A pioneering study demonstrates the feasibility of treating SMA prenatally using risdiplam, a drug administered to an expectant mother during pregnancy. No identifiable features of SMA have been observed in a 2.5-year-old child, suggesting a promising outcome for future research.
The FDA has approved vimseltinib, a targeted therapy, for treating symptomatic tenosynovial giant cell tumor (TGCT). Vimseltinib demonstrated significant reduction in tumor volume and improvement in quality of life for patients, with fewer side effects compared to pexidartinib.
The number of US work stoppages decreased by 23.8% in 2024 compared to the previous year, with a notable drop in one-day strikes. The approximate number of workers involved in stoppages also declined by 45.5%.
A new experimental concept called ultrafast vortex electron diffraction allows for direct visualization of electron movement in molecules. This technique effectively isolates coherent electron dynamics, enabling deeper insights into energy transfer and material behavior.
Global glacier melt accelerated over the last decade, with a 36% increase in meltwater compared to the previous decade. This poses significant risks to drinking water supplies, particularly in South America and Asia due to rising sea levels and increased flooding after the melt season.
Assistant Professor Tova Holmes at University of Tennessee Knoxville received a $75,000 Sloan Research Fellowship for her work on searching for new fundamental particles using colliders in high-energy particle physics research.
The Columbia Climate School has launched a one-year master's degree program in Climate Finance, combining courses in climate science, adaptation, mitigation strategies, international climate finance, capital markets, and more. The program aims to equip students with financial decision-making skills needed to respond to the climate crisis.
The University of Texas MD Anderson Cancer Center received nearly $23 million in CPRIT funding to advance cancer research, translational science, and clinical trials. The funding will support the recruitment of a first-time tenure-track faculty member and enhance the understanding of cancer biology.
A new study by Connecticut College reveals that palm trees once thrived in subarctic Canada during the late early Eocene, approximately 48 million years ago. This finding indicates a warmer climate with ice-free winters, unlike previous assumptions.
UTA research projects contributed $59 million to the national economy in 2024, supporting student development and collaboration with other research organizations. The university's research infrastructure, including cutting-edge equipment, helped drive economic impact in North Texas and beyond.
A new study suggests that a menthol cigarette ban could be less effective due to the emergence of an illegal market. The research found that demand for menthol cigarettes would remain high even with limited access to e-cigarettes, leading to a significant black market. This could blunt the intended public health benefits of the ban.
A study published by the American Academy of Neurology found that smoking is a key factor in unexplained strokes among younger adults. Researchers discovered that heavy smokers had nearly four times the risk of stroke compared to non-smokers, with the highest risk seen in male participants and those aged 45-49.
Researchers at WashU created a new model that uncovers brain mechanisms behind focusing amid distractions, finding people ignore past distractions but stay open to other inputs. The model demonstrates attention control by modulating focus on distractors and target tasks.
Kimberly Stegmaier appointed as Chair of Pediatric Oncology at Dana-Farber Cancer Institute and Associate Chief of Division of Hematology/Oncology at Boston Children's Hospital. She will focus on acute leukemias and pediatric solid tumors, pioneering genomic approaches to identify new therapies for childhood cancer.
A new study reveals US hospital occupancy has surpassed pre-pandemic levels, driven mainly by a 16% reduction in staffed hospital beds. This could lead to a bed shortage as early as 2032, posing significant risks to patient safety and mortality rates.
Researchers found that large language models use a semantic hub mechanism to process diverse data, integrating information from various modalities. They demonstrated that models can change their outputs by intervening with text in the dominant language, even when processing other languages.
Researchers at Yale University have created a new method for converting industrial carbon dioxide into a renewable fuel, namely methanol. The breakthrough involves a two-step chemical reaction and demonstrates the potential for large-scale industrial applications.
Researchers have used CRISPR gene editing to study the regulation of the Unusual Floral Organs (UFO) gene in plants, uncovering the importance of conserved non-coding DNA sequences in controlling flower formation.
A new study of over 1400 adults found loot box buying associated with real-world gambling, video gaming addiction, and mental health issues. Researchers highlight the need for regulations to address this growing concern.
A new study reveals that asymptomatic neonatal HSV infections in mice can lead to persistent CNS infection and long-term cognitive decline. Maternal vaccination may prevent this cognitive impairment, suggesting a potential strategy for reducing neurological damage in infected offspring.
Researchers at Incheon National University have pioneered a novel resonant tuning rectifier (RTR) for parallel compensated receivers in wireless power transfer. The RTR enhances efficiency via dynamic frequency adaptation, reducing circuit impedance and minimizing interference with other devices.
A new study reveals that dust storms are associated with a heightened risk of asthma, culture-negative pneumonia, and other health conditions. The research found an increase in emergency department visits for these conditions in three Southwestern U.S. states between 2005 and 2018.
A long-term study found that Roux-en-Y gastric bypass outperforms sleeve gastrectomy in treating obesity, with patients losing more excess body mass index. The Swiss Multicenter Bypass or Sleeve Study demonstrated the superiority of Roux-en-Y gastric bypass over sleeve gastrectomy for patient weight loss.
A new laser-based device can analyze gas samples with high precision, detecting molecules at minute concentrations. The technology has potential applications in medical diagnostics, tracking greenhouse gas emissions, and more.
Record-breaking temperatures and devastating floods ravaged Southern Appalachia in 2024, claiming lives and destroying homes. The region faced unpredictable conditions, including scorching heat and heartbreaking losses from flooding.
Thousands of Medicare beneficiaries developed postoperative infections up to six months after coronary artery bypass grafting or aortic valve replacement. Women had a 60% greater odds of developing infections, including urinary tract, pneumonia, and sepsis.
A study published in The Journal of Immunology found that supplementing maternal diet with vitamin E during pregnancy can reduce the development of food allergy and anaphylaxis in newborn mice. This potential breakthrough could help address the alarming increase in peanut allergy among children.
A study published in Mayo Clinic Proceedings found that patients who can exercise during cardiac stress testing have a lower mortality rate than those who cannot. The researchers discovered that assessing a patient's ability to exercise during testing provides a stronger distinction between high- and low-risk patients.
Researchers have developed two therapeutic cocktails that inhibit key molecules, stopping immune cells from overreacting to allergens. The treatments reduced asthma attacks in mice by erasing the immune system's memory of asthma-causing allergens.
Plastic Back and a US-based recycler partner to scale low-temperature chemical recycling technology converting hard-to-recycle plastics into valuable byproducts. The partnership aims to address the global plastic waste crisis, reducing landfill waste and dependency on virgin raw materials.
A new device has been designed to effectively treat cerebral venous sinus thrombosis (CVST) by navigating complex venous anatomy and removing large thrombi. The device features controllable axial and longitudinal maneuverability, improving clinical outcomes for patients with CVST.
A Canadian study of over 2,500 adolescents and young adults found that supplement users are more likely to experience muscle dysmorphia. The study suggests a potential link between muscle-building supplement use and the development of this condition.
An international team of researchers has created a detailed map of individual cells in the adult lung, including those affected by chronic lung disease. The AI-driven finding shows that some lung tissue in patients with idiopathic pulmonary fibrosis (IPF) exhibits signs of the disease before significant structural changes occur.
A study published in the journal Memory found that intoxicated people have difficulty accurately recalling internal facial features, while still remembering external details like hair style. This suggests that alcohol narrows attention to more noticeable external features, impairing memory for critical internal features.
UT Health San Antonio has earned the prestigious Research 1 designation from the American Council on Education and the Carnegie Foundation for its exceptional research expenditures and number of doctoral degrees awarded. The institution has made significant strides in biomedical discovery, medical education, and economic growth.
A synthetic retinoic acid-inducible gene I (RIG-I) agonist RNA has been shown to induce innate immune signaling and death of hepatocellular carcinoma cells in vitro. The addition of recombinant interferon-b potentiated this cell death, suggesting a potential new mechanism for treating patients with liver cancer.
Researchers develop dual-stage E+S-band bismuth-doped fiber amplifier for next-generation optical communication systems. The device achieves unprecedented broad bandwidth, high gain and low noise, making it suitable for boosting optical signals.
Researchers developed innovative RE³⁺-doped monolithic glasses capable of tunable full-color emission under NIR laser excitation. These glasses overcome key obstacles faced by existing technologies and demonstrate the potential as materials for dynamic, full-color laser-based volumetric displays.
A study found that emergency clinician prescribing of buprenorphine increased in California, leading to more patients starting treatment for opioid use disorder. The efforts were successful in getting patients started, with at least one in three filling a second prescription within 40 days.
Ketamine has been shown to rapidly reduce depressive symptoms in patients with treatment-resistant depression, often within hours of administration. However, the long-term efficacy and safety of ketamine therapy remain uncertain, with potential risks including cognitive impairment and cardiovascular effects.
Research advances higher-order networks to capture multi-agent interactions, enabling accurate modeling of biological, social, and physical systems. The Dirac-Bianconi operator provides a powerful generalization of the graph Laplacian, encoding local and global interactions across different topological dimensions.
Researchers have discovered double negative memory B cells, a novel subset of immune cells that are more dysfunctional when in close contact with tumors. These cells may be a useful diagnostic marker and a potential target for developing new immunotherapies.
Researchers at UCSF have identified unique, cancer-specific proteins created through mistakes in RNA splicing. These antigens could be used to create potent immunotherapies that recognize and attack hard-to-treat tumors. The discovery offers new hope for glioma patients and expands the number of targets available for cancer therapy.
Researchers discovered a genetic mutation that increases glycine decarboxylase enzyme, linked to schizophrenia behaviors in mice. The study provides a direct genetic link to psychosis and sheds light on the biochemical pathways involved.
Three early-career scientists, Dr. Omar Abudayyeh, Dr. Caleb Lareau, and Dr. Yuzhong Liu, are awarded $150,000 grants for their innovative research on human immunology, vaccine discovery, and cancer immunotherapy. Their proposals aim to advance our understanding of the immune system and develop new treatments for deadly diseases.
A study by NYU Abu Dhabi researchers found that children from the Fulani group have a distinct immune response to malaria, with key differences in immune cell activity offering greater protection. The study highlights the impact of genetics and lifestyle on immune responses.
Stanford researchers have developed a practical and low-cost method to remove atmospheric carbon dioxide from the air using common minerals. The new process, known as enhanced weathering, uses heat to transform silicates into materials that capture and store CO2, offering a potentially scalable solution to mitigate global warming.
Fossil discovery in Australia rewrote the evolutionary history of theropod dinosaurs, revealing a predator hierarchy unique to Cretaceous Australia. The findings showcase the world's oldest known megaraptorid fossils and the first evidence of carcharodontosaurs in Australia.
A pilot study shows that a text messaging system can safely reduce the amount of time some patients spend receiving cancer treatment. The platform, which was tested in a clinical trial, allowed patients to complete symptom checks and receive approval for fast-tracking their treatments, saving them over an hour per visit.
Cancer cells work together to source nutrients from their environment, a cooperative process that can be targeted for treating cancer. Researchers identified key enzymes and mechanisms behind this cooperation, including the enzyme CNDP2, which can be inhibited by the drug bestatin.
Researchers at Newcastle University have developed a new environmentally-friendly mortar made from recycled plastic and silica aerogel, which improves insulation and reduces plastic waste. The new mortar mix reduced heat loss by up to 55% while maintaining the required strength for masonry construction.
A representative study of adults experiencing homelessness in California found a high proportion of current drug use and unmet need for treatment. Improving access to treatment tailored to their needs could improve outcomes.
Professor Kazunari Domen's research develops novel materials and techniques for efficient solar energy harvesting and scalable hydrogen production. His work enables the successful development of large-scale solar-driven hydrogen production units, paving the way for a clean energy future.
Advances in orbit determination using GNSS observations and inter-satellite ranging enhance accuracy and computational efficiency for large LEO constellations. The research introduces stepwise autonomous methods reducing computational burden while improving precision.
A new study finds that US hospital staffed beds have decreased by 16%, leading to a potential national bed shortage. The US could reach an 85% occupancy rate as early as 2032, with some states at higher risk than others.
A consortium of researchers and hospitals in Madrid has created a children's exoskeleton for domestic use, enabling children with gait impairments to walk at home or outdoors. The prototype features four motors that mimic natural muscle function and adapts to the child's growth.
A large-scale study examined the relationship between nutrients and sleep using data from people who used mobile applications to track their eating and sleeping habits. The results showed that participants with high protein, monounsaturated fatty acid, and polyunsaturated fatty acid intake had improved sleep outcomes.
The Dark Energy Spectroscopic Instrument (DESI) has discovered a treasure trove of actively feeding black holes in small galaxies, revealing surprisingly few are of intermediate mass. The team identified 300 new intermediate-mass black hole candidates and 2500 active black holes in dwarf galaxies.
A new classification system for SJS/TEN divides the disorder into five types based on causative factors and diagnostic algorithms. This typology aims to bring clarity to diagnosis and treatment by providing consistent criteria for identifying underlying causes.
Physicists from ISTA reveal that the contact history of materials determines how they exchange charge, explaining the unpredictability of contact electrification. By analyzing identical materials, they discovered a triboelectric series and found that repeated contact allows samples to evolve and order correctly.