Articles tagged with Lungs
Researchers found that oxygen therapy can increase peroxynitrite levels in the lungs, leading to inflammation, hemorrhaging, and swelling. A new compound, peptide 326, has been developed to interfere with this process, offering hope for reducing lung damage.
Researchers found that chronic infection with Stenotrophomonas maltophilia is independently linked to an increased risk of exacerbations in CF patients, as well as lower lung function.
Researchers will study proteins that trigger cell activity and functions, aiming to understand how they malfunction and cause heart disease. The project, led by UCLA, involves seven institutions worldwide and focuses on mitochondria and proteasomes, which may contribute to heart disease when defective.
Researchers at WUSTL will explore therapies and diagnostic tools for heart and lung diseases using nanotechnology. The project aims to improve treatment options for cystic fibrosis, acute lung inflammation, and atherosclerosis.
Children with chronic lung disease of prematurity who attend daycare are nearly four times more likely to experience serious respiratory symptoms than those who do not. Daycare attendance is associated with increased emergency room visits, medication use, and breathing problems in these vulnerable children.
A recent study by the Pitt/Iowa team reveals that a structural molecule and cellular pump influence pneumonia severity. Excess cardiolipin disrupts surfactant function, leading to tissue damage.
Researchers at the NHLBI found that adding tiotropium bromide to low-dose inhaled corticosteroids is more effective than doubling corticosteroids alone and as effective as adding a long-acting beta agonist. The treatment showed significant improvements in asthma control, including increased symptom-free days.
A new study by the American Lung Association finds that helping smokers quit saves lives and offers significant economic benefits to states. States can expect a 26% return on investment for every dollar spent on smoking cessation treatments, with some states receiving even higher returns.
Kendall Hunter will use non-invasive ultrasound measurements and invasive heart catheterization to diagnose and predict progression of PAH. The grant aims to improve diagnosis and treatment of this fatal disease in children and adults.
A study published in Science shows that neutrophils release enzymes that cause collateral damage to surrounding tissue, leading to chronic lung diseases. However, another enzyme LTA4H degrades a molecular fragment PGP, breaking the cycle and preventing damage.
A new study published in the Journal of Leukocyte Biology suggests that our innate immune systems are a major contributor to chronic lung diseases like silicosis. Researchers found that mice with an inactive adaptive immune system developed more severe silicosis, highlighting the importance of reducing chronic inflammation.
Researchers successfully differentiate embryonic stem cells into lung tissue using a natural cell-depleted lung matrix, demonstrating improved cell retention and organization. This breakthrough finding holds promise for developing clinical applications for engineered lung tissue.
Researchers found that sulfasalazine enhances the body's ability to clear fungal debris from the lungs, reducing inflammation and promoting better lung function. The study offers a new avenue for research on Pneumocystis pneumonia and may lead to improved treatment options for patients with weakened immune systems.
A report found that certain vena cava filters, used to prevent blood clots from reaching the lungs, can fracture and cause life-threatening complications. The filters were found to have a high rate of fracture, with some fragments traveling to the heart and causing symptoms such as rapid heartbeat or fluid buildup.
Researchers at the University of Texas Medical Branch have developed new techniques to identify specific asthma subtypes using protein patterns in airway lining fluid. This allows for targeted medication and potentially improved treatment outcomes. The study aims to reduce trial and error in asthma diagnosis and treatment.
A study has identified the BRF2 oncogene as specifically associated with lung squamous cell carcinoma, potentially serving as an identification marker and novel therapeutic target. Genetic analysis found frequent activation of BRF2 in pre-invasive stages of the disease, suggesting its role in tumorigenesis.
The International Society of Heart and Lung Transplantation has published comprehensive guidelines for the care of heart transplant recipients. The guidelines cover peri-operative care, rejection management, and long-term issues such as cardiac allograft vasculopathy and immunosuppressive adverse effects.
A randomized controlled trial found that nitric oxide treatment did not improve overall survival or reduce poor lung development in preterm infants. However, black babies showed a higher survival rate compared to non-black babies. The study suggests that ethnic origin may affect the response to nitric oxide treatment.
Smokers exposed to wood smoke face a higher risk of COPD due to increased lung function reduction and epigenetic changes. Wood smoke exposure synergistically increases the risk when combined with cigarette smoking.
Researchers found a significant link between African ancestry and pulmonary measurement in both men and women across all ages. Accounting for genetic ancestry improves prediction of normal lung function over a simple race-based classification, potentially leading to reclassification of severity in many lung diseases.
Researchers found that home care equivalent to hospital care for patients with cystic fibrosis does not compromise lung function recovery, with optimal duration of therapy ranging from 7-10 days. Longer treatment courses do not offer additional benefits.
A study found that genetic ancestry data correlates to physiologic measures, providing new evidence for personalized medicine. The research used genetic tools to estimate individual genetic ancestry and found a significant association between ancestry and lung function.
Researchers have developed a diagnostic blood test that can identify lymphangioleiomyomatosis (LAM), a rare but serious lung disease affecting women. The test analyzes serum VEGF-D levels, showing high accuracy in diagnosing LAM, and may help screen for the disease in women with Tuberous Sclerosis Complex.
A systematic review by Cochrane Researchers concludes that alpha-1 antitrypsin replacement therapy has no clinically important effect on lung function, may cause modest harm, and is extremely expensive. The treatment should not be recommended due to the lack of evidence and potential adverse effects.
A study found significant variability in 5-year patient survival rates for lung transplantation centers in the US, with risks of death ranging from 30% lower to 70% higher. Despite controlling for procedural volume, center performance remained significant, suggesting true differences in quality of care.
A new study found that ultrafine particles from vehicular emissions can boost allergic inflammation in the lungs, exacerbating asthma. The researchers used a real-time testing method to isolate the effects of ultrafine particles on the immune response in mice, and found significant enhancement of allergic airway inflammation with expos...
The International Society for Heart and Lung Transplantation has developed a standardized nomenclature for cardiac allograft vasculopathy, which will benefit heart transplant patients. The new classification system defines four levels of CAV severity, allowing for more accurate treatment options and improved patient outcomes.
A Yale University-led team of scientists has made an important breakthrough in regenerating fully functional lung tissue that can exchange gas. The researchers successfully implanted cultured lung cells into rats, which efficiently exchanged oxygen and carbon dioxide, mimicking the natural lungs' function.
A new UNC study found that African Americans with two or more medical conditions had almost zero surgeries, while white patients in the same situation had surgery just as often. The study also found that lack of a regular source of care led to significantly lower surgical rates for black patients.
A new study reveals that certain T cells delay their arrival to fight tuberculosis-causing bacteria, reducing the immune response. Regulatory T cells activate at the same time as effector T cells, hindering the body's ability to combat TB.
Researchers at the University of Michigan's Congenital Heart Center led a groundbreaking trial on shunts used to direct blood flow to the lungs, improving outcomes for kids born with hypoplastic left heart syndrome. The study found that one type of shunt was more effective over the first year, but its long-term impact is still uncertain.
Researchers at Mount Sinai School of Medicine have discovered that bone marrow cells play a crucial role in fighting respiratory viruses. The study found that cells produced by the bone marrow migrate to the lungs to help fight infection and produce infection-fighting proteins.
A study of 2,230 patients with chronic obstructive pulmonary disease (COPD) found that long-term treatment with beta-blocker medications was associated with fewer respiratory flare-ups and longer survival. The study also showed that beta-blockers may reduce the risk of exacerbations in patients with COPD.
Research on older cystic fibrosis patients reveals significant differences in disease outcomes between males and females, with females living longer and having delayed but equally severe disease. The study's findings provide valuable insights into the future treatment of cystic fibrosis as this population continues to grow.
Researchers found that nearly half of healthy children experience lung dysfunction after intense exercise, with symptoms linked to bronchoconstriction and airway constriction.
Researchers found that inhaled N-acetylcysteine (NAC) preserves more lung function in some patients with mild idiopathic pulmonary fibrosis than no therapy. This novel study provides encouraging evidence to pursue a potential treatment for IPF, a lung disease characterized by progressive scarring.
Researchers found that WTC workers had decreased sensitivity to odors and irritants, with nearly 75% experiencing impaired ability to detect irritants. The study suggests regular evaluation of sensory function is crucial for WTC responders and workers with pollutant exposures.
A gene network controlling lung development has been identified as responsible for the failure of lungs to form due to vitamin A/retinoic acid deficiency. This network, which balances two opposing pathways, can be corrected, potentially preventing lung defects in animals.
The LungPoint System enables accurate and efficient biopsy procedures for diagnosing and treating lung cancer by providing pre-procedure mapping and visual guidance during bronchoscopy. This technology allows physicians to plan their path ahead of time, reducing the need for invasive procedures.
Researchers identify GRP78 as key factor in mucormycosis pathogenesis, providing new avenue for therapeutics development. PET probes detect distinct immune cell populations, suggesting wider use for immune modulating therapies.
Researchers found MP-376 reduced P. aeruginosa density and improved lung function in CF patients, with the highest dose showing the most significant effect. The treatment was well-tolerated and showed a 79% reduction in need for other antimicrobials.
Vitamin A supplementation before, during, and after pregnancy significantly improved lung function in preadolescent children. Children whose mothers received vitamin A had a greater forced expiratory volume and vital capacity compared to those who received beta-carotene or placebo.
Scientists at the Trudeau Institute have identified two crucial signals that enable virus-fighting T cells to migrate to the lungs, where they can fight future infections. This breakthrough could lead to the development of vaccines designed to promote respiratory immunity.
Children and adolescents with cystic fibrosis who received azithromycin did not experience improved lung function compared to those receiving placebo. However, they showed a significant reduction in pulmonary exacerbations and weight gain.
Researchers at Johns Hopkins Medicine found serum amyloid A as a key protein trigger for sarcoidosis, an inflammatory disease affecting hundreds of thousands of Americans. The discovery opens the path to developing drug treatments or vaccines to block inflammation.
Researchers at the University of Pittsburgh School of Medicine have identified a molecular mechanism for idiopathic pulmonary fibrosis (IPF), a chronic and usually lethal disease. The study found that microRNA changes contribute to IPF, with let-7d being significantly reduced in affected tissues.
A new experimental model using pigs with a CF-causing gene mutation has provided valuable insights into the development of lung disease in people with cystic fibrosis. The study's findings suggest that infection precedes inflammation in CF lungs, supporting early and aggressive treatment to delay or prevent lung disease.
Research found that extremely preterm infants have abnormal lung function and are twice as likely to have asthma. Lung function impairment persists into middle childhood, especially those with bronchopulmonary dysplasia. Early monitoring and treatment can minimize long-term respiratory problems.
A recent study published in the World Journal of Gastroenterology reports successful treatment of cystic fibrosis (CF) and Crohn's disease using infliximab. The therapy improved colonic lesions and overall condition without compromising lung function, suggesting a potential anti-inflammatory effect on both colon and lung.
Researchers identified LPCAT1 as a key protein in lung surfactant production, essential for air breathing transition in mice. Decreased LPCAT1 expression may underlie fatal respiratory distress syndrome in premature infants.
Researchers identified childhood cancer survivors at increased risk for deteriorating lung health due to bone marrow transplants. Long-term monitoring and early intervention, as well as educating high-risk patients on avoiding tobacco smoke and air pollution, are recommended to prevent respiratory problems.
A new study by the University of Edinburgh found that respiratory syncytial virus (RSV) claims the lives of up to 200,000 children globally each year. The research also showed that about 3.4 million children require hospital treatment for severe lung infection caused by RSV.
The study found that Poly-ICLC treatment increased lung bacterial load and damage in mice infected with Mycobacterium tuberculosis. This was attributed to the recruitment of myeloid immune cells, which supported bacterial growth and exacerbated lung damage.
Scientists from University of Southampton and Synairgen Research Ltd begin Phase II study on interferon beta for virus-triggered asthma exacerbations. The drug aims to prevent sudden deterioration in lung function and hospital admissions.
A study of nearly 13,000 FDNY rescue workers found that those exposed to World Trade Center (WTC) dust suffered a persistent decline in lung function, with no meaningful recovery. The largest decline was observed among workers who arrived at the WTC site on 9/11.
Researchers developed a new test that uses CT scans to measure blood flow in the lungs, identifying smokers most at risk of emphysema. The study found subtle differences in blood flow patterns between smokers with normal lung function and those with early signs of emphysema.
A recent study identifies the GLRX5 gene as essential for generating iron-sulfur clusters and maintaining normal iron levels in human cells. The protein deficiency leads to sideroblastic anemia by impairing heme biosynthesis and depleting cytosolic iron in red blood cells.
A new study published in the Journal of Thoracic Oncology found that sleeve lobectomy offers superior survival and better postoperative pulmonary function compared to pneumonectomy in selected patients. The study analyzed 210 lung cancer patients and reported lower mortality rates for those who underwent a sleeve lobectomy.
Researchers have identified a compound in blackcurrants that reduces lung inflammation and complements the body's natural immune response. This discovery could lead to the development of foods containing these compounds as a natural alternative to assist conventional drug treatments for asthma.
A new study by Cedars-Sinai Medical Center found that the number of living donor organs available for transplant has declined over the past five years, while the number of deceased donors decreased in 2008. This decline has resulted in a widening gap between the number of organs available and the number of patients awaiting a donor organ.