Researchers at NIT Puducherry unveiled an energy-efficient model predictive current control (MPCC) method that enhances induction motor drive performance in electric vehicles. The CSVVV-based MPCC introduces a novel way to synthesize voltage vectors, reducing switching losses and current ripple.
A team of researchers identified a unique protein signature that can predict which patients are likely to resist standard therapies, paving the way for personalized treatments. By blocking a specific transporter system, they made tumors more sensitive to treatment, suggesting a promising new avenue for treating colorectal cancer.
A team of scientists has created a detailed model of how cells regulate traffic through the nuclear pore complex, revealing that flexible protein chains create an entropic barrier that admits only properly escorted cargo. This breakthrough sheds light on diseases like cancer, Alzheimer's, and ALS, where this transport system fails.
A new control strategy for hybrid magnetic bearing systems is proposed, employing an improved cascaded reduced-order linear active disturbance rejection controller. The strategy significantly enhances rotor suspension stability by employing feedforward compensation, reducing displacement fluctuations and improving system robustness. Ex...
AI accelerates pathogen evolution prediction and enables new target discovery, facilitating efficient compound design and optimization. This technology compresses the development cycle by focusing on key applications like phenotype-driven target identification and validation.
Research reveals that even native ecosystems can't adapt to extreme drought conditions, leading to significant impacts on plant growth and productivity. Productivity declines by up to 77% in four years under consecutive extreme droughts.
A sub-study of KEYMAKER-U03 found pembrolizumab-based triplet combinations to be effective in treating advanced renal cell carcinoma, with an objective response rate of 78% and a median progression-free survival of 31.8 months. The most promising combination included pembrolizumab, belzutifan, and lenvatinib.
Patients receiving mRNA-based COVID vaccines showed improved survival rates and responses to immunotherapy, especially in 'cold' tumors with low PD-L1 expression. The study suggests that these vaccines can reprogram immune responses against cancer, potentially improving outcomes for patients with treatment-resistant disease.
A recent study found that patients with advanced lung and skin cancer who received a COVID-19 mRNA vaccine within 100 days of starting immunotherapy drugs lived significantly longer than those who did not get the vaccine. The observation marks a significant step toward a long-awaited universal cancer vaccine to boost tumor-fighting eff...
The VT3989 trial demonstrated a disease control rate of 86% in refractory mesothelioma patients, with notable partial responses and stable disease. The YAP-TEAD inhibitor also showed an encouraging safety profile, supporting continued clinical development in this unmet clinical need.
A clinical trial showed a new drug combination reduced deaths in patients with recurrent prostate cancer after surgery or radiation therapy. The combination of hormone therapy and enzalutamide cut the risk of death by 40%, offering a meaningful treatment option for high-risk patients.
A new antibody drug conjugate (ADC) sacituzumab govitecan has been shown to improve progression-free survival in patients with advanced triple-negative breast cancer who are ineligible for immune checkpoint inhibitors. The ADC targets the protein Trop2 on TNBC cells and delivers a potent chemotherapy drug directly to tumor sites.
The European Society of Endocrinology has published a new Clinical Practice Guideline for the Management and Evaluation of Menopause and the Perimenopause. The guideline provides guidance on evaluating and managing women with menopause-related symptoms, including hormone therapy benefits and risks. It also discusses alternative treatme...
A novel cofactor engineering approach using phosphite dehydrogenase enables the scalable and efficient biosynthesis of lactate-based copolymers in Escherichia coli. The method yields higher yields of poly(3-hydroxybutyrate-co-lactate) without disrupting bacterial growth, paving the way for sustainable bioplastic manufacturing.
A Phase II clinical trial led by researchers at the University of Texas MD Anderson Cancer Center demonstrated significant tumor shrinkage and disease control in patients with advanced pheochromocytoma and paraganglioma. Belzutifan showed a 26% objective response rate, with sustained clinical benefits for those who responded to treatment.
A phase 3 study found that giredestrant plus everolimus significantly improved progression-free survival in patients with ER-positive, HER-2-negative advanced breast cancer. The treatment combination reduced the risk of disease progression or death by 63% in patients with ESR1 mutations.
A randomized trial found that patients with metastatic clear-cell renal carcinoma lived longer without disease progression when treated with lenvatinib and everolimus compared to cabozantinib. The study suggests that lenvatinib plus everolimus may offer a more meaningful benefit as second-line treatment for these patients.
A new class of anti-cancer agents—antibody-drug conjugates (ADCs)—has unveiled compelling evidence that can dramatically improve outcomes for patients with early-stage HER2-positive breast cancer. The phase III DESTINY-Breast05 and DESTINY-Breast11 trials have shown superior efficacy and improved disease-free survival rates, positionin...
A study combining DNA barcoding and production/trade data identifies global freshwater eel consumption patterns, revealing over 99% of global consumption consists of three threatened species. East Asia emerges as the global center for eel consumption driven by cultural preferences and purchasing power.
A new study from SFU's School of Sustainable Energy Engineering (SEE) has proposed an innovative standardization framework to address the long-standing inconsistencies in testing indoor solar technology. The framework aims to provide accurate performance characterization, reporting, and benchmarking for indoor photovoltaics, enabling r...
Researchers developed efficient deep-blue light-emitting diodes (PeLEDs) using colloidal CsPbBr3 nanoplatelets, achieving record-breaking performance with a maximum external quantum efficiency of 6.81%. The devices also exhibit stable deep-blue emission and precise color coordinates that fully satisfy the stringent Rec.2020 requirement.
A new artificial intelligence model developed by the URV team combines clinical and magnetic resonance data to predict breast cancer recurrence with high accuracy. The model identifies key factors such as tumour texture, symmetry between breasts, and hormone receptor status to make predictions.
Researchers developed a clean process to transform microalgae and agricultural residues into biofuels, bio-adsorbents, and fluorescent carbon nanodots. The study offers a sustainable way to reuse biomass resources, contributing to renewable energy production and environmental protection.
Artificial materials with subwavelength structures enable shrinking optical setups onto tiny chips. Meta-surfaces manipulate fundamental light properties, boosting photon pair generation efficiency. This allows for on-chip quantum light sources, single-photon detection, and ultra-precise quantum metrology sensors.
A new analytical framework separates how nitrogen moves through three key hydrological pathways—surface flow, subsurface flow, and baseflow—and found that each pathway behaves differently across landscapes and seasons. The study offers crucial guidance for policymakers to adapt strategies to reduce nitrogen loss.
Recent studies from Sylvester have uncovered links between breast cancer, Superfund sites and social adversity. Researchers are also exploring the use of artificial intelligence (AI) in interpreting mammograms more accurately.
A new monoclonal antibody has shown dose-dependent full protection against the malaria parasite with minimal side effects. Researchers found that a single injection of the antibody could provide months-long protection, offering a fundamentally different way to prevent infection before it starts.
Kevin Bowers, CSO of Jump Trading, joins the Hertz Foundation Board of Directors bringing his experience in high-performance computing and finance. He credits the foundation with helping him earn his degrees and recognizes the importance of community and mentorship.
The Hertz Foundation has elected three new members to its board of directors, including Kevin Bowers, Sri Kosaraju, and Jordan Chetty. The new board members bring diverse experience in national security, biotechnology, and finance.
McGill researchers have found that Montreal's methane emissions are unevenly distributed across the island, with the highest concentrations in the city's east end. The study identified over 3,000 hotspots and found that inactive landfills and natural gas leaks are major contributors to the pollution.
The LiteRBS algorithm outperforms classical algorithms like A* and Bidirectional A*, scaling well even in large or dense maps. It achieves fast and memory-efficient pathfinding through an aggressive bidirectional forward search with a reserve-queue fallback strategy.
SourceELSP·JournalRobot Learning·TypeComputational simulation/modeling·DateOct 17, 2025
Sri Kosaraju, former Inscripta CEO, has been elected to the Hertz Foundation Board of Directors. He brings a wealth of experience in technology, life sciences, and healthcare to the role. Kosaraju aims to contribute his expertise to support fellows in these areas and expand the foundation's impact.
Jordan Chetty, a Ph.D. in electrical engineering from UC Berkeley, has been elected to the Hertz Foundation Board of Directors. He aims to expand the organization's impact through community engagement and connection-making.
Researchers developed innovative blood-based biomarkers to predict long-term blood pressure improvements after bariatric surgery. The study analyzed pre-surgery blood tests and identified top 10 molecules linked to improved blood pressure outcomes.
Researchers highlight the importance of designing 'human-in-the-loop' systems with expert input for AI model training and validation. Machine learning models offer more interpretable results, but generative AI requires robust safeguards to protect patient data.
Researchers at Shandong University and Zhengzhou University introduce a new design principle for ultra-high-performance ceramics by incorporating nitrogen into (Ti, Zr)C carbide ceramic. This reduces stacking fault energy, unlocking a previously suppressed toughening mechanism that significantly improves both hardness and toughness.
A new study from Iceland's Surtsey island reveals that birds played a crucial role in colonizing the island by carrying seeds in their guts or droppings. This challenges traditional beliefs about plant dispersal, highlighting the importance of bird-animal interactions in shaping ecosystems.
Researchers found a protein that lets cancer cells reshape their mitochondria to protect themselves from venetoclax, a standard treatment for acute myeloid leukemia. Blocking this protein with experimental compounds restored the drug's effectiveness and prolonged survival in mice.
Researchers from Poland, USA, and Slovenia found a mathematical description of stalagmite shapes, revealing that shape matters for climate science. The study provides an analytical solution for the growth of ideal stalagmites in constant cave conditions.
A study found that preexisting hyperlipidemia in pregnancy is associated with heightened risks of obstetric complications and early cardiovascular events postpartum. Women with high cholesterol are at increased risk of arrhythmias, acute coronary syndrome, gestational diabetes, and labor delivery complications.
Researchers found that overactive Runx1 gene accelerates age-related degeneration of intervertebral discs, causing premature cellular aging and unhealthy tissue changes. Targeting Runx1 may be a promising strategy to prevent or slow disc aging.
Dr. Sandra Shi has been recognized as a 2025 STAT Wunderkind for her innovative research using national Medicare claims to create a frailty index, which measures the health status of older adults. Her work aims to predict how people will respond to surgeries and medications, tailoring treatment based on results.
A new study reveals that limiting temperature overshoot can prevent hundreds of thousands of premature deaths while avoiding trillions of dollars in economic damages. The research found significant health benefits by improving air quality, particularly in regions with high population density.
Scientists have found that environmental coatings on microscopic plastic particles can bypass some skin cells' defenses, allowing them to stay inside the body longer. This highlights the importance of studying the interaction between nanoplastics and human skin, as well as the potential health risks associated with these tiny particles.
Researchers developed a new human brain tissue platform called miBrains, integrating all major brain cell types and modeling brain structures, cellular interactions, activity, and pathological features. The models can be customized through gene editing and are derived from individual patients' genomes.
A global study by the University of Jyväskylä found that our most emotionally resonant music comes from our teenage years, peaking around age 17. This 'reminiscence bump' helps explain why songs from adolescence remain meaningful even decades later.
Researchers from Donghua University introduce electrospun ceramic nanofiber-based aerogels (ECNFAs) offering a transformative approach to designing lightweight, flexible, and multifunctional ceramic frameworks. These materials bridge the gap between structural performance and functional versatility.
Dr. Kathryn Colby, NYU Langone Health's chair of ophthalmology, has received the prestigious Castroviejo Medal for her pioneering work on Fuchs endothelial corneal dystrophy. Her research explores a new surgical procedure to stimulate corneal regeneration.
The new German center, Instruct-DE, joins pan-European distributed research infrastructure Instruct-ERIC to make high-end technologies freely available to researchers across Europe. Partner institutions include top-tier German research centers, enhancing European collaboration in structural biology.
The new Global Multidimensional Poverty Index (MPI) report finds that nearly 8 in 10 people living in multidimensional poverty are directly exposed to climate hazards. Exposure to these hazards exacerbates daily challenges faced by poor people, reinforcing their disadvantages.
Stroke survivors' lived experiences reveal key factors that shape their physical and emotional wellbeing during recovery. The study highlights the importance of integrating lived experiences in stroke research to improve care models.
The National Champion Tree Program at the University of Tennessee Institute of Agriculture has compiled a compilation of more than 80 years of big tree history. The program marks two years at the university after moving in 2023 and is still taking nominations for potential trees through December 1.
Researchers from the University of Göttingen have identified oxygen isotopes in 'cherts' as indicators of heat flow on early Earth. The study reveals that cherts record paleo-heat flow on the Shatsky Rise oceanic plateau, providing insights into the conditions on the Earth's surface up to 3.5 billion years ago.
A joint research team found that countries with stricter environmental regulations see increased sales of green products like electric vehicles. This challenges the traditional 'pollution haven' hypothesis and suggests a link between strong regulations and eco-friendly product competitiveness.
Researchers discovered a gain-of-function mutation in the TREM2 gene that impairs microglial function and increases risk for Alzheimer's disease. The study found that female mice with the T96K mutation had reduced microglial activity, leading to increased amyloid beta accumulation.
Researchers discovered that neurons in the brain's auditory cortex show large bursts of activity tied to specific moments in a task, suggesting a deep connection between behavior and sound processing. This 'tuning' mechanism enables the brain to produce smaller but more distinctive responses to sounds guiding task performance.
Researchers Tsvi Tlusty and Jean-Pierre Eckmann found a simple recipe to return rotating systems precisely to their starting point by rescaling the driving force and applying it twice. This discovery reveals that even complex rotations conceal a fundamental order, ensuring there is always a way to reset the system.
A new poll found that 67% of U.S. adults believe students should have access to plant-based meals and nondairy beverages in schools. Plant-based meals can help fight obesity, type 2 diabetes, and early signs of heart disease.
A Cornell University study found that middle school-age Cherokee students cited cultural activities, financial privilege, and substance abuse as common stereotypes about themselves or other Native Americans. The research highlights the importance of understanding prevalent stereotypes to support students' development and counter them.
Researchers at WVU are enhancing the calibration of radio telescopes to measure dark energy by analyzing the '21-centimeter signal' from neutral hydrogen atoms. This technique aims to improve the ability of radio telescopes to detect large-scale structures in the universe, such as galaxy clusters and voids.