Articles tagged with Growth Factor Pathways
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Researchers found that colorectal cancer cells stimulate cancer-associated fibroblasts to produce collagen through TGF-β1-induced de novo glycine synthesis. PHGDH is identified as a potential therapeutic target for treating colorectal cancer.
A study by Toho University researchers reveals a cellular communication network that promotes liver fibrosis. FGF18 and osteopontin enhance the production of OPN, which activates quiescent stellate cells to propagate fibrotic activity. This discovery highlights the critical roles of these molecules in driving liver fibrosis.
Scientists have found a way to effectively 'intercept' pancreatic cancer by targeting the KRAS and FGFR2 genes. This approach slows tumor formation and reduces the number of 'early versions' of cancer in the pancreas. Researchers believe this therapy could be a game-changer for patients with a family history of pancreatic cancer.
Researchers at University of Pittsburgh developed a new treatment approach for anthrax by reactivating the ERK pathway with a combination of growth factors. This method shows promise for treating the disease beyond its typical point of no return, offering hope for patients diagnosed late in the illness.
A new blood-based biomarker, placental growth factor (PlGF), has been identified as a potential tool for detecting early brain changes associated with cognitive impairment and dementia. Elevated PlGF levels were found to be linked to increased vascular permeability, leading to white matter injury and subsequent cognitive decline.
Researchers discovered beta-catenin as a new player in the formation of the main body axis during mammalian embryogenesis. A novel embryo-like model system was developed to identify this key player, revealing its importance in axis formation.
Researchers at Kyoto University have discovered a signal protein called ERK that plays an active role in causing growing lung tissue to curve. This finding reveals a previously unknown regulatory system governing the development of intricate branching patterns in mouse lungs.
A new link has been discovered between FBXW7 mutations and EGFR signaling activity in colorectal cancer. The study found that the mutated form of the FBXW7 gene could no longer degrade the EGFR protein, leading to increased signaling activity and a decreased response to anti-EGFR treatment.
Researchers found that ASCOT reverses some age-related protein expression changes, enriching processes related to the complement cascade and immune system in patients with poor ovarian response. In contrast, patients with premature ovarian insufficiency showed enrichment in responses to oxygen-containing compounds and growth hormones.
Researchers discovered that midgestation leptin surge in preeclampsia leads to endothelial dysfunction, blood vessel constriction, and restricted fetal growth. This finding highlights the crucial role of leptin in pregnancy and its potential consequences on maternal and infant cardiovascular health.
In a mouse model, stromal cells developed before weaning age promote the maturation of the intestinal barrier by forming a specialized niche. Absence of these cells induces defect in postnatal growth and increases susceptibility to intestinal inflammatory diseases.
Researchers have found that two receptors on the surface of endothelial cells come together to enable new blood vessel growth. The discovery reveals a new connection between copper metabolism and angiogenesis, highlighting CTR1 as a potential therapeutic target for conditions like ischemic heart disease.
Researchers at ETH Zurich have developed a new method to distribute bioactive molecules in three-dimensional space, allowing them to guide the growth of nerve fibers and other biological processes. This innovation has potential benefits for medicine, including improving recovery from neural injuries.
A new function of Pseudomonas aeruginosa lectin LecB has been discovered: it blocks the cell cycle in host cells, leading to slowed or halted wound healing. This impairment occurs through the silent internalization of growth factor receptors, triggering intense vacuolization and cell death.
Researchers found genetic changes in Batwa and Andamanese populations that influenced growth factor binding pathways and cardiac muscle tissue development. This suggests a connection between short stature and cardiac problems in these populations.
A new study published in the British Journal of Clinical Pharmacology demonstrates pain relief in humans using a Trk inhibitor. The study involved 20 participants and compared the inhibitor with pregabalin, ibuprofen, and placebo.
Researchers at Penn State create artificial system using DNA-laced hydrogel that releases signaling protein in response to chemical signal. The system, which uses aptamers and double-stranded helical molecules of DNA, can repeat the sequence, releasing proteins until there are no more to release.
Researchers discovered that alpha-synuclein, a protein involved in Parkinson's disease, blocks signals from the important brain growth factor BDNF. This 'tug of war' between alpha-synuclein and BDNF affects brain cells' survival and explains why dopamine-producing neurons are more vulnerable to degeneration.
Researchers found that hematopoietic stem cells can directly detect bacterial infections and begin dividing without signals from growth factors. This reaction damages the cells' regenerative ability, potentially leading to malignant diseases at advanced age.
The study provides the first visual evidence of a physical link by which genes can receive mechanical cues from their microenvironment. The images show thread-like cytofilaments reaching into and traversing a human breast cell's chromatin-packed nucleus, revealing a direct connection to the nucleus.
Researchers have developed a method to observe nanometer-sized patterns of biomolecules such as proteins in an arrested but living state. This allows for the recording of molecular activity and interactions without causing cell death, revealing new insights into cellular behavior and processes.
The University of Texas at Austin researchers have developed an injectable, regenerative gel that delivers proteoglycans and a growth factor to stimulate the growth of blood vessels and restore blood flow in the lower limbs. The treatment has shown promising results in mice with ischemia and diabetes, with 85% recovery of blood vessels.
Researchers at EPFL have developed bioengineered growth factors that significantly enhance wound healing, bone repair, and new blood vessel formation. The engineered growth factors display improved binding affinity to extracellular matrix proteins, leading to faster tissue closure and granulation tissue production.
A recent study by Chinese Academy of Sciences and University of Calgary reveals a molecular feedback loop that governs the earliest steps of placenta formation, which is crucial for diagnosing and treating related pregnancy complications. The research found that this feedback loop involves Gcm1 and Fzd5 signaling cascades.
Rodal's lab aims to understand the interplay between neuronal firing and growth factor transport in neurons, with potential applications for ALS and Alzheimer's treatments. She will use a fruit fly model system to study the relationship between electrical activity and receptor trafficking.
Researchers discovered a molecular mechanism allowing signals from target cells to support neuron survival. Activated protein Rac plays a crucial role in long-range signaling and retrograde transport of neuronal survival signals.
Heparan sulfate on human cells modifies growth factor proteins' connection to cell surfaces. The structure and interaction of heparan sulfate chains with growth factors determine normal cell growth.
Researchers identified gambogic amide, a compound in tree bark, that mimics NGF's effect on brain cells by binding to TrkA. This finding suggests potential as a therapeutic treatment for neurodegenerative diseases such as Alzheimer's and stroke.
Researchers at IRB Barcelona identified a new signaling mechanism in Drosophila melanogaster that allows two independent groups of cells to collaborate and send signals to target cells. This mechanism is crucial for proper cell function and development.