Articles tagged with Scientific Journals
Researchers explore CDK9 inhibitors as a promising combination partner in treating hematological malignancies. They discuss the role of cyclin-dependent kinases (CDKs) in these diseases and highlight the potential synergism with other drugs.
Researchers developed innovative techniques to treat challenging cancers and manage therapy side effects. Inhibitors targeting PRMT5, a histone-modifying enzyme, alleviated cisplatin-induced hearing loss, while nano-pills delivered combination drugs to liver cancer cells.
Researchers investigated H3K27me3 expression patterns in pediatric brain tumors, finding a global loss of this epigenetic mark in diffused midline glioma (DMG). This loss was associated with high relapse rates and poor survival, highlighting the potential for targeting H3K27me3 as an epigenetically guided cancer therapy.
Bound states in the continuum (BICs) provide a generalized approach to achieve extremely high-Q resonant cavities. BICs offer powerful mechanisms for enhancing light-matter interactions and have been explored in various photonic structures over the past few decades.
The study found that network-level variables significantly improved model fit and displayed strong independent associations with oral health outcomes. Network proportion needing dental treatment was positively associated with current dental treatment needs, while exposure to reported dental visits decreased odds of no recent dental vis...
Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...
Researchers have identified KIAA0930 as a key factor causing muscle atrophy in cancer cells, which could lead to the development of new anti-cachexia therapies. The study found that KIAA0930 knockdown cells showed increased muscle mass and weight compared to control cells.
A new multiplex assay has been developed to assess activated p300/CBP in circulating prostate tumor cells, revealing correlations with clinical outcomes and potential therapeutic targets for castration-resistant prostate cancer. The study found that patients with upregulated p300/CBP activity had shorter response times to ARSI therapy.
A study analyzing films shows that characters with facial disfigurement who undergo successful plastic surgery are more likely to have happy endings. The researchers found that 67% of characters had fortunate or happy endings, while the rest had misfortunate endings.
A new study by NASA and Japan's Osaka University suggests that rogue planets, drifting through space without a star, may outnumber stars with orbiting worlds. The Roman Space Telescope could discover up to 400 Earth-mass rogue planets, according to the findings.
Research reveals non-native English speakers need up to twice as much time to read and write papers, with 2.5 times higher rejection rates for papers written in English. This disproportionately affects early career stage researchers from lower income countries.
Researchers report a case of a 15-year-old boy with recurrent intrathoracic synovial sarcoma who achieved partial response with BRAF inhibitor Vemurafenib treatment. The study highlights the importance of routine next-generation sequencing to drive treatment choice and investigate BRAF mutations in SS tumors.
The American Phytopathological Society has published a focus issue on critical biosecurity gaps in US plant disease diagnostics, highlighting the need for harmonized diagnostics within the agricultural biosecurity system. The focus issue addresses assay validation methods, including high-throughput screening and PCR/RPA techniques.
The American College of Chest Physicians has launched CHEST Pulmonary, a new online publication dedicated to pulmonary and sleep medicine. The journal features original research, case series, and reviews on various topics, including implementation science and artificial intelligence applications.
Professor Coppedè's appointment aims to enhance the journal's focus on cutting-edge genomics research, covering topics like genome sequencing and functional genomics. He will lead Current Genomics to greater success by staying at the forefront of genomics discoveries and advancements.
Prof. Dr. Marta Litter takes over as Editor-In-Chief of Journal of Photocatalysis, bringing her extensive expertise and experience to lead the journal into a new era of excellence. Her research on heterogeneous photocatalysis and iron-based nanomaterials has led to over 250 scientific publications.
A team of conservation researchers warns that Indonesia's tropical rainforest and endangered species are under threat from government interference and corporate interests. The researchers advocate for data transparency, online 'safe houses', and anonymized journals to protect environmental research and promote nature conservation.
A new study found critical gaps and disparities in access to Parkinson's disease care among Medicare beneficiaries. Only 9% of people with Parkinson's disease receive care from movement disorder specialists.
Patients undergoing bilateral total knee arthroplasty are at a higher risk of complications such as pulmonary embolism, stroke, and blood loss anemia compared to those undergoing unilateral TKA. The study found that the risks of these complications were approximately doubled in the bilateral TKA group.
Research leaders collaborate with organizations and regulators to develop digital tools for Parkinson's clinical trials. The Digital Drug Development Tools initiative accelerates the regulatory endorsement of these tools, enabling more objective and patient-centered measures.
A new study published in Wildlife Society Bulletin reveals that lead exposure from hunting ammunition is sickening and killing bald eagles, making them more susceptible to other dangers. The research, funded by Morris Animal Foundation, used innovative modeling tools to demonstrate the impact of lead poisoning on eagle populations.
Researchers demonstrate that AI language models like ChatGPT can generate high-quality fraudulent medical articles with standard sections and references. The study highlights the need for increased vigilance and enhanced detection methods to combat potential misuse of AI in scientific research.
A study published in Management Science found that the UK's Covid vaccine mandate caused a 3-4% reduction in staffing in elderly care homes, equivalent to 14,000 to 19,000 employees. The policy led to an increase in reliance on agency workers and persisted even after the mandate was lifted.
A recent study published in Science of the Total Environment found a scarcity of studies on microbial and chemical drinking water contamination in Appalachia and associated health outcomes. Only 85 publications met the criteria, with many gaps remaining to be filled.
The study investigates the effects of DPDT on human colon cancer HCT116 cells and non-tumorigenic MRC5 fibroblasts. The results show that DPDT preferentially targets HCT116 cells, inducing apoptosis and G2/M cell cycle arrest, likely through DNA topoisomerase I poisoning.
Researchers found that treatment with tranexamic acid (TXA) is associated with a decreased incidence of heterotopic ossification (HO), a common complication of abnormal bone formation. The study showed a significant reduction in HO risk, with an odds ratio of 0.49 and a 50% lower risk compared to patients not receiving TXA.
Researchers discuss the potential of glucocorticoid-induced TNFR-related protein (GITR) as a target for cancer immunotherapy. Preclinical studies have shown potent anti-tumor efficacy, but clinical trials have yielded inconsistent results due to complexities in immune responses and antibody structure.
A new study by CNIC researchers reveals that low-grade systemic inflammation triggered by subclinical atherosclerosis accelerates epigenetic aging in otherwise healthy young individuals. The study found a strong association between atherosclerosis progression and accelerated biological age, with potential reversibility through lifestyl...
A second-generation all-inside meniscal repair system demonstrates a high successful repair rate of 84-88% at 10 years, with low failure rates and no correlation to patient characteristics or surgical techniques. Patient-reported outcomes improve after meniscal repair and ACL reconstruction.
A new study published in JMIR Cardio reveals the potential of AI-QCA in analyzing coronary angiography, providing accurate measurements of coronary stenotic lesions similar to IVUS. This technology has the potential to improve patient outcomes and support clinical decision-making.
Researchers from Universitat de Barcelona and Universitat Internacional de Catalunya discuss the non-receptor protein tyrosine kinase Src as a good example of an oncogene. Targeting the Src N-terminal regulatory element (SNRE) has potential as oncotargets to inhibit Src activity only in cancer cells.
A team of researchers developed a tool to identify AI-generated academic science writing with high accuracy, using characteristics such as predictability, paragraph structure and vocabulary. The model outperformed existing AI text detectors and has potential applications in assessing student essays.
The American Phytopathological Society published a special issue on key discoveries in plant pathology, highlighting groundbreaking findings over the past 50 years. These discoveries have significantly impacted plant health, food security, and food safety worldwide.
Researchers found GRB 221009A's jet exhibited a narrow core with wide sloping wings, differing from standard jets. This unique structure may explain the event's extreme energy release and prolonged visibility.
A study published in JMIR Formative Research found that wearable sleep devices show promise in positively impacting sleep health among marginalized populations. Participants perceived the device as easy to use and comfortable to wear, suggesting its potential for improved sleep health. However, barriers to adoption, such as housing sta...
Researchers successfully detect X-ray signature of individual atoms, enabling the identification of materials at an atomic level. The breakthrough technique has potential applications in environmental and medical sciences, as well as advancing technology.
Researchers can reduce stigma in scientific literature by implementing practices such as referencing language guides, updating terminology, and connecting with the community. This change is crucial for promoting non-stigmatizing language and respecting preferred terms used by individuals living with HIV.
Three Amazonian Morpho butterfly species have been sequenced for the first time, revealing genetic differences that maintain reproductive isolation despite sympatry. The study found Z-chromosome rearrangements and genetic divergence among gene copies, suggesting a role in speciation.
Global experts have developed a new checklist called iCHECK-DH to standardize the quality of reporting and improve implementation standards for digital health technologies. The 20-item checklist aims to aid researchers and practitioners in ensuring complete, accurate, and consistent reports.
Paderborn researchers develop innovative approach to generating higher harmonics in silicon metasurfaces, increasing efficiency through the Fano effect. The study enables third harmonics to be generated much more efficiently than with previous known structures.
A new study from City University London suggests that the Research Excellence Framework (REF) has led to significant increases in high-quality published research, but not active academics. The study highlights areas of improvement needed in the assessment framework, including greater collaboration between domestic competitors.
A study published in The Journal of Bone & Joint Surgery reports high 10-year implant survival and patient satisfaction rates for robotic-assisted medial knee arthroplasty. The procedure showed excellent outcomes, with over 90% of patients remaining satisfied without revision.
A new study published in JMIR Diabetes found that Fitterfly's diabetes digital therapeutics program improved glycemic control and weight management in participants with type 2 diabetes. The 90-day program led to significant reductions in hemoglobin A1c levels and body weight.
A new systematic literature review reveals that virtual consulting can reduce carbon emissions in healthcare by minimizing patient travel time. The review found significant reductions in carbon emissions through the adoption of telemedicine appointments and video-based visits, which will continue to mitigate climate change as health sy...
The Journal of Dental Research (JDR) has published a special issue on aging and oral health, featuring research on biological mechanisms underlying age-related conditions such as cognitive decline. The issue aims to improve oral health care in older populations, promoting general health and well-being.
A comprehensive review of 169 clinical trials found that the effect of fructose-containing sugars on adiposity varies among food sources and energy control. High doses of certain sources, like SSBs, lead to increased body weight, while others, such as fruit and honey, show moderate beneficial effects when consumed in moderation.
Researchers developed a new sociotechnical framework to assess eHealth tool quality and impact. The framework balances technical, social, and organizational aspects and considers implementation challenges.
The 18th Key Symposium on Healthy Ageing and Longevity takes place in Okinawa, bringing together world experts to discuss the latest research on blue zones. The symposium aims to promote both longevity and healthy ageing to reduce age-related diseases and healthcare burden.
Jeong Min Lee, KSR President and professor at Seoul National University Hospital, is honored with ARRS membership. He has published over 470 scientific articles and serves on the editorial board of several publications.
A new study found that a handful of key Twitter influencers effectively countered vaccine misinformation and promoted accurate information about vaccines. Social media influencers can use their social capital to challenge the spread of conspiracy theories.
Impact Journals will participate as an exhibitor at the AACR Annual Meeting 2023, showcasing Aging's growth in impact factor to 5.955. The meeting theme focuses on Advancing the Frontiers of Cancer Science and Medicine.
Impact Journals' Oncotarget participates in the AACR Annual Meeting 2023, highlighting its focus on oncology and biomedical sciences. The meeting theme of Advancing the Frontiers of Cancer Science and Medicine aligns with Oncotarget's research goals.
A study published in the journal Cancer found that long-term pancreatic cancer survivors have a robust immune response and enriched gut microbiome species, including Faecalibacterium prausnitzii. The research suggests that these bacterial species may promote immune response to pancreas cancer.
A team led by Bill Ballard has published a new study in GigaScience to propose Cooinda, an Alpine dingo, as the model specimen to represent a typical dingo. The study presents genomic and brain imaging data that sheds light on the evolutionary history of dingoes and their domestication process.
The High Seas Treaty aims to establish cooperative approaches to improve ocean management, but scientists argue that more research is needed to effectively implement the agreement. The treaty proposes massive marine protected areas covering 30% of the ocean by 2030, which could significantly improve ocean conservation.
The article provides 12 recommendations to enhance the quality of surveys, including transparency, clarity, and correcting the record. The recommendations aim to address challenges in survey research, such as biased responses and inaccurate forecasts.
A University of Cambridge analysis identified 98% of reports from trials evaluating new school-based physical exercise programs as lacking key details about teacher training. The study urged journal editors to update their submission guidelines to encourage better reporting, with seven journals already altered their guidance.
Researchers at Chalmers University of Technology have developed a propeller design optimisation method that paves the way for quiet, efficient electric aviation. The new design can reduce noise emissions by up to 5-8 dBA, comparable to going from a normal conversation voice to a quiet room.
Higher body mass index patients undergoing unicompartmental knee replacement (UKR) experience lower revision rates with cementless implants, according to a new study. Cementless fixation is preferred in higher-BMI patients, reducing the risk of revision surgery by up to 40%.
A new study shows that transcatheter mitral valve repair significantly reduces hospitalizations by almost 50 percent and death by nearly 30 percent in heart failure patients with severe mitral regurgitation. The procedure, using Abbott's MitraClip system, improves symptoms, reduces hospitalizations, and leads to longer survival.