Articles tagged with Immunity
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers at La Jolla Institute for Immunology have discovered immune cells, such as tissue resident memory cells, in the upper airway that can fight infections and build long-term immunity. These findings may lead to better vaccines and a deeper understanding of immunity against respiratory pathogens.
Researchers developed a universal influenza vaccine that targets the internal structural proteins of the virus, providing lifetime immunity against evolving viruses. Six out of 11 nonhuman primates inoculated with the vaccine survived exposure to the H5N1 virus, while unvaccinated primates succumbed to the disease.
Research by Associate Professor Shannon Bosch challenges Russia's classification of foreign fighters as mercenaries, arguing that international law and Ukrainian domestic legislation protect their rights. The study highlights the need for full combatant immunity and prisoner of war status for these foreign fighters.
A study published in Clinical Infectious Diseases found that regular booster doses of bivalent vaccines can maintain a person's ability to neutralize multiple SARS-CoV-2 strains, including XBB.1.5. This is especially important for immunocompromised groups, such as solid organ transplant recipients.
Researchers found TIMP-1 enhances antitumor immunity through self-stimulation and activates immune cells. Increasing TIMP-1 expression could improve cancer immunotherapies in patients with deficient immune responses.
Researchers at Northwestern University discovered an attenuated virus that can help eliminate cancer in mice and prevent future tumor development. The therapy works by raising 'red flags' on tumors to alert immune cells to attack them.
Researchers found that tumor-associated macrophages respond to physical properties of fibrosis by synthesizing injury-associated collagens, resulting in metabolic changes that suppress CTL function. This provides an alternative explanation for why anti-tumor immunity is impaired in fibrotic solid tumors.
Researchers found that repeat COVID-19 vaccinations elicit cross-reactive neutralizing antibodies capable of targeting multiple SARS-CoV-2 variants and distantly related coronaviruses. The findings suggest periodic re-vaccination may help build a stock of protective antibodies against emerging variants.
A study by the University of Cambridge and Fudan University found that children born by C-section are up to 2.6 times more likely to fail their first measles vaccination compared to those born naturally. Two doses of the vaccine are necessary for robust protection against measles.
Researchers developed a synthetic biomarker technology that can differentiate between prior Zika and dengue virus infections. The technology, using epitope surrogates, correctly identified people previously infected with Zika virus 85.3% of the time.
Researchers have identified a promising new vaccine adjuvant called C100, derived from chitin, which stimulates key sensing and signalling molecules to regulate anti-tumour immune responses. The discovery offers hope for developing effective adjuvants for in situ vaccines in cancer immunotherapy.
A team of scientists has developed a novel vaccine approach that induces long-lasting protective immunity against SARS-CoV-2 virus in pre-clinical models. The Clec9A-RBD antibody construct targets specific dendritic cells, leading to exceptional durability of immune responses and potential to address shortcoming of current mRNA vaccines.
Researchers found that T cells and memory B cells provide durable protection against symptomatic SARS-CoV-2 infection, with levels attainable after two doses of mRNA vaccination. The study suggests a two-dose vaccination regimen for children against COVID-19.
A Brazilian study found that a major bivalent COVID-19 vaccine induces neutralizing antibodies against the original coronavirus strain and subvariants of omicron. The vaccine's effectiveness was confirmed, but its importance in controlling disease was limited by its focus on the original strain.
Researchers at H. Lee Moffitt Cancer Center & Research Institute discovered a new therapeutic target for non-small cell lung cancer by targeting the Jagged2 protein. Disrupting this signaling pathway activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
Researchers at Insilico Medicine have developed a novel PTPN2/N1 inhibitor with improved oral absorption and robust antitumor efficacy using the company's generative AI engine. The new compound demonstrates enhanced biological activities compared to existing inhibitors, offering new treatment possibilities for cancer patients.
Researchers found that Mpox antibodies decrease significantly within a year of MVA-BN vaccination, especially in individuals without prior smallpox vaccination. In contrast, antibody levels remained high in those with childhood smallpox vaccination, suggesting long-term protection.
A Swedish study reveals that neutralising antibodies to the monkeypox virus decline significantly after two doses of the MVA-BN vaccine within the first month. The findings suggest that a booster dose may be necessary to maintain immunity, emphasizing the need for scientific evidence before policy decisions are made.
Austrian researchers report a breakthrough mpox infection in a fully vaccinated man who received two doses of the Jynneos vaccine. The case highlights the potential durability of protective immunity after complete vaccination and emphasizes the importance of clinical suspicion in high-risk groups.
A long-term analysis of over 8,000 samples revealed that SARS-CoV-2 infection and vaccine-induced antibody responses are long-lasting. Booster vaccination equalized differences in antibody concentration between participants with and without pre-existing immunity.
Researchers developed a new recombinant flu vaccine called Hexaplex, which provided superior protection against H1N1 and H3N2 viruses in animal models. The vaccine's combination of six proteins from different groups resulted in strong antibody production and T-cell activation, offering broader immunity.
A large-scale study published in the BMJ found that children born in October are most likely to be vaccinated and least likely to be diagnosed with influenza, confirming public health guidance of getting flu vaccinations in October. The study analyzed over 800,000 children's health records from 2011-2018.
A study by UC Davis Health found that a single dose of BCG reduced liver tumor burden and extended the survival of mice with liver cancer. The vaccine boosted the body's immunity, leading to tumor shrinkage and improved liver function.
Researchers at Texas A&M discovered that immune genes are frequently exchanged between Myotis bat species during seasonal mating swarms, potentially helping humans fight emerging diseases. The study's findings have opened new questions about the importance of hybridization in evolution and its impact on genomicists' knowledge.
Researchers have discovered that plant immune receptors and growth-related proteins share a common evolutionary ancestry, allowing for the creation of hybrid receptors with enhanced functionality. This breakthrough could lead to the development of disease-resistant crops by isolating and engineering immune receptors from various plants.
A recent study published in Lancet Microbe suggests that immunocompromised patients are at higher risk for COVID infections, but prolonged infections lasting weeks to months are uncommon. The study found that specific conditions, such as B-cell cancers and autoimmune diseases, increase the risk of prolonged infections.
Researchers have revealed CD4+ T cells can work effectively on their own to control melanoma, challenging conventional understanding. Harnessing their potential therapeutically holds great promise for improving current cancer immunotherapies.
Research reveals memory T cells formed after Omicron breakthrough infection provide enhanced immunity against future variants. The study suggests the immune system adapts to combat emerging strains, leading to higher chances of inducing memory T cell defenses.
A new vaccine design has been developed by a UC Riverside-led research team, which uses preexisting immunity to the influenza virus to help kickstart the production of antibodies against SARS-CoV-2. The vaccine aims to speed up the immune response and provide better protection for people who still lack immunity to the coronavirus.
A new study by University of California Riverside researchers found that high-fat diets affect not only obesity and colon cancer but also the immune system, brain function, and potentially COVID-19 risk. The study, which analyzed genetic changes in mice fed different types of fat, showed that polyunsaturated fatty acids in soybean oil ...
Researchers found that vaccinated B cell-deficient individuals have a robust T cell response to SARS-CoV-2, despite lack of anti-spike antibodies, resulting in markedly reduced rates of hospitalization and severe COVID-19. This study provides reassuring evidence for immunocompromised patients to get vaccinated.
Researchers at UChicago find that trans-vaccenic acid (TVA), a fatty acid in meat and dairy, enhances CD8+ T cell immunity against tumors. TVA also improves response to immunotherapy treatments for patients with higher levels of the nutrient in their blood.
A study of over 2,300 patients found that HIV-1 neutralizing antibody response decreases over time but highly potent broadly neutralizing antibodies remain detectable. This finding suggests a possible permanent vaccine response and is an important step toward developing an effective HIV-1 vaccine.
A recent study led by Duke-NUS Medical School found that prior maternal dengue immunity substantially increases the risk of severe birth defects induced by Zika virus infection during pregnancy. Pregnant mothers with pre-existing dengue antibodies are more likely to experience microcephaly and brain damage in their foetuses after Zika ...
A study published in Cell Host and Microbe found that gender-neutral HPV vaccination is effective in preventing cervical cancer by inducing a stronger herd immunity. The vaccine protects against high-risk HPV types 16 and 18, which cause 70% of all HPV-related cervical cancers, and also provides cross-protection against low-risk types.
A recent study found that insufficient antibody transfer to newborn beef calves leads to negative health effects, including increased medical treatment needs and mortality rates. Researchers recommend beef calf-specific colostrum intervention strategies and better vaccine management for pregnant cows and heifers.
Researchers in Ireland have identified a critical threshold of IgG antibodies for protection against COVID-19. This finding suggests that individuals with IgG antibody levels above this threshold are likely to be immune to all SARS-CoV-2 variants, providing a valuable tool for monitoring and managing the pandemic.
Novel vaccine candidates using Computationally Optimized Broadly Reactive Antigens (COBRAs) protect against multiple influenza B strains, including those from different lineages. These vaccines show long-lasting protection, potentially reducing the need for yearly updates.
Researchers developed a ceria nanoparticle-immobilized mesenchymal stem cell nanovesicle hybrid system to treat rheumatoid arthritis. This approach provides both immediate pain relief through ROS scavenging and long-term immune tolerance by delivering immunomodulatory cytokines.
A new model predicts the evolution of SARS-CoV-2 variants by analyzing massive data on infections and vaccinations. Human immunity now drives the virus's evolution, with continued surveillance crucial to inform future vaccines.
A new study published in JAMA Network Open found live vaccinations safe and effective for children who have received liver or kidney transplants, offering protection against life-threatening conditions. The study showed high antibody levels and minimal adverse events following vaccination.
A new study from Linköping University has found that the appearance of the thymus gland in chest CT scans is linked to immune system ageing. The researchers examined over 1,000 Swedish individuals aged 50-64 and found that fatty degeneration of the thymus was more common in men and those with abdominal obesity. Lifestyle factors such a...
A University of Massachusetts Amherst team demonstrates a protein antigen from a childhood vaccine can be delivered into malignant tumor cells to refocus the immune system against cancer. The bacteria-based intracellular delivering system shows promise in treating pancreatic, liver, and metastatic breast tumors.
Researchers at Tulane University discovered that prior exposure to Cytomegalovirus (CMV) significantly reduces the risk of birth defects and miscarriage during pregnancy. The study found that pre-existing immunity effectively limits transmission and protects against associated birth defects.
A new study reveals that changing nutrient use can reprogram immune cells, potentially treating cancer and infections. By blocking choline metabolism, researchers found a 'tremendous reprogramming of the immune profile' in mice, suggesting this knowledge could lead to novel therapies.
Researchers found that antigen testing significantly reduces the probability of cluster occurrence by identifying and isolating infected persons. However, it may not be effective against highly infectious mutant strains like Omicron, highlighting the need for booster vaccination campaigns and other infection control measures.
Scientists have developed a trivalent vaccine candidate that provides broad and long-lasting protection against COVID-19 infection by delivering the vaccine via the nose. The vaccine triggers a strong neutralizing antibody response and protects mucosal areas, preventing disease symptoms.
Researchers have created an 'immune cell map' that reveals the origin of neutrophils' subcellular response to microbes. The study found that a specific type of glycoprotein is responsible for the restricted subcellular origin, and this discovery may lead to refined personalized immune responses.
Research finds that immune cells in older adults are similar to those in newborns and children, but less effective at recognizing infected cells. The study, published in Nature Immunology, suggests that tailored vaccines and therapies could be developed for different age groups based on the unique characteristics of killer T cells.
Scientists have found that lung-resident memory B cells, critical for pulmonary immunity, require interferon-gamma produced by T follicular helper cells to differentiate. These long-lived immune cells migrate to the lungs from draining lymph nodes and lie in wait to react quickly to future infections.
A study of 50,000 COVID-19 cases found that immunity following infection provides better protection against transmission than vaccination, but only for a short period. Vaccination reduces contagiousness over a longer time, making it essential to consider simple public health measures like air filtration and mask-wearing.
Researchers found that plant-to-plant interactions can modulate disease susceptibility in both wheat and rice, with 23 same-species mixtures showing a significant effect. This phenomenon, known as Neighbor-Modulated Susceptibility, may be used to design varietal mixtures with embedded crop protection.
A new editorial paper explores the effectiveness of the third dose booster vaccine against SARS-CoV-2 in immunocompromised individuals. Researchers found that while the vaccine improves vaccine effectiveness across various measures, its benefits are not as significant for patients with cancer.
Researchers tracked infections among Connecticut correctional facility residents to find that high exposure to the virus reduces vaccination and prior infection effectiveness. Hybrid immunity provides higher protection in such settings.
A new study found a significant increase in severe Strep A cases in Australia, with rates among Indigenous children being twice that of non-indigenous children. The study highlights the need for an effective vaccine against Strep A, which causes serious infections and kills over 500,000 people globally every year.
Researchers have uncovered how aberrant nucleoside storage in lysosomes leads to constitutive activation of TLR7 and TLR8, driving histiocytosis in SLC29A3 disorders. The study suggests that TLR7/8 stress response is a key player in the condition's pathogenesis.
A new study found that individuals exposed to common cold-causing coronaviruses have immune responses that may protect them from future SARS-CoV-2 infections. Researchers hope this insight will inform global infectious disease outbreak preparedness and vaccine development.
Scientists have discovered that SARS-CoV-2 can infect cells using multiple entry points beyond ACE2, explaining its ability to jump between species. This finding highlights the need for continued monitoring of coronaviruses and their potential to cause future pandemics.
Researchers found that GSDMD's N-terminal fragment induces the transcription of MHCII molecules in intestinal epithelial cells, leading to an increase in Type 1 regulatory cells and ultimately food tolerance. The study provides new insights into the treatment of food allergies.
A new study has found that children raised in rural areas with plenty of outdoor time and animal exposure develop better-regulated immune systems than urban counterparts. Early life immune development is highly dependent on living environment and lifestyle factors, and researchers say this can have long-term consequences for disease risk.