Articles tagged with Gene Targeting
Researchers at VCU Massey Cancer Center discovered the inactivation of NF1 as a potential genetic driver for pancreatic cancer. The study suggests that targeting NF1 could create vulnerabilities for therapeutic advantage in mutant KRAS-bearing tumors.
Scientists at Medical College of Georgia discover a new target to intervene in coronary artery disease, the most common type of heart disease. The target is ATIC, a gene essential for purine production, which increases in response to arterial disease.
The new PASTE tool combines precise targeting of CRISPR-Cas9 with integrases to insert large chunks of DNA into the genome without inducing double-stranded breaks. This approach holds promise for treating diseases with multiple mutations, such as cystic fibrosis, with high efficiency and minimal unwanted effects.
Researchers have identified a protein that can predict how well breast cancer patients will respond to chemotherapy. Increasing levels of this variant p53 makes breast cancer cells unresponsive to existing therapies, highlighting its potential as a target for enhanced treatments.
UVA researchers developed a new tool to analyze genetic data, reducing noise and bias in cancer diagnosis. The tool uses mathematical modeling to identify patterns in chromatin, helping scientists detect tiny numbers of disease cells.
Kevin McHugh, a Rice bioengineer, has received the Distinguished Scientist Award from The Sontag Foundation for his work on gene editing to defeat glioblastoma multiforme. His approach involves delivering gene therapy agents directly to tumor cells, aiming to improve survival and reduce side effects.
In a recent study, researchers targeted the POL theta enzyme to inhibit DNA production in cancer cells. The approach represents a new method for developing specific therapies for patients with BRCA1 mutations.
A new study by Weill Cornell Medicine investigators discovered that error-prone DNA replication and repair may lead to mutations and cancer in individuals with BRCA1 gene mutations. The team identified a faulty DNA repair mechanism called microhomology-mediated break-induced replication (MMBIR) as a key contributor to genomic instabili...
A study in Japan reveals that universal screening methods for biliary atresia, a rare and severe lung condition in infants, are cost-effective. The research found that stool color card screening and direct bilirubin testing gained significant clinical benefits and saved lives.
Researchers at West Virginia University are exploring a new approach to produce clean hydrogen fuel using low-tech organic materials. They aim to create efficient and economically viable gasification systems that can transform biomass into ultrapure hydrogen, reducing greenhouse gas emissions.
Scientists developed a novel exciton with intralayer charge-transfer characteristics in a moiré superlattice, exceeding conventional parameterized models. The discovery has potential applications in optical sensors and communication technology.
Researchers at North Carolina State University developed a CRISPR-based system that uses engineered bacteriophages to deliver genetic payloads to specific bacteria, even in complex environments. This technology enables precise single-letter changes to the genome without double-strand DNA breakage.
The HUSH complex is involved in normal brain development, neuronal individuality, and connectivity. The complex also regulates repetitive-like gene clusters, including protocadherin gene clusters, which are essential for neuron-to-neuron interactions.
Researchers have developed a new gene therapy that selectively targets overactive brain cells, reducing excitability and suppressing seizures in mice. The treatment shows promise for treating neurological disorders such as epilepsy, Parkinson's disease, schizophrenia, and pain disorders.
At AHA22, Smidt Heart Institute experts will cover various cardiology topics, including atrial fibrillation treatment and high-impact trials in intervention and surgery. Experts like Christine Albert, Joanna Chikwe, and Jon Kobashigawa will present their research on the effects of Omega-3 fatty acids and stroke management.
Two new discoveries led by Cedars-Sinai Cancer investigators improve understanding of ovarian cancer's development and suggest personalized therapeutic approaches. They identified four new genetic regions linked to increased ovarian cancer risk and found that some tumors may develop resistance to chemotherapy from an early stage.
During the early months of the COVID-19 pandemic, patients with hypertension took less frequent blood pressure measurements and reported higher readings. Blood pressure control worsened due to disruptions in healthcare access, including telemedicine and home monitoring.
Researchers found that reducing SAMHD1 levels made brain tumor cells sensitive to chemotherapy drugs and slowed cell growth. They also suspect that glioblastoma alters SAMHD1's function to aid its own survival and treatment resistance.
Researchers at MIT have developed a new control system for synthetic genes that can precisely regulate protein production in mammalian cells. The system uses CRISPR proteins to activate target genes and can be tuned to produce specific quantities of proteins, such as monoclonal antibodies.
The Alpha Stem Cell Clinic will develop preclinical studies into early and later phase clinical trials with the goal of establishing advanced regenerative medicine treatments. The clinic will also foster greater collaboration with eight similar clinics across the state and educate the public about stem cell and related therapies.
Researchers at Weill Cornell Medicine have developed a new computational method to map the architecture of human tissues in unprecedented detail. This approach enables powerful new diagnostic strategies for a wide range of diseases, including cancer and chronic conditions.
Johns Hopkins Medicine researchers have developed a novel genetic engineering approach to deliver gene therapy by utilizing a cell's natural process to
Researchers created predictable, novel expression patterns of fluorescent proteins using engineered gene circuits. They also redesigned root architecture by tuning the number of root branches using similar gene circuits.
The study found that BRAF alterations, particularly Class I mutations like v600E, are associated with improved overall survival in adults with glioma. However, the effectiveness of targeted therapies depends on the specific type and combination of genetic alterations driving the cancer.
Researchers have found a drug that targets the key, cancer-causing gene MYC has been able to inhibit its function safely and effectively. Eight out of 12 patients showed stabilisation of disease after treatment with OMO-103, with one patient experiencing a reduction in tumour-derived DNA circulating in the blood stream.
Researchers at VCU Massey Cancer Center have identified a new therapeutic target for triple-negative breast cancer (TNBC), a more aggressive and deadly form of disease. Using CRISPR/CAS9 screening, scientists pinpointed the UBA1 enzyme as an ideal target, which can be inhibited by the novel drug TAK-243 to effectively kill cancer cells.
Researchers have developed a drug compound that stops cancer cell growth in mice with little effect on normal healthy cells, making it potentially nontoxic for patients. The therapy targets the epidermal growth factor receptor gene, which is overexpressed in about half of all triple-negative breast cancer cases.
A genetic variant associated with low levels of HDL 'good' cholesterol and high triglycerides has been identified in Polynesian people. This discovery provides new insights into the genetic causes of high cholesterol and may lead to the development of more effective treatment options.
Researchers have discovered a family of selfish genes, wtf, that have survived for over 100 million years in yeast, contradicting established beliefs on their longevity. These 'killer meiotic drivers' transmit themselves to half of offspring and destroy reproductive cells without being suppressed by natural selection.
Researchers at Mount Sinai's Tisch Cancer Institute have discovered a new gene, PDZK1IP1, essential to colon cancer growth. The study found that surrounding inflammation activates the super enhancer, promoting tumor cell survival and growth.
Researchers have found evidence of genetic diversity in the prion protein gene of endangered Eld's deer, which could provide resistance to chronic wasting disease. The study suggests reducing the frequency of a variant associated with the disease and implementing strict management practices to prevent exposure.
Researchers discovered that animal models with germline alteration rs55705857 developed gliomas significantly faster than those without the alteration. The study offers new insights into tumor formation and may lead to novel therapies targeting this specific change.
Scientists at Northwestern University have identified a new gene that activates an aggressive subtype of small-cell lung cancer with no current effective treatment. Deleting this gene kills cancer cells in deadly subtype.
The event will cover various topics including microbiota dysbiosis, oral and vaginal microbiota, and their impact on diseases like depression, cancer, and respiratory infections. The meeting aims to accelerate Microbiota medicine applications through strategic discussions.
Scientists have identified long interspersed nuclear element-1 (L1) RNA as a promising new target for treating progeroid syndromes. Increased L1 RNA expression in cells from patients with these disorders led to deactivation of an enzyme, causing cell aging.
A UNIGE team identified a three-step mechanism that allows our body to defend itself against hepatitis B. The complex detects the viral DNA, traps it, and inhibits the virus' chromosome.
Researchers at the University of Pittsburgh discovered that a cellular channel outside the kidneys plays a crucial role in maintaining healthy blood pressure levels. The study found that subtle mutations in this channel can influence blood pressure, providing a potential new target for existing medications.
Researchers developed a computational platform to identify metabolic vulnerabilities in ovarian cancer genes, suggesting opportunities for targeted therapies. The study found that certain genetic alterations can create vulnerabilities in cancer cell metabolism, which can be exploited to selectively kill cancer cells.
Researchers at the University of South Australia are using new technologies to speed up blood cancer diagnosis and treatment. The project aims to identify genetic variants that cause cancer, enabling clinicians to provide targeted treatments and improve patient management.
Researchers have identified a complex of proteins in a tiny marine invertebrate that share similarities with the human immune system, suggesting an earlier origin for the building blocks of our immune system. The study could ultimately guide the development of new immunotherapies and improve understanding of transplant rejection.
Researchers at the University of Helsinki have identified target genes of the MYC oncogene responsible for its growth-promoting effects. By modifying these genomic binding sites, they slowed down cell growth. This finding has significant implications for developing new cancer treatments.
Brown algae's unique pigments have evolved through a complex genetic pathway, enabling them to harness more light energy than green plants. This discovery could lead to insights into fucoxanthin's health applications and improved photosynthetic efficiency for biofuels production.
Researchers have discovered how a common blood stem cell mutation, DNMT3A R882, alters gene activity and produces abnormal blood cells that increase cancer risk. The study found that the mutant cells produce more red blood cells and platelets, leading to higher cardiovascular disease risks.
A team of researchers has identified TSG101 as a crucial regulator of the PARP1 enzyme, which is responsible for repairing DNA damage. In cancer cells with BRCA mutations, TSG101 is essential for PARP1 activation, making it a promising target for cancer treatment.
Researchers are exploring ways to target and manipulate the human microbiome, with potential applications in treating diseases such as depression, obesity, and retinal disorders. The conference will feature presentations on innovative strategies and recent findings in modulating microbiota and microbial components.
A new study published in The Crop Journal has identified the gl9 gene variant as a key factor in increasing grain size and reducing chalkiness in rice. By introducing this allele into elite rice varieties, scientists have improved grain length, width, and weight, leading to enhanced appearance quality and yield.
A new study published in the Journal of the American Heart Association found that air pollution may trigger irregular heart rhythms in healthy teenagers, with exposure causing arrhythmias to occur within two hours. The research analyzed data from over 300 adolescents and found a significant impact of fine particulate matter on cardiac ...
A new intracellular checkpoint gene, CISH, has been found to suppress the ability of human T-cells to recognize and attack cancer cells. When CISH is disabled, T-cells more effectively recognize mutated proteins produced by tumors, making them more responsive to existing checkpoint therapies.
Breast cancer recurrence and metastatic spread remain a significant challenge, with researchers identifying a metabolic signature that can predict patient outcomes. The signature could be used to develop new therapies targeting cancer metabolism.
Researchers from Children's Hospital of Philadelphia used advanced mapping techniques to identify causal genes and target pairings in the pancreas linked to type 2 diabetes. The study revealed alpha and acinar cells play a greater role in disease development than previously thought.
Researchers at the Max Planck Institute have successfully generated up to 14 entangled photons using a single atom, enabling efficient creation of quantum computer building blocks. This breakthrough could facilitate scalable measurement-based quantum computing and enable secure data transmission over greater distances.
Researchers at CSU found that a gene called MSH1 helps keep plant mitochondrial genomes mutation-free, allowing for quick sorting of normal and diseased DNA. This process is more efficient in plants than in humans, where mutations are passed down through generations.
Researchers at Gladstone Institutes and UCSF have developed a new approach to introduce long DNA sequences into cells with remarkable efficiency. The technology, which uses single-stranded DNA templates, overcomes the limitations of traditional viral vectors and has the potential to make cell therapies faster, better, and less expensive.
Researchers at WVU are using robots to analyze potential hazards and provide walkability maps in retail environments, aiming to reduce occupational injuries. The team plans to test the robots after hours in an actual retail space, combining camera data with wheel speed measurements to estimate slip risks.
Researchers developed a polygenic risk score to predict sudden cardiac death in coronary artery disease patients. The study found that patients with high genetic risk scores had a 77% increased risk of sudden cardiac death.
A new UCLA-led study has identified multiple new risk genes for Alzheimer's disease and progressive supranuclear palsy (PSP) by combining new testing methods. The researchers used high-throughput testing to simultaneously test 5,706 genetic variants in 25 loci associated with Alzheimer's and nine loci associated with PSP.
Researchers at Michigan Medicine have discovered a molecular mechanism that drives the disease-causing effects of the most common genetic risk factor for lupus. The study suggests that targeting this new pathway could lead to the development of safe and effective treatments for SLE, an autoimmune disease that affects millions worldwide.
Researchers at the University of California San Diego have developed a precision-guided sterile insect technique (pgSIT) to control invasive fruit fly populations. The technology uses CRISPR editing to target key genes in female viability and male fertility, resulting in a fertility dead end for the species.
Researchers found that using the drug erlotinib, which blocks a specific cancer pathway, led to a 30 percent reduction in polyps formed in patients with FAP. The study's findings suggest potential ways to prevent colorectal cancer in the general population at an earlier stage.
Researchers analyzed data from over 3,000 participants and found no association between electrocardiogram measures and telomere length. The study suggests that ECG prolongation is age-dependent but not a marker of biological aging.