Articles tagged with Gene Regulation
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Cardiomyopathy is a deterioration of the heart muscle affecting its pumping ability. MDC-researchers identified RNA binding motif protein 20 (RBM20) as a gene regulating titin splicing, a process connected to the disease. Understanding this mechanism may lead to more efficient molecular diagnosis and therapies for cardiomyopathy.
A team of researchers has developed a new tool to identify conserved motifs in the genomes of trypanosomatids, a group of parasites that include the causing agents of leishmaniasis and Chagas disease. The tool, named LeischCICS, uses bioinformatics tools to pinpoint potentially functional and regulatory sequences.
Researchers have discovered that a retrotransposon element is responsible for inducing anthocyanin production in blood oranges when exposed to cold conditions. This finding has significant implications for the future of blood orange production, potentially allowing for reliable worldwide cultivation and increasing their availability as...
The project 'Clockwork Green' investigates the importance of circadian clocks in plants, exploring their role in survival and reproduction. By releasing transgenic tobacco plants with silenced clock genes in their natural habitat, researchers aim to uncover the functions of circadian-regulated genes and their impact on plant growth.
Researchers discovered that high levels of Amd1, an enzyme in the polyamine synthesis pathway, are essential for maintaining embryonic stem cells' (ESCs) self-renewal ability. The study also found that manipulating polyamine levels could help direct ESC differentiation into clinically useful cell types.
Biologists at the University of Rochester used a genetic tool from jewel wasps to find changes in cell regulator genes that affect wing growth. This discovery could help understand cell growth regulation and underlying causes of some diseases.
A team of scientists led by Bing Ren has discovered how differential DNA methylation in the parental genomes sets the stage for selective expression of imprinted genes. The study found parent-of-origin specific DNA methylation imprints at 1,952 dinucleotide sequences, including previously unknown regions.
Plant steroid hormones brassinosteroids play a crucial role in regulating the number and distribution of stomata on leaves. Research found that brassinosteroids inhibit the protein BIN2, allowing stomata formation when present and inhibiting it when absent.
A new NIH study reveals that certain genes implicated in schizophrenia and autism show increased regulatory activity during a critical period of development, influenced by environmental factors. This discovery highlights the importance of epigenetic mechanisms like DNA methylation in shaping brain function and behavior.
Researchers at the Genome Institute of Singapore have made a groundbreaking discovery by mapping the human genome's three-dimensional structure, revealing how genes interact and influence each other. This study sheds light on the complex regulation of gene expression and its implications for understanding human diseases.
A Canadian-led research team has identified two genetic mutations responsible for up to 40% of glioblastomas in children, a fatal cancer of the brain. The mutations were found to be involved in DNA regulation, which could explain resistance to traditional treatments and have significant implications on other cancers.
Researchers discovered a common mechanism regulating blood pressure in humans through a sweeping genetic analysis of a rare disease. The study identified two genes interacting to control salt and potassium balance in the kidney.
A novel method has precisely pinpointed the location of proteins that read and regulate chromosomes, providing a high-resolution view into gene regulation. This breakthrough could lead to a deeper understanding of normal human development and disease mechanisms.
Researchers identified a new gene, Meg1, regulating nutrient flow from mother to offspring in maize plants, which could help increase global food production. The discovery of this imprinted gene provides scientists with a molecular tool to manipulate and improve seed traits.
Researchers at the Virginia Institute of Marine Science have developed genetic markers to test blue marlin for their ocean of origin. The new test can accurately determine if a blue marlin was taken from the Atlantic or Pacific Ocean, helping federal seafood agents enforce regulations and prevent overfishing.
Scientists have identified a gene switch that regulates the choice of odorant receptor genes in olfactory sensory neurons. Regulatory elements in the genome act as on-off switches to determine which gene is chosen for expression.
Researchers investigate how c-myc gene mutations interact with p53 and Bcl2 genes in Burkitt's lymphoma. The study shows that the nature of the second 'hit' determines immune response against developing tumours, with implications for cancer therapy.
Researchers at Uppsala University have examined the mechanism of gene transcription and found that genes active in the brain are transcribed with a special mechanism. During fetal development, there is a larger proportion of RNA molecules containing introns compared to fully developed brains.
A study published in Nature Genetics finds that both males and females up-regulate X chromosome gene expression to equalize the dosage imbalance caused by having only one copy of the X chromosome. This confirms a longstanding hypothesis and provides new insights into how cells manage genetic imbalances.
Researchers found that young, human-specific genes are more likely to be expressed in the developing human brain. This correlation suggests that these genes may play a key role in constructing the uniquely powerful human brain.
A team of researchers has discovered a pervasive human RNA modification that contributes to obesity and type II diabetes. The study shows that this modification process, called methylation, impacts protein expression and function through its action on a common RNA base: adenosine.
A study has identified a gene, Tomosyn-2, that confers diabetes susceptibility in obese mice by regulating insulin secretion. The protein acts as a brake on insulin release from the pancreas, and its destabilization allows for sufficient insulin production to prevent diabetes.
Researchers at Texas AgriLife Research have discovered a gene regulating sorghum flowering, which can delay flowering and increase biomass accumulation by up to 200 days. This breakthrough enables the development of sorghum as a dedicated bioenergy crop with potential to produce lignocellulosic-based biofuels.
Research identifies a new gene regulatory region on chromosome 17 involved in testicle formation in individuals with XX or XY chromosomes. The discovery sheds light on the complex mechanism of human sex development, revealing a missing link in the testis development system.
Researchers have identified a critical link between p63 and Satb1 genes in regulating skin development. The study found that Satb1 plays an essential role in chromatin remodeling, which is necessary for gene expression and cell differentiation.
Researchers identified parkin as a regulator of fat uptake by liver cells, impacting blood fat levels and potentially linking to Parkinson's disease. The study found that increased parkin protein levels are associated with high-fat diets and mutant human cells.
Researchers at the University of Helsinki identified specific mutations in the MED12 gene as the cause of fibroid tumorigenesis in 70% of studied tumors. This discovery provides hope for targeted therapies and a deeper understanding of fibroid development.
Researchers identified three periods of evolutionary innovation in gene regulation that increased in frequency during different periods in vertebrate evolution. These innovations affected genes involved in embryonic development, cell-to-cell communication, and signaling pathways.
A Gladstone scientist has discovered a genetic factor that regulates heartbeat synchronization, potentially advancing medicine and human health. The study found that abnormalities in this regulation lead to heart arrhythmias, which can be fatal, and may offer new avenues for drug therapy to target these pathways.
A study published in PLOS Biology found that a defect in brain glucose sensing contributes to obesity, while correction of this defect can treat the condition. The researchers discovered a novel role for hypoxia-inducible factor (HIF) in hypothalamic glucose sensing and whole-body energy balance regulation.
A recent stem cell study has found that the protein molecule E-cadherin, which plays a key role in cancer, also regulates up to 25% of genes within cells. This unexpected discovery could lead to new cancer treatments by understanding why some cancer cells are difficult to eradicate.
Researchers at Stowers Institute for Medical Research discovered the role of Super Elongation Complex (SEC) in controlling gene expression during early development. They found that SEC facilitates coordinated and rapid induction of genes, including Hox genes, which are essential for embryonic development.
Researchers at Stowers Institute for Medical Research discovered SAGA's importance in fruit fly development, targeting different genes by interactions with transcription factors. SAGA regulates transcription elongation and is associated with paused polymerase II on developmentally regulated genes.
Researchers have identified Foxp2 as a gene that helps regulate the wiring of neurons in the brain, leading to insights into speech and language disorders. The study found that altering Foxp2 levels impacts the length and branching of neuronal projections, which modulates brain connectivity.
A recent study published in PNAS reveals that a specific microRNA, miR-206, plays a pivotal role in normal muscle development during embryonic stages. This discovery has significant implications for understanding the maintenance and regeneration of healthy muscle tissue, particularly in diseases such as muscular dystrophy and cancer.
A team of scientists has uncovered a novel mechanism regulating gene expression and transcription linked to Spinocerebellar ataxia 7, an inherited neurological disorder. Non-coding RNA plays key role in neurological development and function.
The 2011 Pew Scholars will advance research leading to medical breakthroughs and treatments, covering human diseases like Alzheimer's and diabetes. The program, investing over $125 million, recognizes early-career scientists with innovative ideas.
Researchers identified a critical node, defective proventriculus (dve), in a network regulating Rhodopsin gene expression. This interlocked feed-forward loop (FFL) motif controls cell-type specific expression, restricting and inducing Rhodopsin presence in different photoreceptors.
Researchers at Baylor College of Medicine have identified over 11,000 protein interaction networks that control gene regulation in human cells. These networks, which consist of thousands of multi-protein complexes, play a crucial role in regulating the expression of genes and producing proteins.
A collaborative research proposal by Hebrew University and University of Kentucky teams explores the role of small non-coding RNAs in regulating genetic information. The study aims to understand how organisms interpret genomic information, potentially leading to new therapies for human diseases.
New studies at UCSB reveal wide-ranging variability in retinal neurons among individuals, with potential causal genes identified for cone photoreceptor production. The research contributes to a fuller understanding of retina development and its significance in vision research.
Scientists uncover a highly conserved dual mechanism that regulates both brain development and function across diverse species. The discovery could lead to biomarkers for neurological diseases and potentially cure them with microRNA therapeutics.
James Birchler, a renowned cytogeneticist, has been elected to the National Academy of Sciences for his pioneering work on chromosome structure and function. His innovative techniques have paved the way for introducing disease-resistant and agronomic traits into plants, with significant implications for agriculture and medicine.
A recent study suggests that successful genetic blueprints for mesodermal development are recycled by evolution, rather than being invented anew in different species. The researchers found highly conserved transcription factor binding sites across six fruit fly species, indicating a shared regulatory program.
Researchers studied fruit flies adapting from sub-Saharan Africa to Europe and found that a gene called crm regulates temperature-dependent traits. The study reveals that changes in this gene may have enabled the flies to survive in colder climates.
The ENCODE Project, a massive database cataloging the human genome's functional elements, is being made available as an open resource. The project provides a guide for using the vast amounts of data and resources produced so far, facilitating scientific discovery and public understanding of science.
Researchers at Max Planck Institute for Chemical Ecology sequenced the antennal transcriptome of the tobacco hornworm moth, revealing specific proteins involved in olfaction. The study identifies 18 odorant binding proteins and 21 chemosensory proteins, providing new insights into the insect's ability to detect and process odor molecules.
A study of over 47,000 people found that a genetic variation in the AUTS2 gene is associated with lower alcohol consumption, suggesting its role in regulating drinking behaviour. The researchers also investigated animal models and found that blocking a related gene increased sensitivity to alcohol.
Scientists developed a new method, GROMIT, to study gene regulation by employing a jumping gene as an informant. The technique revealed that each regulatory element can control a broader range of genes than previously thought, and expression levels are fine-tuned at the tissue level.
A protein complex called MSL amplifies the X chromosome in males, allowing enzymes to express genes more freely. This process helps correct the genetic imbalance between X and Y chromosomes in males.
Scientists identified two distinct repressor proteins that use different molecular mechanisms to halt gene expression during development. This study may hold the key to explaining how diseases like cancer and diabetes are caused by genes unable to shift gears properly. By understanding these mechanisms, researchers can begin to see how...
To solve the world's food problems, agriculture needs to use resources more efficiently by integrating various sectors and adopting innovative methods. Researchers are exploring ways to grow crops in areas that were previously unused, such as using wastewater to irrigate and fertilize fruit and vegetables.
Researchers found a gene called RORA that plays a critical role in brain development and is affected by sex hormones. In individuals with autism, aromatase conversion of testosterone to estrogen is reduced, leading to increased male hormone levels and decreased RORA expression.
Researchers at North Carolina State University have discovered a gene associated with the immune system that is overexpressed in placentas of women with preeclampsia, leading to a better understanding of the disorder. The finding may lead to improved screening and prenatal care for these patients and their babies.
Researchers discover that selective activation of nonclassical ER-alpha signaling may help reduce postmenopausal obesity risk by normalizing energy balance. The study found that this type of estrogen signaling is crucial for regulating body weight and preventing metabolic disorders.
A study by Mayo Clinic researchers identifies LRP1, a lipoprotein receptor, as a co-receptor with the leptin receptor that regulates appetite and metabolism. Mice engineered to lack LRP1 gained weight and became obese, indicating its critical role in lipid metabolism and energy balance.
Researchers at Stanford University School of Medicine have identified over 2,000 genetic regions, called enhancers, that trigger gene expression in human embryonic stem cells. These enhancers play a crucial role in regulating cell-type-specific gene expression during early development.
Vivian Cheung, a geneticist at The Children's Hospital of Philadelphia, received the Curt Stern Award for her pioneering work on human gene expression and its impact on disease risks. Her research has transformed the scale of human genetic studies, enabling researchers to analyze thousands of genes simultaneously.
An international study identified 30 genes controlling puberty age and found they also play a role in fat metabolism, linking early maturity to increased obesity risk. The study of over 100,000 women from Europe, US, and Australia highlights the complex biological processes controlling puberty timing.
Scientists have discovered 30 new genes that control the age of sexual maturation in women, which also affect body weight regulation and fat metabolism. The study found associations between these genes and early menarche, as well as increased risk of health problems like obesity, type 2 diabetes, and cardiovascular disease.