Articles tagged with Gene Targeting
Researchers developed a computational platform called IRIS to discover tumor antigens from alternative RNA splicing, expanding cancer immunotherapy targets. Hundreds of predicted TCR targets were found to be presented by human leukocyte antigen molecules.
Researchers identified novel genetic associations between AD and modifiable risk factors, including high HDL cholesterol concentrations and systolic blood pressure. These findings may inspire new drug targets and improved prevention strategies for AD.
Researchers at Aarhus University discover how the SUC transporter recognizes sucrose and uses acid to power its sugar delivery. This breakthrough sheds light on how plants defend themselves from pests and could lead to new ways of protecting plants from harmful bugs.
Glioblastoma steals cognitive faculties as it spreads, but its insidious ability to infiltrate neighboring networks may be its undoing. Researchers found neural activity can restructure connections in surrounding tissue, causing decline. The drug gabapentin blocks this growth-causing activity in mice with glioblastoma.
Researchers found that immune-modulating cells may slow the expansion of bulges in the aorta by creating a less-inflammatory environment. A second study discovered evidence that a COVID-19 infection promotes the enlargement of abdominal aortic aneurysms, which are extremely dangerous and potentially fatal if they rupture.
The Human Pangenome Reference Consortium expands and updates the human genome project with nearly full genomic data from 47 people of diverse ancestry. Researchers at UW Medicine made significant contributions to drafting the pangenome reference and studying variation within repetitive DNA, which could improve equity in human genome re...
Researchers used cancer proteomics data to identify gene candidates for therapeutic targeting, focusing on protein kinases in uterine endometrial cancer cells. Public molecular resources and multi-omics data analysis can prioritize genes of interest for future studies.
Researchers have engineered a new CRISPR-based drug candidate targeting E. coli directly while preserving the microbiome. The innovative treatment has shown promise in reducing E. coli burden in mice and is now in phase 1 clinical trials to treat blood cancer patients and prevent deadly infections.
Research highlights unique effects of Asian American subgroups on heart disease and Type 2 diabetes risk. Variations in cardiovascular risk among Asian Americans indicate the need for individual subgroup data to better understand health risks.
Researchers create high-resolution maps of the 3D genome, revealing interactions between enhancers and promoters that weren't previously seen. The findings suggest many genes interact with dozens of regulatory elements, opening possibilities for studying gene regulation and potentially understanding diseases.
The LY6 gene family has been found to be overexpressed in uterine corpus endometrial carcinoma (UCEC), leading to poor patient survival. Several LY6 genes have been identified as potential tumor-associated antigens and biomarkers for UCEC detection and prognosis.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
A new approach, STING-seq, combines genetic association studies, gene editing, and single-cell sequencing to identify causal variants and genetic mechanisms for blood cell traits. This method can help scientists identify drug targets for diseases with a genetic basis.
Researchers developed NetBID2 to analyze multi-omics data and find hidden druggable targets in cancer. The tool successfully identified previously unappreciated roles for genes like MYC and NOTCH1 in adult lung cancer and pediatric leukemia, highlighting its potential for accelerating clinical trials.
Researchers identified three novel dual-purpose therapeutic targets using PandaOmics, which could treat both aging and glioblastoma multiforme. The target hypotheses include cyclic nucleotide gated channel subunit alpha 3 (CNGA3), glutamate dehydrogenase 1 (GLUD1) and sirtuin 1 (SIRT1).
Researchers at Temple University and the University of Nebraska Medical Center developed a novel dual gene-editing approach that can effectively eliminate HIV infection. The therapy targets both HIV-1, the virus responsible for AIDS, and CCR5, a co-receptor that facilitates viral entry into cells.
Researchers found that CUDC-907 selectively induces apoptosis in cells driven to senesce by p53 expression. The compound showed senolytic properties in different models of stress-induced senescence, depending on its inhibitory effects on HDACs and PI3K.
Researchers have discovered a new genetic culprit in canine bladder cancers, with implications for early detection and targeted treatments. The study found that 13 out of 28 cases had a different type of mutation, which could lead to more precise treatment options.
A team from Nanjing University and Sun Yat-Sen University developed a two-facing Janus OPO scheme for generating high-efficiency, high-purity broadband LG modes with tunable topological charge. The output LG mode has a tunable wavelength between 1.5 μm and 1.6 μm, with a conversion efficiency above 15 percent.
Researchers develop PrimeRoot, a tool for efficient and precise targeted insertion of large DNA segments in plants, achieving efficiencies up to 6% and inserting segments up to 11.1 kb.
Researchers developed a gene signature called CisSig to predict cancer patients' response to cisplatin. The approach aims to overcome the obstacle of interpreting gene signatures in the human body and has been validated in muscle-invasive bladder cancer patients.
Researchers developed machine-learning algorithms to generate proteins with specific structural features, enabling the creation of biologically inspired materials. The models can produce millions of new protein ideas in a few days, allowing scientists to explore unique applications.
Researchers at Indiana University School of Medicine have identified a new target for breast cancer treatment, the gene TONSL, which can make breast cells proliferate indefinitely. The study found that TONSL is amplified in about 20% of breast cancers and more than 30% of metastatic breast cancers.
Researchers at Cedars-Sinai Medical Center identified a genetic variant associated with increased risk of developing perianal Crohn's disease, a debilitating manifestation of Crohn's disease. The study highlights the importance of targeting the alternative complement pathway and Complement Factor B (CFB) in treating this condition.
Researchers from HKUST and CityU developed a metasurface to generate time-varying OAM beams with a time-dependent phase profile. This allows for a higher-order twist in the envelope wavefront structure, increasing capacity for applications such as dynamic particle trapping and information encryption.
Researchers at UMass Amherst microbiologists have identified an enzyme involved in TB pathogen's survival and growth. The discovery offers a potential target for drug therapies for the deadly disease, which has few effective treatments and caused over 1.6 million deaths worldwide in 2021.
A Mayo Clinic study found that people with severe obesity and a genetic pathway variant are at increased risk of developing hypertension. The research identified 168 carriers of the MC4R variant, who had a higher risk of hypertension compared to noncarriers.
Researchers at Washington State University have identified the Arrdc5 gene as a potential target for male contraception. The study found that when this gene is inactivated, it causes significant infertility in males, characterized by decreased sperm count, slowed mobility, and distorted shape.
Researchers have identified hundreds of genes with significant stroke-driven changes and likely relevance in human strokes. The study found alterations in sphingolipid production, which are involved in regulating blood vessels, and pinpointed several molecular pathways that can be targeted for stroke treatment.
Researchers at Massachusetts General Hospital developed a genetic therapy to correct myotonic dystrophy in mice by targeting the abnormal splicing of the Clcn1 gene. The treatment restored muscle strength and corrected muscle stiffness, reversing muscle fiber type transitions.
Researchers found that patients with two or three separate areas of breast cancer in the same breast can opt for lumpectomies followed by whole-breast radiation therapy instead of mastectomies, resulting in better patient satisfaction and cosmetic outcomes. The study also showed that preoperative MRI scans reduced local recurrence rates.
Researchers tracked the evolution of Staphylococcus aureus in patients with eczema, discovering rapid mutations in a gene that enables the bacteria to grow faster on the skin. These findings could lead to targeted treatments by targeting variants of S. aureus associated with eczema symptoms.
Scientists have created a new method to model liver cancer tumor subtypes using CRISPR-Cas9, discovering that specific gene isoforms can lead to different cancer subtypes. This platform could help researchers develop new therapeutic interventions for treating cancer and other diseases.
Researchers at Trinity College Dublin have discovered a new process that explains why cells have unique identities. By studying Polycomb protein complexes, the team found that different forms of these proteins recruit distinct complexes to DNA, shedding light on cellular identity and its potential impact on cancer treatments.
A new study led by Brigham investigators found that people produce shared antibody responses to certain regions of the virus, leading to selective pressure and new variants. The team's findings have implications for our understanding of immunity and public health, particularly in terms of re-infection during the COVID-19 pandemic.
A study from Indiana University School of Medicine found that people with NAFLD have significantly decreased levels of the liver enzyme CYP2C19, which is important for medication processing. This decrease may lead to slower clearance of certain medications and reduced effectiveness of medicines like antidepressants and clopidogrel.
Researchers at Indiana University School of Medicine investigated the protein BVES and its crucial role in muscular dystrophy. They discovered that inhibiting proteasome degradation with Bortezomib can alleviate symptoms of BVES-deficient muscular dystrophy.
A comprehensive study across six continents found intercropping to be effective against pests, with cabbage and squash showing the strongest resistance. The analysis of 44 field studies revealed that interspersed planting schemes were more effective than border plantings.
A new study finds that clear and accurate information about the cause of death, provided in multiple formats, can influence family members' decisions to seek follow-up screening for inherited heart conditions. The study suggests that communication from death investigators and health care professionals is crucial in addressing families'...
Impact Journals will participate as an exhibitor at the AACR Annual Meeting 2023, showcasing Aging's growth in impact factor to 5.955. The meeting theme focuses on Advancing the Frontiers of Cancer Science and Medicine.
A new study led by Marshall University researchers has revealed that the Xie model for NKA receptor/signaling is a key player in regulating sodium balance. The study found that NKA signaling tonically inhibits sodium reabsorption in the renal proximal tubule, shedding light on a novel mechanism of body salt handling.
Researchers found that metformin + leucine (MET+LEU) treatment prevents myotube atrophy by reversing cellular senescence and improving proteostasis. The study used C2C12 myoblasts, aged mouse single myofibers, and human primary myotubes to demonstrate MET+LEU's skeletal muscle cell-autonomous properties.
Researchers found that dexamethasone prevents cytokine storms in severe COVID-19 patients by inhibiting ion channels and reducing immune cell inflammation. This led to improved lung function and reduced mortality rates. The study's findings provide new insights into the mechanisms of steroid treatment in severe COVID-19.
A new American Heart Association scientific statement provides guidance on interpreting incidental genetic variants associated with cardiovascular disease risk. The statement aims to determine whether a variant truly carries a health risk and suggests next steps for individuals and healthcare professionals.
Researchers developed O-ClickFC technology to analyze lipid metabolic state in cells at high speed. The technology combined with genome editing enabled identification of causative genes of metabolic disorders, including FLVCR1 and its role in choline uptake.
The Lp(a) Discovery Project will develop clinical standards for optimal patient care through a new screening measure and quality improvement interventions. The three-year project aims to fill knowledge gaps around Lp(a) and encourage better treatments to reduce cardiovascular risk.
Researchers have found that valosin-containing protein (VCP) is essential for KRAS-mutant pancreatic ductal adenocarcinoma cell growth and survival. Inhibiting VCP, combined with autophagy inhibition, enhances efficacy in preclinical studies.
Researchers from China have identified inosine as a potential broad-spectrum anti-inflammatory agent that improves survival in mice infected with SARS-CoV-2. The study also highlights TBK1 as a promising target for inhibiting cytokine storms and mitigating acute inflammatory lung injury.
Researchers have developed a new simulation method to study polarons in 2D materials, which could lead to breakthroughs in OLED TVs and hydrogen fuel production. The study uses quantum mechanical theory and computation to determine the fundamental properties of polarons in 2D materials.
Researchers identified high expression of glypican-1 in primary solid tumors, correlating with poor prognosis in various cancer types. Suppression of GPC1 attenuated cancer cell proliferation, suggesting its potential as a novel diagnostic tool and target for therapy.
Researchers at Texas A&M University have developed the first molecular therapeutic for Angelman syndrome, a devastating neurogenetic disorder. The therapy targets an evolutionarily conserved region in the UBE3A-AS transcript and has shown promising results in clinical trials.
The study resolves a long-standing question about the structure of respiratory supercomplexes in unicellular eukaryotic organisms. Complex II is found to be part of the supercomplex in these organisms, optimizing ATP formation and revealing a surprising variety in supercomplex construction.
Researchers develop unsupervised machine learning algorithm to classify osteosarcoma at diagnosis based on gene expression modules. This approach enables personalized treatment strategies for osteosarcoma patients.
Researchers found that senescence-associated exosomes (SA-EXOs) from MSCs induce fibrosis and activate invasive characteristics in neighboring cells via the TGF-β pathway. SA-EXOs play a large role in cancer-related fibrosis, and their unique miRNA content influences myofibroblast phenotypes.
Researchers have designed a new RNA sensor that can selectively activate synthetic genes in specific cells, opening up possibilities for targeted therapies for cancer and other diseases. The system uses an enzyme that naturally exists in most animal cells to detect and repair mismatches in double-stranded RNA.
Researchers discovered that targeting two inflammatory regulators simultaneously can boost T cell expansion and increase antitumor immune activity in models. The findings showed at least 10 times greater T cell expansion when both regulators were knocked out, resulting in improved durability.
Researchers discover that inhibiting a gene crucial for DNA production can significantly reduce destructive cell proliferation and disease progression in pulmonary hypertension. This finding presents a potential treatment target for the condition, which affects females aged 30-60 with limited treatment options.
Researchers found a strong association between high levels of telomerase reverse transcriptase (TERT) expression and an elevated immune response in patients with head and neck squamous cell carcinoma. This link suggests a potential new target for cancer immunotherapies, which may lead to improved outcomes for patients.
Researchers developed AI models based on UNet and MobileNet architectures to analyze standardized abnormalities in CT images, accurately identifying object presence and confidence. These models achieved an absolute percentage error of less than 5 percent, comparable to human professionals.
Researchers have identified a gene network underlying rice grain size regulation, revealing a phosphorylation-driven auxin signaling pathway. The study found that OsTIR1–OsIAA10–OsARF4 plays a crucial role in controlling rice grain size and weight.