Research on blood and what it reveals about health. Covers blood biomarkers, occupational exposure, cell-preservation for CAR-T therapy, and blood supply.
Biennial colorectal cancer screening in France's Cote-D'Or region increased the rate of diagnosis of high-risk pre-cancerous adenomas by 89%. The study also found that fecal occult blood testing may be more efficient than colonoscopy for high-risk patients.
A new blood test identifies 9 RNA markers tied to depression, predicting who will benefit from therapy and providing the first objective, scientific diagnosis. The test also shows biological effects of cognitive behavioral therapy, offering personalized medicine approach to people suffering from depression.
A new study has provided clinical guidelines for selecting the best oral blood thinner for patients suffering from deep vein thrombosis. The study, published in JAMA, analyzed 45 randomized trials involving nearly 45,000 patients and found no major differences in effectiveness and safety among eight anticoagulant therapies.
Researchers have identified a novel drug target, Kir7.1, that induces acute and sustained uterine contractions to treat postpartum haemorrhage (PPH), a major global cause of maternal mortality. The treatment bypasses biochemical pathways exhausted during prolonged labour, promising effective treatment at low doses.
Research on Korean adults finds that prolonged work hours are linked to a higher risk of developing coronary heart disease. Employees working 61-80 hours per week face a 42-94% increased likelihood of disease development within 10 years.
The biospleen device uses magnetic beads coated with genetically engineered MBL proteins to remove pathogens and toxins from the blood. In laboratory tests, it filtered out over 90% of key sepsis pathogens within five hours.
A new app-device can quickly and accurately measure two key signs of sepsis, a leading cause of death worldwide. The device has the potential to save over 6 million children in developing countries, where sepsis accounts for 60-80% of all deaths.
A recent study found that individuals with blood type AB are 82% more likely to develop cognitive impairment and dementia than those with other blood types. High levels of factor VIII, a protein related to clotting, were also linked to increased risk of memory problems.
A new study uses genetically modified plants to teach the immune system to tolerate clotting factors, reducing the risk of antibody formation. The treatment, which involves feeding mice with plant capsules, has shown promising results and may offer a cost-effective alternative to current treatments.
A new study found lower testosterone levels in men with sudden cardiac arrest and higher estradiol levels in both men and women were associated with increased risk. The research suggests that hormone levels may play a role in predicting patients' likelihood of suffering from the usually fatal condition.
Researchers found that contaminated blood cultures can serve as diagnostic predictors for more targeted antibiotics. The study showed that highly resistant skin germs could indicate high mortality rates for the actual disease-causing bacteria.
A new study published in Circulation found that low-dose aspirin significantly reduces the risk of new venous blood clots and cardiovascular events. The treatment is especially useful for patients who cannot take long-term anticoagulant medications due to expense or bleeding risks.
Researchers found that Deformed Wing Virus (DWV) is the most affected virus species by Varroa infestation, while Kashmir Bee Virus (KBV) peaks two years after initial infestation and disappears. The study highlights the importance of beekeeper awareness, mite monitoring, and efficient Varroa control.
Researchers found MSCs in patient's blood after severe trauma, suggesting they are released from bone marrow into bloodstream following organ damage. The study provides conclusive evidence for the mobilization and migration of MSCs in humans.
Researchers have identified a 52-character biological signal specific to bacterial infection in newborns' DNA, enabling early detection and diagnosis. This breakthrough could lead to the development of a single-drop blood test, limiting antibiotic overuse and tackling drug resistance.
A study found that delaying cardioversion for more than 12 hours after atrial fibrillation diagnosis increases the risk of strokes and blood clots. Patients with delayed treatment had a higher incidence of thromboembolic complications, highlighting the importance of prompt correction.
Severely overweight patients with hypoventilation can experience low blood oxygen levels during air travel. Experts recommend a pre-flight hypoxic challenge test for better preparedness and potential use of supplemental oxygen or non-invasive ventilation.
Physicians at Johns Hopkins have developed blood and saliva tests that accurately predict the recurrence of HPV-linked oral cancers. The tests screen for DNA fragments of the human papillomavirus shed from cancer cells, with accuracy rates of up to 70% in some patients.
Researchers from University of Southern Denmark and Aarhus University have discovered how the PAI-1 protein behaves, revealing a unique shape change mechanism. This knowledge allows for better control over coagulation, reducing risk of bleeding or blood clots.
A hospital used the ACS NSQIP database to identify a link between postoperative isolation and increased risk of venous thromboembolism. By implementing measures such as designated ambulation areas and spirometer use, the hospital was able to reduce VTE rates and save an estimated $10,000 to $16,000 per potentially affected patient.
A new study led by Dr. Marc Rodger finds that low molecular weight heparin (LMWH) has no positive benefits for pregnant women, and may even cause harm by increasing bleeding and reducing access to anesthesia during childbirth. The study's results are a significant relief for many women who had been prescribed the treatment for decades.
A new analysis compares various anticoagulants after different types of orthopedic surgery. Aspirin may be a suitable option for preventing blood clots in patients undergoing hip or knee replacements, but anticoagulation therapy is more beneficial for those who have undergone hip fracture repairs.
Researchers at Saint Louis University discovered that deleting disordered sections of a protein's structure reveals the molecular mechanism of blood clotting. By crystallizing prothrombin, they found that the deleted version is activated to thrombin faster and provides key information on the mechanism of prothrombin activation.
Researchers found that blood clots are rare in children undergoing spine operations, and most patients can be safely monitored without anti-clotting medication. High-risk groups include children with congenital scoliosis or spinal curvatures part of a syndrome, as well as older children.
Researchers from UCL and the Mayo Clinic argue that labelling people with moderately high blood sugar as pre-diabetic has no health benefits. The term could create significant burdens on healthcare systems without conferring any long-term health benefits.
A recent study of over 500,000 Danish women found no increased risk of venous thromboembolism following quadrivalent HPV vaccination. The research, published in JAMA, used data from national registers to evaluate the potential link between the vaccine and blood clots.
A study by Brown University researchers found that Rhode Island's Lead Hazard Mitigation Law has significantly reduced blood lead levels in children living in compliant buildings. However, only 20% of properties covered by the law were in compliance, with average lead levels still above 5 micrograms per deciliter in noncompliant homes.
A recent study found that even low levels of lead in children's blood are associated with increased risk of behavioral and emotional problems. As blood lead levels increase, so do the problems, highlighting the importance of reducing lead exposure in children.
A study of Chinese preschoolers found associations between moderately elevated blood lead concentrations and teacher-reported behavioral problems. The study suggests that further examination is needed to clarify the biological effects of environmental lead exposure on children's behavior.
Researchers found that people with a specific gene variation have lower blood lipids and a reduced risk of arteriosclerosis. The study, based on two large population studies, suggests that inhibiting apolipoprotein C3 could be an effective target for new drugs to prevent cardiovascular disease.
Researchers discovered four rare APOC3 gene mutations that lower blood triglyceride levels and reduce the risk of coronary artery disease by 40%. The study suggests a powerful strategy for developing new drugs against heart disease.
Researchers developed biomarkers from whole blood gene expression profiles to predict disease status at 12 months in children with newly diagnosed JIA. The study found strong predictive properties for disease status after four months of therapy, and identified different mechanisms of response in RF positive patients.
A new assay can detect toxic prions in blood samples from humans with variant Creutzfeldt-Jakob Disease (vCJD) and asymptomatic animals. The test, developed by French researchers, was tested on vCJD patients and non-infected controls, accurately identifying infected individuals.
Researchers found that persons with lower blood vitamin D levels were twice as likely to die prematurely as those with higher levels, regardless of bone disease risks. The study supports previous findings on low vitamin D being hazardous and provides reassurance on safe dosing up to 4,000 IU/day.
Researchers at Mount Sinai Hospital discovered that a protein called Sirtuin1 (SIRT1) is essential for maintaining healthy aging of blood stem cells. The study found that loss of SIRT1 leads to impaired regeneration and resembles aged, defective stem cells in mouse models.
A recent study found that frequent use of permanent dyes and perming treatments may expose hairdressers to banned aromatic amines, linked to increased cancer risk. The researchers recommend protective measures such as wearing gloves to minimize skin exposure.
Researchers at Mayo Clinic have developed an optical blood oxygen sensor attached to an endoscope that can identify pancreatic cancer with a sensitivity of 92% and specificity of 86%. The device measures changes in blood flow near the pancreas, which tumors alter to grow. Early detection is crucial as most pancreatic cancers are diagno...
A study by University of Illinois Chicago found that patients with alcohol in their blood had a reduced risk of developing cardiac and renal complications, resulting in lower mortality rates. The protective effect was observed even after the alcohol was metabolized.
A large study finds that high levels of certain air pollutants are associated with a higher risk of cardiovascular problems, including irregular heart rhythms and lung blood clots. The research suggests that particulate matter is particularly harmful for elderly people.
A study found that preventive implantation of ICDs in patients with less severe heart failure (LVEF 30-35%) significantly reduces mortality rates at 3 years compared to those without an ICD. The analysis also showed improved survival in patients with LVEF < 30%.
A study from Duke University Medical Center found that implantable cardioverter defibrillators improve survival among heart failure patients with a left ventricular ejection fraction of 30-35%. The device reduces three-year mortality rates by 3.6% in patients without ICDs.
A standardized prevention program implemented in a hospital department of surgery significantly reduced the rate of deep venous thromboses (DVT) and pulmonary emboli among patients. The program, which scored individual risk factors and provided risk-based prophylaxis, led to an 84% drop in DVT rates and a 55% decrease in pulmonary emboli.
Researchers tracked real-time virus replication and drug clearance in HCV patients, revealing a lag between liver and blood viral decay. The findings suggest the need for tailored therapy to achieve viral eradication and may inform vaccine development.
A new Vanderbilt University study found that women with blood in their urine were less likely to be referred to a urologist for further tests than men with the same issue. The disparity may contribute to delayed diagnoses and worse mortality rates among women with bladder cancer.
Research at Washington University School of Medicine found that vitamin D supplements had a limited benefit for asthma treatment. Patients who achieved sufficient blood levels of vitamin D showed improved asthma control, including reduced treatment failures and asthma attacks.
A new study found that a single episode of binge drinking can cause bacterial leakage from the gut into the bloodstream, leading to increased levels of toxins. This results in an immune response, producing fever, inflammation, and tissue destruction, according to researchers at UMMS.
A new study by Uppsala University reveals that high levels of PCBs in the blood significantly increase the risk of dying among smokers and former smokers. For non-smokers, no elevated risk was found after eight years.
Researchers discovered that elephant seals have high levels of carboxyhemoglobin, similar to those found in heavy human smokers. The team suggests that this may provide protective effects against oxidative damage, potentially benefiting the animals' health. Further study is needed to fully understand the significance of these findings.
A blood test has been developed to predict impending preterm birth, distinguishing between true and false labor in 70% of cases. The new test outperforms existing methods by using a set of nine genes coupled with clinical data, allowing for all women to be screened as part of routine blood work.
A study by Intermountain Medical Center found that AFib patients on blood thinning medications are at higher risk of developing dementia if their doses are not within the optimal recommended range. Patients with dosages outside this range were 4.5 times more likely to develop dementia.
GDF11 protein improves the exercise capability of aging mice by making their brains and skeletal muscles more like those of young health mice. The protein also restores DNA damage associated with aging in muscle stem cells, leading to improved function in unmanipulated muscle.
A study published in ACS' Journal of Proteome Research found that whey protein slows down stomach emptying and lowers fatty acid levels, increasing insulin levels in obese adults. The results suggest that whey protein may be a beneficial addition to diets for those at risk of developing type-2 diabetes and cardiovascular disease.
A recent study published in Scientific Reports analyzed the DNA recovered from a relic attributed to Louis XVI and found it did not match his expected genetic profile. The analysis revealed a clear French and Italian component, contradicting historical accounts of Louis XVI's physical appearance.
A study published in Cell Transplantation found that injecting autologous peripheral blood stem cells into the brain of stroke patients improved their motor function. The treatment was safe and feasible in patients who suffered a prior stroke, with significant improvements in clinical outcomes measures.
A new prediction tool can help doctors identify patients at highest risk for respiratory failure after surgery, allowing them to take measures to prevent the condition. The tool uses nine predictors to determine a patient's risk level, enabling doctors to assign risk levels and use preventive measures more effectively.
A study analyzing nearly three decades of data found chromium supplements are ineffective in reducing fasting glucose levels in both diabetic and non-diabetic populations. Despite this, the researchers suggest other dietary supplement ingredients may have positive effects on fasting blood sugar levels.
Scientists have developed a device that can process whole blood and isolate genetic material for two potential biomarkers within minutes. This rapid detection method could help determine the course of proper treatment, potentially saving lives.
A study published by Johns Hopkins Medicine found that DNA modifications in the blood of stressed mice correlate with changes in brain tissue, providing a valid comparison between the two. The research linked epigenetic changes to altered gene function, shedding light on the relationship between stress and psychiatric diseases.
Researchers at Lifespan have developed a blood test that can predict a person's risk of sudden cardiac death with high accuracy, enabling more targeted and efficient assessment of patients' needs for implantable cardiac defibrillators. The test is expected to refine the need for such devices and reduce overuse of ICDs.
Research suggests that maintaining healthy blood pressure, sugar levels, and cholesterol as a young adult may help prevent cognitive decline in mid-life. A 25-year study of 3,381 participants found that those with higher risk factors scored lower on cognitive function tests in their 40s and 50s.