Research on blood and what it reveals about health. Covers blood biomarkers, occupational exposure, cell-preservation for CAR-T therapy, and blood supply.
A study found lower risks of heart attack, death, and procedures to re-open the artery in patients receiving drug-eluting stents followed by individualized blood-thinning medication. The results challenge existing guidelines for prolonged anti-platelet therapy after stent placement.
A blood test using high-sensitivity cardiac troponin T can accurately predict heart attack risk in patients with chest pain, allowing for targeted admissions and reduced hospital costs. The test's negative predictive value was found to be 99.8 percent for heart attack within 30 days.
Physicians report success in weaning patient off bypass with intra-aortic balloon pump due to reversible left ventricle dysfunction and minimal atherosclerosis. The pump can be an option for patients with mild to moderate aortic insufficiency who don't have severe atherosclerosis.
A study found that death certificates often fail to list alcohol as a cause of death in traffic crashes, with injuries being the leading cause of death for Americans younger than 45. Researchers need reliable data to study the effects of policies aimed at reducing alcohol-related deaths.
A new stool-based screening test, Cologuard, detected 92% of colorectal cancer and 42% of advanced pre-cancerous lesions, outperforming a commercial occult blood fecal immunochemical test. The non-invasive test allows patients to collect samples at home, increasing the potential for higher cancer screening rates.
Researchers used an age-adjusted D-dimer threshold to safely exclude pulmonary embolism in elderly patients. This approach significantly reduced false positives, especially in older adults.
Scientists have identified a previously unrecognized gene variation associated with healthier blood lipid levels and reduced risk of heart attacks. The discovery uses a new approach to scan the genome for variations in genes that change protein function.
Researchers at Aarhus University found that patients with blood poisoning are twice as likely to develop a blood clot in the brain or heart. The risk is highest within 30 days of infection, and only 0.2% among the general population.
Researchers found that statins significantly reduced VTE events following total hip and knee replacements, with a 48% lower risk compared to non-statin groups. The study, which included over 400 patients, suggests that statins may have anti-inflammatory effects that contribute to their ability to decrease VTE risk.
DVT can lead to post-thrombotic syndrome, causing chronic leg pain, fatigue, swelling, and skin ulcers; interventional radiologists offer minimally invasive treatments to prevent this complication
A blood test has been developed to accurately screen for infection with the agent responsible for variant Creutzfeldt-Jakob disease. The test found 71.4% of patients with vCJD correctly tested positive, making it suitable for screening large populations.
A new therapy has been developed to treat atrial fibrillation by targeting misbehaving nerves that cause the condition. The therapy, which involves adding four or fewer injections of 98% ethanol to radio wave ablation, appears to be more effective than standard surgical therapies.
Researchers found that early but not advanced forms of atherosclerotic plaques in mice regress when 'bad' cholesterol is lowered. The study suggests that preventative cholesterol-lowering treatment could prevent more advanced plaque development and reduce the risk of stroke or heart attack.
A new scientific blood analysis uses biomarkers and NMR spectroscopy to predict short-term mortality in the next five years. The study found that biomarker concentrations are crucial for normal metabolism, regardless of known risk factors.
Researchers have identified four biomarkers in blood samples that can predict mortality from any disease within five years. The study used NMR spectroscopy to analyze over 17,000 healthy individuals and found that these biomarkers were independent of traditional risk factors, indicating a general frailty in the body.
The updated guideline recommends oral anticoagulants for people with nonvalvular atrial fibrillation to prevent stroke. The new drugs are at least as effective as established treatment and have a lower risk of bleeding, making them suitable for many previously undertreated patients.
Researchers found an antibody to KIR4.1 protein in the blood of people with multiple sclerosis (MS) years before symptoms appeared, suggesting a potential role in disease development. The study's findings may help detect MS earlier, enabling better treatment and prevention strategies.
A simple blood test can identify 85% of post-surgical heart attacks, which often go undetected due to a lack of symptoms. Heart attacks are the leading cause of death within 30 days of surgery, with 10% mortality rate.
African-Americans are 39 times more likely to die from a stroke after an infection compared to other ethnic groups. Infection promotes blood clot formation and fat buildup in arteries, contributing to higher stroke mortality rates among blacks.
Scientists have successfully engineered dermo-epidermal skin grafts that contain functional blood and lymphatic capillaries, which can rapidly supply tissue fluid and prevent accumulation. This breakthrough could improve wound healing and organ structure of these skin grafts.
Researchers discovered that valproic acid activates AMPK, which reduces fat accumulation in the liver and lowers blood sugar levels in obese mice. Treated mice showed decreased blood sugar levels and a stabilization of weight.
A study involving 186 Type II diabetes patients found that health coaching significantly improved oral health by reducing biological markers for periodontitis by 50% and long-range blood sugar levels. The coaching group also showed increased self-efficacy in handling illness and health issues.
A device called MEDIC combines engineering and biochemistry to monitor specific drug levels in the bloodstream, offering potential for tailored prescriptions. The device uses microfluidic chambers lined with gold electrodes to detect target molecules in real-time.
A study found that higher vitamin D levels are associated with lower risk of new brain lesions, relapses, and faster decline in brain volume. Patients with low vitamin D levels early on may experience long-term increased MS activity and progression.
Researchers at the University of Toronto found that the popular blood type diet theory is not valid, as associations between diets and health markers are independent of an individual's blood type. The study suggests that adherence to a sensible vegetarian or low-carbohydrate diet is key to improving health, regardless of blood type.
A new on-field blood test can accurately diagnose sports concussions, distinguishing them from physical exertion. S100B levels rise significantly after a concussion, making it a promising biomarker for head injuries.
Researchers at Case Western Reserve University are developing imaging technology to improve treatment and survival rates for ischemic heart disease patients. The new technology uses high-speed computer analysis to help doctors determine if stents are restoring circulation as designed, reducing the risk of failure.
A new study from Uppsala University reveals that one night of sleep deprivation can increase morning blood concentrations of NSE and S-100B in healthy young men. These molecules are typically found in the brain and may indicate a loss of brain tissue. The findings suggest that good sleep is crucial for maintaining brain health.
A retrospective analysis of inpatients found that hyperhomocysteinemia and abnormal blood lipids exert synergistic effects on the onset of stroke. Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke, highlighting the importance of managing both conditions.
A daily bout of exercise significantly reduces detrimental health impacts from short-term overeating and inactivity. Exercise prevents unhealthy metabolic changes and disrupted nutritional balance, even when consuming thousands of calories more than burned.
Researchers used high-speed photography to study how ultrasound-stimulated microbubbles dissolve killer blood clots. The team found that the bubbles deform the clots' boundaries before burrowing into them, creating fluid-filled tunnels that break up the clots from the inside out.
Researchers found that diabetes drugs have different effects on the hearts of men and women, with metformin improving heart function in women but worsening it in men. The study suggests that sex differences play a role in how patients respond to treatments.
Research presented at EuroEcho-Imaging 2013 found that HIV patients with a positive blood viral load have a significantly higher incidence of structural heart disease. The study suggests that HIV itself might be an independent causal agent, and having a detectable blood viral load nearly doubles the prevalence of heart disease.
A Swedish study of 1,000 men aged 75 found that low vitamin B12 levels increased the risk of fractures by up to 70% in six years. The researchers used a new method to measure vitamin B12 uptake and found that physical activity and quitting smoking can help prevent fractures.
Researchers discovered HDL acts upon inflammatory processes by activating ATF3, downregulating chronic inflammation in macrophages. This finding suggests a molecular approach for treating inflammation in diseases like diabetes.
Scientists at the University of Eastern Finland have created a new diagnostic tool for migraines, detecting 'hot spots' in pulsatile perfusion and asynchronous facial blood supply. The Blood Pulsation Imaging technique has significant implications for predicting, diagnosing, and monitoring migraine treatment.
Researchers have developed a tiny capsule that can detect occult blood in the stomach at very low levels, enabling early diagnosis of stomach cancer. The device is non-toxic and acid-safe, and has been shown to be reliable and simple to use.
Researchers developed a diagnostic method that reveals factors behind conditions thought to have environmental triggers by decoding an individual's immune system. The process identifies disease-specific antibodies and their corresponding antigens, providing insight into conditions like Type-1 diabetes, autism, and Alzheimer's disease.
Research finds that treating arteriovenous malformations (AVMs) in the brain can increase risks of stroke and death, while managing symptoms may be safer. The study suggests observing patients with AVMs for at least five more years to confirm this finding.
Researchers have discovered a blood biomarker that accurately diagnoses concussions and predicts long-term cognitive disability. The protein SNTF levels were found to correlate with brain tissue damage, making it a potential tool for identifying patients at risk of persistent cognitive deficits.
The ENGAGE AF-TIMI 48 trial found edoxaban to be at least as effective as warfarin in preventing stroke or systemic embolism, while significantly reducing bleeding and cardiovascular death. High-dose edoxaban showed a 21% reduction in stroke risk and a 20% decrease in major bleeding compared to warfarin.
Researchers used CBC lab testing information gathered from the JUPITER Trial to evaluate the Intermountain-derived CBC risk score, finding it a powerful tool to predict death. Individuals with lower CBC risk scores were unlikely to die, while those with higher scores had more than 50% higher risk of death.
Researchers at MU School of Medicine found a new protocol using preventive blood thinners reduces life-threatening blood clots in brain-injured patients. The study compared outcomes between 107 and 129 patients treated with or without the medication, showing zero instances of deep-venous clotting among those who received it.
Danish researchers have identified a clear link between narrowed heart valves and high levels of lipoprotein(a) in the blood, which may help prevent valvular heart disease. The study found that people with very high levels of lipoprotein(a) are two to three times more likely to develop aortic stenosis.
The new guideline identifies four major groups of patients who will benefit from statin therapy to prevent stroke and heart attacks. Adopting a heart-healthy lifestyle is also crucial in preventing high blood cholesterol.
A recent study published in JAMA Internal Medicine reveals that women and African Americans are at a higher risk of heart attack due to atrial fibrillation. The study found that patients with AF, especially women and African-Americans, have a more than double increased risk of heart attack compared to those without AF.
Cerebral microbleeds are common in older individuals and can contribute to neurological changes. Researchers recommend considering microbleeds when treating other brain-related issues like stroke.
Scientists have developed a new therapeutic approach for Type 2 diabetes using a novel single molecule hormone that acts on GLP-1 and GIP receptors. The hormone reduces weight and improves blood sugar levels, and may offer unprecedented potential for personalized therapies.
Researchers have discovered that tumors with specific microRNA segments are more likely to recur after surgery. Elevated blood levels of these genetic markers may also indicate a higher risk of recurrence. The findings suggest a potential for using microRNA profiles to classify thyroid tumors and monitor cancer progression.
A study published in the British Journal of Sports Medicine found that DIY and gardening activities can decrease total sedentary time, reducing heart attack/stroke risk by 27-30%. These routine activities are as good as exercise for older adults who struggle to achieve recommended exercise intensity levels.
The Sudden Death in the Young Registry aims to collect comprehensive data on sudden unexpected death in youths up to age 24, with a focus on heart-related conditions and epilepsy. The registry will help researchers define the scope of the problem and set future research priorities.
A hands-free ultrasound device combined with a clot-busting drug was safe and effective in treating ischemic stroke patients, with 65% returning home or to rehabilitation. The technology opens up more arteries in the brain, helping stroke patients recover, according to researchers.
Researchers identified a host blood RNA transcriptional signature that can form the basis of a simple diagnostic test to differentiate TB from latent TB and other diseases. The test showed high sensitivity and specificity in distinguishing between these conditions, with promising results for potential use in African health facilities.
A study suggests that Indi's blood test can accurately distinguish between benign lung nodules and early-stage lung cancer by detecting a specific combination of proteins in the blood. The test, powered by advanced protein detection technology, has a 90% accuracy rate and could complement current clinical risk factors.
Researchers at MIT have created a noninvasive diagnostic test that detects blood clots in urine, enabling early detection and treatment of life-threatening conditions such as strokes and heart attacks. The test uses nanoparticles to detect thrombin, a key factor in blood clotting, allowing for rapid screening and diagnosis.
A survey of over 32,000 appendix samples found abnormal prion protein in 16 people, indicating a prevalence of 493 per million population. Researchers estimate one in 2,000 people are likely to be carriers, with no particular age group or geographic region affected.
A new blood test has been identified as a reliable biomarker for Irritable Bowel Syndrome (IBS), distinguishing it from Inflammatory Bowel Disease (IBD). The test targets high levels of vinculin antibodies in patients, offering a simple and effective diagnostic tool.
A study found that Hispanics are less likely to receive a kidney transplant, despite being equally likely to be placed on the waitlist as non-Hispanic whites. The disparity is largely attributed to differences in patient blood type and regional variability of organ supply.
A study comparing the effects of crystalloid and colloid fluids on survival in critically ill patients found no significant difference in 28-day mortality rates between the two groups. The use of colloids was associated with a lower risk of death at 90 days, but this finding requires further investigation.
A team of forensic experts found no genetic link between the mummified head and three Bourbon descendants of King Henry IV. The analysis ruled out a maternal connection as well, making it highly unlikely that the head belonged to the French king.