The ACC Cardio-oncology Course aims to equip clinicians with the latest strategies and best practices for managing cardiovascular health in cancer patients. The course will feature joint presentations of oncologists and cardiologists, showcasing real-life patient care and collaboration across teams.
A new study reveals that the HOXB13 protein regulates PSMA expression, even when the androgen receptor is absent, and identifies amino acids that are upregulated in low-PSMA tumors. This complex system of PSMA control has multiple subtypes, suggesting optimally targeted therapies.
Researchers at St. Jude Children's Research Hospital developed a novel combination therapy approach that uses both BET and GSK3 inhibitors against KMT2A mutated leukemia, overcoming drug resistance without increasing toxicity. The approach was confirmed in cell lines and xenograft mouse models, and holds promise for further development.
A study led by Tokyo University of Science researchers identified Dectin-1's role in promoting colorectal cancer by enhancing PGE2 production and suppressing IL-22BP expression. The study used mouse models and clinical samples to validate the findings, which have immediate clinical implications for CRC patients.
A simulation modeling study finds that involuntary displacement worsens overdose and hospitalizations, decreases treatment initiation, and contributes to deaths. The study projects substantial increases in morbidity and mortality over a 10-year period in cities with such displacements.
A new study found that more than 60% of parents had heard of PrEP, with relatively low levels of knowledge and high intentions to discuss and support their adolescents' PrEP care. The study highlights the importance of educating parents about PrEP to increase self-efficacy and uptake among at-risk populations.
The 2023 Internet2 Community Exchange brings together emerging and established leaders to share perspectives on digital transformation, digital inclusion and equity, accessibility, cybersecurity, cloud strategy, and more. The event highlights innovative solutions and collaborative projects to drive the R&E community forward.
Researchers develop soft, self-charging bio-inspired power sources for space applications, addressing lithium-ion battery limitations. The new technology uses electric fish-inspired charge-separation principle to produce high-voltage power, potentially recharging from available resources like sunlight.
Researchers found record-breaking rates of sea-level rise of about a half an inch per year since 2010, three times higher than the global average over the same period. The acceleration is attributed to man-made climate change and natural climate variability.
Research finds that tailings storage dams disrupt life cycles, cause intolerance to lentic conditions, and introduce non-native species in affected streams. This study reveals a decline in catfish species, including armored catfish, in Brazilian streams impacted by TSDs.
Researchers developed an optimized genome-editing method that vastly reduces mutations, enabling more effective treatment of genetic diseases. The new technique uses a 'safeguard gRNA' to control DNA cleavage, reducing off-target effects and cytotoxicity.
Purdue University has received two grants of $1 million each from the US Department of Agriculture's National Institute of Food and Agriculture to develop more resilient food systems. The grants will support research, education, and extension efforts aimed at enhancing sustainable agricultural systems in Eastern U.S. forests and Midwes...
Researchers at Texas A&M University have identified a new circuit element called the meminductor, which exhibits memory-like properties. The discovery was made using a two-terminal passive system and proved the existence of meminductance in an inductor circuit element.
Researchers developed a biologically inspired 'vaping robot' to mimic human breathing patterns and tested commercially available e-liquids containing menthol. The study found that menthol vapers took shallower breaths and had poorer lung function compared to non-menthol smokers, regardless of age or smoking history.
Researchers at Kyoto University have successfully created silicon-based photovoltaics at room temperature using a hybrid PEDOT:PSS/silicon heterojunction. This breakthrough technology offers improved production speed and cost, with power generation efficiency above 10%. The new process has the potential to facilitate large-scale diffus...
A Penn Medicine study identified a developmental sequence in brain maturation during adolescence, revealing regions supporting cognitive and social functions remain malleable until late adolescence. The study found that socioeconomic environments have a significant impact on brain development in these regions.
Researchers developed a chelator-free-radiolabeled polymersome capable of long-term multiday PET imaging in vivo. The nanovesicle meets key requirements for targeted cancer therapy, including precision targeting, stable radiotracer binding, and biocompatibility.
Tulane University researchers discovered a possible genetic cause of hypermobility and hypermobile Ehlers-Danlos syndrome, linking it to folate deficiency due to the MTHFR gene variation. Elevated folate levels in blood tests can aid in diagnosis, while methylated folate has shown promising treatment results for patients.
Targeted testing for HIV in emergency departments has led to a significant increase in diagnoses, with numbers more than tripling in Spain. Early diagnosis is key to avoiding the spread of HIV infection, and targeted screening has been shown to be effective, especially in increasing tests ordered and diagnoses made.
Researchers at the Earlham Institute have successfully engineered tobacco plants to produce moth sex pheromones using precision gene engineering techniques. The production of these molecules can be efficiently managed without hampering normal plant growth, providing a potential alternative to traditional pesticides.
A novel biorefinery process has been developed to minimize the usage of external utilities by reusing by-products from biomass production. The process successfully reduced the total process energy and supplied it by itself, as well as utilizing excess solid by-products for building materials and other purposes.
The study used LED imaging to visualize droplet spreading during dental procedures and found that extra-oral and intra-oral suction devices reduced droplet and aerosol spread by 97.8% and 92.1%, respectively. Understanding the dynamics of aerosols and droplets is crucial for preventing infectious diseases like COVID-19.
The study reveals that intratumoral natural killer cells' loss of membrane protrusions impairs their ability to recognize and kill tumor cells. Researchers developed a single-immunocyte mass spectrometry technology to detect the decrease in sphingomyelin, which can restore protrusion formation and improve NK cells' killing capacity.
Researchers have developed a new design of cathode materials in Li-Cl2 batteries, achieving high specific capacities of up to 2000 mAh/g and stable performance for over 500 cycles. The use of NH2-functionalized MOFs enhances the redox reaction kinetics and improves low-temperature stability.
A team of scientists created a new, fast, and precise method for analyzing cells in tissue samples from cancer patients without the need for a trained pathologist. The method uses artificial intelligence to evaluate data produced by a technique called real-time deformability cytometry.
Researchers at Weill Cornell Medicine have identified an antibody that blocks infection by all dominant COVID-19 variants, including Omicron. The discovery could lead to new antibody-based treatments and more effective vaccines.
A new deep learning-based model estimates breast density with high precision, correlating it to cancer risk. The model's performance is comparable to that of human experts, but it can be trained faster and on smaller datasets.
New research at ECCMID 2023 presents 19 gold complexes effective against at least one hard-to-treat bacterium, including MRSA and Pseudomonas aeruginosa. The gold-based drugs use a multimodal mechanism to kill bacteria, preventing antimicrobial resistance from developing.
Research suggests that lonely people process information in unique ways, differing from their peers, even with large social networks. This difference may lead to a reduced sense of understanding and further challenges in achieving social connection.
Researchers at Hokkaido University have developed a simplified Birch reduction method that avoids liquid ammonia and can be carried out in ambient air, making it faster and more eco-friendly. The mechanochemical approach uses a ball mill to break through the surface layer on lithium metal, enabling the Birch reduction to proceed.
Dominique Higgins and his team found that a specialized diet can induce ferroptosis, a type of cell death, in glioblastoma cells, making chemotherapy drugs more effective. This approach has shown promise in animal models and is being explored as a potential treatment for brain tumors.
The American Association for Cancer Research (AACR) has elected 23 new Fellows of the AACR Academy, who have made groundbreaking contributions to cancer research. The new class includes pioneers from various scientific disciplines, including bioorthogonal chemistry, immunotherapy, and breast cancer research.
New research reveals that expanded alternative licensure pathways can lead to attenuated pay for new elementary school teachers. The study found that districts hiring more than 50% of their new teachers through alternative routes experienced stagnating teacher pay after policy implementation.
Researchers propose a new method of clustering colorectal cancer patients using differential presence of exons (DPE) sequencing, which can provide valuable information on CRC progression and response to therapy. This analysis may also reduce costs and time required for staging CRC patients.
Researchers at Mayo Clinic Arizona have developed a new intravesical chemotherapy delivery system called TAR-200, which is safe and shows initial evidence of effectiveness in treating muscle-invasive bladder cancer (MIBC) in frail patients. The treatment has been shown to limit cancer growth while minimizing toxic effects.
A Rutgers study found that nearly one in five LGBTQ people experienced an increase in intimate partner violence after the COVID-19 pandemic began. Those living in the southern US were more likely to report this increase, with intimate partner violence also linked to greater depressive symptoms.
A national-level analysis found substantial adverse maternal outcomes among pregnant patients with COVID-19 infection during the early pandemic period. The study highlights increased odds of severe respiratory complications among these patients at delivery.
Researchers at Binghamton University and Brookhaven Lab used advanced spectroscopy techniques to study the effects of peroxides on copper oxide surfaces. They found that peroxides significantly enhanced CuO reducibility in favor of H2 oxidation, while acting as an inhibitor to suppress CO oxidation.
Researchers at Johns Hopkins University discovered how histone H3 controls cell specialization in worms, offering insights into cell differentiation and potential links to diseases. The study used CRISPR gene-editing technique to track the role of histones in development.
Researchers created the integrated-gut-liver-on-a-chip platform to examine how gut and liver cells interact, particularly in relation to non-alcoholic fatty liver disease. The study showed significant changes in gene expression and DNA damage when free fatty acids were introduced, leading to cell death similar to severe cases of NAFLD.
The labor force participation rate for people with disabilities increased to a record 40.2% in March 2023, surpassing the rate for those without disabilities (77.6%). This growth reflects an ongoing recovery from the COVID-19 pandemic and may be driven by factors such as increased job opportunities and family needs.
Researchers have found that a strong electric field can create hydroxide, which reacts with pollutants and greenhouse gases, altering our understanding of atmospheric chemistry. This new mechanism changes how scientists build computer models to forecast air pollution.
Researchers developed an ASO treatment that improves bile duct development and prevents fibrosis and cell death in animal models of Alagille syndrome. The study offers a potential therapeutic option for patients with this condition, potentially bypassing the need for liver transplant.
A randomized controlled trial of High School FLASH, an LGBTQIA+ inclusive evidence-based sex education curriculum, found that the program reduced homophobic and transphobic beliefs among both LGBTQ and straight/cisgender students. The study also showed improved feelings of safety and connection to peers among LGBTQ students.
Researchers compared woolly mammoth genomes with modern-day elephants to find unique traits. They identified genes responsible for small ears, fat metabolism, and cold perception, which became more defined over time.
A study led by Dr.Ningli Wang and Dr.Yuan Xie found that retinal microvasculature alterations can predict acute mountain sickness (AMS). The researchers used optical coherence tomography angiography to measure retinal capillary blood flow density, revealing increased perfusion pressure as a key mechanism in AMS pathogenesis.
Researchers at Trinity College Dublin have discovered a new process that explains why cells have unique identities. By studying Polycomb protein complexes, the team found that different forms of these proteins recruit distinct complexes to DNA, shedding light on cellular identity and its potential impact on cancer treatments.
A new study calls for internet access to be declared a basic human right to address socio-economic disparities. In developing countries, internet access can determine education, healthcare, housing, and employment outcomes. The study advocates for free internet access and digital skills training to ensure equal opportunities.
A team led by Prof. ZHANG Kaiming solved six conformations in the second-step self-splicing of Tetrahymena ribozyme, revealing its mechanism on an atomic level. The researchers used cryo-EM to resolve RNA structures, providing insights into the advantages of this technique for studying heterogeneous molecules.
A new study reveals that targeting the SWI/SNF protein complex can disrupt PU-1-directed enhancer programs in AML cells, leading to therapeutic responses and rapid tumor regression. The findings also show that these inhibitors have manageable side effects on normal blood cells.
Researchers find that changes in wind patterns caused by warmer tropical waters are steering storms closer to the US East and Gulf coasts, increasing risk for residents. The study reveals that this phenomenon is linked to stronger hurricane frequency due to climate change.
A comprehensive review of e-nose methods and algorithms aims to improve smell detection capabilities. The study highlights limitations of current gas sensors and provides an outlook on algorithm design.
A new study reveals a steady decline in native leaf-litter ants and simultaneous increase in nonnative ants in Florida, even in protected natural areas. Nonnative ants are most likely arriving with goods transported to the state from around the world.
A Dartmouth College study found that more than 500 home runs since 2010 can be attributed to higher-than-average temperatures due to climate change. Rising temperatures could account for 10% or more of home runs by 2100, with some stadiums experiencing significant spikes in home run totals.
Researchers at Argonne National Laboratory and University of Chicago developed a hybrid simulation process using IBM quantum computers to solve electronic structure problems. The new method uses classical processing to mitigate noise generated by the quantum computer, paving the way for future improvements.
A new research approach suggests integrating biodiversity auditing into conservation plans to effectively support a wider range of important species. This method has been successfully tested in the UK's East Anglia region and could benefit biodiversity nationally, including the European Union's 2030 Biodiversity Strategy.
A recent study led by Children's Hospital of Philadelphia identifies two different regulatory T cell populations, one related to autoimmunity and the other to protective immunity. The findings could pave the way for new treatments that target the immune system selectively.
The Princeton-led team measured the dark matter's 'clumpiness,' finding a value of 0.776 that conflicts with the Cosmic Microwave Background's value of 0.83. The discrepancy suggests the standard model might be incomplete or has an error, prompting further investigation.
Research from Amsterdam UMC reveals that all prominent migrant groups are suffering more from long-covid than the native Dutch population, with rates ranging from 26-50% higher. The study highlights the need for awareness and accessible healthcare services in ethnic minority and migrant communities.
A UC Riverside-led study found that reduced PTPN2 activity in intestinal epithelial cells leads to decreased Paneth cell antimicrobial peptide production, disrupting the gut microbiota and increasing E. coli. This loss can serve as a marker of IBD disease.