Articles tagged with Immunity
Researchers at the University of Pittsburgh have discovered a novel tool to help stratify rejection risk in kidney transplantation. They found that mismatching SIRP-alpha between donors and recipients contributes to worse rejection, scarring, and graft failure in humans, suggesting improved transplant outcomes.
Researchers at University of Queensland have discovered a nanobody to combat two highly lethal viruses with no approved vaccine or cure. The DS90 nanobody can access hard-to-reach areas of the virus to block infection.
Researchers discover a novel metabolic pathway, glyoxalase system, that regulates excessive immune responses by targeting a previously underexplored metabolic pathway. The GLO2-SLG-D-lactylation pathway suppresses inflammatory signaling, reducing inflammation in acute and autoimmune disease settings.
Researchers review classification, mechanisms of action and clinical application of bispecific antibodies in treating non-small cell lung cancer. Bispecific antibodies demonstrate improved anti-tumor efficacy and a safe profile for NSCLC patients resistant to targeted therapies or immune checkpoint inhibitors.
Recent CAR-T cell modification strategies have enhanced recognition, immunity stimulation, killing activity, and safety. The new designs counteract tumor immune escape and immunosuppressive microenvironments.
Deepshika Ramanan, a Salk Assistant Professor, has been recognized as a Rita Allen Foundation Scholar for her innovative research on maternal immunity and lactation. She will receive annual grants of up to $110,000 to conduct groundbreaking work in neuroscience, cancer, immunology, and pain.
Sara Poletti's research reveals how childhood trauma triggers persistent neuroinflammation pathways and alters brain structure, creating lifelong vulnerability to psychiatric disorders. Her work identifies biological markers of trauma and explores prevention strategies to reduce mental illness odds.
A high-throughput neutralisation assay reveals how individual immunity gaps shape flu strain success, highlighting personalised immunity and its impact on virus evolution. The study used large-scale sequencing to quantify antibody responses against circulating H3N2 flu strains in children and adults.
Researchers identified specific antibody features that limit Mtb growth, revealing critical insights into antibody-immune cell interactions. The study lays groundwork for potential antibody-based therapies or vaccines against tuberculosis, an urgently needed treatment for the deadly infectious disease.
Researchers explore how plants use ubiquitination to fend off pathogens, developing molecular tools for disease resistance. The team aims to design synthetic E3 ligases that can switch on immune pathways and target pathogen proteins, enhancing crop resilience.
Recent advances and challenges in T cell immunotherapy highlight the need for deeper understanding of T cell fate determination mechanisms to overcome immunotherapy resistance. Key regulatory factors, transcription factors, and metabolic pathways govern T cell differentiation and function.
Scientists discovered that certain bacteria can trigger their own cell death as a defense mechanism against viruses, utilizing components of the bacterial immune system. This phenomenon could be exploited to develop novel antimicrobial treatments and fight drug-resistant infections.
A new study models cholera transmission after interventions in the Democratic Republic of the Congo, highlighting the importance of environmental reservoirs in maintaining endemic diseases. The research suggests that vaccination may have a smaller impact on preventing transmission compared to water, sanitation, and hygiene improvements.
The European Centre for Disease Prevention and Control reports a significant increase in measles cases across EU/EEA countries, with eight out of ten unvaccinated individuals contracting the disease. Vaccination levels fall short of the 95% target, leaving vulnerable populations susceptible to measles.
A study suggests that pre-existing immunity against seasonal H1N1 flu can reduce the severity of bird flu in ferrets. In the study, ferrets with prior H1N1 immunity were protected against severe disease and death caused by H5N1 bird flu, whereas those without prior immunity had more severe illness and fatal outcomes.
A cross-sectional study found that perceived stress, inadequate social support, racial discrimination, and neighborhood deprivation negatively impacted systemic and tumor immunity in Black women. These findings may inform prevention and public health interventions for cancer health disparities.
Researchers at Salk Institute discover SSRIs like Prozac regulate immune response, preventing sepsis in mice. The findings suggest a potential new use for the popular drug, which could lead to life-saving treatments and enhanced global preparedness for pandemics.
Researchers discovered immune cells that can recognise influenza (flu) viruses even as they mutate, providing a potential solution to the annual updates of flu vaccines. The study found that certain T cells, which play a critical role in fighting infections, can detect multiple flu strains, even those that have evolved over a century.
The EU/EEA has detected circulating vaccine-derived poliovirus type 2 (cVDPV2) in sewage samples, prompting increased vigilance. To prevent a return of the disease, countries must maintain high vaccination rates and close vaccination gaps, as well as strengthen environmental surveillance.
Researchers at the University of Melbourne have identified a rare type of immune cell, called stem-like T cells, that holds the key to maintaining powerful, long-term immune responses. ID3+ T cells have the remarkable ability to resist burnout and maintain a powerful immune response over time.
A systematic review and meta-analysis found that cold-water immersion can reduce stress levels within 12 hours, improve sleep quality, and boost quality of life. However, these benefits may fade after three months. Cold showers also showed promise in reducing sickness absence and improving mood.
The International Alliance for Primary Immunodeficiency Societies has partnered with Rockefeller University Press to launch the Journal of Human Immunity, an open-access journal focused on human immunity and inborn errors of immunity. The journal aims to provide a platform for groundbreaking research and attract top-tier submissions.
A new self-destructing vaccine provides improved safety and protection against TB in macaque monkeys, outperforming the standard BCG vaccine. The 'kill switch' mechanism eliminates the risk of accidental infection, offering a safer vaccination option for immunocompromised individuals.
Neuroscientist Professor Raz Yirmiya reveals a vital link between inflammation and depression through groundbreaking research. His work suggests that both activation and suppression of the immune system can trigger depressive symptoms, highlighting the need for personalized treatment approaches.
Researchers created an advanced computational model to optimize maternal vaccine design and protect high-risk populations. The model helps reveal which antibodies can pass through effectively and when, enabling the development of safer, more effective vaccines.
The study presents a unified theory for predicting pathogen invasion and evolutionary potential. Researchers found that population-level immunity can predict whether new and old strains will co-circulate. The model shows that most competing strains can spread in the presence of their competitors across common human pathogens.
Participants who received 2 doses of MVA-BN vaccine showed comparable or lower mpox antibody responses at 12 months compared to those receiving 1 dose. Protective immunity may be waning in individuals vaccinated with this vaccine, according to a recent study.
Researchers found that natural immunity from previous flu infections enhances vaccine efficacy, leading to stronger and broader antibody responses. This could benefit individuals who contract the flu each year, potentially improving protection against future strains.
A modelling study suggests that slow waning of MMR vaccine-induced immunity may contribute to rising measles cases in double-vaccinated people. However, the MMR vaccine remains the most effective measure to prevent measles infection, and community vaccination levels above 95% are essential to prevent outbreaks.
Researchers identified T. immunophila as a key player in breaking down the gut's protective immune barrier, leading to increased susceptibility to pathogens and delayed repair of the gut barrier. The discovery provides a promising new avenue for treatment of inflammatory bowel disease, Crohn's, and ulcerative colitis.
Researchers at Gladstone Institutes used computational tools to predict the 3D shapes of nearly 70,000 viral proteins, uncovering a powerful way viruses evade host immune defenses. The study found that bacteria-infecting and animal viruses share an ancient mechanism to evade immune systems.
Researchers from Osaka University discovered that Ikaros binds to Foxp3 to inhibit the expression of target genes, including Ifng, in regulatory T cells. This interaction is crucial for maintaining immune homeostasis and preventing autoimmune disorders.
Two proteins, viperins and argonautes, play important roles in human immunity, originating from Asgard archaea. These defense systems have been passed down for billions of years, providing a crucial line of defense against viruses.
A new study reveals a connection between metabolic genes and immune system T cells, suggesting a potential new class of inborn errors of immunometabolism. Researchers identified genetic overlap between disorders of metabolism and immunity, pointing to a continuum between the two conditions.
Researchers uncovered how combining immunotherapies targeting PD1 and LAG3 enhances CD8+ T cell responses, leading to improved cancer-killing prowess and enhanced survival rates. The studies also revealed that relatlimab is not inert and can be combined with other immunotherapies to improve responses.
Researchers developed a lipid nanoparticle formulated miR-193a-3p mimic that enhances T cell mediated immune responses and induces immunogenic cell death in tumors. This study demonstrates the potential of this therapy to prolong animal survival and reduce metastasis, offering new hope for cancer treatment.
Researchers used spatial transcriptomics to analyze liver biopsies from patients with CHB, uncovering distinct gene expression signatures and unique immune cell compositions. The study sheds light on the intricate interplay between the virus and the immune system, paving the way for developing novel therapeutic strategies.
Researchers at La Jolla Institute for Immunology have discovered immune cells, such as tissue resident memory cells, in the upper airway that can fight infections and build long-term immunity. These findings may lead to better vaccines and a deeper understanding of immunity against respiratory pathogens.
Researchers developed a universal influenza vaccine that targets the internal structural proteins of the virus, providing lifetime immunity against evolving viruses. Six out of 11 nonhuman primates inoculated with the vaccine survived exposure to the H5N1 virus, while unvaccinated primates succumbed to the disease.
Research by Associate Professor Shannon Bosch challenges Russia's classification of foreign fighters as mercenaries, arguing that international law and Ukrainian domestic legislation protect their rights. The study highlights the need for full combatant immunity and prisoner of war status for these foreign fighters.
A study published in Clinical Infectious Diseases found that regular booster doses of bivalent vaccines can maintain a person's ability to neutralize multiple SARS-CoV-2 strains, including XBB.1.5. This is especially important for immunocompromised groups, such as solid organ transplant recipients.
Researchers found TIMP-1 enhances antitumor immunity through self-stimulation and activates immune cells. Increasing TIMP-1 expression could improve cancer immunotherapies in patients with deficient immune responses.
Researchers at Northwestern University discovered an attenuated virus that can help eliminate cancer in mice and prevent future tumor development. The therapy works by raising 'red flags' on tumors to alert immune cells to attack them.
Researchers found that tumor-associated macrophages respond to physical properties of fibrosis by synthesizing injury-associated collagens, resulting in metabolic changes that suppress CTL function. This provides an alternative explanation for why anti-tumor immunity is impaired in fibrotic solid tumors.
Researchers found that repeat COVID-19 vaccinations elicit cross-reactive neutralizing antibodies capable of targeting multiple SARS-CoV-2 variants and distantly related coronaviruses. The findings suggest periodic re-vaccination may help build a stock of protective antibodies against emerging variants.
A study by the University of Cambridge and Fudan University found that children born by C-section are up to 2.6 times more likely to fail their first measles vaccination compared to those born naturally. Two doses of the vaccine are necessary for robust protection against measles.
Researchers developed a synthetic biomarker technology that can differentiate between prior Zika and dengue virus infections. The technology, using epitope surrogates, correctly identified people previously infected with Zika virus 85.3% of the time.
Researchers have identified a promising new vaccine adjuvant called C100, derived from chitin, which stimulates key sensing and signalling molecules to regulate anti-tumour immune responses. The discovery offers hope for developing effective adjuvants for in situ vaccines in cancer immunotherapy.
A team of scientists has developed a novel vaccine approach that induces long-lasting protective immunity against SARS-CoV-2 virus in pre-clinical models. The Clec9A-RBD antibody construct targets specific dendritic cells, leading to exceptional durability of immune responses and potential to address shortcoming of current mRNA vaccines.
Researchers found that T cells and memory B cells provide durable protection against symptomatic SARS-CoV-2 infection, with levels attainable after two doses of mRNA vaccination. The study suggests a two-dose vaccination regimen for children against COVID-19.
A Brazilian study found that a major bivalent COVID-19 vaccine induces neutralizing antibodies against the original coronavirus strain and subvariants of omicron. The vaccine's effectiveness was confirmed, but its importance in controlling disease was limited by its focus on the original strain.
Researchers at H. Lee Moffitt Cancer Center & Research Institute discovered a new therapeutic target for non-small cell lung cancer by targeting the Jagged2 protein. Disrupting this signaling pathway activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages.
Researchers at Insilico Medicine have developed a novel PTPN2/N1 inhibitor with improved oral absorption and robust antitumor efficacy using the company's generative AI engine. The new compound demonstrates enhanced biological activities compared to existing inhibitors, offering new treatment possibilities for cancer patients.
A Swedish study reveals that neutralising antibodies to the monkeypox virus decline significantly after two doses of the MVA-BN vaccine within the first month. The findings suggest that a booster dose may be necessary to maintain immunity, emphasizing the need for scientific evidence before policy decisions are made.
Austrian researchers report a breakthrough mpox infection in a fully vaccinated man who received two doses of the Jynneos vaccine. The case highlights the potential durability of protective immunity after complete vaccination and emphasizes the importance of clinical suspicion in high-risk groups.
Researchers found that Mpox antibodies decrease significantly within a year of MVA-BN vaccination, especially in individuals without prior smallpox vaccination. In contrast, antibody levels remained high in those with childhood smallpox vaccination, suggesting long-term protection.
A long-term analysis of over 8,000 samples revealed that SARS-CoV-2 infection and vaccine-induced antibody responses are long-lasting. Booster vaccination equalized differences in antibody concentration between participants with and without pre-existing immunity.
Researchers developed a new recombinant flu vaccine called Hexaplex, which provided superior protection against H1N1 and H3N2 viruses in animal models. The vaccine's combination of six proteins from different groups resulted in strong antibody production and T-cell activation, offering broader immunity.
A large-scale study published in the BMJ found that children born in October are most likely to be vaccinated and least likely to be diagnosed with influenza, confirming public health guidance of getting flu vaccinations in October. The study analyzed over 800,000 children's health records from 2011-2018.
A study by UC Davis Health found that a single dose of BCG reduced liver tumor burden and extended the survival of mice with liver cancer. The vaccine boosted the body's immunity, leading to tumor shrinkage and improved liver function.