Articles tagged with Scientific Journals
A new study found that postmenopausal women exhibit smaller cortical surface areas in certain brain regions, reduced thalamic subnuclei volumes, and decreased functional connectivity, suggesting a link between menopause-related symptoms and brain changes.
The journal features five original articles from Kennedy Krieger faculty members, providing actionable insights on caring for children with autism. The volume addresses a significant gap in resources for pediatric clinicians and researchers globally.
A long-term study found that coronary heart patients who live in greener areas have a significantly lower risk of mortality after undergoing bypass surgery. The study, which followed over 3,000 patients for 14 years, found that living in a green environment was associated with better chances of survival.
Researchers assessed the feasibility of dual PD-L1/CTLA-4 checkpoint inhibition in Stage II or III hormone receptor-positive, HER2-negative breast cancer. Eight patients received upfront durvalumab and tremelimumab prior to neoadjuvant chemotherapy, showing mixed responses and limited benefit.
Researchers found that chlorogenic acid enhances osteoblast proliferation and differentiation, while inhibiting RANKL-induced osteoclastogenesis. Administration of chlorogenic acid antagonizes ovariectomized-induced bone loss in rats.
Researchers found that nontraditional stroke risk factors like migraines are as important as traditional risk factors like high blood pressure for adults younger than ages 35-45. The association between stroke and nontraditional stroke risk factors was stronger in adults younger than 35 years old.
A team of biophysicists used computational physics modeling to understand how cells sort themselves into different groups during development. They found that high-density particles do not separate using temperature or energy injection, highlighting the need for alternative mechanisms.
A new study finds that extreme tropical cyclone rainfall is increasing across the continental US, while climate warming restricts 'outdoor days' for people living in developing countries. Additionally, air pollution increases mortality risks from heat, especially when combined with other factors like wildfires and reduced aerosols.
NeXT Personal assay detects up to ~1,800 somatic variants specific to the patient's tumor with a detection threshold of 1.67 PPM and 99.9% specificity. The assay showed linearity over a range of 0.8 to 300,000 PPM.
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
A groundbreaking scientific drilling project has unearthed the world's longest geological record of the Cretaceous period, spanning over 50 million years. The project, led by Professor Wang Chengshan, has provided crucial insights into paleoclimate research and will continue to aid in predicting future climate trends.
A new study published in the journal Stroke found that African American veterans with PTSD had a significantly higher risk of re-hospitalization after a stroke compared to those without PTSD. This was not observed among white veterans. The study highlights the importance of targeted care for high-risk populations and reducing modifiabl...
Researchers discovered GZ17-6.02's ability to interact with proteasome inhibitors in a greater than additive fashion to kill multiple myeloma cells and alone inhibit inhibitor-resistant cells. The compound combination also activated key pathways and increased autophagosome formation, leading to tumor cell killing.
Researchers investigated combining Sacituzumab govitecan with platinum-based chemotherapeutics for triple-negative breast cancer, urinary bladder carcinoma, and small-cell lung carcinoma. The study showed additive to synergistic antitumor effects in vitro and in vivo, with improved outcomes in tumor-bearing animals.
Researchers observed an individual orca, nicknamed Starboard, killing a 2.5-meter juvenile great white shark within two minutes. The study challenges conventional cooperative hunting behaviors among killer whales, providing new insights into their predatory dynamics and potential impact on marine ecosystems.
A new study published in Oncotarget reveals a higher prevalence of germline BRCA1 and BRCA2 mutations in ovarian cancer patients from the Salento peninsula, with 28.6% having familial cases and 39.7% having sporadic cases. The study found that 29.8% of patients were carriers of BRCA1/2 mutation.
Research suggests polar climates are adjusting to a warming climate with changes in regional climate dynamics. Altered ocean-sea ice interactions may be driving recent fluctuations in sea ice extent, according to new studies.
Researchers found GZ17-6.02 alone and in combination with standard-of-care agents was effective in killing MF cells, activating key pathways including ATM, AMPK, NFκB, and macroautophagy. The compound's unique multi-factorial mechanism suggests potential for treating mycosis fungoides.
Researchers identified a putative paclitaxel response predictive biomarker for glioblastoma and breast cancer using the whole genome CRISPR knockout screen. The biomarker candidate was validated in two independent breast cancer patient cohorts that received taxane treatment.
Researchers found that a compound called BAM15 makes mitochondria less efficient at producing energy, extending life span and improving body composition in fruit flies. The study also showed reduced age-related decline in motor activity. Further studies are needed to confirm these findings in humans.
Researchers identified NTRK gene fusion in 1.5% of Finnish papillary thyroid cancer patients, with notable co-occurring genetic alterations and favorable treatment outcomes. The study highlights the potential for biobank samples linked to electronic health records to describe patient characteristics and outcomes.
Researchers at TU Darmstadt have successfully demonstrated a quantum-processing architecture with over 1,000 individually controllable atomic qubits. This breakthrough enables the development of highly beneficial applications in fields such as drug development and traffic optimization.
A study published in Oncotarget has identified specific mutational and therapeutic landscapes of pancreatic cancer in the Russian population. By applying machine learning models to full exome individual data, researchers received personalized recommendations for targeted treatment options for each clinical case.
The MIT Press is accepting applications for its shift+OPEN initiative, which provides funding and support to convert subscription-based journals to diamond open access. Selected journals will receive three-year funding, professional publishing services, and sustainable funding model development support.
A recent study published in the Journal of the American College of Cardiology found that salt substitutes can help maintain healthy blood pressure in older adults. The study, which included 611 participants, showed that those using salt substitutes had a 40% lower incidence of hypertension compared to those using regular salt.
Researchers found Mad2 gene expression levels correlate with chromosomal abnormalities in esophageal squamous cell carcinoma, highlighting potential as a clinical biomarker. The study also revealed the deregulation of the Rb-E2F1 circuit and its impact on histone modifications.
The study evaluated the effectiveness of ruxolitinib in treating relapsed/refractory multiple myeloma. Researchers found that ruxolitinib inhibited JAK signaling, leading to enhanced anti-tumor effects and improved patient outcomes.
A new study published in the American Heart Association journal Hypertension found that tirzepatide significantly lowered systolic blood pressure levels in nearly 500 adults with obesity. The results suggest treating obesity with this weight loss medication may be an effective strategy for preventing or treating high blood pressure.
The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
Researchers have uncovered the molecular and ultrastructural features of BCAS1+ cells in diffuse gliomas, highlighting their proliferative capacity and distribution. The study provides a comprehensive characterization of the BCAS1+ cell population within diffuse gliomas, shedding light on its role in tumor malignancy.
A study reveals thyroid cancer's genetic changes contribute to resistance to BRAF inhibitors and can lead to tumor dedifferentiation. Researchers identify potential targets for new therapies, including dual-targeted treatments and immunotherapy combinations.
The American Heart Association has outlined three target needs for improving cardiac arrest outcomes by 2030: increasing bystander CPR rates, defibrillation, and survival after cardiac arrest. The goal is to double survivorship to 20% through increased access to lifesaving care in underrepresented communities.
Researchers report a case of a patient with EGFR L858R mutant non-small cell lung cancer (NSCLC) who experienced durable disease improvement after empirical treatment with osimertinib. The 'Lazarus effect' refers to the phenomenon where cancer appears to recur after seeming to be in remission.
Researchers found decreased BMAd density and altered distribution profile in MGUS patients who developed MM, indicating early changes in bone marrow adipose tissue. These findings suggest the potential for timely interventions and personalized treatment strategies.
Researchers identified gartisertib as a potent ATR inhibitor that enhances cell death in patient-derived glioblastoma cell lines. The study also showed synergy between gartisertib and TMZ+RT treatment, with higher sensitivity to gartisertib observed in MGMT promoter unmethylated cells.
The American Journal of Clinical Nutrition has launched a new article series, Nutrition for the Clinician, aimed at educating physicians and healthcare professionals on the fundamentals of nutrition. The series provides continuing education that enhances clinical reasoning and use of best nutrition evidence in practice.
Researchers discuss reductive carboxylation of glutamine as a potential target in acute myeloid leukemia (AML), an aggressive cancer with poor patient outcomes. The approach aims to weaken tumor cell survival mechanisms, potentially leading to novel therapies and improved patient outcomes.
Researchers unveiled a previously unknown effect of PG545 in ovarian cancer cells, inducing DNA damage and promoting autophagic degradation of RAD51. This breakthrough could aid in selecting the most appropriate treatments for ovarian cancer patients with PARPi resistance.
A recent US study challenges the notion of a replication crisis in psychology, arguing that flawed intuition and low power in replication studies are to blame. The researchers propose using formal models to estimate expected replication rates, rather than relying on intuitive assumptions.
Cancer stem cell-derived exosomes (CSC-Exos) are essential for communication between CSCs and other cells in the tumor microenvironment, contributing to cancer progression. The editorial highlights their potential as a novel clinical tool for diagnosis, prognosis, prevention of tumor recurrence, and therapeutic strategy
GFH009 inhibits tumor growth and induces apoptosis in various HHM-derived cell lines. The compound's mechanism of action involves rapid 'on-off' inhibition of CDK9, which exerts a proapoptotic effect on cancer cells.
Researchers from Brazil discuss the management of refractory or relapsed classic Hodgkin lymphoma in adults, highlighting novel agents such as brentuximab vedotin and immunotherapy. The Brazilian healthcare system's constraints are also considered when making treatment decisions.
The European Societies and European Journal of Cultural and Political Sociology journals will transition to diamond open access with the MIT Press, starting in 2025. The move is driven by the growing acceptance of open access in academic fields and the European Union's new requirements.
Researchers revisited melatonin's effects on cancer in mice, finding that nighttime administration inhibits chemically induced mammary tumor development. The study highlights the importance of timing in using this freely available compound for cancer prevention and treatment.
Researchers at Johns Hopkins Medicine have identified six protein markers that can predict and manage acute kidney injury (AKI), a condition marked by serious inflammation. The study's findings offer hope for non-invasive assessments of AKI, potentially reducing the need for invasive kidney biopsies.
A new study found that deaths from infective endocarditis decreased overall in the US, but rose sharply among people ages 25-44, likely linked to the opioid crisis. Researchers call for more investigation into the trends and recommend comprehensive care plans including substance use disorder screening and treatment.
Researchers explore the properties of cytostatic persisters in cancer treatment, highlighting their therapeutic potential and challenges. The study suggests that targeting these persisters before resistance emerges can reduce cancer recurrence.
A systematic review has identified 29 primary risk factors associated with long-term arm morbidities following breast cancer treatments. The main risk factors include removal of lymph nodes, high body mass index, mastectomy, radiation therapy, chemotherapy, infection, and trauma to the affected arm.
Researchers found that BCMA-positive extracellular vesicles (EVs) in plasma levels correlated with myeloma patient responses to belantamab-mafodotin therapy. High EV levels preceded FLC progression and were associated with mafodotin-induced eryptosis.
A new study published in the Journal of the American Heart Association found that many couples around the world share high blood pressure. The research analyzed data from over 50,000 couples in four countries and found a strong association between partners' blood pressure status.
Researchers discovered that Osteopontin induces mitochondrial biogenesis in deadherent breast tumor cells, which aids metastatic success. The study suggests a possible mechanism and targets for treating cancer metastasis by increasing ATP levels and mitochondrial mass.
Archaeologists recommend using state-of-the-art techniques, such as micromorphology, to analyze evidence and increase confidence in claims about human evolution. This approach aims to rewrite our understanding of human ancestors by uncovering hidden clues in ancient sediments.
Research found a significant linear relationship between age of coronary heart disease onset and dementia, highlighting the detrimental influence of premature cardiovascular events on brain health. Adults diagnosed with coronary heart disease at a young age may be at increased risk of developing dementia, Alzheimer's disease, and vascu...
Researchers discuss CRISPR's limitations in generating accurate cancer models, including variable mutations and indels. Despite these challenges, the technology holds promise for cancer research due to its potential for natural selection and Darwinian evolution.
Researchers predict that vampire bats will expand their locations in search of more stable climates, potentially linked to a spillover of rabies. The team's work aims to identify and track the bats by traveling to Colombia to contain the spread.
Researchers identified 38 unique pathogenic variants in 57 patients, including novel variants specific to the Kazakh population. These variants were associated with an increased risk of triple-negative breast cancer and family history of breast cancer.
Virginia Tech researchers analyzed partisan media sentiment toward AI and found that liberal-leaning media tend to have a more negative tone than conservative media. The study suggests that this opposition can be attributed to concerns over AI amplifying existing social biases, such as racial and income disparities.
The gender gap among top-cited scientists is narrowing, with women now representing 32% of top-cited authors in certain fields, according to a study analyzing 5.8 million international scientific authors. However, significant disparities remain, and efforts to address promotion pathways for gifted female researchers are still needed.
Researchers propose network-based methodology to contextualize scientific publication impact, allowing for more accurate assessment of interdisciplinary discoveries. The new approach normalizes citation counts, mitigating biases in existing methods.
Researchers found that tumor-resident T-cell receptor sequences showed high complementarity with the cancer testis antigen DDX53, suggesting an immune response that selects for DDX53-negative cells. This association was correlated with worse disease-free survival rates, highlighting a potential early esophageal cancer antigen.