Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The American Heart Association has released its list of top cardiovascular research for 2024, focusing on prevention, treatment and the benefits of anti-obesity medications. The research highlights improvements in assessing cardiovascular risk, identifying early prevention opportunities and treating heart failure.
A study reveals that lower-income and minority mothers face disproportionate challenges in postpartum health due to inadequate social support systems. The research emphasizes the need for targeted policy interventions to improve maternal health equity, strengthen postpartum care, and reduce health disparities.
A 35,000-year-old ritual complex in the Manot Cave offers insight into the spiritual practices of Paleolithic hunter-gatherer groups. The discovery reveals evidence of human-made engravings, ash remains from fire, and acoustic tests that suggest a unique auditory experience for communal activities.
The collaboration aims to evaluate the potential of AMB-066 as a first-in-class treatment option for patients with colorectal cancer and minimal residual disease. MD Anderson researchers have identified a potential opportunity for AMB-066 to effectively treat MRD-positive CRC, based on robust preclinical data.
Insilico Medicine has nominated ISM8969, an orally available NLRP3 inhibitor, as a potential treatment for various inflammatory diseases. The compound has shown promising results in preclinical evaluation studies, including balanced druggability and efficacy against inflammation.
Researchers discovered a new pathway to pain management by modulating pain signals with solvent molecules, offering an alternative to traditional pain medications. The study showed that deuterated water suppressed pain signal transmission and achieved effective analgesia.
Dr. Edo Ronald de Kloet shares insights on cortisol's dual role in protecting and damaging the brain through mineralocorticoid receptors (MR) and glucocorticoid receptors (GR). His discovery has transformed our understanding of stress-related mental disorders and led to novel therapeutic pathways.
A new review published in Blood Cancer Discovery outlines how research supported a recent FDA committee decision to allow minimal residual disease as an endpoint for accelerated approval in multiple myeloma. This decision could cut a decade off the drug development process, enabling faster innovation in cancer treatment.
A new detection method has been used to identify over 100 small asteroids in the main asteroid belt, ranging from bus-sized to stadium-wide. This breakthrough could aid in tracking potential asteroid impactors and provide insights into meteorite origins.
A new research paper published in Oncotarget introduces an innovative AI tool combining CT scans and body composition data to predict severe liver problems in primary sclerosing cholangitis (PSC) patients. The model achieved impressive results, correctly identifying at-risk patients with 97% accuracy.
Researchers from Woods Hole Oceanographic Institution and partners uncover a fast-swimming predatory amphipod species at depths of up to 8,000 meters. The newly discovered species highlights the importance of continued deep-ocean exploration and biodiversity discoveries in the Atacama Trench.
Southwest Research Institute has launched a joint industry project to develop technologies for hydrogen-powered heavy-duty refueling operations. The four-year program aims to strengthen existing refueling station equipment and procedures, exploring alternatives to address supply chain issues and technical challenges.
Researchers at Lund University Diabetes Centre have mapped out differences in the atherosclerotic process in people with type 2 diabetes. The study found that high blood sugar levels can lead to reduced ability to form protective connective tissue in atherosclerotic plaques, increasing cardiovascular risk.
Researchers found that a ketogenic diet's beta-hydroxybutyrate (BHB) improves tumor control and survival in mice with diffuse-large B-cell lymphoma. A BHB supplement also boosts CAR T cell expansion and activation in laboratory models of human cancer.
Researchers used CT scans to examine giant hailstones formed during a 2022 thunderstorm in Catalonia. The study revealed irregular internal shapes and heterogeneous growth patterns, overturning previous assumptions about hailstone formation.
Three Sanford Burnham Prebys faculty members, David A. Brenner, Randal J. Kaufman, and Tariq M. Rana, are recognized for their significant scientific influence. Their publications have been cited top 1% globally by number of citations.
Researchers at Texas A&M University developed a non-toxic pesticide using neem seed extract and nanotechnology. The new formulation shows improved targeting ability and reduces environmental pollution by up to 80-90% of sprayed pesticides missing their target entirely.
Researchers have identified a key protein that plays a crucial role in energy production in muscle cells, which can be activated by physical exercise. This discovery may lead to the development of treatments for over 200 disorders related to muscle energy production.
Three Texas A&M biologists have received NIH Maximizing Investigators’ Research Awards to support their research on type IV pili, darter fish social behaviors and bacteriophages. Drs Koch, Moran and Ramsey will explore bacterial behavior, genetic mechanisms and neural basis of paternal care in fish.
A team of researchers discovered that a previously ignored microRNA, mir-193, is the actual melanic color switch in butterflies and moths. Disrupting mir-193 eliminated black and dark wing colors in three butterfly species.
A new study has discovered that close spatial proximity serves as an indicator of friendship in feral female buffalo, with individual personalities playing a key role. The research found that buffalo with similar social tension, vigilance, and general dominance traits tended to spend more time together.
Insilico Medicine has successfully integrated cutting-edge generative AI models into its platform, achieving significant increases in accuracy and speed. The company's AI-powered solutions have shown promising results in preclinical candidates and Phase II clinical trials.
A team of scientists, including Binghamton University's Molly Patterson, is drilling into the Ross Ice Shelf to retrieve geological records and gain insights into the ice sheet's response to global warming. The project aims to provide crucial data for adapting to sea-level rise and mitigating greenhouse gas emissions.
A Virginia Tech researcher has received a collaborative grant to improve cancer therapies by developing 3D liver organoids and employing cutting-edge microscopy technology. The project aims to identify the most effective treatments for cancer, enabling better-targeted treatments.
The open-access journal Seed Biology has been successfully indexed in the Emerging Sources Citation Index (ESCI) in the Web of Science. This milestone strengthens the journal's academic discourse and impact, making its articles searchable and citable worldwide.
A team of researchers has successfully identified a compound with record-breaking performance in film capacitors, a crucial component in renewable energy technologies. The breakthrough was achieved using a machine-learning technique that screened nearly 50,000 chemical structures to find the optimal material.
The partnership integrates Answer ALS’s Neuromine Data Portal with the AD Data Initiative's AD Workbench, providing a unified platform for data sharing and analysis. This collaboration enables integrative analysis of ALS and Alzheimer’s data, streamlining efforts and enhancing research impact.
A previously unknown population of neurons in the hypothalamus has been discovered to regulate food intake and respond to leptin. This discovery could lead to new targets for obesity drugs and potentially reduce hunger.
The US Naval Research Laboratory (NRL) will present its latest advancements in Earth and space sciences at the American Geophysical Union (AGU) Conference. NRL researchers will share their work on topics such as atmospheric data assimilation, ocean sciences, and geostationary ocean color.
A USC-led study found that neurogenesis in adults supports verbal learning and memory, enabling people to have conversations. The discovery could lead to new approaches to restore cognitive function in patients with epilepsy and other conditions.
Researchers propose a new model for understanding how information is transmitted in the brain by describing a unique axon morphology that changes size and modulates action potential speed
Researchers at the University of Konstanz have discovered that different mutations of the tumour suppressor p53 affect pancreatic carcinomas differently. The study found that two variants of p53 selectively control distinct metabolic pathways, providing new insights into cancer development.
The study reveals a high degree of technical mastery in the use of animal tendons, reed wood, and birch bark pitch to create bows and arrows. The findings shed new light on Neolithic archery techniques and materials in Europe.
Researchers have discovered a major setback in the use of AZD7648 to promote precise gene editing, which causes massive genetic changes and genome instability. Despite this, scientists remain optimistic about advancing CRISPR-Cas technology to treat diseases.
A landmark photosynthesis gene discovery has been made in a poplar tree that enhances plant growth by up to 200% and increases biomass production. The gene, named Booster, has the potential to boost crop yields without requiring more land, water or fertilizer.
Researchers found that as cells age, they lose regenerative capacity and become less susceptible to cancer. The study's findings suggest that therapies targeting ferroptosis may be less effective in older patients.
Researchers are using AI to find undocumented orphaned wells across the US, which can leak toxic substances into water sources and contribute to climate change. By analyzing historical topographic maps and modern sensors, they aim to locate and assess these forgotten relics.
Researchers at UCSF found a brain signature of resilience in mice that suggests a new way to treat severe depression. Stress changes activity in the amygdala, distinguishing resilient from less resilient mice. By stimulating neurons, the team improved decision-making and reduced ruminating in less resilient mice.
Researchers have developed a non-invasive strategy that assesses blood flow through skeletal muscle to detect early signs of sepsis. The technique, combining hyperspectral near-infrared spectroscopy and diffuse correlation spectroscopy, was tested in rodents and detected sepsis before vital organs were affected.
A new study reveals that glyphosate exposure in mice can cause lasting brain inflammation and accelerate Alzheimer's disease-like pathology, even after a significant pause from exposure. The herbicide's byproducts have been found to accumulate in brain tissue, raising serious concerns about its safety for human populations.
A new study published in the Journal of the American Heart Association found that Mexican American women are more likely to miss prescribed doses of stroke prevention medications. The study highlights sex-associated disparities in stroke care, particularly among racial and ethnic minorities.
Evo, a generative AI model, uses patterns in microbial genomes to write new genetic code, expanding the length of sequences models can process and improving resolution. Researchers use Evo to understand microbial and viral genomes, fashion new proteins, and reprogram microbes for remarkable tasks.
A team of scientists analyzed smartphone videos and amateur photos of a rare blue-dominant aurora in Japan to estimate its area and confirm findings with spectrophotometers. The research revealed longitudinal structures aligned with magnetic field lines, spanning about 1200 km in longitude.
Valentin Fuster, MD, PhD, has made significant contributions to the understanding of atherosclerosis through his research on inflammation, thrombosis, and treatment breakthroughs. His work has led to major advances in diagnosis and therapy, including the development of a cardiovascular 'polypill' that reduces cardiovascular mortality.
Researchers have found that B7-H4 helps ACC tumors evade the immune system, leading to poor survival outcomes. A new drug targeting B7-H4 showed promising results in shrinking tumors in aggressive cases.
Researchers have identified UBA1 enzyme as key mediator for immune response to tumors, inhibiting its activity increases T-cell recruitment and lowers tumor resistance. Pairing UBA1 inhibitors with immune checkpoint blockade therapies may make immunotherapy more effective for patients with 'cold' tumors.
Five University College Dublin academics receive €2 million each for projects on Law, Philosophy, Biomechanical Engineering, and Information and Communication Studies. The grants aim to establish independent research teams and develop promising scientific ideas.
Mass General Brigham researchers presented research discoveries and outcomes from clinical trials on immune thrombocytopenia, early phase therapies, myeloproliferative syndromes, advances in treatment of lymphomas and leukemias. A novel prognostic score for relapsed/refractory mature T-cell and NK-cell lymphomas was also developed.
Dr. Seymour Reichlin's centennial celebration highlights his ongoing scientific impact, with recent collaborations yielding new insights into hormone therapies for cognitive enhancement and emotional homeostasis. His work has established neuroendocrinology as a distinct field, bridging neuroscience, endocrinology, and clinical medicine.
Max Delbrück Center researchers have uncovered new features of the molecular architecture of synaptic vesicles using cryo-electron tomography. The study reveals a persistent association between V-ATPase and synaptophysin, suggesting an important function in neurotransmission.
Hebrew University researchers Prof. Dina Schneidman and Prof. Yoel Greenberg have been awarded €2 million European Research Council grants for their innovative projects. Their work aims to transform immune research, advance vaccine development, and revolutionize music theory.
Researchers at Princeton Chemistry have developed a promising combination-drug treatment for melioidosis, a bacterial infection that causes fever, pneumonia, and sepsis. The approach targets the pathogen's unique metabolic vulnerabilities with low-dose antibiotics, leaving gut microbiome bacteria unscathed.
Researchers have discovered a new photosynthesis gene, BOOSTER, that enhances plant growth and increases biomass production. This breakthrough could lead to higher yields in crops and potentially trigger more efficient use of atmospheric CO2.
Researchers found that tumor cell secreted DNA in extracellular vesicles acts as a 'danger' signal to activate an anti-tumor response in the liver, reducing liver metastasis risk. The discovery improves understanding of cancer progression and anticancer immunity.
A team of researchers discovered a novel cause of cytokine storm in fatal COVID-19 cases, linking the renin-angiotensin-aldosterone system (RAAS) to the hyperinflammatory response. This finding holds potential for identifying patients at risk and developing targeted interventions.
A prestigious professorship in immunology has been established at the Walter and Eliza Hall Institute, continuing Sir Gustav Nossal's groundbreaking work on immune tolerance. The position aims to nurture new generations of researchers and advance understanding of immune diseases such as lupus and rheumatoid arthritis.
Researchers found that female locust's digging valves wear down significantly despite being used only 3-4 times in a lifetime. The study demonstrates the 'good enough' principle in evolution, where extra resources are not invested in organs with specific purposes performed adequately.
A Kennesaw State University professor has received a grant to analyze the relationship between access to cancer treatment and patient outcomes in Kenya. The research aims to identify cost-effective and sustainable treatment protocols that improve survival rates and address financial barriers to care.
A new discovery by researchers at Tohoku University reveals that the movement of atoms and molecules within glass can relax internal stress, making the material more resistant to fractures. The breakthrough has wide-ranging implications for industries such as consumer electronics, construction, and automotive manufacturing.
Researchers discovered that sea anemones reshape their entire bodies to maintain the same overall form after injury, contrary to other regenerating animals. This process involves molecular changes across the body, including the activation of metalloproteases, to restore proportionate shape and function.