A team led by Prof. Orna Amster-Choder will investigate rapid physical and chemical changes in bacterial cells to adapt to stress, challenging traditional assumptions about gene expression.
Neutron scattering reveals a new type of protein motion that depends on the surrounding environment within assemblies. The observed behaviour, known as non-Fickian diffusion, shows that molecular motion can no longer be described by a single uniform rule across the whole system.
Researchers will use DNA-encoded chemical libraries and artificial intelligence to screen hundreds of millions of potential drug compounds, identifying those most likely to succeed in treating Alzheimer's. The project aims to shorten the timeline for identifying new treatments, bringing them to patients faster and with greater precision.
A new study reveals that bacteria can actively limit the spread of antibiotic resistance genes by deploying molecular gatekeepers called YokF. This mechanism blocks the transfer of beneficial genes, giving microbes a competitive advantage in dense microbial communities.
Researchers found that black grouse can't see dark shades of red and have limited visual contrast, making certain colors ineffective at warning them away from fatal cables. To mitigate this risk, they recommend using large, strongly contrasting markers to provide enough time for the birds to react.
Researchers developed a sequential error-robust FISH spatial mapping platform to profile complex microbial communities at single-cell resolution. The platform enabled autonomous execution and revealed structured microbial clustering and species co-occurrence patterns.
A cross-sectional study of patients with de novo metastatic breast cancer found racial and ethnic disparities in disease presentation. De novo metastatic breast cancer disproportionately contributes to breast cancer mortality in the U.S., emphasizing the need for tailored interventions to improve care delivery and outcomes.
Tirzepatide significantly reduces cardiovascular risk in high-risk patients, including those undergoing percutaneous coronary intervention (PCI) and transcatheter aortic valve replacement (TAVR). The study found tirzepatide consistently reduced major adverse cardiovascular events and mortality across multiple time points.
A new study transforms apple pomace into valuable bioethanol and animal feed ingredients through SHF and SSF. The research highlights the potential of agro-industrial waste as a renewable energy source and nutritious food supplement.
A new analysis of a major clinical trial found that vitamin D supplementation reduced diabetes risk in prediabetic adults with certain variations in the vitamin D receptor gene. The study suggests personalized medical care could delay or prevent diabetes onset for millions of Americans living with prediabetes.
Muscle size, strength, and performance can be improved without exhausting exercises. Eccentric exercises, which involve lengthening muscles during movement, generate more force with less energy than traditional exercises.
A cross-sectional study found no association between longer breastfeeding duration and cognitive performance in unadjusted models, however, a positive correlation emerged after controlling for socioeconomic factors. Longer breastfeeding durations were more common among low-income families, highlighting the need for continued support.
Researchers at the University of Melbourne have uncovered the formation process of the Twelve Apostles, revealing that tectonic plate movements lifted and tilted the giant structures out of the sea. The study found that the Apostle's age is actually younger than previously thought, with layers dating back to 8.6-14 million years.
A cross-sectional study found intestinal Candida albicans abundance correlates with subclinical coronary atherosclerosis in metabolic dysfunction-associated steatotic liver disease. Cirrhosis patients showed higher Candida albicans levels and more severe atherosclerosis.
Hyperbaric oxygen therapy (HBOT) exhibits dual effects in glioblastoma management, enhancing radiosensitivity and chemotherapy efficacy while promoting tumor progression. HBOT normalizes the tumor microenvironment via vessel normalization and immune cell modulation, attenuating cancer stem cell properties.
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
Researchers at NTNU have developed a model that calculates which high-speed passenger routes can be operated with zero-emission express ferries. The study shows that a combination of batteries and fuel cells is necessary to meet the goal, emphasizing the importance of smart energy management.
Transcatheter arterialization of the deep veins (TADV) significantly improves quality of life in patients with severe CLTI, reducing concerns about poor circulation and daily activities. Six months post-procedure, patients showed a 50% reduction in circulation concerns, improved sleep patterns, and reduced foot wound symptoms.
A new transcatheter mitral valve replacement (TMVR) procedure has shown significant benefits for patients with severe mitral regurgitation, reducing symptoms and improving quality of life. The study found that the treatment sustained clinical improvements over one year, with no major complications.
Researchers found that patients with single-vessel runoff maintained excellent patency through three years, and could safely benefit from minimally invasive treatment. The study results showed no significant difference in outcomes for patients with one or more vessels running blood to the lower leg.
Metabolic dysfunction-associated steatotic liver disease (MASLD) affects approximately 32% of the US adult population. Obesity was identified as the strongest independent MRF among Asians, Whites, and Hispanics, particularly in individuals younger than 50 years, whereas hypertension was the strongest independent MRF in Blacks.
A new sub-study suggests that using a sirolimus-eluting balloon can reduce the number of stents needed, making it a safe and effective way to treat certain heart attacks or unstable chest pain. At one year, the rates of target vessel failure and cardiac death were low and similar between the two groups.
A registry analysis found that while men and women with acute myocardial infarction-related cardiogenic shock differ in treatment options, clinical decisions are driven by objective markers of illness severity rather than sex. The study suggests significant differences in how treatment options are discussed with patients and caregivers.
The CERAMICS registry found that most patients survived hospital discharge, with 71% overall survival and 60% of those in the most severe stage E shock. Early use of a small heart pump improves outcomes in patients experiencing cardiogenic shock after a heart attack and stenting procedure.
A recent study found that people with higher isoflavone consumption experienced fewer breathing-related symptoms and improved lung health. Isoflavones, commonly found in legumes and soy-based foods, may play a key role in reducing COPD symptoms.
The Keck School of Medicine of USC and Tempus are creating a system-wide framework to integrate clinical care, clinical trials, and research through AI-powered precision medicine tools. The goal is to enhance patient care and accelerate research and innovation.
A national study found that people with severe strokes have a five times higher odds of developing dementia. Stroke severity also affects thinking and memory after stroke, highlighting the need for close monitoring and treatment of dementia risk factors.
A study mapped early molecular and cellular changes in the jaw joint that may trigger temporomandibular joint osteoarthritis. The research found structural and molecular changes in joint tissues, including inflammation, fibrosis, and metabolic shifts. Single-cell sequencing revealed diverse cell populations interacting within the synov...
A UC San Diego study found that diabetes is associated with changes in biological signals in the blood linked to Alzheimer's disease and brain damage in Latino adults. Researchers suggest that metabolic health may play a role in shaping future dementia risk.
The study found that the Turkana Rift has been significantly thinned, with the crust about 13 kilometers thick, compared to over 35 kilometers farther from the rift. This thinning is a sign of a process called 'necking' where the crust stretches and becomes weaker, promoting continued rifting.
Researchers developed nanoribbons with tailored electronic properties, enabling flexible electronics, ultra-small circuits and more efficient solar cells. The discovery paves the way for unprecedented control in next-generation technologies.
Researchers discovered a massive magma intrusion on São Jorge Island in the Azores, which stalled just 1.6km below the surface, avoiding an eruption. The study used seismometers and satellite data to reconstruct the underground movement of magma, revealing how it rose through a main fault system.
Researchers have identified a single genetic change that drives the development of myeloid leukaemia in children with Down Syndrome. The study reveals a common vulnerability and treatment target, suggesting potential repurposed treatments. The genetic change, related to the GATA1 gene, is present at all stages of the disease.
A new American Heart Association scientific statement recommends that children and adolescents with certain heart conditions participate in physical activities after a detailed individualized risk assessment. Light-to-moderate intensity exercise may be suitable to maintain physical fitness and quality of life, while structured physical...
Scientists have mapped the structure of Vibrio bacteria with unprecedented detail, revealing a new target for treatment. The findings could provide a solution to life-threatening infections linked to antibiotic resistance.
Researchers discovered a specific type of water in interstellar comet 3I/ATLAS that contains deuterium, revealing it came from a colder environment. This finding suggests the conditions that led to our solar system's formation are not ubiquitous throughout space.
Researchers at McMaster University developed a new generative AI model that designed a brand-new antibiotic in early tests, drastically speeding up drug discovery. The model generated structurally novel antibiotic candidates from a vast chemical space of 46 billion possible compounds.
A study published in Scientific Reports reveals a connection between ADHD-related traits and chronic pain, highlighting the importance of addressing ADHD in pain management. The research suggests that treating ADHD may help reduce chronic pain severity.
Researchers investigate whether micro- and nanoplastics contribute to liver disease through oxidative stress, fibrogenesis, and inflammation. They emphasize the need for increased research into plastic-induced liver injury and its potential impact on human health.
A study finds that rectal cancer mortality is increasing rapidly among adults under 45, with Hispanic and Western US populations experiencing the steepest rises. The study calls for earlier screening and increased awareness to combat this growing trend.
Researchers at NYU Langone Health found that high levels of a toxic molecule in the gut may trigger lupus nephritis. The study suggests using antibiotics as an alternative treatment instead of immunosuppressants.
Dr. Kwak's research proposes a new paradigm for robots in everyday environments, integrating perception and cognition capabilities into objects and spaces. Her work has led to practical implementations, such as educational robots and smart furniture, demonstrating the potential for human-centered robot design.
Researchers found that restoring a young microbiome can reverse features of aging in the liver, including inflammation and DNA damage. The study suggests that a healthy gut microbiome plays a key role in preventing liver cancer.
A new study suggests that eating late at night can disrupt bowel function and lead to constipation and diarrhea. Individuals who experienced high levels of chronic stress and ate more than 25% of daily calories after 9pm were more likely to report bowel problems, highlighting the impact of meal timing on gut health.
A new procedure, duodenal mucosal resurfacing, has shown promising results in preventing weight regain after GLP-1 therapy discontinuation. The study found that patients who underwent the procedure maintained over 80% of their weight loss and regained less weight compared to those who received a sham procedure.
Researchers have found that combining pembrolizumab and lenvatinib shows promise in treating recurrent clear cell ovarian and endometrial cancers with poor responses to standard treatments. The LARA trial provides encouraging responses for patients with this rare and difficult-to-treat cancer subtype.
Researchers investigated the α7 nAChR-PARP1 axis as a therapeutic target for Parkinson's disease. The study found that activating α7 nAChRs suppresses PARP1 activity, reducing neurotoxicity and improving motor function in mouse models. This discovery provides a scientific foundation for developing novel therapies targeting this axis.
Researchers have developed a novel approach to fabricate high-performance nanophotonic devices with record-breaking ultra-deep nanohole waveguides. The technique enables the creation of nanostructures with extreme depth-to-diameter ratios, overcoming long-standing limitations in single-pulse nanolithography.
The review highlights key considerations for selecting an optimal drug target, including therapeutic hypothesis, druggability and safety, commercial tractability, and combination value. AI's capacity to process complex multimodal data enables researchers to navigate biological complexity and uncover disease-associated targets.
A novel nickel-based Pickering emulsion catalyst enables gram-scale synthesis of high-purity benzaldehyde with co-produced hydrogen, offering a sustainable alternative to traditional fine chemical synthesis. The synergistic effect of photon-heteroatom jointly promoted redox cycling accelerates the dehydrogenation reaction.
A new study reveals that nurse-delivered models of care can effectively manage common sleep problems like insomnia and OSA, but designing services with patients and staff is critical. The review found strong potential for GP nurses to deliver treatments like CBTi and support patients on CPAP machines.
Researchers developed a compact metasurface polarimeter for cancer tissue analysis, offering label-free imaging with reduced variability. The device's miniaturization opens the door to portable polarization-based confocal microscopy for routine histopathology screening.
A multi-institutional team has discovered a novel immune regulatory mechanism mediated by antibodies that selectively shut down overactive immune responses. The 'immune-induced TCR-like antibody' (iTab) can reduce disease severity and delay its onset in a mouse model of autoimmune disease.
Scientists have developed a novel catalyst that selectively repels chloride ions while accelerating oxygen evolution in alkaline seawater electrolysis. The optimized NiFe-LDH/Ce(OH)CO3 system delivers exceptional catalytic metrics and achieves energy efficiency of 68.59% at 500 mA cm-2.
Researchers at Saitama University discovered that mannanases, enzymes degrading glucomannan, are also essential for its synthesis in plants. The study found that Golgi-localized atypical mannanases play a crucial role in preventing aggregation of growing glucomannan chains.
A study from the University of Oregon found that heavy drinking takes a toll on college students' cognition, with impaired memory, attention, and decision-making. The research tracked participants over several weeks, revealing a link between alcohol consumption and cognitive lapses.
Researchers found that consumers are willing to pay more for glass wine bottles, with Gen Z willing to spend $35.38. Providing sustainability information about packaging can influence willingness to pay, with a significant discount relative to glass packaging.
A machine learning approach improves how roaring behaviour can be studied by detecting long-distance roaring based solely on acceleration data. The algorithm works reliably with both male and female lions, even with mixed signals when walking while roaring.
A new Northern White Rhino embryo has been successfully produced, boosting hopes for the species' survival. The BioRescue Consortium's work has also underscored the importance of public engagement, communication, and ethical reflection in wildlife conservation.
A Swedish study found that children adopted into families with better home environments showed improved adult psychosocial outcomes, including lower criminal convictions and higher educational achievements. The benefits also extended into the next generation, with offspring displaying modestly higher psychosocial functioning.