Articles tagged with Lungs
A randomized controlled trial found that nitric oxide treatment did not improve overall survival or reduce poor lung development in preterm infants. However, black babies showed a higher survival rate compared to non-black babies. The study suggests that ethnic origin may affect the response to nitric oxide treatment.
Smokers exposed to wood smoke face a higher risk of COPD due to increased lung function reduction and epigenetic changes. Wood smoke exposure synergistically increases the risk when combined with cigarette smoking.
Researchers found a significant link between African ancestry and pulmonary measurement in both men and women across all ages. Accounting for genetic ancestry improves prediction of normal lung function over a simple race-based classification, potentially leading to reclassification of severity in many lung diseases.
Researchers found that home care equivalent to hospital care for patients with cystic fibrosis does not compromise lung function recovery, with optimal duration of therapy ranging from 7-10 days. Longer treatment courses do not offer additional benefits.
A study found that genetic ancestry data correlates to physiologic measures, providing new evidence for personalized medicine. The research used genetic tools to estimate individual genetic ancestry and found a significant association between ancestry and lung function.
Researchers have developed a diagnostic blood test that can identify lymphangioleiomyomatosis (LAM), a rare but serious lung disease affecting women. The test analyzes serum VEGF-D levels, showing high accuracy in diagnosing LAM, and may help screen for the disease in women with Tuberous Sclerosis Complex.
A systematic review by Cochrane Researchers concludes that alpha-1 antitrypsin replacement therapy has no clinically important effect on lung function, may cause modest harm, and is extremely expensive. The treatment should not be recommended due to the lack of evidence and potential adverse effects.
A study found significant variability in 5-year patient survival rates for lung transplantation centers in the US, with risks of death ranging from 30% lower to 70% higher. Despite controlling for procedural volume, center performance remained significant, suggesting true differences in quality of care.
A new study found that ultrafine particles from vehicular emissions can boost allergic inflammation in the lungs, exacerbating asthma. The researchers used a real-time testing method to isolate the effects of ultrafine particles on the immune response in mice, and found significant enhancement of allergic airway inflammation with expos...
The International Society for Heart and Lung Transplantation has developed a standardized nomenclature for cardiac allograft vasculopathy, which will benefit heart transplant patients. The new classification system defines four levels of CAV severity, allowing for more accurate treatment options and improved patient outcomes.
A Yale University-led team of scientists has made an important breakthrough in regenerating fully functional lung tissue that can exchange gas. The researchers successfully implanted cultured lung cells into rats, which efficiently exchanged oxygen and carbon dioxide, mimicking the natural lungs' function.
A new UNC study found that African Americans with two or more medical conditions had almost zero surgeries, while white patients in the same situation had surgery just as often. The study also found that lack of a regular source of care led to significantly lower surgical rates for black patients.
A new study reveals that certain T cells delay their arrival to fight tuberculosis-causing bacteria, reducing the immune response. Regulatory T cells activate at the same time as effector T cells, hindering the body's ability to combat TB.
Researchers at the University of Michigan's Congenital Heart Center led a groundbreaking trial on shunts used to direct blood flow to the lungs, improving outcomes for kids born with hypoplastic left heart syndrome. The study found that one type of shunt was more effective over the first year, but its long-term impact is still uncertain.
Researchers at Mount Sinai School of Medicine have discovered that bone marrow cells play a crucial role in fighting respiratory viruses. The study found that cells produced by the bone marrow migrate to the lungs to help fight infection and produce infection-fighting proteins.
A study of 2,230 patients with chronic obstructive pulmonary disease (COPD) found that long-term treatment with beta-blocker medications was associated with fewer respiratory flare-ups and longer survival. The study also showed that beta-blockers may reduce the risk of exacerbations in patients with COPD.
Research on older cystic fibrosis patients reveals significant differences in disease outcomes between males and females, with females living longer and having delayed but equally severe disease. The study's findings provide valuable insights into the future treatment of cystic fibrosis as this population continues to grow.
Researchers found that inhaled N-acetylcysteine (NAC) preserves more lung function in some patients with mild idiopathic pulmonary fibrosis than no therapy. This novel study provides encouraging evidence to pursue a potential treatment for IPF, a lung disease characterized by progressive scarring.
Researchers found that WTC workers had decreased sensitivity to odors and irritants, with nearly 75% experiencing impaired ability to detect irritants. The study suggests regular evaluation of sensory function is crucial for WTC responders and workers with pollutant exposures.
Researchers found that nearly half of healthy children experience lung dysfunction after intense exercise, with symptoms linked to bronchoconstriction and airway constriction.
The LungPoint System enables accurate and efficient biopsy procedures for diagnosing and treating lung cancer by providing pre-procedure mapping and visual guidance during bronchoscopy. This technology allows physicians to plan their path ahead of time, reducing the need for invasive procedures.
Researchers identify GRP78 as key factor in mucormycosis pathogenesis, providing new avenue for therapeutics development. PET probes detect distinct immune cell populations, suggesting wider use for immune modulating therapies.
A gene network controlling lung development has been identified as responsible for the failure of lungs to form due to vitamin A/retinoic acid deficiency. This network, which balances two opposing pathways, can be corrected, potentially preventing lung defects in animals.
Researchers found MP-376 reduced P. aeruginosa density and improved lung function in CF patients, with the highest dose showing the most significant effect. The treatment was well-tolerated and showed a 79% reduction in need for other antimicrobials.
Vitamin A supplementation before, during, and after pregnancy significantly improved lung function in preadolescent children. Children whose mothers received vitamin A had a greater forced expiratory volume and vital capacity compared to those who received beta-carotene or placebo.
Scientists at the Trudeau Institute have identified two crucial signals that enable virus-fighting T cells to migrate to the lungs, where they can fight future infections. This breakthrough could lead to the development of vaccines designed to promote respiratory immunity.
Children and adolescents with cystic fibrosis who received azithromycin did not experience improved lung function compared to those receiving placebo. However, they showed a significant reduction in pulmonary exacerbations and weight gain.
Researchers at Johns Hopkins Medicine found serum amyloid A as a key protein trigger for sarcoidosis, an inflammatory disease affecting hundreds of thousands of Americans. The discovery opens the path to developing drug treatments or vaccines to block inflammation.
Researchers at the University of Pittsburgh School of Medicine have identified a molecular mechanism for idiopathic pulmonary fibrosis (IPF), a chronic and usually lethal disease. The study found that microRNA changes contribute to IPF, with let-7d being significantly reduced in affected tissues.
A new experimental model using pigs with a CF-causing gene mutation has provided valuable insights into the development of lung disease in people with cystic fibrosis. The study's findings suggest that infection precedes inflammation in CF lungs, supporting early and aggressive treatment to delay or prevent lung disease.
Research found that extremely preterm infants have abnormal lung function and are twice as likely to have asthma. Lung function impairment persists into middle childhood, especially those with bronchopulmonary dysplasia. Early monitoring and treatment can minimize long-term respiratory problems.
A recent study published in the World Journal of Gastroenterology reports successful treatment of cystic fibrosis (CF) and Crohn's disease using infliximab. The therapy improved colonic lesions and overall condition without compromising lung function, suggesting a potential anti-inflammatory effect on both colon and lung.
Researchers identified LPCAT1 as a key protein in lung surfactant production, essential for air breathing transition in mice. Decreased LPCAT1 expression may underlie fatal respiratory distress syndrome in premature infants.
Researchers identified childhood cancer survivors at increased risk for deteriorating lung health due to bone marrow transplants. Long-term monitoring and early intervention, as well as educating high-risk patients on avoiding tobacco smoke and air pollution, are recommended to prevent respiratory problems.
A new study by the University of Edinburgh found that respiratory syncytial virus (RSV) claims the lives of up to 200,000 children globally each year. The research also showed that about 3.4 million children require hospital treatment for severe lung infection caused by RSV.
The study found that Poly-ICLC treatment increased lung bacterial load and damage in mice infected with Mycobacterium tuberculosis. This was attributed to the recruitment of myeloid immune cells, which supported bacterial growth and exacerbated lung damage.
Scientists from University of Southampton and Synairgen Research Ltd begin Phase II study on interferon beta for virus-triggered asthma exacerbations. The drug aims to prevent sudden deterioration in lung function and hospital admissions.
A study of nearly 13,000 FDNY rescue workers found that those exposed to World Trade Center (WTC) dust suffered a persistent decline in lung function, with no meaningful recovery. The largest decline was observed among workers who arrived at the WTC site on 9/11.
Researchers developed a new test that uses CT scans to measure blood flow in the lungs, identifying smokers most at risk of emphysema. The study found subtle differences in blood flow patterns between smokers with normal lung function and those with early signs of emphysema.
A recent study identifies the GLRX5 gene as essential for generating iron-sulfur clusters and maintaining normal iron levels in human cells. The protein deficiency leads to sideroblastic anemia by impairing heme biosynthesis and depleting cytosolic iron in red blood cells.
A new study published in the Journal of Thoracic Oncology found that sleeve lobectomy offers superior survival and better postoperative pulmonary function compared to pneumonectomy in selected patients. The study analyzed 210 lung cancer patients and reported lower mortality rates for those who underwent a sleeve lobectomy.
Researchers have identified a compound in blackcurrants that reduces lung inflammation and complements the body's natural immune response. This discovery could lead to the development of foods containing these compounds as a natural alternative to assist conventional drug treatments for asthma.
A new study by Cedars-Sinai Medical Center found that the number of living donor organs available for transplant has declined over the past five years, while the number of deceased donors decreased in 2008. This decline has resulted in a widening gap between the number of organs available and the number of patients awaiting a donor organ.
A new study found that chest x-rays can predict which H1N1 patients are likely to become sicker. Abnormal findings in the periphery of both lungs were associated with poor clinical outcomes. The study's findings suggest that chest x-rays may help clinicians better identify high-risk patients who require close monitoring.
A new technique has been developed to reduce tobacco smoke damage to lungs in mice by blocking the GM-CSF protein. This research holds promise for identifying more effective therapies for cigarette smoke-induced lung damage.
Researchers identified YfiBNR signaling system in P. aeruginosa responsible for SCV formation and persistence in CF patients. c-di-GMP triggers massive exopolysaccharide production and reduced growth rates, conferring resistance to macrophage phagocytosis.
Researchers develop culturally-tailored intervention program to reduce tobacco exposure, improve medication adherence and enhance attack readiness. The program has already proven useful in other populations, resulting in significant reductions in emergency department visits, hospitalizations and school absences.
Researchers found that CT scan screening for lymphangioleiomyomatosis (LAM) is cost-effective among non-smoking women aged 25-54 with a collapsed lung. The study suggests that early diagnosis can improve quality of life and treatment outcomes for patients.
Researchers found that high-resolution CT-scans are the most cost-effective strategy to screen for lymphangioleiomyomatosis (LAM) in non-smoking women between 25-54 with collapsed lung. Screening can identify LAM earlier, improving quality of life and allowing for early treatment and clinical trial enrollment.
A new technology delivers nicotine directly to the lungs, providing immediate relief of withdrawal symptoms and reducing throat irritation. This innovative approach combines vapor phase pyruvic acid and nicotine for a more effective and tolerable smoking cessation therapy.
The University of Cincinnati researchers will investigate ways ILD appears in patient groups with autoimmune diseases and develop more efficient diagnosis and treatment methods. The study aims to identify specific biomarkers and medical records characteristics that predict the best treatment outcomes for ILD patients.
Mayo Clinic's first lung transplant from a donor after cardiac death (DCD) was successful in a 59-year-old man with alpha-1antitrypsin deficiency. The recipient, who had limited lung function before the transplant, is now able to walk and breathe normally.
Researchers at Imperial College London have made a groundbreaking discovery that could lead to new treatments for conditions like deep vein thrombosis and haemophilia A. The study found that factor VIII, a key protein in blood clotting, is produced by lung blood vessels rather than just the liver.
Researchers developed a simple blood test to predict which idiopathic pulmonary fibrosis (IPF) patients are likely to become severely ill. The test targets immune cells called CD4 T-cells, which lose their CD28 protein markers as disease severity increases, indicating a greater likelihood of grave illness.
Researchers have successfully developed a new stem cell treatment that can arrest acute lung injury in mice, paving the way for potential treatments of respiratory diseases. The experimental treatment uses transplantable lung cells derived from human embryonic stem cells and has shown promising results in tests on mice with damaged lungs.
A study led by Dr. David Granville identified Granzyme B as a protein-degrading enzyme abundant in AAAs, which can be targeted to slow progression and improve survival. This discovery may lead to the development of pharmaceuticals to treat aneurysms without surgery.
Researchers found that inhibiting sestrin protein improves lung elasticity and gas exchange in mice with emphysema. This suggests a new therapeutic approach to alleviate critical symptoms associated with COPD.
A group of UK anaesthetists designed and tested three prototype low-cost ventilators that could provide effective ventilation for patients in emergency situations. The devices operate on a gas-efficient principle and have been shown to consume less oxygen than commercially available ventilators.
Research reveals that school classroom air contains significantly higher levels of ultrafine particles than polluted outdoor air, posing a risk to students' lung health. The study found elevated particle levels during art activities and cleaning with detergents.
A new study from Columbia University Medical Center researchers found that even mild cases of chronic obstructive pulmonary disease (COPD) can limit the heart's ability to pump effectively. The study, which involved over 2,800 adults, suggests a link between lung function and heart function.