Articles tagged with Lungs
A study of 50 APECED patients found that 40% developed pneumonitis, a condition often misdiagnosed or missed. Targeting T and B cells resolved symptoms and improved lung function in five treated patients.
Researchers identified a master cell that coordinates the body's immune defenses in the first days after TB infection. Boosting this cell's activity could help prevent TB and reduce new infections. The findings suggest a new avenue for TB control and may aid development of more effective vaccines.
A new study found that irregular sleep patterns are associated with a higher risk of metabolic disorders, including obesity and high cholesterol. The research suggests that maintaining a regular sleep schedule has beneficial effects on metabolism.
Researchers found that catastrophic genome rearrangements can occur as early as childhood and lead to lung cancer decades later. Gene fusions in non-smokers mostly occur early on, sometimes as early as childhood or adolescence, and are often dormant for several decades before progressing into cancer.
A new study found that even short stays in polluted cities can cause significant breathing problems and coughing in healthy adults, which can take at least a week to recover from. The research team analyzed lung and heart health in travelers visiting highly polluted cities like India and China.
A new study found that a mobile phone app designed for physically inactive women increased their daily physical activity and helped them sustain it over nine months. The app, combined with an activity tracker and personal counseling, provided motivational messages and interactive feedback, leading to short- and long-term fitness benefits.
A 1-year-old Rottweiler named Stella received a groundbreaking treatment using fish skin grafts for her second- and third-degree burns after escaping a house fire. The innovative therapy, developed by Michigan State University, leveraged the anti-inflammatory properties of Icelandic cod skin to aid in healing and tissue regeneration.
Smokers of unfiltered cigarettes face a significantly higher risk of dying from lung cancer and all causes than those who smoke filtered cigarettes. Researchers found that light or ultralight cigarettes do not offer any lung cancer death reduction benefits, but smokers may be less likely to quit.
A team of McGill University Health Centre scientists identified a new role for the lipid mediator Leukotriene B4 in regulating the immune response to influenza infection. They found that LTB4 can reduce inflammation and enhance host survival, promising clinical implications for flu treatment.
Research at ATS 2019 reveals that smokers with severe lung function limitation are more likely to die from respiratory causes. In contrast, smokers with mild impairment face a higher risk of heart disease and lung cancer.
Researchers developed a novel technique called LAMPOON to prevent left ventricular outflow tract obstruction, a common complication of transcatheter mitral valve replacement. The study found that the new method increased treatment options for high-risk patients and achieved better survival rates compared to other methods.
A new magnetic resonance imaging (MRI) protocol has been developed to identify premature babies with chronic lung disease, allowing for earlier diagnosis and personalized treatment. The study, published in Thorax, reveals increased T2 and decreased T1 relaxation times in MRI data, indicating the presence of Bronchopulmonary Dysplasia.
A multidisciplinary team from Columbia Engineering and Vanderbilt University has demonstrated regeneration of severely damaged lungs in a clinically relevant model. The researchers developed a cross-circulation platform that maintained lung viability and function, enabling the recovery of lungs unsuitable for transplant due to injury.
Researchers at Vanderbilt University Medical Center developed a cross-circulation technique to rehabilitate damaged lungs, extending the assessment time from six hours to 36 hours. The regenerated lungs meet transplantation criteria, potentially increasing organ availability.
A large study found that adults with high fitness levels had a lower risk of developing lung and colorectal cancer, as well as improved survival rates after diagnosis. Fitness testing is common among adults and may provide valuable information about cancer risk and prognosis.
A new study demonstrates the safety of a potential treatment for ischemia-reperfusion injury in human lung transplant patients, showing no dose-limiting toxicities or 30-day mortality. The treatment, Regadenoson, has the potential to improve survival rates and quality of life for lung transplant recipients.
A multi-site international trial has shown promise in reducing the incidence of thoracotomy conversion for VATS/robotic anatomical lung resection. The use of an ultrasonic vessel-sealing device resulted in fewer bleeding complications and a faster recovery time, with no postoperative bleeding from divided PA branches.
Research highlights the association between chronic obstructive pulmonary disease (COPD) and type 2 diabetes, emphasizing the importance of collaborative care to address underlying systemic inflammation. Achieving optimal glucose control is crucial in patients with coexistent T2 DM and COPD.
A new policy expanding lung transplant boundaries has led to increased costs due to longer travel distances, resulting in reduced organ availability for local donors. The study found that patients at smaller transplant programs are disadvantaged by the policy, particularly those in economically disadvantaged areas.
A University of Michigan researcher has found that the mechanics producing wheezing and crackling noises with every breath are likely a cause of injury and inflammation. This new understanding could change how lung diseases are treated and represent a paradigm shift in doctor-patient interactions.
A study found that filtering tiny particles from diesel exhaust increased nitrogen dioxide levels, impairing lung function and exacerbating allergy symptoms. The effects were most pronounced in genetically susceptible individuals.
Researchers developed a biophotonic technique that uses ultraviolet and red light irradiation to eliminate bacteria and viruses from organs before transplantation. The method significantly reduced viral load in eight patients and completely eliminated the virus in two others.
New research by Imperial Brands shows that vaping blu e-vapor produces a similar effect on human lung tissue as normal air. The study found that exposure to blu vapour had no cytotoxic impact on human airway tissue, unlike conventional cigarette smoke.
A study found that a common food additive, tert-butylhydroquinone (tBHQ), can hinder the immune system's ability to fight off flu viruses, making vaccines less effective. In mice exposed to tBHQ, CD4 and CD8 T cells showed reduced functionality, leading to increased inflammation and mucus production in the lungs.
A new study has found that cystic fibrosis patients who have a common virus may experience faster disease progression. Cytomegalovirus infection was the most important factor linked to disease progression, with patients having the virus referred for lung transplants at a much younger age and dying ten years earlier on average.
A new study by Australian researchers has discovered that dietary fiber reduces lung inflammation and damage, improving lung function. The findings suggest that consuming high amounts of fiber may help prevent chronic obstructive pulmonary disease (COPD), a condition affecting 1 in 7 Australians over the age of 40.
Researchers found that mucus build-up and inflammation are the initial causes of lung damage in CF patients. Early treatments that thin out mucus may delay the onset of lung disease and improve patient outcomes.
A new study led by University of Manchester biologists reveals how glucose levels in the lungs control immune responses during inflammation. The research found that blocking sugar receptors may reduce inflammation in chronic conditions, while inhalation therapy could enhance immune response against some infections.
A study led by Queen Mary University of London found that shorter stature is associated with higher risk of heart disease, primarily due to impaired lung function. The researchers suggest assessing lung function alongside height to better predict heart disease risk.
Researchers at VUMC and TGen are studying Idiopathic Pulmonary Fibrosis (IPF), a progressive and irreversible lung disease affecting 50,000 Americans annually. The grants will help identify specific gene expression changes driving the disease, potentially leading to earlier diagnosis and more effective treatments.
TGen has received two grants totaling $6.1 million to study deadly lung diseases such as Idiopathic Pulmonary Fibrosis (IPF), with an estimated 50,000 US patients diagnosed annually. Researchers aim to identify genomic factors driving the disease and develop more precise treatments.
A study published in JAMA reveals significant improvement in the survival rate of extremely preterm babies in Sweden, rising from 70% to 77%, while complications decreased, between 2014-2016 and 2004-2007.
A study found that a protein associated with cancer growth is linked to idiopathic pulmonary fibrosis, a chronic and progressive lung condition. Introducing normal cells to inhibit the protein PD-L1 may reduce disease severity in laboratory mice and human tissue samples.
Researchers found that a mother's diet during pregnancy can affect the expression of genes regulating lung health in her offspring. Epigenetic changes may contribute to increased rates of lung disease, such as asthma, in children born to undernourished mothers.
A study published in The Lancet Respiratory Medicine found that the composition of a child's nose microbiome is altered in cases of respiratory infections compared to healthy peers. This difference can predict disease severity, hospital stay duration, and likelihood of recovery without antibiotics.
A non-invasive imaging biomarker called Parametric Response Mapping (PRM) can identify small airway damage in Chronic Obstructive Pulmonary Disease (COPD). This technique measures lung density during inhalation and exhalation, helping to predict patients who will lose lung function.
A VA study examined the use of video-assisted thoracoscopic lung resection in patients with known or suspected lung cancer from 2002 to 2015. The proportion of this minimally invasive procedure increased significantly over time, but its adoption varied by VA region.
Researchers have found that an approved drug can function as a molecular prosthetic, restoring infection-fighting properties in lung tissue and treating cystic fibrosis. The approach bypasses defective proteins and could benefit all types of CFTR mutations.
Researchers found that the medication amphotericin helps lung cells function, making it easier for patients to fight chronic bacterial infections. The finding holds special promise for a subset of patients who do not respond to current treatments.
Researchers at the University of Bradford have identified a new biomarker that could help diagnose PAH earlier, potentially leading to better treatment options. The study reveals how a faulty gene affects cell death regulation in the blood vessels.
Researchers at University of Tsukuba uncover how stratifin causes lung adenocarcinoma to emerge, identifying two drugs with other clinical uses that could be applied effectively in this disease. The study's findings raise hopes for more powerful treatment tools and value drug repositioning as a potential solution.
Researchers have developed a new vaccine strategy for tuberculosis that protects against the disease by delivering a vaccine directly into the lungs through a spray. The new formulation shows promise in mice studies, with significantly reduced lung inflammation and tissue damage compared to current vaccines.
A study published in Nature Communications reveals that genes in lung cells lose synchronized behavior with age, leading to changes in gene activity and metabolic pathways. The researchers also found alterations in the extracellular matrix surrounding lung cells, affecting protein composition.
A new study by the University of Rochester Medical Center found that adult vapers are nearly twice as likely to experience wheezing, a precursor to serious health conditions. The research also highlights the potential for vaping to cause lung damage and long-term respiratory issues.
A study of over 278,000 births in Finland found an association between steroid treatment and reduced birth weight. Babies exposed to steroids were on average born with lower birthweights, regardless of whether they were premature or full-term.
Researchers discovered 139 new genetic differences affecting lung health and COPD risk, showing both smokers and non-smokers can develop the disease. These findings could lead to new treatments for COPD, impacting global health.
A study found that suboptimal antibiotic doses may lead to lower lung microbial diversity, while therapeutic doses result in decreased diversity and lower levels after treatment. This could influence patient outcomes in cystic fibrosis, a genetic disease causing recurrent lung infections.
Researchers at University of Cologne decipher mechanism by which intestinal microbiota amplifies inflammatory reactions in lungs. Candida albicans stimulates Th17 cells, leading to cross-reactivity and immune system imbalance.
Researchers at the University of Warwick and Children's Hospital of Philadelphia have developed a computer simulator that predicts lung damage from ventilator settings. The study identified strategies to reduce tidal volumes and driving pressures, potentially improving patient outcomes.
Boston University School of Medicine has been awarded a five-year, $482,400 NIH grant to bolster the development of physician-scientists. The grant will support a summer research program for first-year medical students, providing them with research experience and opportunities to present their work at national conferences.
The UVA Health System is launching a program that uses telehealth to connect primary care providers in Appalachia with specialists to improve lung disease prevention, diagnosis, and treatment. Residents in the region have higher-than-average rates of lung cancer and COPD, and limited access to subspecialty physicians.
A Vanderbilt University Medical Center study found that using bag-mask ventilation during tracheal intubation improves outcomes and reduces the rate of severely low oxygen levels in half. The procedure, which involves squeezing air from a bag into the mouth for 60 seconds, is now being routinely used at the hospital.
A large European study found that small lung spots in rhabdomyosarcoma patients do not affect survival prospects or require aggressive treatment, unlike larger metastases.
A University of Colorado study shows that low-molecular weight PAHs, commonly found in secondhand smoke and environmental exposures, can cause cancer-promoting changes in lung cells within 30 minutes.
A new study published in ERJ Open Research directly compares new heated tobacco devices with vaping and traditional cigarettes, showing that all three are toxic to human lung cells. The study's findings suggest that these newer electronic nicotine delivery devices may not be a safer substitute for cigarette smoking.
Immunology researchers at the Babraham Institute discovered how lung tissue is remodelled to support an immune response to influenza, producing antibodies with cross-protection against multiple strains. The findings may lead to more robust seasonal influenza vaccination and new therapeutic strategies for autoimmune diseases.
A comprehensive exposome approach by Barcelona Institute for Global Health (ISGlobal) reveals early life exposure to parabens, phthalates, and PFAS associated with reduced lung function in children. The study highlights the importance of preventing exposure to chemical substances through regulation and labelling of consumer products.
Researchers at Washington University School of Medicine identified a process that may prevent antibody-mediated rejection in lung transplants. They found that giving immunosuppressive drugs can help the lungs survive and induce growth of lymph node-like structures within the grafts, which contain cells that dampen immune responses.
Two common e-cigarette chemical flavorings, diacetyl and 2,3-pentanedione, have been linked to impaired lung function by altering gene expression related to cilia production. This study suggests that even low levels of these chemicals can be hazardous, highlighting the need for stricter safety standards.
Researchers developed a blood test that detects severe lung transplant rejection early, even when no signs are present. The test uses DNA sequencing and has shown promising results in improving transplant outcomes.