The Rice University lab has developed a new noninvasive technique, called REMIS, that can measure gene expression and gene therapy delivery in specific brain regions using ultrasound. This technology could revolutionize brain-based gene therapy for neurodegenerative diseases.
A UofL cardiologist is leading a Phase II clinical trial of a new stem cell therapy for heart failure, the first in the US to use intravenous delivery. The trial aims to determine whether one or multiple doses of mesenchymal stem cells improve health and quality of life for patients.
Scientists at Tohoku University create a novel technology to harness ambient low-power RF signals, enabling battery-free operation for electronic devices and sensors. The developed compact spin-rectifier technology converts faint ambient RF signals to DC power.
Researchers found that powerful waves triggered deep within the Earth can cause continental surfaces to rise by over a kilometre. The study explains why parts of continents experience substantial uplift and erosion, forming sweeping elevated regions known as plateaus.
Scientists at St. Jude Children's Research Hospital found a link between a SARS-CoV-2 protein and the onset of multisystem inflammatory syndrome in children (MIS-C). A region of the SARS-CoV-2 nucleocapsid protein shares high sequence and immunogenic similarities to human protein SNX8, sparking an inflammatory response.
Research published in Nature Communications found an association between prenatal exposure to bisphenol A (BPA) and autism in boys. The study suggests that BPA may disrupt hormone-controlled male fetal brain development, leading to autism symptoms.
A Kobe University research team found that insects, specifically camel crickets, act as primary consumers of fruit and dispersers of dust-like seeds. The study confirmed the importance of insects in seed dispersal for light-harvesting plants.
Researchers have made significant progress in understanding the function of APE1 in DNA damage response, showing that it promotes SSB-induced ATM DDR through two mechanisms. The study provides direct evidence for APE1's active role in activating ATM kinase to promote the repair of single-strand DNA damage.
Researchers have identified distinct molecular and immune subtypes across individuals with Down syndrome, providing new insights for personalized medicine approaches. The study's findings could lead to tailored diagnostics and therapeutic approaches, addressing the unique manifestations of co-occurring conditions.
Researchers used synchrotron X-ray tomography to image growth rings in fossilized tooth roots, estimating lifespans and growth rates of early mammals. The study found that the modern mammal growth pattern emerged around 130 million years ago, with earlier animals growing more slowly and living longer.
Researchers found that fishing impacts not only caught fish but also those left behind, causing widespread behavioral change. Single males at fished sites were twice as likely to flee and took two and a half times longer to return to their territories than fish at unfished sites.
Researchers developed a machine learning-based system to analyze satellite data and provide farmers with information on pasture productivity and quality. The approach uses remote sensing and AI-driven processing to gather data on large areas, providing a scale-neutral solution for small- and large-scale farms.
Researchers at Wake Forest University School of Medicine will test a multilevel intervention, FinFit, to address financial hardship among adolescent and young adult cancer survivors. The five-year trial aims to reduce financial burden by targeting education, insurance, and financial asset levels.
Researchers at the University of Buffalo have successfully fabricated the world's highest-performing high-temperature superconducting (HTS) wire segment, achieving critical current density and pinning force values previously unseen. The breakthrough could significantly improve the price-performance metric for commercial coated conducto...
A new study from the University of Surrey found that higher faecal bacterial diversity at one month old is positively associated with the athletic performance of Thoroughbred foals. Lower bacterial diversity in early life also increases the risk of respiratory disease and soft-tissue issues.
Researchers from Stellenbosch University discovered that using work-related content during golf sessions reduces performance, whereas personal activities have little to no effect. The study suggests a clear distinction between leisure and professional use of smartphones in recreational settings.
A new study by Emory University researchers found that increased ventilation in childcare settings may not be effective in preventing flu virus spread. The team used a play-based model using ferrets to study the spread of flu viruses in a setting that closely mimics a childcare venue.
In Illinois, youth emergency room visits for depression and anxiety decreased significantly after the COVID-19 shutdown and plateaued at lower rates. Social media use is believed to be a contributing factor, with increased smartphone usage leading to reduced social interaction and sleep disturbances.
Researchers found a significant spike in fine-particle air pollutant levels after the display, with some areas exceeding 1,000 micrograms per cubic meter, compared to NYC's average daily concentration of 15 micrograms.
A new study published in Cell Reports Medicine found that a ketogenic diet can reduce beneficial gut bacteria and increase unfavorable fats in the blood. The diet, which is high in fat and low in carbohydrates, may have long-term health implications such as increased risk of heart disease and stroke.
Researchers have found that the coevolution between water fleas and a parasitic bacterium has been ongoing for at least 15 million years, preserving genetic diversity. This process, known as balancing selection, ensures that multiple genetic variants for surface molecules are always preserved in the water flea without one ever prevailing.
A new study by Dr. Meir Barneron found that genetically diverse groups outperform homogeneous groups in making collective judgments, suggesting genetic diversity enhances collective intelligence.
Recent studies highlight the vital role of fruits, vegetables, and co-products in preventing chronic diseases. A diet rich in these foods can lower blood pressure, reduce heart disease risk, and improve overall health.
A UC Irvine-led team discovered how the TREM2 R47H genetic mutation causes abnormal protein clumps in brain areas associated with late-onset Alzheimer's disease. The study provides first-of-their-kind insights into the effects of the mutation on gene expression and cellular functions.
A University of Michigan-led study found that higher levels of metals in blood and urine are associated with a greater risk for ALS and shorter survival. Occupational exposure to metals was also linked to increased metal levels, emphasizing the need for accounting for environmental factors when evaluating overall exposure risk.
A study from Michigan Medicine researchers found that over 15 million adult Americans regularly consume herbal and dietary supplements containing potentially toxic liver ingredients. The largest proportion of users took turmeric or green tea supplements, while others used garcinia cambogia for weight loss.
A recent study from Simon Fraser University's Beedie School of Business found that people who express ambivalence about political topics are disliked by those who disagree and those who agree but feel their position isn't strong enough. The study exposes a mismatch between expectation and social reality, suggesting that nuanced positio...
Researchers used WES to identify a novel deletion variant in the DSP gene associated with sudden cardiac death. This finding highlights the importance of post-mortem genetic testing for accurate risk assessment and personalized medicine.
A new poll finds that over 30% of people in their 50s and early 60s provide care to at least one person with a health issue or disability, while 1 in 10 juggle taking care of three or more people. The majority of caregivers are caring for someone with a physical disability or mobility problem, followed by memory or thinking issues.
Researchers discovered that mutations in the SYNGAP1 gene disrupt prolonged human neuron development, leading to accelerated maturation and altered cognitive function. This finding has implications for understanding and treating intellectual disabilities and autism.
Researchers discovered that certain bacteria living inside ticks are essential for their survival and reproduction. These bacteria produce vital nutrients, making them a potential vulnerability in tick populations that could be exploited to control tick numbers and reduce the incidence of tick-borne diseases.
Research from the University of Birmingham found that British society has shifted towards 'situational heroism', where heroic actions and situational awareness are valued over traditional heroic figures. Ordinary people like Darryn Frost and Steve Gallant, who confronted a terrorist attacker, exemplify this new mode of heroism.
A recent study found that type 2 diabetes significantly increases the risk of fractures in older women. The increased risk is thought to be primarily caused by impaired physical function rather than skeletal characteristics.
A recent study published in JAMA Network Open demonstrated the effectiveness of AI in detecting myopia, strabismus, and ptosis using smartphone images. This technology has the potential to facilitate early detection of pediatric eye diseases in a convenient and accessible manner.
New research reveals that diaphragmatic hernia is associated with inflammatory processes involving immune cells, leading to underdeveloped lungs. Scientists have identified specific pro-inflammatory signalling processes and propose a novel therapy using amniotic fluid stem cell extracellular vesicles.
A randomized crossover clinical trial reveals that swapping refined corn flour for a blend of refined corn flour and corn bran lowers LDL cholesterol concentrations by 5-13.3%. The study found significant reductions in LDL cholesterol among 70% of participants who consumed the blend, while whole-grain corn meal had no impact.
A five-year randomized control trial found that diets high in fruits and vegetables lower blood pressure, reduce cardiovascular risk, and improve kidney health. The study also suggests that incorporating fruits and vegetables into treatment plans can be more effective than traditional medication approaches.
This review article sheds light on histopathologic characteristics of ICI-induced myocarditis, highlighting the role of macrophages in diagnosis. Quantifying CD68+ macrophage abundance may enhance diagnostic sensitivity, providing valuable insights into clinical outcomes.
A 10-year follow-up study reports significant and lasting improvement in outcomes with posterior decompression and fixation surgery for patients with Thoracic Ossification of the Posterior Longitudinal Ligament (T-OPLL). Decompression and fixation yielded long-term benefits in neurological function, quality of life, and pain management.
Researchers discovered a monthly treatment that extended the lives of mice by 9%, allowing them to live healthier for longer periods. The treated mice retained their physical function and overall frailty until the end of their lives, unlike controls, which showed significant declines in health.
Researchers at Brown University found that temperature increases enterovirus transmission, with a similar effect seen in polio historically and more recent enteroviruses causing hand, foot and mouth disease. Climate change may lead to increased intensity of outbreaks, particularly in regions with larger seasonal temperature ranges.
A new study warns that exposure to wildfire smoke may lead to increased rates of underlying health conditions among patients undergoing surgery. The researchers hope their findings will inform anesthesia clinicians about the potential impact of wildfire smoke on patient outcomes, leading to better management and reducing complications.
A new study has discovered the world's smallest adult arm bone, dating back 700,000 years, which provides crucial evidence on the evolution of Homo floresiensis. The fossil, found at Mata Menge in Indonesia, suggests that early humans were even smaller than previously thought.
Researchers developed a novel clustering technique that considers both basic characteristics and target material properties, enabling the categorization of over 1,000 oxides into material groups. This approach uses machine learning to predict target properties and incorporates basic feature information into the analysis.
A recent study found that behavioral nudges in social media ads had limited ability to encourage COVID-19 vaccination across countries. Nudge ads with messages appealing to norms and family/ community protection performed better than placebo ads, but only in certain contexts.
A new study by the University of Vienna found that visiting an art exhibition can reduce xenophobia and increase acceptance of immigration. Participants reported increased social awareness and empathy, which lasted for up to a week after their visit.
A new editorial published in Aging suggests that starting targeted cancer therapies with high concentrations may slow down the selection for resistance. This approach could potentially be used as a preemptive measure to minimize the development of resistance.
Mark Lumley, a distinguished professor at Wayne State University, received the 2024 Nathan W. Perry Jr. Award for Career Service to Health Psychology. He was recognized for his decades-long contributions to the field of health psychology, particularly in chronic pain disorders.
Research reveals that social determinants such as access to healthy food, health insurance, and physical activity spaces are key drivers of obesity disparities. Successful interventions like community-based programs can reduce disparities, but more work is needed to expand these initiatives at local, state, and national levels.
Researchers at Linköping University have created soft electrodes made of gold nanowires and silicone rubber, capable of stimulating nerve signals and capturing electrical signals. The material is expected to last for at least three years and has potential applications in medical devices.
Researchers analyzed data from 63,700 patients in five clinical trials to understand the impact of clonal hematopoiesis of indeterminate potential (CHIP) on heart disease. They found that patients with CHIP had a 30% higher risk of initial heart attacks but not recurrent events.
Researchers develop a general strategy for fabricating vertically stacked skin-like active-matrix displays, eliminating obstacles in existing parallel structures. This approach enables the creation of high-quality AMOLEDs with ultrahigh aperture ratios and improved resolution.
Studies in mice reveal that orexin plays a key role in deciding between physical activity and consuming food, particularly when both options are available. By understanding this process, scientists aim to develop strategies to overcome exercise barriers and address the global obesity epidemic.
A new study by SMU seismologists confirms that earthquakes in the Permian Basin occurring before 2017 were causally linked to underground wastewater injection. The study uses advanced earthquake location methods to reveal a spatial and temporal correlation with shallow injection activities since 2009.
Researchers found that six clam species co-occurring in a single burrow are all yoyo clams, contradicting the competitive exclusion principle. In laboratory experiments, host-attached clams were killed by mantis shrimp, while burrow-wall clams were unaffected.
A new approach incorporating machine learning and a novel radar technique has solved the 'cloud cover' problem in remote sensing, improving land surface temperature tracking accuracy. This is achieved by combining better elevation models with multiple radar echoes from SAR images to reconstruct optical data.
Researchers question the effectiveness of new amyloid immunotherapy drugs in reducing Alzheimer's disease impact, citing limited eligibility and high costs. The drugs showed small effect sizes that may not outweigh the risk of adverse events.
This review article delves into the production methods of nanofibers, including centrifugal jet spinning, plasma-induced synthesis, and solution blow spinning, to enhance drug delivery. Nanofibers' extensive surface area relative to their volume makes them valuable for numerous applications.
Scientists have developed a new compound, ZTA-261, which selectively binds to the thyroid hormone receptor beta (THRβ) to treat lipid disorders. Mice administered the drug showed decreased lipid levels in the liver and blood with fewer side effects compared to existing compounds.
The International Olympic Committee should sever its ties with Coca Cola to promote athlete health and sustainability, despite the brand's lucrative sponsorship deal. The IOC's continued association with Coca Cola puts the Games at risk of being complicit in global epidemics of poor nutrition and environmental degradation.