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What’s your gut telling you?

Researchers have created a tiny pill-like electromagnetic device that can provide medical professionals with diagnostic information about the inner workings of the gastrointestinal tract. The device, when swallowed, delivers data to a smartphone as it passes through the body using electromagnetic technology similar to MRI machines.

SourceNYU Tandon School of Engineering·JournalNature Electronics·DateFeb 13, 2023

Single dose of common antibiotic reduces mothers’ risk of death during childbirth, study finds

A single dose of azithromycin has been shown to decrease sepsis and death by half in women in labor, making it an important tool for keeping mothers safe before, during, and after delivery. The antibiotic was found to be beneficial for vaginal childbirth as well, reducing mortality rates and the risk of developing sepsis.

SourceUniversity of Virginia Health System·JournalNew England Journal of Medicine·DateFeb 9, 2023

HETDEX reveals galaxy gold mine in first large survey

Astronomers have cataloged over 51,863 Lyman-alpha-emitting galaxies, 123,891 star-forming galaxies, and 4,976 active galactic nuclei using HETDEX's spectroscopic data. The survey is a non-targeted, moon-sized survey that collects spectra from 35,000 fiber optic cables, providing a unique dataset for future galaxy mapping.

SourceUniversity of Texas at Austin, Texas Advanced Computing Center·JournalThe Astrophysical Journal·TypeExperimental study·DateFeb 9, 2023

Use of methotrexate is associated with an increased risk of skin cancer

A study by University of Gothenburg researchers found a significant association between methotrexate use and an increased risk of basal cell carcinoma, squamous cell carcinoma, and cutaneous malignant melanoma. The study suggests that higher doses of methotrexate may increase the risk of SCC and BCC, while no dose-response relationship...

SourceUniversity of Gothenburg·JournalBritish Journal of Cancer·TypeData/statistical analysis·DateFeb 7, 2023

Tuberculosis vaccine does not protect elderly against COVID-19

A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.

SourceUniversity Medical Center Utrecht·JournalClinical Microbiology and Infection·TypeRandomized controlled/clinical trial·DateFeb 2, 2023

Kobe University and AGC successfully convert dry cleaning solvent into useful chemical compounds

Researchers developed a new photo-oxidation method to efficiently synthesize pharmaceutical intermediates and polyurethane from perchloroethylene, a common dry cleaning solvent. The method yields high-quality compounds with minimal environmental impact, offering a promising alternative for sustainable chemical recycling.

SourceKobe University·JournalACS Omega·TypeExperimental study·DateJan 31, 2023

Cancer-selective supramolecular chemotherapy by disassembly-assembly approach

Researchers developed a cancer-selective therapeutic agent that targets cancer cells' unique acidic pH microenvironment, inducing mitochondrial dysfunction and killing only cancer cells. The agent, Mito-SA, forms charge-shielded nano-assemblies that selectively disassemble in the tumoral environment.

SourceUlsan National Institute of Science and Technology(UNIST)·JournalAdvanced Functional Materials·DateJan 26, 2023

Dartmouth-led study finds that team-based coaching reduces risks of acute kidney injury after heart procedures

A Dartmouth-led study found that team-based coaching significantly improves the risk of acquiring post-procedural acute kidney injury (AKI) when compared to other interventions. The Collaborative with Surveillance intervention reduced the odds of AKI by 46 percent, making it a promising approach to address this prevalent adverse event.

SourceThe Geisel School of Medicine at Dartmouth·JournalClinical Journal of the American Society of Nephrology·TypeRandomized controlled/clinical trial·DateJan 19, 2023

Scientists re-writes an equation in FDA guidance to improve the accuracy of the drug interaction prediction​

Researchers from KAIST and Chungnam National University have developed a new equation to predict drug interactions, improving accuracy by 80% compared to the existing FDA formula. The new equation takes into account factors such as gut bioavailability and enzyme concentration.

SourceThe Korea Advanced Institute of Science and Technology (KAIST)·JournalClinical Pharmacology & Therapeutics·TypeData/statistical analysis·DateJan 18, 2023

New tropical kelp forest discovered in the Galapagos Islands

A new species record of mesophotic kelp was discovered in the Galapagos Islands, characterized by its extensive and dense kelp forest at depths of ~50m. The research highlights the importance of these forests as ecosystem engineers and supports for marine life, with potential implications for carbon sequestration.

SourceUniversity of Malaga·JournalMarine Biology·TypeExperimental study·DateJan 17, 2023

AI discovers new nanostructures

Researchers at Brookhaven National Laboratory have successfully discovered new materials using artificial intelligence and self-assembly. The AI-driven technique led to the discovery of three new nanostructures, expanding the scope of self-assembly's applications in microelectronics and catalysis.

SourceDOE/Brookhaven National Laboratory·JournalScience Advances·DateJan 13, 2023

New study from Pusan National University explores artificial intelligence in fashion

A new study from Pusan National University explores the use of collaborative artificial intelligence models in fashion design, finding that human designs offer unique originality and creativity. The researchers propose a human-AI collaborative network to produce novel designs, which can also be used as a learning tool for non-experts.

SourcePusan National University·JournalThinking Skills and Creativity·TypeComputational simulation/modeling·DateJan 12, 2023

Scientists improve the equation in FDA guidance predicting drug interactions

Researchers have improved the FDA's equation for predicting drug interactions by addressing fundamental limitations and incorporating new models. The modified equation has shown a significantly increased accuracy of about 80%, which is expected to contribute to increasing the success rate of new drug development.

SourceInstitute for Basic Science·JournalClinical Pharmacology & Therapeutics·TypeComputational simulation/modeling·DateJan 12, 2023

Clinical trial shows boiled peanuts could help overcome child peanut allergy

A clinical trial found that boiling peanuts for up to 12 hours can desensitize children with peanut allergies. The therapy involved sequential doses of boiled and roasted peanuts, achieving high success rates in participants. While promising, the study's findings require confirmation in larger trials.

SourceFlinders University·JournalClinical & Experimental Allergy·TypeRandomized controlled/clinical trial·DateJan 11, 2023

Enhanced cancer immunotherapies through cytokine-labeled T cells

A new method utilizes an unnatural sugar to anchor cytokines to T cells, enhancing their functions without systemic side-effects. The approach has shown promise in stimulating the host immune system against tumor cells and inhibiting tumor growth in mice with melanoma.

SourceWyss Institute for Biologically Inspired Engineering at Harvard·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJan 10, 2023

Multidisciplinary, cross-border collaboration and stable levels of funding extend knowledge of the oceans

Researchers analyzed 300 oceanographic projects funded by FAPESP, revealing a shift from USP to other institutions. FAPESP's support for long-term projects and collaborative research has significantly increased knowledge of Brazilian oceans. Deep-sea research remains a gap to be filled, requiring further collaboration and funding.

SourceFundação de Amparo à Pesquisa do Estado de São Paulo·JournalBiota Neotropica·TypeSystematic review·DateJan 4, 2023

A CNIC study shows that cells possess 2 mechanisms to allow them to respond to different force ranges

The CNIC study reveals two distinct mechanisms by which cells detect and respond to forces of varying strength, one mediated by caveolae and the other by newly discovered dolines. This finding has significant implications for understanding pathological processes such as atherosclerosis and neurodegenerative diseases.

SourceCentro Nacional de Investigaciones Cardiovasculares Carlos III (F.S.P.)·JournalNature Cell Biology·TypeExperimental study·DateJan 2, 2023

Artificial intelligence tool developed to help make real-time diagnoses during surgery

A new AI tool developed by Brigham and Women's Hospital improves the accuracy of time-critical pathology diagnostics during surgery. The tool, which leverages deep-learning technology, translates frozen tissue samples into high-quality images, increasing diagnostic accuracy and reducing the need for lengthy laboratory tests.

SourceBrigham and Women's Hospital·JournalNature Biomedical Engineering·TypeObservational study·DateDec 23, 2022