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Coronary heart disease before age 45 may increase risk of dementia later in life

Research found a significant linear relationship between age of coronary heart disease onset and dementia, highlighting the detrimental influence of premature cardiovascular events on brain health. Adults diagnosed with coronary heart disease at a young age may be at increased risk of developing dementia, Alzheimer's disease, and vascu...

SourceAmerican Heart Association·JournalJournal of the American Heart Association·DateNov 29, 2023

Most-cited scientists: Still mostly men, but the gender gap is closing

The gender gap among top-cited scientists is narrowing, with women now representing 32% of top-cited authors in certain fields, according to a study analyzing 5.8 million international scientific authors. However, significant disparities remain, and efforts to address promotion pathways for gifted female researchers are still needed.

SourcePLOS·JournalPLOS Biology·TypeMeta-analysis·DateNov 21, 2023

A potential early esophageal cancer antigen: DDX53

Researchers found that tumor-resident T-cell receptor sequences showed high complementarity with the cancer testis antigen DDX53, suggesting an immune response that selects for DDX53-negative cells. This association was correlated with worse disease-free survival rates, highlighting a potential early esophageal cancer antigen.

SourceImpact Journals LLC·JournalOncoscience·TypeObservational study·DateNov 17, 2023

First comprehensive guideline on using biomarkers for monitoring Crohn’s disease

The American Gastroenterological Association released a new guideline recommending the use of biomarkers to help manage Crohn’s disease. Biomarkers such as C-reactive protein and fecal calprotectin can measure levels of inflammation, helping doctors assess disease activity and guide treatment decisions.

SourceAmerican Gastroenterological Association·JournalGastroenterology·TypeSystematic review·DateNov 17, 2023

Endangered thick-billed parrots at risk of losing newly identified, unprotected Sierra Madre forest habitats to logging, deforestation, study shows

Researchers tracked endangered thick-billed parrots using solar-powered satellite transmitters, revealing new critical habitat and migratory routes. Less than 20% of the newly identified habitat is protected from timber industry, highlighting the urgent need for conservation efforts.

SourceSan Diego Zoo Wildlife Alliance·JournalGlobal Ecology and Conservation·TypeData/statistical analysis·DateNov 9, 2023

STAT3 as a target in H3K27M-mutant DMGs

Researchers discovered the STAT3 signaling pathway as a potential target for treating H3K27M-mutant diffuse midline gliomas (DMGs), a uniformly lethal central nervous system malignancy. The current standard of care, including palliative radiation and chemotherapy, remains ineffective in this disease.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateOct 10, 2023

SwRI study suggests large mound structures on Kuiper belt object Arrokoth may have common origin

A new SwRI study posits that the large mounds on Kuiper Belt object Arrokoth are similar in size and shape, suggesting a common origin. This finding supports the streaming instability model of planetesimal formation, where gentle collision speeds allowed objects to accumulate and form Arrokoth.

SourceSouthwest Research Institute·JournalThe Planetary Science Journal·TypeObservational study·DateOct 3, 2023

An ancient anti-cancer mechanism: DISE

Researchers at Northwestern University identified a new evolutionarily conserved RNAi-based form of cell death called Death Induced by Survival gene Elimination (DISE), which targets essential survival genes in cancer cells. This mechanism is ancient and effective against all cancers tested.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateOct 3, 2023

Reassessing COVID-19 precautions in 2023

The article discusses the need to reassess COVID-19 precautions in 2023, particularly for patients with hematologic malignancies. The researchers highlight the increased risk of poor response to vaccination and worse outcomes from COVID-19 infection among these patients.

SourceImpact Journals LLC·JournalOncotarget·TypeCommentary/editorial·DateSep 27, 2023

Global policymakers call for effective infodemic management to be a substantive article in the pandemic accord

The Intergovernmental Negotiating Body Bureau emphasizes the importance of social media regulation and digital health literacy in managing infodemics, which can spread false information on public health matters. Effective infodemic management is seen as a critical component of the Pandemic Accord to safeguard lives worldwide.

SourceJMIR Publications·JournalJMIR Infodemiology·DateSep 21, 2023

New guideline details dental pain management strategies for pediatric patients

The American Dental Association has released a new clinical practice guideline recommending the use of acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs) as first-line treatments for managing short-term dental pain in children under 12. The guideline has been endorsed by the American Dental Association.

SourceAmerican Dental Association·JournalThe Journal of the American Dental Association·DateAug 25, 2023

New Journal of Pharmaceutical Analysis articles showcase promising therapeutic candidates for treating cancer and hearing loss

Researchers developed innovative techniques to treat challenging cancers and manage therapy side effects. Inhibitors targeting PRMT5, a histone-modifying enzyme, alleviated cisplatin-induced hearing loss, while nano-pills delivered combination drugs to liver cancer cells.

SourceCactus Communications·JournalJournal of Pharmaceutical Analysis·TypeExperimental study·DateAug 8, 2023

Study explores the influence of social networks on oral health outcomes

The study found that network-level variables significantly improved model fit and displayed strong independent associations with oral health outcomes. Network proportion needing dental treatment was positively associated with current dental treatment needs, while exposure to reported dental visits decreased odds of no recent dental vis...

SourceInternational Association for Dental, Oral, and Craniofacial Research·JournalJDR Clinical & Translational Research·TypeData/statistical analysis·DateJul 28, 2023

Breakthrough in solid-state storage innovates how biological materials are stored and handled

Researchers at California Polytechnic State University have developed a novel method for storing biological materials such as RNA and proteins in a solid-state, resembling a pill or tablet that dissolves in water for on-demand use. This innovation overcomes current limitations in storage and handling, making it easier to access these m...

SourceCalifornia Polytechnic State University·JournalACS Synthetic Biology·TypeExperimental study·DateJul 26, 2023

A multiplex assay to assess activated p300/CBP in circulating prostate tumor cells

A new multiplex assay has been developed to assess activated p300/CBP in circulating prostate tumor cells, revealing correlations with clinical outcomes and potential therapeutic targets for castration-resistant prostate cancer. The study found that patients with upregulated p300/CBP activity had shorter response times to ARSI therapy.

SourceImpact Journals LLC·JournalOncotarget·TypeExperimental study·DateJul 24, 2023

The cost of being a non-native English speaker in science

Research reveals non-native English speakers need up to twice as much time to read and write papers, with 2.5 times higher rejection rates for papers written in English. This disproportionately affects early career stage researchers from lower income countries.

SourcePLOS·JournalPLOS Biology·TypeSurvey·DateJul 18, 2023

Conservation in Indonesia is at risk, a team of researchers who study the region argues

A team of conservation researchers warns that Indonesia's tropical rainforest and endangered species are under threat from government interference and corporate interests. The researchers advocate for data transparency, online 'safe houses', and anonymized journals to protect environmental research and promote nature conservation.

SourceCell Press·JournalCurrent Biology·TypeCommentary/editorial·DateJul 10, 2023