Researchers at Osaka Metropolitan University developed an engineered yeast that can produce record-high yields of D-lactic acid from methanol, a key compound used in biodegradable plastics and pharmaceuticals. The optimized yeast strain achieves a 1.5-fold boost in production compared to other methanol-based methods.
The Systems Metabolomics Centre will focus on three key areas: profiling populations of healthy people and those living with specific illnesses, leveraging state-of-the-art metabolomic technologies to drive biomarker discovery and metabolism research. The centre aims to develop non-invasive tests, detect diseases earlier and guide doct...
A new method detects epileptic seizures in infants using a video-based approach, enhancing accuracy for diagnosis and disease management. The technique involves feature recognition and utilizes an optimized 3D-ResNet architecture to extract key features from video frames.
Researchers at the Advanced Science Research Center have developed a groundbreaking method to excite phonon-polaritons using an electrical current, enabling the creation of novel nanoscale lasers and efficient electronic device cooling. The discovery could lead to transformative advancements in energy-efficient, compact technologies.
This study found that aging impacts the gut microbiome composition and metabolites differently in male and female rats, influenced by biological sex and mitochondrial DNA. The researchers analyzed fecal samples from genetically diverse rats to assess bacterial changes with age, revealing more significant shifts in females.
Researchers have identified a type of immune cell that produces extracellular matrix, strengthening the skin's defensive function and maintaining its integrity. This discovery may lead to new strategies for treating skin diseases, inflammation, diabetes, and age-related conditions.
Researchers found evidence of biological material in desert rocks, suggesting the presence of microorganisms that can survive without light. The discovery has sparked interest in the global carbon cycle and its potential impact on climate change.
A new AI model developed by Tokyo University of Science's researchers predicts dendritic growth in thin films, offering a powerful pathway for optimizing thin-film fabrication. The model analyzes morphology using persistent homology and machine learning with energy analysis, revealing conditions that drive branching behavior.
The analysis of DESI data, combined with other measurements, suggests that dark energy's impact may be weakening over time. Researchers confirm previous findings of evolving dark energy but acknowledge the need for further evidence to reach statistical significance.
The latest DESI data suggests that dark energy's impact on the universe's acceleration may be weakening over time. Researchers are seeing hints that evolving dark energy could be a more accurate explanation for their findings, which are backed by multiple lines of evidence from different experiments.
A study of 733 older female participants found that those with increasing sleepiness had double the risk of stable sleepers. Poor sleep quality in midlife and delayed dream phase are also linked to a higher risk of dementia. The study adds to recent research on the relationship between sleep patterns and dementia.
The new DESI results show that the impact of dark energy may be weakening over time, suggesting a fundamental shift in how we think about dark energy. The collaboration's findings are consistent with other measurements, including supernovae and the light left over from the dawn of the universe.
A new AI tool, NicheCompass, visualizes a cell's social network to help treat cancer. By analyzing millions of cells from patient samples, the tool predicts molecular changes and identifies potential targets for personalized treatments.
The new laboratory complements HonorHealth's two decades of investigational therapeutics and will help take the Institute to the next level. The Center aims to translate scientific breakthroughs into new devices, drugs, and preventative measures that improve patient lives.
The Department of Energy's Office of Science offers two undergraduate internship programs: SULI and CCI. These programs provide hands-on experience with national laboratory scientists and engineers, supporting the DOE mission. The application deadline is May 21, 2025.
Distributed acoustic sensing systems face data processing speed limitations; researchers leverage photonic neural networks to overcome these challenges. The TWM-PNNA system achieves high recognition accuracy above 90% with low power consumption, outperforming electrical GPUs by orders of magnitude.
Researchers have identified distinct protein degradation patterns in key brain regions for individuals who witnessed trauma, differing from those who experienced it firsthand. Sex-specific differences also emerge, with implications for targeted treatments and a better understanding of PTSD development.
Researchers found that giving plasma, rather than whole blood, improves outcomes in patients with traumatic brain injury (TBI) or shock. Plasma recipients had distinct proteomic profiles associated with later stages of clot formation, neuron survival, and wound repair.
A Rice University statistician has received a $1 million CPRIT award to advance AI-powered precision medicine for prostate cancer. The project aims to identify lethal forms of prostate cancer earlier and improve treatment selection using AI tools and advanced imaging techniques.
Scientists have identified a key component in launching immune activity and overactivity, providing a potential target for therapies that could prevent debilitating illnesses. The researchers discovered a protein in cells that spurs the release of infection-fighting molecules, which is essential for controlling the disease.
A new study by UCLA Health has discovered a drug that fully reproduces the effects of physical stroke rehabilitation in model mice. The drug, DDL-920, excites parvalbumin neurons, leading to significant recovery in movement control after stroke.
A new bacterial protein, BeeR, has been identified and its structure is being used to develop protein nanoparticles for targeted cancer drug delivery. The protein forms a hollow tube with a cavity capable of containing drug molecules.
Scientists at the University of Rochester have discovered a way to create artificial atoms within twisted monolayers of molybdenum diselenide, retaining information when activated by light. This breakthrough could lead to new types of quantum devices, such as memory or nodes in a quantum network.
Researchers found that suppressing ZNF638 triggers an antiviral immune response in glioblastoma patients, making them more susceptible to treatment. This finding offers a potential new treatment strategy for the disease, which has remained challenging despite recent advances in immunotherapy.
Researchers have discovered that rhombohedral graphene can exhibit novel magnetism and superconductivity, as well as the quantum anomalous Hall effect, depending on applied gate electric fields. This unique property allows for continuous tuning of band gaps and electron densities without altering the material composition.
Impact Journals is proud to exhibit at the AACR Annual Meeting 2025, featuring its esteemed journals Aging-US, Oncotarget, Oncoscience, and Genes & Cancer. The meeting highlights significant advancements in cancer research, aligning with Impact Journals' mission to disseminate impactful scientific research.
Researchers at Rice University have gained insights into ADAR1's molecular mechanisms, which could lead to improved treatments for cancer and autoimmune diseases. The study found that ADAR1's editing activity depends on RNA sequence, duplex length, and mismatches near the editing site.
The study found that tunneling nanotube-like structures connect cells in the heart, enabling long-distance intercellular communication essential for heart formation. Disruption of these structures resulted in impaired ventricular wall morphogenesis and defective myocardial growth.
Researchers discovered how bacterial swarms transition from organized movement to chaotic flow as confinement radius increases. The study reveals intermediate states between order and turbulence through large-scale experiments, computer modeling, and mathematical analysis. These findings provide insights into the universal properties o...
Researchers have acquired direct evidence of rare, pulsing pear-shaped structures in the nucleus of Gadolinium-150, a long-lived radioactive isotope. The study provides definitive proof of a strong collective 'octupole excitation' and opens a new window into the quantum world.
A research team at Tokyo University of Science has identified two new tetranins in spider mite saliva that reduce reproduction and increase defense responses in plants. The findings have potential for organic farming techniques and more resilient crops, contributing to sustainable agriculture and enhanced food safety.
Researchers from HKUMed identified Chchd10 as a novel regulator of adipose tissue homeostasis, accelerating subcutaneous fat formation and regulating antioxidant capacity. The study suggests that targeting Chchd10 levels could be a potential therapeutic strategy for treating obesity.
A study published by HKUMed has found that C-reactive protein (CRP) can worsen inflammation in diabetic kidney disease through the Smad3-NLRP3 inflammasome-dependent mechanism. The research suggests that targeting CRP or the Smad3-NLRP3 pathway may provide new treatment options for patients with DKD.
Scientists have discovered a potential new treatment strategy for pancreatic cancer by identifying the molecule Neuropeptide Y (NPY) as a key driver of its spread. Blocking NPY's function has been shown to reduce cancer cell movement and metastatic outgrowth, potentially limiting disease progression.
A recent study led by Emily Hackworth and colleagues found that youth with internalizing mental health symptoms are more likely to turn to nicotine products. The analysis showed a strong association between non-combustible product use, including e-cigarettes, and poor mental health among adolescents.
A University of Minnesota research team has been awarded a $3.8 million grant to develop a new cell therapy targeting Alzheimer's disease. The project aims to adapt cancer treatment techniques to create specialized immune cells that can clear harmful proteins from the brain.
A new type of RAS inhibitor, daraxonrasib (RMC-6236), has shown significant promise when combined with immunotherapy in preclinical models of pancreatic cancer. The study found that the treatment not only inhibited tumor growth but also reshaped the tumor microenvironment to make it more receptive to immunotherapy.
Researchers have found a way to reactivate the body's natural ability to destroy excess cancer proteins by introducing synthetic RNA fragments that increase poison exon inclusion. This discovery could lead to game-changing therapies for aggressive cancers such as triple-negative breast cancer and certain brain tumors.
Researchers discovered that trapped pockets of liquid can form inside ice, leading to extreme pressure that breaks glass. To prevent this, ensure water freezes slowly by supercooling or use containers with water-repelling surfaces.
An international team of scientists has unveiled the first chromosome-scale genome of a wild barley species, identifying critical genetic adaptations that enable efficient nutrient intake under alkaline stress. The study developed a new hexaploid crop, Tritordeum, which exhibits significant yield improvements in harsh conditions.
Researchers at Weizmann Institute create innovative method to track rapid material changes using two laser beams, enabling precise reconstruction of optical delay changes. This advance could lead to the development of fastest processors possible, increasing data transmission speed.
Researchers discovered that the spatial arrangement of nearest Br-N atomic pairs is the major factor on organic-inorganic interactions, leading to emission enhancement under high pressure. The study provides valuable guidance for designing materials with targeted optical properties.
Researchers at the WEHI have made a major breakthrough in understanding Parkinson's disease by determining the first ever structure of human PINK1 bound to mitochondria. This discovery paves the way for the development of new drugs to treat the condition, which currently has no cure or drug to stop its progression.
The study discovered a giant deformation potential of 123 eV, leading to exceptionally long polarization response times and enhanced spin lifetimes. Small polaron formation was confirmed through various techniques, including optical Kerr spectroscopy, X-ray diffraction, and phonon dynamics.
Researchers at Stanford University used machine learning to analyze high-resolution remote-sensing data of ice movements in Antarctica, gaining new insights into the fundamental physics governing the large-scale movements of the Antarctic ice sheet. The study reveals that most of the ice shelf is anisotropic, with different physical pr...
Researchers have discovered a novel imaging tool that captures functional activity in mouse models of TMJ injury and inflammation, revealing the simultaneous activity of over 3,000 trigeminal ganglion neurons. This finding suggests that CGRP antagonists could offer a promising solution for TMJ pain relief.
Researchers discovered that exposure to similar behaviors within a person's social network is the most significant factor predicting individual prevention behaviors. Household-level interventions targeting entire families could result in more effective prevention strategies.
Researchers identified fibronectin and smooth muscle actin as associated with resistance to immunotherapy treatment. Cancer-associated fibroblasts produce these proteins, which contribute to the suppression of the anti-tumor immune response.
Researchers have discovered how severe COVID-19 can destroy immune cells' ability to repair the lungs, leading to lingering effects of long COVID. By enhancing damaged organelles using a FDA-approved drug, they found improved lung healing and reduced inflammation.
UCLA doctoral student Yilin Wong noticed spiral patterns on her Germanium chip sample after leaving it overnight. The patterns were influenced by residual stress in the metal film, with different changes in experiment parameters generating various shapes.
Researchers have developed novel membranes that can pull lithium directly out of salt-lake brines using electricity, leaving other metal ions behind. The process could reduce the environmental impact of lithium mining and contribute to more efficient energy storage systems for renewable energy sources.
Researchers propose a revolutionary link between time and dark energy, suggesting that the mysterious force driving the universe's expansion may be used to measure time. The study could pave the way for groundbreaking new fundamental theories and breakthroughs in our understanding of the universe.
Researchers at MD Anderson have made significant breakthroughs in understanding pancreatic cancer's evolutionary process and developing new treatment strategies. They also discovered that surgical resection can enhance antitumor response in patients receiving immune checkpoint therapy for advanced kidney cancer.
The Rubin Observatory will capture more data than any other observatory in history using its 3200-megapixel LSST Camera. The camera's installation marks a significant step forward in the decades-long story of its design, construction, and transport to Chile.
The study found that Black patients have a higher prevalence of PD-L1 overexpression, TP53 mutations, and KRASG12R mutations compared to White patients. This could affect how their cancer progresses and responds to treatment.
Researchers have developed a new method to deliver antibiotics directly into the bladder tissue, eliminating over 90% of bacteria from the bladder. The nanogel-based drug delivery system shows promise in treating UTIs and could potentially lead to an eventual cure.
Biomolecular condensates constantly shift their phase, affecting movement and chemical activities within the cell. Researchers have discovered that aging-associated interactions can lead to dysfunction and disease, and manipulating surface signals may help promote healthy biological reactions.
Researchers at the University of Texas at Austin and Argonne National Laboratory have developed a comprehensive analysis of thermal stability in high-nickel cathode materials. The team discovered that each material has a critical state of charge defining its safe operating limit, which influences metal-oxygen bonds and surface reactivity.
Research at the University of Arizona Health Sciences found that certain terpenes in Cannabis sativa are effective at relieving post-surgical and fibromyalgia pain in preclinical models. Terpenes have been shown to provide significant pain relief in mouse models, with geraniol providing the most significant level of pain relief.
The study highlights the role of the Nwd1 gene in liver disease and its potential as a therapeutic target. Mice with Nwd1 gene deletion exhibited liver pathologies mirroring MASH, including excessive lipid accumulation and increased ER stress.