Researchers at Massachusetts General Hospital analyzed data from March 2020 to June 2022 to assess the severity of SARS-CoV-2 Omicron BA.2 subvariant compared to earlier variants. The study found that BA.2 was associated with lower mortality rates and reduced need for hospitalizations, invasive ventilation, and intensive care admissions.
Researchers controlled magnetic bacteria to cross blood vessel walls and infiltrate tumor tissue, delivering liposomes with fluorescent dye to demonstrate their ability to carry therapeutic agents. This approach may revolutionize bacterial cancer therapy by increasing efficacy and reducing side effects.
Scientists warn that climate change is at the door and pounding hard due to rising global temperatures, natural disasters, and infectious diseases. The report highlights urgent need to protect nature, eliminate fossil fuel emissions and support socially just climate adaptations.
Researchers at La Jolla Institute for Immunology have developed a new therapy for Lassa fever using a trio of rare human antibodies that can block viral infection. The therapy, called Arevirumab-3, was tested in non-human primates and proved 100% effective in treating the disease.
RedHill Biopharma's Talicia demonstrates high potential for H. pylori eradication while minimizing systemic antibiotic exposure, outperforming generic rifabutin regimens. Movantik data shows improved patient quality of life and symptom improvement in opioid-induced constipation.
A new study reveals that urolithin A from pomegranates can rejuvenate T cells by recycling and renewing mitochondria, enhancing their ability to fight tumors. The researchers plan to investigate the application of urolithin A in clinical trials for colorectal cancer.
The NCI-MATCH precision medicine cancer trial found a promising signal for the AKT inhibitor ipatasertib, meeting its primary endpoint with a 22% response rate in patients with rare AKT1 E17K tumor gene mutations. The study demonstrated clinically significant activity in patients, warranting additional studies.
A recent investigation by The BMJ reveals dozens of UK companies offering private blood tests with misleading claims, contradicting official medical guidance and potentially harming individuals. Experts argue for regulation to protect consumers and prevent unnecessary costs for the NHS.
Dr. Ivor Benjamin is recognized for his decades-long commitment to cardiovascular science, with a focus on proteostatic networks, stem cell biology, and redox homeostasis. He has led numerous initiatives to expand biomedical research and patient care, aiming to reduce health disparities and improve healthcare equity.
New research finds that believing COVID-19 is a hoax can lead to increased belief in conspiracy theories and even suspect the 2020 presidential election was stolen from Donald Trump. The study proposes the 'gateway conspiracy' hypothesis, suggesting that one conspiracy theory triggers distrust in institutions.
Researchers created predictable, novel expression patterns of fluorescent proteins using engineered gene circuits. They also redesigned root architecture by tuning the number of root branches using similar gene circuits.
A study found subarachnoid hemorrhage rates disproportionately higher in Black people, increasing by 1.8% per year. Incidence also increased with age and was higher in women than men, with an average of 13 cases per 100,000 people among women.
A study by the University of Bonn elucidated an important immune mechanism crucial for making hemophilia treatment effective. The researchers found that regulatory T cells can activate a self-destruct button on B cells against factor VIII, leading to its tolerance.
Researchers have developed a method that uses urea from urine to trigger the production of proteins in bacteria, replacing costly 'inducer' molecules. The new system produces similar quantities of protein as standard methods while being cheaper and easier to use, opening up new avenues for biotech industries.
Researchers have discovered that aluminous silicas play a significant role in transporting water into the Earth's deep interior. These minerals can hold large amounts of water even at high temperatures, challenging previous assumptions about the water cycle in the mantle.
Researchers have identified a messenger substance called ANGPLT4 that promotes tumor growth locally but suppresses metastasis when released into the bloodstream. This discovery sheds light on why metastases often appear after the original tumor has been surgically removed.
A new study by Syracuse University researchers found that more conservative state policies were associated with higher mortality rates among US workers. The study suggests that liberalizing policies on gun safety, labor, and tobacco taxes could lower mortality rates.
A Tel Aviv University study shows that pressure chamber therapy can improve social skills and reduce neuroinflammation in the autistic brain. The treatment, which involves high-pressure chambers with oxygen enrichment, was found to increase blood and oxygen supply to the brain, leading to improved brain function and social behavior.
A randomized clinical trial found that applying topical antibiotics to the upper digestive tract can improve survival rates in mechanically ventilated intensive care patients. The study, published in JAMA, also showed a significant reduction in new hospital-acquired infections.
Researchers create liquid metal circuitry using a desktop laser printer, enabling rapid printing of functional circuits onto various surfaces. The method produces devices that display images, tag RFID, sense temperature and sound, expanding the applications of liquid metal circuits.
Researchers assessing the environmental impact of future 'Higgs factories' propose a new figure of merit: carbon footprint per Higgs boson produced. Circular colliders emerge as a promising option due to their excellent physics capability and energy efficiency, which could significantly reduce the environmental cost.
Researchers at FAU aim to empower amputees to maximize their individual potential for controlling the full dexterity of artificial hands using a novel bimodal skin sensor and machine learning algorithms. The project will develop customized prosthetic sockets and training programs to overcome limitations with current sensing technology.
Researchers discovered that stopping GH activity in fat cells improves health and increases lifespan in mice. The study found approximately 23% lifespan extension due to GHR disruption, with improved insulin sensitivity and reduced frailty scores.
Researchers at Penn State aim to create a minimally invasive system using machine learning and multimodal biosensing platforms to detect Alzheimer's disease in its early stages. The system has the potential to improve detection accuracy and reduce false positives.
A meta-analysis published in Neurology found an association between traffic-related air pollution and an increased risk of dementia. Fine particulate matter exposure was linked to a 3% increase in dementia risk, highlighting the importance of reducing air pollution to prevent this disease.
A study published in American Journal of Roentgenology found that a PACS tool improved completion rates of clinically necessary follow-up imaging. The tool identified socioeconomically disadvantaged patients at increased risk of failure, and referrer agreements played a crucial role in improving recommendations.
A team of researchers from Johannes Gutenberg University Mainz have successfully developed a new approach to improve the way data is processed and stored. By combining chirality in spin configurations and molecules, they aim to create faster, smaller, and more efficient data storage devices.
Researchers have developed a pioneering gene editing strategy that can repair faulty genes in immune cells, offering new hope for patients with conditions like CTLA-4 insufficiency. The technique uses CRISPR/Cas9 to target and correct the faulty gene, preserving important regulatory mechanisms.
Dr. Christine E. Seidman, a renowned physician-scientist, has made groundbreaking discoveries in genetics and cardiomyopathy, leading to new pharmacological treatments. Her work has improved our understanding of disease risks and has led to unique targeted therapies.
The Midwest AIDS Training and Education Center at UIC will expand its services nationwide, using the $3 million grant to train medical professionals in patient care. The center aims to increase access to care and end the HIV epidemic by 2030.
Researchers used cryo-EM to obtain high-resolution images of actin filaments in three states, revealing the movement of hundreds of water molecules and their role in ATP hydrolysis. The study provides new insights into the assembly and aging of actin filaments, potentially leading to therapeutic applications.
A 6-month randomized clinical trial found that a low-carbohydrate diet intervention resulted in larger reductions in hemoglobin A1c (HbA1c) levels compared to usual diet among adults with elevated untreated HbA1c. The study suggests that this dietary approach may be useful for preventing and treating type 2 diabetes.
Researchers have discovered a newly found protein, CTENO189, that controls the unique locomotion of comb jellies. The protein is essential for the rippling movement of their comb plates, which propels them through the water.
Scientists from Harvard John A. Paulson School of Engineering and Applied Sciences have created a machine that uses surface tension of water to grab and manipulate microscopic objects, enabling nanoscopic manufacturing. The device can braid micrometer-scale fibers of synthetic material Kevlar, opening doors for high-frequency conductors.
Researchers explore the role of nutrition in cancer development, finding that precise nutritional strategies can be used to supplement treatment and treat cancer. Intermittent fasting is being studied as a promising approach to fight cancer, with studies showing it may increase toxicity on tumour cells and reduce side effects.
A study using contract tracing data in New York City found the city's program was efficient, producing data that informs neighborhood-level interventions like vaccination and reactive restriction. The researchers also identified large heterogeneity in reported close contacts and secondary infections across neighborhoods.
A phase I clinical trial found that Omomyc (OMO-103) has few side effects and can stabilize disease in some patients. The treatment showed stabilization of disease in 8 out of 17 evaluable patients, including one patient with pancreatic cancer who remained on the study for over six months.
Researchers at NUS discovered a new mechanism in water electrolysis that triggers a brand new electro-catalytic reaction when exposed to light. This breakthrough improves the efficiency of producing hydrogen, which can be used as a cleaner fuel source, and could revolutionize industrial processes.
A new ancient whale genus has been discovered in Morocco, dating back to around 40 million years ago. The species likely employed manatee-like swimming and feeding habits.
A study by Professor Dennis Murphy Odo found that automatic text simplification (ATS) software makes authentic materials more comprehensible for L2 learners with high reading proficiency. However, the tool's effectiveness is limited for learners with lower reading proficiencies. The researcher suggests that ATS tools need to be further...
The study of Bronze Age Politiko-Troullia in Cyprus reveals farming practices for sheep and cattle. Analysis of animal isotopes indicates communal feasting on wild game like deer and pigs during special occasions.
Dr. Eldrin F. Lewis, a clinician scientist at Stanford University School of Medicine, has been awarded the 2022 Clinical Research Prize by the American Heart Association. His work focuses on improving quality of life and care delivery models for patients with heart failure through point-of-care initiatives.
A study published in Science Advances reveals that physical exercise triggers a neuromuscular circuit that links the production of interleukin-6 to muscle fat breakdown. This circuit is crucial for weight loss and has significant implications for obesity treatment.
Researchers at UC San Diego identified a new signaling process involving GPCRs, suggesting untapped potential for therapies, including for multiple forms of cancer. The study challenges traditional views on GPCR-mediated signaling, revealing a new mechanism that originates at endosomes and propagates into the nucleus.
Researchers from Osaka University have developed a novel method for hydrogen purification using liquid organic hydrogen carriers, achieving high efficiency and purity. This breakthrough could increase the mid- and long-term prospects of hydrogen as a sustainable energy source.
The THERACAT project aims to deliver drugs only to tumor sites using bio-orthogonal catalysis, a promising approach for targeted cancer treatment. Researchers developed nanoparticles bearing metal catalysts to efficiently convert inactive pro-drugs into active drugs at the tumor site.
An automated texting program supported primary care patients after hospital discharge, resulting in significant reductions in acute care resource use. The patient-centered approach may serve as a model for improving post-discharge care.
Researchers at Rutgers University found that patients who participate in multiple outpatient visits early in treatment are more likely to continue care. Nearly half of these patients remained in treatment for six months or more, compared to just 2.9% of those with less frequent visits.
Two studies found that cigarette smoke and e-cigarette vapor have similar cardiovascular effects due to airway irritation. This irritation can lead to vascular damage and impaired blood vessel function. The research suggests that dual product use may be worse than single product use, highlighting the need for stricter regulations.
A study published in The BMJ found a small increased risk of thrombosis with thrombocytopenia syndrome (TTS) after vaccination against the Covid-19 virus, particularly with adenovirus vaccines. Researchers recommend considering these risks when planning future immunization campaigns and vaccine development.
In a patient trial, the AKT inhibitor ipatasertib showed signs of effectiveness in treating advanced cancers. 22% of patients experienced tumor shrinkage, while 56% had stable disease. Further research is needed to understand why some patients responded and others did not.
Dr. Bibbins-Domingo's research focuses on racial disparities in cardiovascular disease prevention, incidence, and outcomes. She explores long-term effects of early and poorly treated high blood pressure and develops strategies to prevent and manage CVD.
Researchers aim to use quantum computer-based AI to accelerate drug discovery, cutting costs and time by exponentially increasing processing power for complex problems. Quantum AI models have higher capability to approximate desired functionality compared to classical neural networks.
Physicists have observed novel quantum effects in a topological insulator at room temperature, opening up new possibilities for efficient quantum technologies. This breakthrough uses bismuth-based topological materials to bypass the need for ultra-low temperatures.
A new study by the University of Nottingham reveals that people who experience workplace bullying are more likely to engage in conspiracy theorizing. The research found that both bullying and conspiracy theories share similar psychological factors, such as feelings of paranoia. This can lead to a vicious cycle where victims of bullying...
Researchers at ICIQ have demonstrated that single molecules can retain properties even when the stimulus disappears, breaking previous expectations. This discovery has significant implications for molecular data storage and could lead to new possibilities for storing multifunctional information.
The INSPIRE project aims to close the gender gap in research careers and promote inclusivity. It will create a sustainable centre of excellence, set the worldwide standard for research on inclusive gender equality, and provide practical support for institutions implementing gender equality plans.
Researchers create a material with disordered molecular structure that conducts electricity well, defying conventional theories. The material's stability and versatility make it promising for new electronic devices.
Researchers from Northwestern University have synthesized open-channel superlattices with pores ranging from 10 to 1,000 nanometers in size. The new findings will enable the use of these colloidal crystals in molecular absorption and storage, separations, chemical sensing, catalysis, and optical applications.
Oregon State researchers have engineered inhalable lipid nanoparticles that effectively deliver messenger RNA to the lungs, prompting lung cells to manufacture a protein needed to thwarts the disease. The therapy shows promise in treating cystic fibrosis, a progressive genetic disorder affecting 30,000 people in the US.