Complete text of all IUCr journals back to 1948 now online!
The International Union of Crystallography (IUCr) is excited to announce the availability of 50+ years of groundbreaking crystallographic research on your desktop! The complete text of all IUCr journals - back to 1948 - is now online. The IUCr is enabling unprecedented access to its complete journal collection. The Crystallography Journals Online... view more... (2002-02-03)
The International Union of Crystallography (IUCr) is excited to announce the availability of 50+ years ... its complete journal collection. The Crystallography Journals Online service (journals.iucr.org) now offers full-text access back to ... Crystallographica Section A: Foundations of Crystallography (journals.iucr.org/a) - 1968 to dateActa Crystallographica Section B: Structural Science ... dateActa Crystallographica Section D: Biological Crystallography (journals.iucr.org/d) - 1993 to dateActa Crystallographica Section ...
Starfish-shaped treatments for food poisoning
Embargoed until 19:00 GMT 9 February 2000 view more (2000-02-08)
... binds to cells, using X-ray crystallography to obtain three-dimensional pictures of the molecules.The team, which includes ... a PhD student, has used crystallography to see how the Starfish molecule binds to the toxin. ... His results give hope that the design can be extended to provide inhibitors for other toxins - such as the one which causes cholera.Professor Read cautioned that this ...
RTS and Syrrx Announce Partnership
RTS Life Science International (RTS) and Syrrx announce a partnership to develop and market high throughput structural biology automation solutions. This will be known as the HTSB Factory™ and it allows the user to set-up hundreds of thousands of experiments for a target and increase the crystallization rate significantly. Dr. Wendell... view more... (2003-05-01)
... using automation to manufacture protein crystallography on an industrial scale, we have linked up with RTS ... well as their use in co-crystallography with drug candidates, has greatly enhanced and accelerated the productivity ... commented: "In the past, protein crystallography was repetitive and slow, hampered by a lack of automation. ... same in structural biology. Nanovolume crystallography accelerates protein crystal formation tenfold and ...
Scientists make first step towards 'holy grail' of crystallography
Scientists from Imperial College London and the University of Surrey have developed a new technique for crystallising proteins, a discovery which could help speed up the development of new medicines and treatments. view more (2006-01-09)
... a major bottleneck for X-ray crystallography. This problem has become increasingly acute with the advent of ... of thousands of proteins. Protein crystallography plays a major role in this understanding because proteins, being ... the major machinery of living things, are often targets for drugs. To direct the proteins to become crystals, researchers use a substance called a nucleant, which does this ...
Structure of key cancer drug target identified
Researchers from Monash's Department of Biochemistry and Molecular Biology have determined the structure of the protein JAK2 kinase, a discovery with huge implications for the design and development of new cancer drugs. view more (2005-10-26)
... Isabelle Lucet, from Monash's Protein Crystallography Unit headed by Dr Jamie Rossjohn, was part of the ... Cytopia Limited and the Protein Crystallography Unit. The JAK kinases, which were first discovered by Cytopia's ... chief scientific officer Dr Andrew Wilks, are a well-validated drug target. Dr Lucet said the discovery of JAK2 kinase's structure had allowed an internationally competitive structure-based drug design ...
Scientists reveal fine detail of cell`s energy machinery
A molecular pump that helps to keep cells flush with energy has been visualised by scientists at Imperial College, London. The structure of the pump, a key enzyme in bacterial respiration, reveals for the first time one of the molecular mechanisms that underpins cellular respiration, and confirms a Nobel Prize-winning theory proposed over 40... view more... (2002-03-05)
... the Laboratory of Membrane Protein Crystallography, Imperial College Centre for Structural Biology describe in Science (8 ... Iwata`s Laboratory of Membrane Protein Crystallography is one of a small number around the world that ... membrane protein structures using X-ray crystallography. Membrane proteins are technically difficult targets for structural biologists to ... the Laboratory of Membrane Protein Crystallography, Centre for Structural Biology, Imperial College ...
Poxvirus Potency Uncovered in New Atomic Map
Scientists at the University of Alabama at Birmingham (UAB) and Saint Louis University used X-ray crystallography to uncover new details about the infectious potency of poxviruses, furthering the understanding of how viral infections can subvert the body's immune system. view more (2008-02-04)
... Saint Louis University used X-ray crystallography to uncover new details about the infectious potency of poxviruses, ... shows this blocking ability through crystallography, the science of mapping the atomic structure of molecules by ... looking at their interaction with an X-ray beam.
Poxviruses include many classes of the invasive organism, including smallpox, cowpox and monkeypox. Smallpox in particular has played a tragic role ...
Key heart and Alzheimer's disease protein imaged for first time in native state
Researchers for the first time have created a three-dimensional image of apolipoprotein E, a protein long associated with cardiovascular disease and more recently with Alzheimer's disease, as it appears when it is bound to fat-like substances known as lipids. view more (2006-01-16)
... the technique known as x-ray crystallography, scientists at the Gladstone Institute of Cardiovascular Disease (GICD) have ... first successful use of x-ray crystallography to reveal the structure of a protein bound to lipids," ... cardiovascular and neurological disease. X-ray crystallography is a technique for determining the three-dimensional structure of a ... molecule by analyzing the x-ray diffraction patterns of crystals that make up ...
IUPUI scientists report first 3-D view of anti-cancer agent
Researchers from the Indiana University School of Medicine and the Purdue School of Science at Indiana University-Purdue University Indianapolis have created the first three-dimensional image of how a well-established chemotherapy agent targets and binds to DNA. view more (2008-03-19)
... wide range of cancers.
Using X-ray crystallography, the scientists produced the first 3-D molecular level images of ... bleomycin bound to DNA. X-ray crystallography is a widely used analytical technique in which X-rays are ... directed through crystals and results are deduced from the pattern of diffraction of the X-rays.
"Although bleomycin has been studied for 40 years and much is known about the ...
Double binding sites on tumor target may provide future combination therapy
Researchers from the University of Pennsylvania School of Medicine and colleagues at Merck Serono Research in Germany have found that two drugs bind to receptor sites on some tumors in different places at the same time, suggesting the possibility of a new combination therapy for certain types of cancer. view more (2008-04-09)
... and signaling tumor growth. X-ray crystallography provided a snapshot of the interaction between Erbitux and the ... found - again using X-ray crystallography -- that matuzumab binds in a different place from Erbitux. ... Their binding does not overlap, and they can bind to EGFR at the same time.
"These findings imply that a combination therapy using both types of EGFR drugs could ...
The structure of a key enzyme for infectious diseases solved at ESRF
A European team of scientists from the University of Dundee (UK), the Technical University of Munich (Germany) and the European Synchrotron Radiation Facility, ESRF, (France) have determined the structure of a key target enzyme for novel drug development to treat infectious diseases including malaria, tuberculosis and sexually transmitted... view more... (2003-08-12)
... on one of the macromolecular crystallography beamlines at the ESRF. This kinase helps to produce many ... About the technique Protein crystallography consists of the production of highly pure protein samples. These ... samples are then crystallised to produce single crystals of the protein. When X-rays interact with single crystals, the interaction between the constituents of the crystal and the X-rays ...
Collaborative study successfully applies neutrons to study hydrogen transfer in biological systems
An innovative collaboration among scientists at Los Alamos National Laboratory, Fox Chase Cancer Center and the University of Tennessee has successfully applied neutron diffraction to create a three-dimensional map of the structure of the enzyme D-xylose isomerase. view more (2006-05-16)
... isomerase in 1984 using X-ray crystallography. "However, this technique does a poor job of locating hydrogen ... of determining molecular structure, X-ray crystallography bombards crystallized molecules with X-rays, which scatter-diffract-to create patterns that ... when it opened its protein crystallography station at the Los Alamos Neutron Science Center in 1997. ... ...
Antibody key to treating variant CJD, scientists find
Scientists at the University of Liverpool have determined the atomic structure of the 'binding' between a brain protein and an antibody that could be key to treating patients with diseases such as variant CJD. view more (2009-03-04)
... scientists at Liverpool used X-ray crystallography technology to build a three-dimensional picture of the binding between ... the protein we used X-ray crystallography, pioneered by Nobel Prize winner Max Perutz. Significantly we found ... that the point at which the protein and antibody came together was also where scientists at the Medical Research Council (MRC) Prion Unit had identified a single amino ...
Discovery offers new understanding of diabetes drug target
Scientists at the University of Leicester have published findings about a new advance in the study of major diabetes drug target. view more (2008-09-26)
... the sophisticated technique of X-ray Crystallography, it was not clear how PPAR gamma is naturally activated ... naturally activated in the body.
X-ray Crystallography is the principal method by which the detailed 3- dimensional ... structures of molecules - especially the molecules of living systems - have been discovered. It is achieved by firing X-rays at the target and creating its structures by ...
£4 Million for New Centres for Structural Biology
The Biotechnology and Biological Sciences Research Council (BBSRC) today announces its intention to fund four more UK Centres for Structural Biology. view more (1999-02-01)
... Centre for Structural BiologyLondon X-ray crystallographyBioinformatics Professor Janet Thornton DNA damage, recognition, repair and signalling Chaperones ... Centre for Structural Biology X-ray crystallography NMR Professor Sir Tom Blundell FRS Structural biology of cell ... Biology Centre NMRElectron microscopy X-ray crystallography Professor Simon Phillips Protein/nucleic acid interactions Membrane proteins Protein folding ... at York Molecular Modelling X-ray crystallography Professor Rod Hubbard Transcription complexes Molecular ... | 
