Articles tagged with Gene Targeting
Researchers at VCU Massey Cancer Center found that simultaneous activation of Prdm16 and Smad4 proteins slows down pancreatic cancer progression. The study suggests a novel therapeutic approach to tackle this deadly disease.
Gene therapy using CRISPR-Cas9 lipid nanoparticles has been shown to be highly effective in reducing target protein expression in mice. The new delivery system increases the efficiency of in vivo gene therapy, paving the way for safe and effective treatment.
Researchers identify duplicated gene as cause of social deficits and seizures in autism type, finding that reducing PRRT2 levels can restore normal brain activity and behavior. This discovery could lead to novel therapies for neurodevelopmental disorders with brain over-activation.
Researchers found that severe herpesvirus infections can strongly activate host cellular immunity, leading to a therapeutic effect on refractory adult T-cell leukemia/lymphoma. This activation may play an important role in the survival of patients with this intractable disease.
Direct incorporation of a metasurface in a laser cavity enables spatiotemporally modulated laser pulses. Giant nonlinear saturable absorption allows pulsed laser generation via Q-switching process.
A single gene controls a switch between two alternative cell fates in a species of sea anemone, enabling the transition from a piercing cell to a sticky cell. This finding suggests that the nematocyte cell may have evolved from a spirocyte thanks to the development of the NvSox2 gene.
Researchers created adaptive optical phantoms by combining multiple pigments to mimic target tissue's optical properties, successfully validating them in extensive experiments. The new platform enables broader band spectra for emerging hybrid modalities and novel instruments.
Researchers used AgRenSeq genomic discovery method to identify two genes protecting experimental wheat plants against wheat blast. The study highlights the power of heritage wheat varieties and wild grass relatives in providing disease-fighting diversity.
A team of researchers from the University of Minnesota Medical School identified approximately 100 genes associated with fat deposition in women. One gene, SNX10, was found to be strongly associated with cholesterol and triglycerides, which has implications for cardiovascular health.
Researchers employed computer vision to extract social behaviors and linked them to brain synchronization patterns in a novel approach. During cooperative play, brain synchronization was strongest when participants shared gaze, while individual play showed increased within-brain synchronization.
Researchers at CU Cancer Center have discovered a way to activate the p53 tumor suppressor gene, which can kill cancer cells. By inhibiting two repressors of p53, the Integrated Stress Response is activated, leading to cancer cell death in multiple cancer types.
Scientists have discovered that wrinkles in the cellular nucleus may be involved in common metabolic diseases such as diabetes and fatty liver disease. The new findings suggest that targeting these wrinkles could lead to novel treatments for non-alcoholic fatty liver disease, which affects 40% of people over age 70.
A new study found that high physical activity does not offset obesity risk among preteens with high screen time, highlighting the importance of limiting screen time. Parents are advised to encourage physical activities, such as sports and outdoor play, to help combat childhood obesity.
Researchers from Nanjing University have proposed the first scheme to practically generate N-photon states deterministically using a lithium-niobate-on-insulator platform. The scheme involves deterministic parametric down-conversion and demonstrates feasibility for generating multiphoton qubit states.
The NCI is funding a $587,000 research grant to improve KRAS treatment resistance in pancreatic cancer. Dr. Andrew Waters aims to develop personalized medicine approaches by studying unique resistance mechanisms.
Researchers evaluate an integrated NGS system, delivering accurate diagnoses in under 24 hours and expanding targeted treatments available to patients with myeloid neoplasms. The assay identified 80-92% of genetic variants, demonstrating promising results for accelerating precision therapies.
Researchers found that patients treated with butylphthalide experienced milder neurological symptoms and better functioning at three months after a stroke compared to those who received a placebo. The study suggests potential benefits of this celery seed-derived medication in treating ischemic strokes.
A £5.4 million project, backed by Innovate UK, aims to develop a new value chain to convert industrial waste gases into sustainable materials for consumer products. The consortium, including Unilever and BASF, will seek to demonstrate how the UK can cut 15-20 million tonnes of carbon dioxide emissions per year.
Researchers developed an AI algorithm to predict prime editing efficiency and accuracy, enabling faster and more precise genome editing. By analyzing a large data set of over 100,000 pegRNAs, the tool identifies key properties influencing prime editing success.
Researchers from Purdue University have received funding from the Trask Innovation Fund to develop and test their innovations. The awards will support projects in various fields, including plant phenotyping, genome editing, and radiative cooling paints, aiming to enhance commercial value and industry applications.
A study found white-tailed deer are harboring SARS-CoV-2 variants that were once widely circulated but no longer found in humans. The deer may have become infected through contact with humans, and the virus has adapted to the deer population, potentially making it more transmissible between them.
Researchers found that clearance of p16Ink4a-positive cells did not impact β-cell mass, but improved β-cell function and proliferative capacity in a subset of HFD mice. The targeted subpopulation of β-cells is non-proliferative and non-SASP producing.
Researchers found that seminal fluid protein sex peptide alters the female fly's behavior by changing the expression of genes involved in metabolism and the circadian clock. Post-mating, sex peptide increases egg-laying, aggression, activity and feeding while reducing sleep and interest in mating.
Scientists have identified horizontally transferred genes in insect genomes as valid targets for selectively killing green peach aphids and whiteflies. Silencing these genes using RNA interference reduces pest survival by up to 40%, with potential expansion to other insects through 'stacking' multiple targets.
A diabetes screening program in an urban emergency department found high rates of undiagnosed prediabetes and type 2 diabetes among racial and ethnic minority individuals and low-income patients. The study suggests that targeted outreach to those with higher hemoglobin A1c levels may be more cost-effective.
Researchers developed a novel technology to engineer proteins targeting specific DNA sequences, offering a new approach to gene therapies. The system generates engineered zinc fingers that bind to any given sequence of DNA, potentially treating diseases caused by genetic mutations.
Researchers studied cavefish metabolism to understand how humans might adapt over long periods of inactivity, finding genetic changes that enable muscle endurance and efficient energy storage. The study suggests potential implications for understanding and mitigating the negative effects of sedentary lifestyles on human health.
A $2.3 million grant from the US Department of Energy funds a 'solar testbed' at I-79 Technology Park in Fairmont, supporting research on battery storage, grid integration, and cybersecurity. The project aims to assess solar panel health and monitor grid interactions with solar power.
A new study led by Mayo Clinic researchers found that women carrying specific genetic changes, such as BRCA1 and BRCA2, have a twofold increased risk of developing contralateral breast cancer. Premenopausal women with these mutations are more likely to develop cancer in both breasts.
Researchers found that certain gene signaling pathways, such as interferon γ and beta-catenin, can lead to tumor hyperprogression after immunotherapy. Targeting these pathways may prevent hyperprogression in preclinical models.
The CABBI team successfully demonstrated precision gene editing in miscanthus, a promising perennial crop for sustainable bioenergy production. The results will accelerate efforts to tap the huge potential of this highly productive but genetically complex grass as a source for biofuels, renewable bioproducts, and carbon sequestration.
Researchers report the discovery of photonic hopfions, a new family of 3D topological solitons with freely tunable textures and numbers. These structures exhibit robust topological protection, making them suitable for applications in optical communications, quantum technologies, and metrology.
A recent study found that genomic testing can identify genetic causes of childhood hearing loss and provide critical information on its clinical characteristics. The researchers detected variants responsible for hearing loss in 43 different genes, and the severity of hearing loss varied by gene.
Researchers developed a flexible genetic hacking system to convert split gene drives into full gene drives, enabling safe testing and potential real-world applications. The new system revealed surprising fitness costs of full drive systems, with slower-than-predicted spread rates in cage experiments.
Researchers identified 17 clusters of single cells in peripheral blood, showing upregulation of antigen processing and presentation pathways and downregulation of genes involved in ribosome pathways with age. The study also found senescent T cells resistant to apoptosis, potentially targeted for treatment.
Researchers at Massachusetts General Hospital created a new class of technologies called CRISPR-associated transposases (CASTs) to overcome diverse disease-causing mutations. The optimized approach improves product purity and genome-wide specificity, offering a potential solution for inserting entire genes into the genome.
Researchers found that abnormal methylation processes lead to disruption of gene expression essential for brain development in people with Williams syndrome. The study suggests targeting treatments to correct these disruptions.
A multidisciplinary team reviews genomic test results and recommends treatment options for patients with gastrointestinal cancer, identifying clinical trials suitable for most patients. The program has been successful in providing expert treatment guidance for over 500 patients and can be a model for other cancer centers.
Hiroshima University researchers have generated a high-quality genome assembly of red perilla, allowing scientists to harness its abundance of potentially useful bioactive chemicals. The study enables targeted gene editing for enhanced phytochemical production, paving the way for new medical applications.
A team of researchers has developed an experimental method to manipulate the Rydberg state excitation in hydrogen molecules using bicircular two-color laser pulses. By controlling the photon effect and field effect, they were able to generate Rydberg states while varying the extent to which each effect contributed to the process.
The three-year effort aims to establish a widely accepted protocol for comparing lidar performance. The first year's tests evaluated range, accuracy, and precision of eight automotive-grade lidars using a survey-grade reference. Results showed the distribution of measured values was not Gaussian, with significant errors in some cases.
Researchers from prominent institutions discuss hepatocellular carcinoma's pathogenesis, genomic heterogeneity, and targeted therapy options. The review aims to characterize HCC's complexities and develop clinically relevant biomarkers for better management.
Researchers developed a blood test using circulating microparticle proteins to predict placenta accreta spectrum (PAS) cases as early as the second trimester. The study found five unique proteins that can distinguish PAS patients from control patients, enabling safe predication before delivery.
Researchers identified the molecular mechanism underlying Weiss-Kruszka syndrome, a rare neurodevelopmental disorder characterized by craniofacial anomalies and autistic features. The study reveals that the ZFP462 gene mutation leads to a failure to safeguard neural lineage specification during early embryonic development.
Researchers have developed a new spectroscopy technique called filament- and plasma-grating-induced breakdown spectroscopy (F-GIBS), which improves the sensitivity of trace metal detection in liquid samples. The technique uses fluid jets to analyze aqueous solutions and achieves high precision by avoiding detrimental influences of liqu...
A study in Serrana, Brazil showed that mass vaccination reduced severe cases and death rates even while gamma and delta variants were circulating. Vaccination coverage reached 80% of the target population.
UCSF researchers identified glioma's cellular source of recurrent disease, finding cells shift to mesenchymal, radiation-resistant phenotype in response to standard therapy. Paracrine signals from tumor microenvironment drive this transition through AP1 pathway, leading to therapy resistance and tumor recurrence.
Patent thickets and evergreening strategies hinder generic competition, leading to higher brand name drug prices. Generic entry can drop prices by 90%, affecting patient welfare. Patent expert Sean Tu advocates for a balanced patent system that promotes innovation while preventing monopolies.
A new neuronal cell-based reporter system has been developed to identify compounds that inhibit histone deacetylase 2 (HDAC2) with minimal effect on its partner enzyme HDAC1. This innovation holds promise for dementia drug development by targeting the root cause of memory impairment.
Researchers have discovered a way to promote hair cell regeneration in mature animals using cell reprogramming with transcription factors ATOH1, GFI1, and POU4F3. This approach has shown promise for advancing the treatment of long-term hearing loss.
A study published in PLoS Genetics reveals the mechanism by which a selfish gene in yeast, wtf4, enables its function using a poison-antidote strategy. This strategy involves the production of poison protein that can kill spores, but is countered by an antidote protein produced only by those spores that inherit the drive allele.
Researchers at the University of Huddersfield used ancient DNA to reveal large-scale immigration in Early Bronze Age Orkney, contrary to popular belief. The findings also showed unusual female-dominated immigration during this period.
Researchers at Cornell University discover how to modulate the affinity of Cas proteins, enabling precise gene editing and reducing off-target effects. By modifying guide RNAs, they can tune Cas removal, contributing to future CRISPR applications.
Researchers developed a small molecule inhibitor that successfully shrunk tumors or stopped cancer growth in preclinical models of pancreatic cancer. The drug, MRTX1133, not only targets cancer cells but also cooperates with the immune system to produce a durable response to treatment.
Researchers found that women experiencing prolonged mental health issues after childbirth had genetic evidence of higher immune system defense mechanism activation. The study also identified reduced antiviral immune response genes, which may offer protection from pathogens.
Researchers at VCU Massey Cancer Center discovered the inactivation of NF1 as a potential genetic driver for pancreatic cancer. The study suggests that targeting NF1 could create vulnerabilities for therapeutic advantage in mutant KRAS-bearing tumors.
Scientists at Medical College of Georgia discover a new target to intervene in coronary artery disease, the most common type of heart disease. The target is ATIC, a gene essential for purine production, which increases in response to arterial disease.
The new PASTE tool combines precise targeting of CRISPR-Cas9 with integrases to insert large chunks of DNA into the genome without inducing double-stranded breaks. This approach holds promise for treating diseases with multiple mutations, such as cystic fibrosis, with high efficiency and minimal unwanted effects.
Researchers have identified a protein that can predict how well breast cancer patients will respond to chemotherapy. Increasing levels of this variant p53 makes breast cancer cells unresponsive to existing therapies, highlighting its potential as a target for enhanced treatments.
UVA researchers developed a new tool to analyze genetic data, reducing noise and bias in cancer diagnosis. The tool uses mathematical modeling to identify patterns in chromatin, helping scientists detect tiny numbers of disease cells.