Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A study by the University of Zurich found that CEOs who expressed empathy during COVID-19 pandemic conference calls had better stock prices. The researchers analyzed data from 510 CEO calls and discovered a 2.49 percentage point increase in cumulative returns for companies with human care statements.
Researchers at Tokyo University of Science discovered a new ribozyme, R3C ligase, that catalyzes the formation of a 3',5'-phosphodiester linkage between two RNA molecules. This finding sheds light on the molecular evolution of RNA and its potential applications in nanobiotechnology.
Researchers have achieved record speeds of up to 900 m/s by moving magnetic skyrmions using electrical currents. This breakthrough offers new prospects for developing higher-performance and less energy-intensive computing devices.
Researchers investigate the neuroprotective effects of tocotrienols in alleviating obesity-induced cognitive decline. The study found that T3s treatment improved cognitive function and mitigated oxidative stress in mice fed with a high-fat, high-sucrose diet.
Researchers at the University of Toronto have discovered a DNA repair mechanism that uses nuclear metamorphosis to fix double-strand breaks in human cells. This discovery has significant implications for cancer treatment and premature aging, and may lead to new therapeutic avenues.
Scientists at Salk Institute explore the clinical potential of cannabinol (CBN) in treating traumatic brain injury, Alzheimer's disease, and Parkinson's disease. They identify four CBN analogs with improved neuroprotective ability and drug-like efficacy.
Researchers have developed an active learning strategy to accelerate the synthesis of high-performance engineered biochar with enhanced CO2 uptake. The approach nearly doubled CO2 capture performance, showcasing its transformative impact.
Researchers developed sensors that detect plant signaling molecules, allowing farmers to monitor potential threats and intervene early. The sensors reveal distinctive patterns of stress responses, providing a real-time warning system for crops.
The American Heart Association has awarded $15 million to researchers studying the role of inflammation in cardiac and brain diseases. The four-year project aims to better understand the body's response to inflammation and prevent or treat inflammation-driven cardiovascular diseases.
Paleontologists have unearthed what may be the largest known marine reptile, a gigantic ichthyosaur measuring over 25 meters long. The fossilized remains of its second jawbone were found on a beach in Somerset, UK, and have been identified as belonging to a new species.
A new study from Israel found that nearly 1 in 5 adults with congenital heart disease developed an abnormal heart rhythm during a five-year study. Those who developed arrhythmias had twice the risk of early death and increased hospitalization rates compared to those without irregular heart rhythms.
A study published in the New England Journal of Medicine provides recommendations for protein, carbohydrates, fat, fiber, and water intake at various stages of life to support overall health. The guidance, developed by Dr. Steven Heymsfield and Dr. Sue Shapses, aims to promote personalized diets with key macronutrients.
Researchers have discovered a star orbiting a massive black hole 33 times heavier than the sun's mass, located 1500 light-years away from Earth. The binary system Gaia BH3 contains an ordinary star that seems to have formed over ten billion years ago.
Oregon State University researchers have developed a new pigment based on divalent chromium, which could be used as energy-efficient coatings for vehicles and buildings. The pigments are stable and reflective of heat from the sun, leading to potential energy savings.
A team of scientists at Tokyo University of Science has discovered a novel substituent migration reaction that enables the creation of complex benzofurans. This breakthrough synthesis method uses alkynyl sulfoxide and trifluoroacetic anhydride to produce highly functionalized benzofurans with high yields.
A study claiming a decline in disruptive patents was based on a measurement error, researchers found. The correct analysis suggests that both disruptive and consolidating research are still needed to build upon existing knowledge and drive innovation.
Researchers at Insilico Medicine have identified a new class of Polθ inhibitors featuring central scaffolding rings, designed using Chemistry42, with significant enzymatic and cellular potency. The discovery showcases the potential of AI in medicinal chemistry for precise molecular modifications.
Researchers have developed a urine-based test that detects pieces of DNA fragments released by head and neck tumors, providing a non-invasive alternative to traditional blood-based biomarker tests. The test has been shown to detect cancer recurrences far earlier than would typically happen based on clinical imaging.
A team of scientists has identified a specific gene expression pattern associated with an increased risk of childhood asthma. By understanding this mechanism, they aim to develop novel drugs that can correct the defense defect and prevent the progression of the disease.
Researchers identified DlBGAL9 as pivotal in enhancing β-galactosidase activity for cell wall thickening and stress response in Longan. The study found that AGL61/80 regulates DlBGAL9, promoting early somatic embryogenesis and increasing longan resistance to heat stress.
Researchers discovered that rats without prior knowledge of numbers can develop a sense of numbers when trained with sounds representing two or three numbers. The study found that the brain has a specific area for dealing with numbers, which is separate from the processing of magnitude.
A research team has made a significant breakthrough in understanding the GPR156 receptor protein's role in maintaining auditory function. The study reveals that GPR156 exhibits sustained activity even without external stimuli, highlighting its potential as a target for treating congenital hearing impairments.
Mayo Clinic researchers have invented a new class of artificial intelligence (AI) algorithms called hypothesis-driven AI, which can help discover the complex causes of diseases like cancer and improve treatment strategies. This emerging class of AI offers an innovative way to use massive datasets to guide individualized medicine.
Researchers at UNC-Chapel Hill have found that tardigrades can increase DNA repair genes' production in response to radiation, making them more resilient to damage. This discovery could lead to new ideas on protecting other animals and microorganisms from damaging radiation.
A comprehensive atlas of ageing human muscle reveals genetic and cellular processes behind muscle deterioration, including new cell populations that may explain age-related differences. The study also identifies compensatory mechanisms to counteract ageing, offering avenues for future therapies.
Researchers have identified a rare genetic condition, Glutamine Synthetase Stabilization Disorder, which causes seizures and delayed development. The study found that genetic variants increase the stability of an enzyme producing glutamine, disrupting brain development.
Researchers create butterfly-shaped nanographene with four unpaired π-electrons, demonstrating potential for advancements in quantum computing. The unique structure has highly correlated spins, extending coherence times of spin qubits.
A new study reveals that 'crosstalk' between pancreatic cancer cells and macrophages is the first step towards the onset of cachexia. The research provides evidence of an underlying mechanism for the development of this debilitating muscle-wasting condition, which affects pancreatic cancer patients.
A massive ancient galaxy, JWST-ER1g, has been found to have a high dark matter density, puzzling physicists. Researchers offer an explanation that suggests a mechanism compressing the dark matter halo could be responsible for the high density.
Researchers at Osaka Metropolitan University developed a process to create solid sulfide electrolytes with world-high sodium ion conductivity and glass electrolytes with high reduction resistance. This breakthrough enhances the practical use of all-solid-state sodium batteries.
A new American Heart Association Scientific Statement highlights the importance of patient-centered care in cardiovascular health, combining expert knowledge with consideration of patients' beliefs, preferences, and values. The statement provides practical guidance on incorporating person-centered care into routine clinical practice.
Researchers found that severe intraoperative anemia is a significant contributor to higher female mortality rates after heart bypass surgery. Women tend to arrive in surgery with lower red blood cell counts and smaller body size, making them more susceptible to anemia's effects.
Thorsten Hoppe and Jens Brüning received 2.5 million euros in funding from the European Research Council to investigate protein degradation and neural circuits of metabolic control, respectively. Their projects focus on preventing neurodegeneration and developing new drugs for obesity treatment.
Using advanced imaging techniques, researchers found that the substrate material responds to changes in electricity like a semiconductor, revealing its potential as an electronic switch. The discovery could lead to faster and more efficient electronics.
A recent Mayo Clinic study investigated lucid episodes in people living with later stages of dementia, revealing that 75% were reported to have Alzheimer's Disease. The researchers identified distinct patterns or types of lucid episodes, suggesting they may be related to the level of cognition and circumstances surrounding the episode....
A new study has identified alpha-1-antichymotrypsin as a blood protein marker that can predict delayed recovery of concussion in children. The study found that children with low levels of alpha-1-antichymotrypsin were more likely to experience delayed recovery, highlighting the potential for early diagnosis and targeted treatment.
A new study published in the Journal of the American Heart Association suggests that treating gum disease after a heart rhythm ablation procedure can lower oral inflammation and reduce the risk of AFib recurrence. Researchers found that an index measuring the severity of gum inflammation was associated with the return of AFib, highligh...
Researchers have discovered a direct link between the C122Y mutation in the Kir2.1 potassium channel and life-threatening arrhythmias in Andersen-Tawil syndrome, which affects fewer than 1 in a million people. The study highlights the importance of understanding the molecular mechanisms underlying cardiac arrhythmias.
Researchers at UNC School of Medicine discovered the detailed protein structure of the TAS2R14 bitter taste receptor, revealing how it identifies and activates bitter tastants. The discovery has potential applications in drug development for metabolic diseases like obesity and diabetes.
Researchers at Princeton University have discovered a novel quantum effect termed “hybrid topology” in a crystalline material made of arsenic atoms. This finding combines two forms of topological quantum behavior—edge states and surface states, creating a new state of matter.
A new study found that mums with insecure attachment traits showed more brain-to-brain synchrony with their children, while fathers and children had stronger brain-to-brain synchrony. The research suggests that high or low synchrony can signal interaction difficulties in families.
Researchers at INRAE discovered that female sex pheromones can remotely modulate the circadian rhythm of males in the African cotton moth, Spodoptera littoralis. This finding paves the way for exploring biocontrol methods targeting the pest.
This study identified 49 candidate bZIP coding genes in black and red raspberries, revealing a closer evolutionary relationship among roses, raspberries, and strawberries. Gene ontology annotation highlighted their involvement in nitrogen metabolism and stress responses.
The St. Jude survivorship portal provides a rich dataset for researchers to study childhood cancer survivors, including genomic and clinical information. The portal facilitates breakthroughs in pediatric cancer survivorship research through dynamic visualization and customizable charts.
Researchers visualize chiral interface state at atomic scale for the first time, allowing on-demand creation of conducting channels. The technique has promise for building tunable networks of electron channels and advancing quantum computing.
Climate change causes melting of ice sheet, resulting in loss of about 5,000 meteorites per year. Researchers call for urgent action to preserve the scientific value of meteorites and reduce greenhouse gas emissions.
Researchers at The University of Manchester have developed a new ruthenium catalyst, proven to be long-term stable in air while maintaining high reactivity. This breakthrough enables the user to run simultaneous reactions, streamlining optimisation procedures and reducing waste accumulation.
A Mediterranean marine worm has evolved massive eyes, rivaling those of mammals, to see in the dark. The worms use their exceptional vision to detect bioluminescent signals and may have a secret language through light communication.
A new statistical-modeling workflow can quickly identify molecular structures of products formed by chemical reactions, accelerating drug discovery and synthetic chemistry. The workflow also enables the analysis of unpurified reaction mixtures, reducing time spent on purification and characterization.
Researchers at Insilico Medicine developed QFASG, a quantum-assisted algorithm generating novel small-molecule structures from fragments. The tool successfully designed inhibitors for cancer-related proteins, showcasing its potential in accelerating drug discovery and development.
A study published in JCI Insight reveals that an unexpected mechanism is responsible for the loss of kidney cells' ability to filter toxins from blood in primary membranous nephropathy. The researchers found that signaling in the C3a/C3aR pathway plays a critical role in disease progression.
This special issue highlights photonics developments in Latin America, the Middle East, Eastern Europe, India, and China, showcasing regional growth and progress. The papers emphasize the importance of global cooperation and collaboration to address challenges and seize opportunities in the field.
MD Anderson researchers presented studies on combination therapies for AML and lung cancer, tumor microbiomes in immunity, and improved HPV screening. Genetic markers predict extended survival with KRAS inhibitors and may identify patients who benefit from novel combinations.
Researchers develop a computational approach to predict mutations leading to better proteins, with potential applications in neuroscience research and gene therapy. The technique uses a convolutional neural network to create a fitness landscape, enabling faster optimization of proteins.
Researchers at the University of Colorado Anschutz Medical Campus have discovered a mechanism by which a bacterial virus limits Salmonella's ability to cause infection. By compromising protein synthesis, the virus can allow the host to rehabilitate and potentially treat resistant cases.
Researchers at the University of Oklahoma have discovered how pancreatic cancer cells exploit an acidic environment to their advantage, finding ways to survive and grow. This knowledge is crucial for developing new therapeutic approaches to target the cancer.
Researchers found a symbiotic relationship between cyanobacteria UCYN-A and marine algae, B. bigelowii, where UCYN-A fix nitrogen gas into ammonium without regulating dinitrogen use. This suggests they may be on the path to becoming organelle-like structures.
A recent study on the Tor network found that one in five onion domains shared child sexual abuse material. The researchers also discovered that users sought CSAM through popular search engines and found that viewing violent material correlates with addiction, while seeking help is often hindered by lack of resources.
Researchers at MIT have discovered a new way that neutrons can interact with materials, potentially providing insights into material properties and quantum effects. The discovery involves the binding of neutrons to nanoscale atomic clusters called quantum dots.
Researchers at Mass General Cancer Center presented advancements in rapid nucleic acid detection for cervical cancer screening using CRISPR technology. They also showcased improvements to CAR T cell therapy for pancreatic cancer, highlighting the importance of dynamic functional control to enhance its efficacy.