ability to infect wheat and spread disease. Deleting the gene responsible for NX production reduces toxin levels and disease severity, providing potential control methods.
Researchers at Mass General Cancer Center treated 16 patients with a BRAF/MEK inhibitor, resulting in a 91% reduction in tumor size and complete response in all patients who received one or more cycles of therapy. The treatment showed unprecedented success in targeting brain tumors using precision medicine approaches.
Mass General Cancer Center researchers have pinpointed the APOBEC3A protein as a primary driver of drug resistance in non-small-cell lung cancer. The study reveals that this protein causes mutations and accelerates tumor growth, making it a promising target for new therapies.
A new study by Yale University reveals that combining pembrolizumab with other treatments reduces tumor size and improves response rates for patients with advanced NSCLC. The treatment regimens resulted in higher survival outcomes, particularly in patients with specific biomarker-defined subgroups.
Researchers at UCLA Jonsson Comprehensive Cancer Center confirmed genetic variants of unknown significance are verified mutations that increase the risk of kidney cancer. The findings could lead to new treatment options for people with hereditary leiomyomatosis and renal cell cancer (HLRCC).
A recent study led by Dr. Itamar Harel reveals that manipulating AMP biosynthesis can extend lifespan and promote metabolic health in vertebrates. The research used the turquoise killifish as a model organism and found remarkable effects on energy metabolism, including a fasting-like profile and enhanced resistance to high-fat diets.
Prof. Dr. Marta Litter takes over as Editor-In-Chief of Journal of Photocatalysis, bringing her extensive expertise and experience to lead the journal into a new era of excellence. Her research on heterogeneous photocatalysis and iron-based nanomaterials has led to over 250 scientific publications.
Professor Coppedè's appointment aims to enhance the journal's focus on cutting-edge genomics research, covering topics like genome sequencing and functional genomics. He will lead Current Genomics to greater success by staying at the forefront of genomics discoveries and advancements.
Researchers at St. Jude Children's Research Hospital created a more accurate hepatoblastoma model to improve therapies, focusing on DNA damage repair pathways. The model identified potential targets and validated the effectiveness of PRKDC inhibition when combined with doxorubicin, enhancing treatment efficacy.
A team from the University of Ottawa has developed a comprehensive screening platform and cellular interrogation tool to facilitate novel drug discovery targeting various human diseases. The 'Tango-Trio' platform can identify small molecule modulators for orphan GPCRs, which have significant untapped therapeutic potential.
Researchers have developed a vaccine that enhances the response of engineered T cells and stimulates the immune system to generate new T cells targeting other tumor antigens. This approach increases the likelihood of tumor eradication in solid tumors like glioblastoma, with a success rate of up to 80% in mice.
Researchers have implemented Orbital Angular Momentum (OAM) as an independent information carrier for optical holography, leading to OAM multiplexed holography. The new design approach, MHC-OAM, uses spatial light modulators to achieve multiramp helical conical beams with different parameters serving as information encryption or decryp...
Researchers use base editing technology to restart fetal hemoglobin expression in SCD patient cells, achieving higher and more stable levels than other genome editing technologies. The approach has potential as a 'one-size-fits-all' treatment for all mutations that cause SCD and beta-thalassemia.
Scientists at Tokyo Institute of Technology identified ApSigma, a nuclear-encoded apicoplast RNA polymerase σ subunit that coordinates gene expression with the life cycle of Plasmodium falciparum and host circadian rhythm. Melatonin is shown to increase apicoplast transcription and expression of the apSig gene.
Inflammatory breast cancer is a rare and aggressive form of breast cancer with poor outcomes. Research highlights the role of ERβ as a mediator of estrogen signaling, demonstrating its tumor suppressive effects in preclinical models. ERβ's antimetastatic activity may hold promise for improving treatment options for IBC.
A recent study confirmed which genes in the HiVir cluster are essential and which contribute partially to the disease. The toxin produced by Pantoea ananatis has broad-spectrum activity, potentially targeting conserved functions within plants.
A Mayo Clinic study reveals that minimally invasive surgical procedure staging laparoscopy can identify cancer spread early and determine the stage of pancreatic cancer. The research found a higher risk of cancer spread in patients with certain factors, such as age and tumor markers.
Researchers investigate MCL-1i-induced Mcl-1 protein accumulation and its implications in B-cell malignancies. The study reveals a complex mechanism contributing to MCL-1 protein stability upon treatment with MCL-1 inhibitors.
Researchers developed a biodegradable nanoparticle that reaches dendritic cells in mice with melanoma and colon cancer, activating an immune response. The nanoparticle improves survival rates for these cancers, with half of mice surviving long-term after treatment.
A third of under-fives attending Paediatric Emergency Departments have unmet vaccination need, with tetanus and MMR vaccination coverage levels below target. Researchers call for catch-up campaigns to reach this vulnerable group.
Researchers at Aarhus University have discovered a new method to activate the complement system using bispecific single-domain antibodies, termed BiCEs. These molecules can specifically target cancer cells and activate the complement system, leading to the killing of targeted cancer cells.
The study found that drug-resistant Leishmania parasites have distinct protein production profiles compared to sensitive parasites, suggesting a global reprogramming of protein synthesis. This pre-emptive adaptation enables the parasite to quickly respond to the presence of the drug and survive when it is absent.
Researchers have identified anti-malarial properties in cancer drugs, offering a potential solution to the growing crisis of drug-resistant malaria. The study found that certain protein kinase inhibitors exhibited strong anti-malarial effects, highlighting a new approach to accelerating drug discovery.
Researchers developed Precious1GPT, a multimodal transformer-based approach for aging clock development and feature importance analysis. The model utilizes methylation and transcriptomic data to predict biological age and identify disease-related genes, providing a pathway for therapeutic drug discovery.
A new analysis found that expanding Medicaid eligibility to more people improved patient outcomes, prevention measures, and screening access. The study suggests that increasing health insurance coverage results in better health outcomes for those with heart disease.
A team of scientists has identified a key player in the coupling between early transcription termination and RNA degradation. The ARS2 protein recruits ZC3H4, which interacts with the NEXT complex to target nascent transcripts for degradation.
Researchers at City of Hope have developed a universal donor stem cell therapy that can treat degenerative brain diseases such as Canavan disease and Alzheimer's. The therapy, which uses an 'off-the-shelf' approach, has shown promising results in preclinical studies, reducing toxic accumulation of metabolites and improving motor function.
Researchers at Washington University School of Medicine developed a catalog to classify protein variants associated with limb girdle muscular dystrophy. The approach enables doctors to determine the pathogenicity of variants, leading to more precise diagnoses and potential therapies.
Researchers are investigating methods to extract critical materials, including lithium for electric vehicle batteries and magnets for electric motors, from diverse water streams. By accelerating evaporation through porous photothermal materials, they aim to reduce energy intensity and improve supply chain security.
Researchers developed CrossDome, a tool that uses genetic and biochemical information to predict T-cell immunotherapy's impact on healthy cells. The tool identified high-risk candidates in cases where treatments mistakenly attacked heart cells.
A new review paper suggests ACSL4 status as a biomarker for breast cancer subtype classification and predictor of response to hormone-based therapies. The enzyme may also serve as a target for developing new treatment modalities in quadruple negative breast cancer.
Researchers developed a new method, photoacoustic spectral analysis (PASA), to analyze the tumor microenvironment without invasive procedures. The technique uses laser light and sound waves to identify different types of tumors with high accuracy.
The FDA has issued a Biomarker Letter of Support for four novel biomarkers identifying drug-induced pancreatic injury. These microRNAs will enhance the detection of acute drug-induced pancreatic injury (DIPI) in phase 1 clinical trials, improving safety and accuracy.
A new study published in Aging-US has identified the p53-p16/RB-E2F-DREAM complex as a critical regulator of cellular senescence. The researchers found that this complex represses multiple target genes involved in cell cycle regulation, DNA repair, and chromatin structure, leading to the stability of the senescent arrest.
CHOP researchers have developed stable, universal MHC-I molecules that can be produced rapidly at scale, allowing for the development of effective and universal immunotherapies. These engineered MHC-I molecules promote peptide exchange across multiple HLA allotypes, covering various forms.
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.
Researchers developed a CRISPR/Cas9-based gene drive system targeting the Drosophila suzukii doublesex gene, resulting in female sterility and high transmission rates. Mathematical modeling predicts efficient population suppression with low release ratios.
Researchers developed a new spectropolarimetric imaging technique called DIP-SP, which integrates a passive polarization modulator into an imaging spectrometer. This approach enables high-dimensional information capture from incomplete measurements and significantly improves image quality.
The new scientific statement highlights the importance of identifying the root cause of pediatric cardiomyopathy to develop effective treatment strategies. Genetic testing is recommended for all children with cardiomyopathy, which may lead to financial and emotional cost savings.
A University of Ottawa team has discovered a vital role for the VGLUT3 transporter protein in modulating the development of Huntington's disease. The study shows that blocking glutamate release through this protein can lead to an amelioration of the disease progression, offering new hope for potential treatment approaches.
A new targeted therapy drug vorasidenib has been shown to extend treatment time without worsening glioma in people with IDH1 and IDH2 mutations. The study suggests a possible new treatment option for slow-growing but deadly brain tumors, delaying chemotherapy and radiation.
A team of researchers found that a small population of nerve cells exists in everyone that could be coaxed to regrow, potentially restoring sight and movement. The discovery provides new insights into how axons grow and could lead to effective therapies for blindness, paralysis, and other disorders caused by nerve damage.
Scientists at Tohoku University discovered a novel approach to enhance the efficacy of immune checkpoint blockade and minimize associated side effects. Targeting tumor-positive lymph nodes with ICIs generates a robust anti-tumor response against local and systemic metastases.
Alternative gene splicing has been linked to an increased risk of alcohol use disorder (AUD), according to a recent study published in Molecular Psychiatry. The researchers identified 27 exon skipping events that may contribute to AUD risk, opening up new possibilities for finding new therapeutics.
A recent study led by UCLA researchers has identified a potential new strategy for treating glioblastoma by targeting a specific metabolic process in cancer cells. The study found that disrupting this process could make glioblastoma cells more vulnerable to cell death, offering hope for new treatment options.
A team of researchers has identified TAK1 as a regulator of skeletal muscle mass, slowing down disease progression and improving muscle function in Duchenne muscular dystrophy. By targeting this protein, they can suppress muscle fiber death and enhance myofiber growth, offering a promising new approach to treatment.
A study found that expert mammogram radiologists exhibit visual hindsight bias, leading to improved performance on blurry images after prior clear images were viewed. This bias can impact the detection of lesions and has implications for negligence lawsuits and patient outcomes.
Scientists at Temple University have developed a novel gene-editing strategy that disrupts the ability of HIV-1 virus to enter host cells by targeting a rare genetic disorder. This approach may offer another target for developing next-generation CRISPR technology for HIV elimination, while avoiding adverse effects on cell mortality.
Researchers developed a computational platform called IRIS to discover tumor antigens from alternative RNA splicing, expanding cancer immunotherapy targets. Hundreds of predicted TCR targets were found to be presented by human leukocyte antigen molecules.
Researchers identified novel genetic associations between AD and modifiable risk factors, including high HDL cholesterol concentrations and systolic blood pressure. These findings may inspire new drug targets and improved prevention strategies for AD.
A new scientific statement co-authored by the American Heart Association recommends teaching CPR to school-aged children as early as age 4, with layers of skill-building throughout childhood. This approach aims to educate generations on responding to cardiac arrest and increasing survival rates globally.