Researchers from Tengion, Inc., present a new study suggesting that growing a replacement organ using the patient's own cells could be an effective and safe treatment option. The technique involves seeding bladder progenitor cells on a biodegradable scaffold, which can then be implanted into the patient.
A new study by NC State University archaeologist Dr. Scott Fitzpatrick reveals that Ferdinand Magellan's circumnavigation of the globe was likely aided by unusual weather conditions, including an El Niño event. This led Magellan to sail far north of the Spice Islands and miss his intended destination.
A large genetic study in mice has identified hundreds of genes involved in the development of cancer by examining the DNA of more than 500 lymphomas. The study found almost 10,000 mutations that together implicate around 350 gene regions in cancer formation.
Research finds higher serum levels of certain organochlorine compounds in mothers correlate with increased incidence of undescended testicles and hypospadias in sons. Maternal exposure to endocrine-disrupting chemicals may contribute to urologic conditions, highlighting the importance of regular well-baby checkups.
Two new papers by leading environmental scientists highlight the 'nitrogen cascade,' where a single atom of reactive nitrogen can cause harm to ecosystems and human health. The researchers suggest minimizing nitrogen use through optimizing plant uptake, recovering nitrogen from manure, and decreasing emissions from fossil fuel combustion.
A team of Penn State researchers created a simple artificial cell with a mix of PEG and dextran polymers to investigate the organization and function of cell components. The model cell exhibited polarity, a critical step in development, and showed the interrelationship between cytoplasm and cell membrane.
Patients with systolic dysfunction are nearly twice as likely to die than those without the condition, according to a study analyzing 2,718 kidney transplant candidates. This increased mortality risk is similar to that seen in patients with cardiac ischemia.
A recent study published in Science Cornell College biology professor Marty Condon and coauthors discovered multiple new species of fruit flies with overlapping niches, exceeding previous expectations. The research found a greater specialization in plant feeding among herbivorous insects than previously thought.
A new study by Rohini Ahluwalia finds that buyers with a relational self-view, who prioritize connectedness, are more open to accepting brand stretches. This understanding can help marketers launch successful product extensions and expand their brand's reach.
Researchers at University of Texas M. D. Anderson Cancer Center found a combination therapy approach that makes cancer cells more sensitive to immune system cells and strengthens the power of these cells, potentially sparing young patients from difficult treatments.
Two studies presented at AUA 2008 found that active surveillance is a viable option for low-risk prostate cancer patients. The studies highlighted the importance of reliable clinical predictors of disease progression and showed that endorectal MRI was the most reliable predictor of disease progression.
A new study by researchers at the University of California, San Francisco found that retired firefighters are at a higher risk of developing bladder cancer. The study, which tested 1,286 active and retired San Francisco firefighters, found two cases of transitional cell carcinoma (TCC) among the participants.
Two studies have shown that ustekinumab is effective in treating moderate-to-severe psoriasis, with dosing every 12 weeks maintaining efficacy in most patients. The PHOENIX studies found that 67-76% of patients achieved PASI 75 at week 12, with long-term response maintained in those given maintenance treatment.
Young children with OCD can benefit from a tailored form of psychotherapy, known as family-based cognitive behavioral therapy (CBT), that addresses their unique developmental needs and family context. The study found that 74% of patients who completed the CBT program achieved remission, compared to 20% in the relaxation treatment group.
Researchers found that electric shocks ranging from 120 to 52,000 volts can cause neurologic and neuropsychological symptoms in humans. Short-term follow-up showed 26% of patients experiencing new symptoms, while one-year follow-up revealed 28% still suffering from these symptoms.
Researchers have identified an embryonic pathway that confers adult stem cell properties to both normal and cancer cells undergoing epithelial-to-mesenchymal transition, offering a potential route to generate unlimited numbers of stem cells. This discovery has major implications for regenerative medicine and cancer treatment.
Researchers from the University of Pennsylvania School of Medicine have discovered a small molecule that selectively targets and dismantles misfolded protein fibers connected to Alzheimer's disease and prion diseases. This breakthrough has implications for treating neurodegenerative diseases.
Childhood cancer survivors who received cyclophosphamide chemotherapy are at a higher risk of developing bladder cancer. Researchers found that the risk increases over time, with a significant increase after 20 years post-treatment.
A team of researchers led by University of Saskatchewan microbiologist Wei Xiao has found a way to trigger a protein combination that sends an SOS signal for cells to fight cancer-causing agents. The discovery could lead to better cancer diagnosis and potentially pave the way for a new type of drug.
Researchers conclude that adding chemotherapy to active symptom control does not improve overall survival or quality of life for mesothelioma patients. However, exploratory analyses suggest that vinorelbine may merit further investigation.
Morbid obesity causes sexual dysfunction in men, but weight loss through gastric bypass surgery can normalize sexual function. The study shows that significant weight loss predicts improvement in all areas of the survey.
Research suggests that being in a low-power role impairs executive functions, including tracking information, parsing out irrelevant details, and planning ahead. Participants in low-power groups made more errors on tasks requiring focus and planning.
Research finds that most ethnic minority teens avoid ethnically-oriented crowds in high school, despite potential benefits for identity and pride. However, certain factors such as friendship groups, socioeconomic status, and experiences with discrimination can lead to association with these crowds.
A first-of-its-kind lung cancer chemoprevention trial found Celebrex reduces precancerous lesion proliferation and is safe for high-risk individuals. The study demonstrated the importance of COX-2 inhibition in preventing lung cancer, with potential implications for cancer prevention and treatment.
The study identifies GATA4 and GATA6 as crucial proteins controlling heart cell formation. Without these proteins, embryonic stem cells fail to develop normal hearts. The findings have significant implications for the production of heart cells from stem cells and may help unravel the mechanisms behind congenital heart disease.
A new analysis of the genome of St Louis encephalitis has shed light on its evolution, tracing the virus back to South America and identifying a single mutation that made it pathogenic to humans. The research suggests that population dynamics and point mutations played a key role in the virus's adaptation to humans.
A recent survey found that nearly 40% of GERD patients on proton pump inhibitors (PPIs) experience breakthrough symptoms, requiring additional over-the-counter (OTC) treatments. More than half of these patients use OTC remedies to manage their symptoms, often using antacids as a stop-gap.
Men aged 75-80 with PSA levels below 3 ng/ml are unlikely to develop aggressive disease and may safely discontinue screening. The study's findings could lead to a reduction in unnecessary treatment for non-aggressive prostate cancers.
A study found that external-beam radiation therapy for localized prostate cancer increases the rate of secondary malignancies, including a 3.0-fold increase in bladder cancer, compared to radical prostatectomy. This predisposition is observed in lung-cancer resections and rectal cancer as well.
Researchers presented findings on Maxi-K gene therapy, showing it to be safe and restoring erectile function in men with moderate to severe ED. The treatment has been shown to enhance sexual behavior, including increases in partial and full erections and a two-fold increase in erection duration.
A new therapeutic vaccine has shown promising results in prolonging survival and improving the quality of life for men with metastatic prostate cancer. The adenovirus/PSA vaccine demonstrated strong immune responses to PSA, leading to improved patient outcomes.
Researchers have found that plants regulate their own genes using small RNAs, similar to how they silence foreign viral RNA. This discovery has implications for fields such as plant pathology, cancer research, and potentially even combating climate change by understanding how plants respond to pathogens.
Researchers analyzed data from a US national survey and found that lower sodium diets were associated with a significantly increased risk of cardiovascular disease. The study casts doubt on long-held assumptions about the risks of high-salt diets.
A recent Australian study found that over 40% of parents have used cough medicine for children under 2 years old, despite warnings from health authorities. The most commonly used medication was paracetamol, and nearly half of parents gave their children anti-histamine-containing medications to treat colds.
In Iraq, penetrating bladder injuries from IEDs and bullets were common among civilians treated at Al Yarmouk Teaching Hospital. Most patients (78.1%) were injured by bullets, with associated bowel injury present in nearly all cases.
The American College of Physicians recommends establishing a national research organization to improve physician and patient access to clinical and cost-effectiveness information. This would help address the current lack of reliable data on healthcare interventions' effectiveness, leading to more informed decision-making.
Researchers identified three primary themes of fatigue in cancer patients undergoing standard radiation therapy: loss of strength, major effects on energy levels, and physical sensations. The study aims to develop a single definition of cancer-related fatigue, enabling healthcare professionals to intervene more effectively with patients.
A new study published in Child Development found that teenagers who feel good about themselves and are comfortable with their peers can be socially successful without being popular. The research suggests that adolescents' feelings of confidence in their own social standing are a protective factor for long-term social functioning.
Researchers predict a rise in kidney stone disease due to global warming, with a potential cost of $1 billion annually by 2050. The southern US is expected to see an expansion of the
A new study by an international team of scientists found that around one-third of the nitrogen entering the world's oceans from the atmosphere is man-made. This has significant implications for global climate change as it leads to increased marine biological activity and CO2 uptake, producing nitrous oxide emissions.
Excess IGF-1R protein indicates reduced responsiveness to Gleevec in gastrointestinal stromal tumors. Alternative treatments may be effective for patients with high IGF-1R levels.
Dr. Fauci outlines the peaks and valleys of HIV/AIDS research, from initial diagnosis challenges to breakthroughs with protease inhibitors and combination therapies. He emphasizes the need for continued research into a cure and prevention through vaccine development.
A study of 600 teenage girls from diverse backgrounds found that they continue to experience sexism, with 90% reporting sexual harassment. Girls' attitudes towards themselves and society influenced their perceptions of sexism, while learning about feminism and feeling pressure to conform to gender stereotypes also played a role.
A study of 1,214 men prescribed cholesterol-lowering drugs found that PSA levels decreased after starting statins and correlated with LDL cholesterol decline. The results suggest a potential role for cholesterol in prostate cancer development and progression.
Researchers found that Jewish and Arab teenagers who valued universalism and low power reported less violent behavior than their peers. In high-risk schools, these adolescents were relatively protected against engaging in violent behavior.
A new small molecule inhibitor of Src kinases was found to eliminate VEGF-induced fluid accumulation in the retina of mice and rabbits. The approach, which involved topical application or intravenous injection, showed promise for reducing vision loss due to VEGF-mediated blood vessel permeability.
Researchers from Germany and Austria used muscle-derived stem cells to repair damaged sphincters. Patients showed significant improvements in continence, with some being completely continent after treatment.
A study by Mayo Clinic researchers found that administering calcium and magnesium before and after oxaliplatin chemotherapy significantly reduces neurological side effects in patients with advanced colon cancer. This reduction enables patients to complete a full course of treatment, increasing the likelihood of successful therapy.
Researchers at Mount Sinai School of Medicine have discovered a new window into the brain, revealing how addictive drugs trigger permanent changes in brain cells. The study's findings provide clues for targeting addiction with new drugs.
A new vaccine targeting human cytomegalovirus (CMV) shows promise in delaying the recurrence of deadly brain tumors, glioblastoma multiforme (GBM). The study found that patients receiving the vaccine experienced a significant delay in tumor regrowth, with overall survival extended to over 20 months.
A study found that stroke patients are at high risk for falls and subsequent injuries after leaving the hospital. Researchers recommend fall prevention strategies such as lower leg strengthening, balance retraining, exercise programs, home hazard assessment, and modification to prevent falls in these vulnerable individuals.
The International Society for Sexual Medicine (ISSM) has established an evidence-based definition of premature ejaculation, which is characterized by early ejaculation and negative personal consequences. This new definition aims to improve diagnosis and treatment options for men suffering from premature ejaculation, allowing them to se...
The Professional Action Coordinating Teams (PACTs) at M. D. Anderson Cancer Center have seen a significant increase in participation among nurses, with a 50% growth in one year. This growth is attributed to the short commitment of time, decisive action, and leadership opportunities provided by PACTs.
A study found that doripenem treatment reduced hospital length of stay and time on mechanical ventilation for patients with ventilator-associated pneumonia. Clinical cure rates were similar to those treated with imipenem-cilastatin.
Researchers discovered a mutation in the MESP2 gene, which completely disrupts its function, leading to congenital vertebral abnormalities. The study provides hope for identifying and preventing Spondylothoracic Dysostosis, a rare genetic disorder affecting Puerto Rican populations.
New research reveals that family stress spillover continues in adolescents' daily lives, affecting attendance, learning problems, and academic performance. Stress lingers for up to four years, with long-term consequences on academic achievement.
A new study strengthens the association between exposure to Agent Orange and an increased risk of developing prostate cancer in aging Vietnam veterans. The study found that twice as many exposed men were diagnosed with prostate cancer, diagnosed at a younger age, and more likely to present with aggressive disease.
Mayo Clinic researchers found that baseline quality of life is a strong predictor of survival in cancer patients, with scores above 83 associated with increased survival time. The study suggests that identifying quality of life deficits can help physicians intervene and improve patient outcomes, potentially extending their length of life.
MIT engineers developed a new material that increases the power output of direct methanol fuel cells by more than 50 percent. The new material is also less expensive and has potential uses in other electrochemical systems, such as batteries.
A study of 600 adolescent girls found that 90% experienced sexual harassment, with varying levels of reporting depending on age, socioeconomic status, and exposure to feminist ideas. Girls who felt pressure to conform to gender stereotypes or were unhappy with traditional roles were more likely to report sexism.