Archaeologists recommend using state-of-the-art techniques, such as micromorphology, to analyze evidence and increase confidence in claims about human evolution. This approach aims to rewrite our understanding of human ancestors by uncovering hidden clues in ancient sediments.
Research found a significant linear relationship between age of coronary heart disease onset and dementia, highlighting the detrimental influence of premature cardiovascular events on brain health. Adults diagnosed with coronary heart disease at a young age may be at increased risk of developing dementia, Alzheimer's disease, and vascu...
Researchers discuss CRISPR's limitations in generating accurate cancer models, including variable mutations and indels. Despite these challenges, the technology holds promise for cancer research due to its potential for natural selection and Darwinian evolution.
Researchers predict that vampire bats will expand their locations in search of more stable climates, potentially linked to a spillover of rabies. The team's work aims to identify and track the bats by traveling to Colombia to contain the spread.
Researchers identified 38 unique pathogenic variants in 57 patients, including novel variants specific to the Kazakh population. These variants were associated with an increased risk of triple-negative breast cancer and family history of breast cancer.
Virginia Tech researchers analyzed partisan media sentiment toward AI and found that liberal-leaning media tend to have a more negative tone than conservative media. The study suggests that this opposition can be attributed to concerns over AI amplifying existing social biases, such as racial and income disparities.
The gender gap among top-cited scientists is narrowing, with women now representing 32% of top-cited authors in certain fields, according to a study analyzing 5.8 million international scientific authors. However, significant disparities remain, and efforts to address promotion pathways for gifted female researchers are still needed.
Researchers propose network-based methodology to contextualize scientific publication impact, allowing for more accurate assessment of interdisciplinary discoveries. The new approach normalizes citation counts, mitigating biases in existing methods.
Researchers found that tumor-resident T-cell receptor sequences showed high complementarity with the cancer testis antigen DDX53, suggesting an immune response that selects for DDX53-negative cells. This association was correlated with worse disease-free survival rates, highlighting a potential early esophageal cancer antigen.
The American Gastroenterological Association released a new guideline recommending the use of biomarkers to help manage Crohn’s disease. Biomarkers such as C-reactive protein and fecal calprotectin can measure levels of inflammation, helping doctors assess disease activity and guide treatment decisions.
Elea Abisamra's STEM writing program at Virginia Tech has been recognized by the journal Cell for its innovative approach to teaching science through storytelling. The program has already helped 95 kids publish books with over 150 tutors as editors, and plans to expand globally.
A study found that pregnant women with high blood pressure who received tight blood pressure control immediately after pregnancy had lower blood pressure levels and improved cardiac function compared to those with usual care. This could lead to a reduced risk of cardiovascular disease, including heart attacks and strokes.
Researchers tracked endangered thick-billed parrots using solar-powered satellite transmitters, revealing new critical habitat and migratory routes. Less than 20% of the newly identified habitat is protected from timber industry, highlighting the urgent need for conservation efforts.
Researchers have engineered a chromosome entirely from scratch, contributing to the production of the world's first synthetic yeast. The tRNA Neochromosome forms part of a wider project that has successfully synthesised all 16 native chromosomes in Saccharomyces cerevisiae, common baker's yeast.
A study published in Oncotarget reveals that HER2 mutant alleles play a crucial role in determining treatment response to neratinib and poziotinib. Researchers found that individual HER2 mutant alleles have distinct effects on therapeutic efficacy, suggesting new targets for breast cancer therapy.
Researchers found that FAAH inhibition reduced breast cancer growth in immunodeficient mice and induced apoptosis of breast cancer cells. The combination of FAAH inhibitors and endocannabinoids was the most effective treatment approach.
A new method called TWC-Swin effectively restores holographic images even under low spatial coherence and arbitrary turbulence, surpassing traditional convolutional network-based methods. The study demonstrates strong generalization capabilities, extending its application to unseen scenes.
Researchers from Columbia University have validated GLS2's ability to promote ferroptosis in murine models. This study suggests that targeting GLS2 may be a potential therapeutic strategy against liver diseases, particularly hepatocellular carcinoma.
A recent analysis of 12 studies found that trigger warnings do not mitigate distress and actually heighten anticipatory anxiety. Despite their lack of effectiveness, some researchers suggest using emotional-regulation training to help people prepare for potentially triggering content.
The American Phytopathological Society has created a new series of distinguished reviews in honor of Harold H. Flor, who developed the gene-for-gene concept in plant pathology. The series presents authoritative reviews on molecular plant-microbe interactions, providing a historical perspective and future directions for research.
Researchers discovered the STAT3 signaling pathway as a potential target for treating H3K27M-mutant diffuse midline gliomas (DMGs), a uniformly lethal central nervous system malignancy. The current standard of care, including palliative radiation and chemotherapy, remains ineffective in this disease.
Researchers classify UGDH as a molecular indicator of tumor progression in multiple cancer types, describing its involvement in key canonical cancer signaling pathways. Methods to inhibit UGDH and its downstream products are also identified.
A new SwRI study posits that the large mounds on Kuiper Belt object Arrokoth are similar in size and shape, suggesting a common origin. This finding supports the streaming instability model of planetesimal formation, where gentle collision speeds allowed objects to accumulate and form Arrokoth.
Researchers at Northwestern University identified a new evolutionarily conserved RNAi-based form of cell death called Death Induced by Survival gene Elimination (DISE), which targets essential survival genes in cancer cells. This mechanism is ancient and effective against all cancers tested.
Researchers have discovered a new species of calcifying phytoplankton, Calciopappus curvus, found in the Sargasso Sea near Bermuda. The species is distinct from others in its genus and boasts intricate skeletons that may aid movement or protection.
Researchers propose analysis protocol to evaluate feasibility of silicon-containing batteries with reduced particle size and uniform dispersion. The study finds promising results from innovative synthesis technology and initial efficiencies exceeding 90% with improved lifespan characteristics.
The article discusses the need to reassess COVID-19 precautions in 2023, particularly for patients with hematologic malignancies. The researchers highlight the increased risk of poor response to vaccination and worse outcomes from COVID-19 infection among these patients.
The MIT Press is expanding its shift+OPEN initiative with a $275,000 NSF grant to flip two high-impact subscription-based journals to diamond OA. The program aims to accelerate STEM and HSS research by providing barrier-free access to scholarly works.
Researchers found that blueberries infected with Colletotrichum fioriniae emit odors repelling spotted-wing drosophila. By recreating this aroma, farmers can trick flies into perceiving healthy fruit as infected, reducing the need for insecticides.
The Intergovernmental Negotiating Body Bureau emphasizes the importance of social media regulation and digital health literacy in managing infodemics, which can spread false information on public health matters. Effective infodemic management is seen as a critical component of the Pandemic Accord to safeguard lives worldwide.
Researchers found that DPP4 inhibition increased sunitinib efficacy in RCC spheroids and upregulated DPP4 in sunitinib-resistant cells. This suggests potential repurposing of DPP4 inhibitors to target therapy resistance in renal cell carcinoma.
Researchers developed a reliable and reproducible real-time live tissue sensitivity assay (RT-LTSA) using fresh tumor samples to predict patients' clinical response to chemotherapy. The study showed improved disease-free survival and reduced recurrence rates in patients who received RT-LTSA sensitive adjuvant regimens.
Researchers discuss new drugs available for HER2-positive breast cancer patients with brain metastasis, showing improved outcomes and quality of life. The development of targeted therapies has led to better survival rates among these patients.
Biodiversity researchers can now incorporate nanopublications into their manuscripts to future-proof their assertions on biological taxa and organisms. The newly released nanopublication workflow enables authors to create machine-actionable, FAIR data that can be easily traced back to its origin.
Researchers have generated nearly deterministic OAM-based entangled states using QDs, enabling hybrid entanglement states in high-dimensional Hilbert spaces. This breakthrough offers a bridge between photonic technologies for quantum advancements.
Researchers discovered that a small subpopulation of AIB1-expressing cells in breast cancer enables invasion and metastasis. The study suggests that these subpopulations play a crucial role in tumor growth and spreading to distant sites.
The American Meteorological Society recognizes Benjamin Santer for his work on climate change detection and attribution. William Kustas receives the Hydrologic Sciences Medal for foundational advances in evapotranspiration measurement and theory. Lixin Wu is awarded the Henry Stommel Research Medal for studies of multi-scale ocean circ...
The study validates a comprehensive genomic profiling assay, NeXT Dx, which detects single nucleotide variants, indels, copy number alterations, and gene fusions. The assay demonstrates high analytic sensitivities and specificity, providing personalized recommendations critical to clinical decision-making.
Rapid Reviews Infectious Diseases will extend the successful preprint review model of Rapid Reviews COVID-19 to new research on infectious diseases like monkeypox, dengue fever, or herpes. The journal aims to accelerate the validation and diffusion of robust scientific findings through rapid peer review.
The American Dental Association has released a new clinical practice guideline recommending the use of acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs) as first-line treatments for managing short-term dental pain in children under 12. The guideline has been endorsed by the American Dental Association.
Researchers developed a 'diversity factor' metric to capture paper's impact on health outcomes for all patients, particularly those in low- or middle-income countries. Most medical papers fail to meet this metric due to lack of diversity among authors and patient populations.
Researchers examine translational studies on peripheral surrogates of tumor burden, including circulating tumor DNA, miRNA, and HPV-specific antibodies, to inform chemotherapy and immunotherapy strategies. These biomarkers show promise as prognostic and predictive markers of response to treatment.
Researchers explore CDK9 inhibitors as a promising combination partner in treating hematological malignancies. They discuss the role of cyclin-dependent kinases (CDKs) in these diseases and highlight the potential synergism with other drugs.
Researchers developed innovative techniques to treat challenging cancers and manage therapy side effects. Inhibitors targeting PRMT5, a histone-modifying enzyme, alleviated cisplatin-induced hearing loss, while nano-pills delivered combination drugs to liver cancer cells.
Researchers investigated H3K27me3 expression patterns in pediatric brain tumors, finding a global loss of this epigenetic mark in diffused midline glioma (DMG). This loss was associated with high relapse rates and poor survival, highlighting the potential for targeting H3K27me3 as an epigenetically guided cancer therapy.
Bound states in the continuum (BICs) provide a generalized approach to achieve extremely high-Q resonant cavities. BICs offer powerful mechanisms for enhancing light-matter interactions and have been explored in various photonic structures over the past few decades.
The study found that network-level variables significantly improved model fit and displayed strong independent associations with oral health outcomes. Network proportion needing dental treatment was positively associated with current dental treatment needs, while exposure to reported dental visits decreased odds of no recent dental vis...
Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
A new multiplex assay has been developed to assess activated p300/CBP in circulating prostate tumor cells, revealing correlations with clinical outcomes and potential therapeutic targets for castration-resistant prostate cancer. The study found that patients with upregulated p300/CBP activity had shorter response times to ARSI therapy.
A study analyzing films shows that characters with facial disfigurement who undergo successful plastic surgery are more likely to have happy endings. The researchers found that 67% of characters had fortunate or happy endings, while the rest had misfortunate endings.
A new study by NASA and Japan's Osaka University suggests that rogue planets, drifting through space without a star, may outnumber stars with orbiting worlds. The Roman Space Telescope could discover up to 400 Earth-mass rogue planets, according to the findings.
Research reveals non-native English speakers need up to twice as much time to read and write papers, with 2.5 times higher rejection rates for papers written in English. This disproportionately affects early career stage researchers from lower income countries.
Researchers report a case of a 15-year-old boy with recurrent intrathoracic synovial sarcoma who achieved partial response with BRAF inhibitor Vemurafenib treatment. The study highlights the importance of routine next-generation sequencing to drive treatment choice and investigate BRAF mutations in SS tumors.
The American Phytopathological Society has published a focus issue on critical biosecurity gaps in US plant disease diagnostics, highlighting the need for harmonized diagnostics within the agricultural biosecurity system. The focus issue addresses assay validation methods, including high-throughput screening and PCR/RPA techniques.
The American College of Chest Physicians has launched CHEST Pulmonary, a new online publication dedicated to pulmonary and sleep medicine. The journal features original research, case series, and reviews on various topics, including implementation science and artificial intelligence applications.
Professor Coppedè's appointment aims to enhance the journal's focus on cutting-edge genomics research, covering topics like genome sequencing and functional genomics. He will lead Current Genomics to greater success by staying at the forefront of genomics discoveries and advancements.
Prof. Dr. Marta Litter takes over as Editor-In-Chief of Journal of Photocatalysis, bringing her extensive expertise and experience to lead the journal into a new era of excellence. Her research on heterogeneous photocatalysis and iron-based nanomaterials has led to over 250 scientific publications.
A team of conservation researchers warns that Indonesia's tropical rainforest and endangered species are under threat from government interference and corporate interests. The researchers advocate for data transparency, online 'safe houses', and anonymized journals to protect environmental research and promote nature conservation.
A new study found critical gaps and disparities in access to Parkinson's disease care among Medicare beneficiaries. Only 9% of people with Parkinson's disease receive care from movement disorder specialists.