Researchers found a link between bipolar disorder and potentially pathogenic mosaic mutations in genes associated with developmental disorders and autism spectrum disorder. Mosaic variants were also discovered in mitochondrial tRNA genes of patients with BD, suggesting a compromised contribution to the disease's molecular mechanisms.
SourceJuntendo University Research Promotion Center·JournalMolecular Psychiatry·TypeExperimental study·DateJun 5, 2023
The study found an objective response rate of 61.3% with a median duration of response of 22.1 months in patients with high HER2 expression. The treatment showed promise in a significant unmet area of clinical need, providing a new option for patients with hard-to-treat HER2-positive cancers.
SourceUniversity of Texas M. D. Anderson Cancer Center·TypeRandomized controlled/clinical trial·DateJun 5, 2023
The study found that only 28% of US youth-serving mental health facilities offered LGBTQ-specific services, highlighting the need for expansion of these services, particularly in underserved areas. Public mental health facilities were less likely to provide such services due to cost concerns.
SourceJAMA Network·JournalJAMA Pediatrics·DateJun 5, 2023
Researchers built personalized brain network models to simulate brain dynamics and found that people with higher fluid intelligence took more time to solve difficult tasks compared to those with lower FI. This suggests that a synchronized brain is better at solving problems but not necessarily faster.
SourceHuman Brain Project·JournalNature Communications·DateJun 5, 2023
CalDigit TS4 Thunderbolt 4 Dock
CalDigit TS4 Thunderbolt 4 Dock simplifies serious desks with 18 ports for high-speed storage, monitors, and instruments across Mac and PC setups.
A new partnership between Patrick Reed and Kenneth Eilertsen is putting a focus on translational research and commercialization at Pennington Biomedical. The team aims to evaluate patentability and marketability of potential disclosures, promoting public benefit from scientific discoveries.
SourcePennington Biomedical Research Center·DateJun 5, 2023
Researchers discovered that targeting specific blood vessel enzymes can enhance immunotherapy effectiveness and prevent breast cancer metastasis. By disabling the enzyme DNMT1 in blood vessels, doctors may bolster anti-tumor immune cells entry and increase patients' response to treatment.
SourceUniversity of Virginia Health System·DateJun 5, 2023
A new, energy-efficient approach to removing CO2 directly from air has been developed at Oak Ridge National Laboratory and licensed to Holocene. The technology uses an aqueous solution containing receptors called Bis-iminoguanidine to absorb carbon dioxide, which can then be stored deep underground.
SourceDOE/Oak Ridge National Laboratory·DateJun 5, 2023
A new study suggests that industrialized countries in the Global North could be liable to pay a total of $170 trillion in compensation or reparations by 2050. This amount would be distributed as compensation to low-emitting countries that must decarbonize their economies faster than required, aiming to meet climate change targets.
SourceUniversity of Leeds·JournalNature Sustainability·TypeData/statistical analysis·DateJun 5, 2023
AmScope B120C-5M Compound Microscope
AmScope B120C-5M Compound Microscope supports teaching labs and QA checks with LED illumination, mechanical stage, and included 5MP camera.
Researchers invent time-resolved assessment of single-cell protein secretion with sequencing (TRAPS-seq) to correlate cell functions with secreted proteins. The technique accelerates the development of new therapeutic strategies for disease treatment, including targeting mechanisms selective for cancer cells.
SourceNational University of Singapore·JournalNature Methods·DateJun 5, 2023
Researchers found an astonishing record of biodiversity trapped on air quality filter samples in the UK, including over 180 plant and animal species. The study suggests that existing air quality monitoring networks could be used to track terrestrial biodiversity on a continental scale.
SourceCell Press·JournalCurrent Biology·TypeExperimental study·DateJun 5, 2023
Researchers discovered a methanogen that converts sulfate into a cellular building block, reassembling a metabolic pathway piece by piece. The microbe assembled the first sulfate assimilation pathway from a methanogen, using genetic tricks to overcome energetic costs and toxic intermediates.
SourceMax Planck Institute for Marine Microbiology·JournalNature Microbiology·DateJun 5, 2023
Researchers at Northwestern University have discovered a way to soften stiff hair follicle stem cells, enabling them to grow hair again. By boosting the production of microRNA-205, they promote hair growth in both young and old mice, offering potential for human hair regrowth.
SourceNorthwestern University·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJun 5, 2023
SAMSUNG T9 Portable SSD 2TB
SAMSUNG T9 Portable SSD 2TB transfers large imagery and model outputs quickly between field laptops, lab workstations, and secure archives.
A new parasitic euglenid species has been discovered within four animal species collected from a Japanese rice field. The flagellate displayed active metaboly without flagella inside the host body, but extended its flagella upon leaving the host to swim.
SourceUniversity of Tsukuba·JournalProtist·DateJun 5, 2023
Researchers found that women with higher-quality cardiovascular fat during midlife had stronger long-term memory and lower inflammation, while those with lower-quality fat had worsening working memory. The study suggests that taking care of heart health during menopause may protect brain health and reduce dementia risk.
SourceUniversity of Pittsburgh·JournalAlzheimer s & Dementia·TypeObservational study·DateJun 5, 2023
A recent study has found that microbes play a crucial role in storing carbon in the soil, with a four-fold greater importance than other processes. This breakthrough could lead to improved soil health and increased food security through targeted farm management practices.
Researchers from Mount Sinai Health System presented new findings on the impact of customized lighting on inpatient sleep, a machine-learned combination of ventilatory, hypoxic, and arousal burdens, and the effects of obstructive sleep apnea and insomnia on cognitive impairment. The studies aim to improve sleep timing and duration, dia...
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalSLEEP·DateJun 5, 2023
Fluke 87V Industrial Digital Multimeter
Fluke 87V Industrial Digital Multimeter is a trusted meter for precise measurements during instrument integration, repairs, and field diagnostics.
Researchers identified ZapE as a key regulator of Pseudomonas aeruginosa biofilm formation, modulating the pqs quorum sensing system. The study suggests that ZapE is a novel target for anti-Pseudomonas compounds and has implications for treating antibiotic-resistant infections.
SourceBeijing Zhongke Journal Publising Co. Ltd.·JournalmLife·DateJun 5, 2023
A new AI model, NeCLAS, can predict how nanoparticles bind to proteins, a crucial step in designing antibiotics and antivirals. This breakthrough could help combat antibiotic-resistant infections and develop new treatments for diseases.
SourceUniversity of Michigan·JournalNature Computational Science·DateJun 5, 2023
Astronomers have detected a surprisingly large water vapor plume spanning over 6,000 miles from Saturn's moon Enceladus using the James Webb Space Telescope. The plume extends far beyond its release region at the southern pole and feeds the torus of Saturn's outermost ring, with 30% of the water staying within it.
SourceNASA/Goddard Space Flight Center·JournalNature Astronomy·DateJun 5, 2023
Researchers at USC Viterbi School of Engineering achieved a quantum speedup advantage in a bitstring guessing game, managing strings up to 26 bits long by suppressing errors. The study demonstrates that with proper error control, quantum computers can execute complete algorithms with better scaling, even in the NISQ era.
SourceUniversity of Southern California·JournalPhysical Review Letters·TypeExperimental study·DateJun 5, 2023
Sony Alpha a7 IV (Body Only)
Sony Alpha a7 IV (Body Only) delivers reliable low-light performance and rugged build for astrophotography, lab documentation, and field expeditions.
A new meta-analysis suggests a strong link between childhood maltreatment and adult alexithymia, with three types of child maltreatment - emotional neglect, physical neglect, and sexual abuse - being particularly predictive. This can lead to difficulties in identifying and describing emotions, harming social and intimate relationships.
SourceStanford University·JournalPsychological Bulletin·DateJun 5, 2023
A new study reveals that previously unknown antibiotic resistance genes are widespread in bacteria across various environments, including the human microbiome. The findings suggest that these genes can pose a significant threat to human health, highlighting the need for enhanced understanding of their development and spread.
SourceChalmers University of Technology·JournalMicrobiome·TypeData/statistical analysis·DateJun 5, 2023
A Phase III trial found that axicabtagene ciloleucel (axi-cel) significantly improved overall survival and progression-free survival in patients with early relapsed or refractory large B-cell lymphoma, compared to standard therapy. The estimated four-year survival rate was 54.6% with axi-cel.
SourceUniversity of Texas M. D. Anderson Cancer Center·JournalNew England Journal of Medicine·DateJun 5, 2023
A new human pangenome reference has been released, representing the genetic diversity of 47 individuals from around the world. This development may lead to breakthroughs in targeted medical treatments and a better understanding of disease responses, as regions previously missed are now being explored.
A systematic review and meta-analysis found that 'Kangaroo mother care' reduces the risk of mortality by 32% and severe infection by 15%. Starting KMC within 24 hours and for at least eight hours a day also appears to be effective in reducing mortality.
SourceBMJ Group·JournalBMJ Global Health·TypeSystematic review·DateJun 5, 2023
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
A recent study found that germline genetic testing after cancer diagnosis is underutilized, with rates significantly lower among Asian, Black, and Hispanic patients compared to non-Hispanic whites. The study, published in JAMA, suggests disparities in access to genetic testing by race.
A new framework developed by Carnegie Mellon University researchers significantly reduces consumers' privacy risk while preserving advertisers' utility in mobile location data analysis. The framework uses machine learning to quantify personalized privacy risks and performs personalized data obfuscation.
SourceCarnegie Mellon University·JournalInformation Systems Research·DateJun 5, 2023
A Houston Methodist study found that COVID-19 variants and severity affect heart function, with microvascular involvement seen less often after nine months. The study recommends PET scans to check for microvascular dysfunction, which may be reversible.
SourceHouston Methodist·JournalEuropean Heart Journal·TypeImaging analysis·DateJun 5, 2023
A recent study found significant differences in the gut microbiome of female southern white rhinos that reproduced successfully versus those that did not. The researchers identified a particular genus of microbes that may be limiting reproductive success in captive breeding programs.
SourceNorth Carolina State University·JournalAnimal Microbiome·TypeObservational study·DateJun 5, 2023
A UC San Diego study reveals that industrial disasters like the Bhopal gas disaster in India may lead to higher rates of disability and cancer for children born to affected mothers. The research found a fourfold increase in miscarriage risk and increased stillbirth and neonatal mortality rates.
SourceUniversity of California - San Diego·JournalBMJ Open·TypeData/statistical analysis·DateJun 5, 2023
Aranet4 Home CO2 Monitor
Aranet4 Home CO2 Monitor tracks ventilation quality in labs, classrooms, and conference rooms with long battery life and clear e-ink readouts.
Researchers identified a Pcc1-like protein in archaeon Sulfolobus islandicus, suggesting it's a homolog of eukaryotic Gon7. The study suggests archaeal KEOPS complex functions independently of t6A modification and supports the archaeal origin of Eukaryotes theory.
SourceBeijing Zhongke Journal Publising Co. Ltd.·JournalmLife·DateJun 5, 2023
Researchers at the University of Utah Health have made a groundbreaking discovery about the role of microglia in controlling anxiety-related behaviors. The study found that specific microglia populations activate anxiety behaviors while others dampen them, and these cells communicate with neurons to invoke behaviors.
SourceUniversity of Utah·JournalMolecular Psychiatry·TypeExperimental study·DateJun 5, 2023
Erdafitinib achieves tumor-agnostic benefits across 16 cancer types, including urothelial, lung, and other cancers. The trial demonstrated a disease control rate of 73.7% and clinical benefit rate of 45.6%, with notable improvements in pancreatic and cholangiocarcinoma patients.
SourceUniversity of Texas M. D. Anderson Cancer Center·DateJun 5, 2023
Researchers analyzed BORIS mutations and protein expression in breast cancer tissue samples, finding frequent mutations associated with breast carcinoma progression. The study suggests the BORIS gene as a potential biomarker for breast cancer.
SourceImpact Journals LLC·JournalOncotarget·TypeObservational study·DateJun 5, 2023
International researchers have identified nutrient-rich black rice varieties with improved agronomic traits, including shorter stem length and early maturity. These findings provide important resources for crop bioengineers to improve pigmented rice for human health and sustainable agriculture.
SourceKing Abdullah University of Science & Technology (KAUST)·JournalNature Food·DateJun 5, 2023
Meta Quest 3 512GB
Meta Quest 3 512GB enables immersive mission planning, terrain rehearsal, and interactive STEM demos with high-resolution mixed-reality experiences.
A new study found that living in urban environments with material and social inequities is associated with premature biological aging. Depressive symptoms also accelerate epigenetic age acceleration, regardless of neighborhood deprivation. The researchers used DNA methylation-based estimators to examine aging at the cellular level and ...
SourceMcMaster University·JournalThe Journals of Gerontology Series A·TypeData/statistical analysis·DateJun 5, 2023
Pre-training in medical data tackles challenges such as data scarcity and privacy concerns using AI techniques like transfer learning and self-supervised learning. Recent advances and new frontiers of pre-training-based techniques are introduced, including applications to medical images, bio-signal data, EHR data, and multi-modality data.
SourceBeijing Zhongke Journal Publising Co. Ltd.·JournalMachine Intelligence Research·DateJun 5, 2023
Researchers at Osaka University developed a highly reproducible genetic screen to investigate Toxoplasma's survival within hosts. The study identified IFN-γ-dependent and -independent virulence factors that promote parasite fitness, providing potential targets for treatment and prevention of toxoplasmosis.
SourceOsaka University·JournalCell Reports·TypeExperimental study·DateJun 5, 2023
Researchers at the University of Oklahoma demonstrate a new method for secure information transfer using spatial correlations in quantum entangled beams of light. The study successfully encodes information into recognizable images, which can only be retrieved by joint measurements of the two entangled beams.
SourceUniversity of Oklahoma·JournalScience Advances·DateJun 5, 2023
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C)
Anker Laptop Power Bank 25,000mAh (Triple 100W USB-C) keeps Macs, tablets, and meters powered during extended observing runs and remote surveys.
A team of astronomers using the James Webb Space Telescope has detected complex organic molecules in a galaxy over 12 billion light-years away. The discovery suggests that the presence of these molecules does not necessarily indicate star formation, contradicting a long-held assumption.
SourceTexas A&M University·JournalNature·DateJun 5, 2023
Researchers have developed a simple blood test that can diagnose De Vivo disease, a rare and disabling neurological disorder. The test, called METAglut1, has a high sensitivity and specificity, allowing for accurate diagnosis in a short amount of time.
SourceInstitut du Cerveau (Paris Brain Institute)·JournalNeurology·TypeRandomized controlled/clinical trial·DateJun 5, 2023
Researchers develop a novel voice spoofing detection method combining physiological and physical features, achieving improved performance over existing methods. The proposed method outperforms single systems in terms of EER and t-DCF scores.
SourceHigher Education Press·JournalFrontiers of Computer Science·TypeExperimental study·DateJun 5, 2023
A new study finds that mycorrhizal fungi store up to 36% of yearly global fossil fuel emissions' carbon, equivalent to roughly 13 gigatons. This vast underground network is essential to both storing carbon and global biodiversity.
SourceUniversity of Sheffield·JournalCell Biology·TypeObservational study·DateJun 5, 2023
Researchers found that plants allocate a significant amount of carbon to mycorrhizal fungi, equivalent to roughly one-third of carbon emitted yearly by fossil fuels. This discovery highlights the importance of understanding fungal networks in soil ecosystems and their role in mitigating climate change.
SourceCell Press·JournalCurrent Biology·TypeExperimental study·DateJun 5, 2023
Apple MacBook Pro 14-inch (M4 Pro)
Apple MacBook Pro 14-inch (M4 Pro) powers local ML workloads, large datasets, and multi-display analysis for field and lab teams.
A new study by the University of Utah Health reveals that people with higher cardiovascular disease risk are more likely to develop musculoskeletal disorders. The study suggests prioritizing cardiovascular health can help prevent these conditions and improve quality of life.
SourceUniversity of Utah Health·JournalJournal of Occupational and Environmental Medicine·TypeObservational study·DateJun 5, 2023
Researchers discovered tirzepatide's unique ability to activate both GLP-1 and GIP receptors, leading to increased insulin secretion. This finding validates the potential of multi-receptor agonists for treating metabolic diseases.
SourceDuke University Medical Center·JournalNature Metabolism·DateJun 5, 2023
A new study by Carnegie Mellon University researchers finds that crime risk assessment tools, such as machine learning models, are prone to cohort bias when ignoring social change dynamics. This bias can generate inequality in the criminal justice system, distinct from racial bias.
SourceCarnegie Mellon University·JournalProceedings of the National Academy of Sciences·DateJun 5, 2023
Researchers at Sanford Burnham Prebys have discovered a new treatment for autoimmune diseases using LY3361237, an antibody that activates BTLA to inhibit the immune system. The study provides insight into the molecular biology of the immune system and could lead to the development of more effective therapies.
SourceSanford Burnham Prebys·JournalStructure·DateJun 5, 2023
Researchers at the University of Liège have made a groundbreaking discovery of a novel organisation of muscle fibres in Parophidion vassali, a fish that produces sounds using specialized muscles. This new arrangement of myofibrils forms an enormous network within the muscle fibre, potentially allowing for rapid contraction while retain...
SourceUniversity of Liège·JournalCell and Tissue Research·DateJun 5, 2023
Nikon Monarch 5 8x42 Binoculars
Nikon Monarch 5 8x42 Binoculars deliver bright, sharp views for wildlife surveys, eclipse chases, and quick star-field scans at dark sites.
The Sooty Bark Disease, caused by Cryptostroma corticale, is a growing threat to European maples and human health. Researchers have developed a DNA-based diagnostic method to detect the pathogen in air samples using volumetric air samplers.
SourcePensoft Publishers·JournalNeoBiota·DateJun 5, 2023
A supervised hospital walking program has been shown to reduce nursing facility admissions for older adults by lowering the proportion of patients discharged to skilled nursing facilities from 13% to 8%. However, low participation rates and limited impact on length of stay or inpatient falls were noted.
SourceAmerican College of Physicians·JournalAnnals of Internal Medicine·TypeRandomized controlled/clinical trial·DateJun 5, 2023
A study published in Archives of Disease in Childhood found that children breastfed for longer had improved educational outcomes at age 16, with modest gains in academic achievement. The research analyzed data from the Millennium Cohort Study and found a strong association between breastfeeding duration and better exam results.
SourceBMJ Group·JournalArchives of Disease in Childhood·TypeData/statistical analysis·DateJun 5, 2023
Researchers at UCSF tested a nitroglycerin patch for treating menopausal women experiencing severe hot flashes. The study found short-term improvements, but benefits did not last past 12 weeks, with some side effects reported.
SourceUniversity of California - San Francisco·JournalJAMA Internal Medicine·DateJun 5, 2023
GoPro HERO13 Black
GoPro HERO13 Black records stabilized 5.3K video for instrument deployments, field notes, and outreach, even in harsh weather and underwater conditions.
Researchers from the BabySeq Project found that over 10% of newborns had unanticipated mutations in disease-associated genes, all medically actionable. The study prompted genetic testing, specialty consultations, and procedures among at-risk family members, including risk-reducing surgeries for mothers.
SourceBrigham and Women's Hospital·JournalAmerican Journal of Human Genetics·TypeRandomized controlled/clinical trial·DateJun 5, 2023
A new study using CRISPR/Cas9 technology has identified a critical gene, SLC4γ, required for young coral colonies to build their skeletons. This gene is unique to stony corals and may have evolved to support skeleton formation.
SourceCarnegie Institution for Science·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJun 5, 2023
A new study found that 63% of children on Medicaid do not receive mental health services within six months after a firearm injury. Children who survive firearm injuries are at increased risk for adverse mental health outcomes, including newly diagnosed trauma-related disorders and substance use.
SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalPEDIATRICS·DateJun 5, 2023
A new study reveals that diverting streams and rivers for irrigation can significantly extend the time microplastics spend in river catchments. Researchers found a strong link between urbanisation and microplastic concentrations, with microplastic loads increasing downstream of more urbanised areas.
SourceUniversity of Birmingham·JournalWater Research·TypeExperimental study·DateJun 5, 2023
Garmin GPSMAP 67i with inReach
Garmin GPSMAP 67i with inReach provides rugged GNSS navigation, satellite messaging, and SOS for backcountry geology and climate field teams.
A team of researchers used MRI and audio recordings to demonstrate the association between caregiver speech and infant brain development. Infants who heard more words had slower-developing white matter, but eventually showed better linguistic performance when they began to talk.
SourceUniversity of Texas at Dallas·JournalDevelopmental Cognitive Neuroscience·TypeImaging analysis·DateJun 5, 2023
Researchers developed a liquid metal-based stretchable soldering sticker patch to resolve the issue of electrical connection between rigid chips and soft conductors. The technology uses freestanding liquid metal-nanowire composites to create a stable interface, allowing for direct connection between elastic electrodes and hard chips.
SourceSeoul National University·JournalAdvanced Functional Materials·DateJun 5, 2023
Researchers have developed a test to detect 'zombie' cells in donor blood, which may help increase the number of suitable hearts available for transplant. The test targets proteins associated with senescent cells, which can impact heart health.