The consortium aims to forge actionable drug development solutions for patients living with AATD by collaborating on endpoints, biomarkers, and clinical trial design. AIRNA brings RNA editing expertise to the consortium's efforts to accelerate drug development for alpha-1 antitrypsin deficiency.
In England, 13,386 patients waited at least three days for A&E treatment in 2025, with numbers spending a whole day in emergency departments increasing by a third since 2023. The prolonged waits are causing harm to patients nationwide, with some saying they'd rather die at home.
A Swedish study of siblings found that adopted children who grew up in more favourable family environments had lower risks of mental health issues, criminality, and social problems. These benefits extended to the next generation, with adopted children's offspring displaying higher functioning and lower risks.
A new study analyzing nearly 100 travellers' diaries reveals that turnpiking improved road conditions, reducing danger and speeding up journeys. The toll-funded system made a major contribution to the Industrial Revolution by reducing freight rates and enabling faster stagecoach travel.
Doctors should exercise caution when commenting on public figures' mental health, as diagnoses require direct assessment. The BMJ opinion article explores ethical tensions and the importance of professional standards in such cases.
The new fiber probe can track three key biomarkers - glucose, lactate, and ethanol - simultaneously, providing a more complete picture of metabolic health. This innovation offers faster, real-time sensing technologies for clinicians to respond rapidly to evolving metabolic crises.
A new UBC study maps climate change's impact on Canada's environment, revealing regions with high unpredictability and lower biodiversity. The team identified over 2.7 million square kilometres of unprotected land that could strengthen the country's conservation network.
Scientists found that specific genetic sequences, known as HAQERs, have a significant impact on human language abilities. These regions evolved before humans and Neanderthals diverged and are thought to be responsible for the development of modern human language.
A new $15 million research network will investigate the causes and treatments of heart valve disease, which affects over 80 million people worldwide. The American Heart Association hopes to develop early warning signs and diagnosis methods to expand treatment options and improve quality of life for patients.
Research from the University of Texas at Austin finds that consumers pay up to $170 extra per vehicle when buying a used car with nearly identical mileage but one digit off, due to left-digit bias. This phenomenon can result in higher prices for cars just below round numbers like 20,000 or 50,000.
Paxlovid helps vaccinated adults recover faster from COVID-19, but does not reduce hospital admissions or deaths. The drug significantly reduces viral load and side effects, making it a valuable treatment option for higher-risk patients.
Penn State professor Greg Fosco emphasizes the importance of parental monitoring, autonomy-supportive parenting, and fostering a sense of purpose in teenagers' lives. Research suggests that when adolescents perceive a stable relationship with their parents, their well-being suffers, while having a sense of purpose is linked to lower su...
A study from the University of São Paulo reveals that neurodegenerative processes extend beyond the central nervous system, affecting various targets throughout the body. The researchers identified over 9,000 autoantibodies linked to immune status, neurological damage, and symptoms specific to each disease.
A new model predicts that the selection of a single follicle for maturation during human pregnancy is entirely random, contrary to prior theories. The model suggests that once one follicle is selected, estradiol levels start rising, causing FSH levels to fall below the threshold, and unselected follicles die off.
A team of researchers has developed a new microbial method for producing medium-chain fatty acids, which are used in various industries, including cosmetics and detergents. The breakthrough enables the use of waste materials as feedstock for fermentation, reducing reliance on palm oil.
A global trial involving 1,670 patients with intracerebral haemorrhage found that treatment with a single pill combination of three low-dose blood pressure medicines reduced the risk of another stroke by 39%. The study showed significant benefits in reducing major cardiovascular events and improving blood pressure control.
Researchers developed liquid biochar mineral complex fertilizers that significantly increase crop yields and improve nutrient efficiency. The nitrogen-enriched formulation delivered the strongest results, achieving positive nitrogen and phosphorus balances while reducing labor and cost.
Researchers found that connected habitats enhance the ability of amphibian skin microbiome to defend against diseases by increasing beneficial bacteria presence. This study highlights a critical link between environmental disturbance, microbial defenses, and disease dynamics.
The SNMMI 2026 Annual Meeting will showcase the latest scientific developments driving advances in nuclear medicine, including earlier diagnosis, personalized treatment, and improved disease management for various conditions. The meeting will feature over 150 scientific sessions, satellite symposia, and a cutting-edge exhibit hall.
A new study from Weill Cornell Medicine found that the protein caspase-5 boosts cell growth in the gut lining by amplifying Wnt signaling. This balance is crucial for maintaining a healthy intestinal lining, replacing injured cells with new ones, and preventing diseases like colorectal cancer and inflammatory bowel disease.
Scientists at St. Jude Children's Research Hospital identified a key regulatory enhancer, ecMYC E1, that drives MYC expression in pediatric medulloblastoma, a type of brain cancer with poor outcomes. Silencing this enhancer reduces MYC transcription and can be targeted to treat the disease.
A recent study published in Neurology found that people with epilepsy who experience poor sleep are at a higher risk of developing dementia compared to those without epilepsy. Optimal sleep, defined as six to eight hours per day, is associated with better cognitive function and lower dementia risk.
Researchers found that modern AI language models can distinguish between categories like commonplace, improbable and impossible events with high accuracy. The models' internal patterns, or vectors, show a correlation with human uncertainty about statement plausibility.
MSK researchers showcased innovative therapeutic advances for HER2-driven rectal and KRAS-driven pancreatic cancers, as well as a promising mRNA vaccine. CAR T cell therapies targeting uPAR showed promise in shrinking solid tumors and overcoming treatment resistance.
A study by Yokohama National University finds that work ability, inclusion, and human resource development are crucial elements for promoting disability inclusion in the workplace. The research suggests a framework to reduce barriers and promote continued success among disabled individuals.
A new study by the American Academy of Neurology found that virtual and in-person visits for new neurology patients have no significant difference in follow-up clinic visits or emergency department hospitalizations. However, some conditions like Parkinson's disease and multiple sclerosis showed a higher need for follow-up evaluations a...
The American Ornithological Society has awarded grants to six early-career researchers from Latin America and the Caribbean to study bird conservation in the region. The projects focus on endemic species and will contribute to broader efforts across the region, strengthening conservation capacity.
The Columbia University Fertility Center has been ranked #1 on Newsweek's list of America's Best Fertility Clinics for the second consecutive year. The center offers cutting-edge innovations such as HELIOS near-infrared light technology to enhance embryo development, and STAR AI-assisted method to retrieve sperm in men with azoospermia.
A recent study found that nearly 69% of former professional football players may have sleep apnea, with many cases going undiagnosed. Untreated sleep apnea is linked to worse mental, cognitive, and physical health outcomes among former athletes.
Researchers developed an electrochemical sensor to detect pancreatic cancer at low concentrations, improving accessibility and effectiveness of treatment. The device identifies CA19-9 protein, a key biomarker for the disease, allowing for early diagnosis and potentially increasing survival rates.
Researchers create model connecting nuclide signal fluctuations to progressive changes in rock structure leading to critical failure. This allows for early warning of geohazards such as landslides and avalanches.
A new NYU study analyzes hourly ridership at 10 major NYC subway stations between 2023 and 2025. Heavy rain affects peak hour travel, while extreme cold has a smaller impact, especially off-peak. The research highlights the importance of considering infrastructure, station design, and surrounding land use in transit planning.
A Princeton-led study examines the complexities of translating natural resource wealth into economic prosperity. Higher social and human capital, as well as institutional safeguards, are critical in avoiding the 'resource curse,' a phenomenon where extraction leads to limited growth and unstable institutions.
A rare case of mucinous ovarian carcinoma was reported in a postmenopausal woman, initially misdiagnosed as a pelvic abscess due to nonspecific symptoms and radiologic features. The diagnosis was confirmed after advanced imaging and tumor marker assessment. Early recognition is crucial for timely diagnosis and effective treatment of th...
The study examines the cumulative physical, cognitive and psychological demands of a Formula 1 season on team personnel. Researchers aim to develop targeted interventions to support performance, recovery and well-being in one of the world's most demanding team environments.
Researchers found that an ASO strategy boosts expression of the closely related HNRNPH1 protein, reducing symptoms of HNRNPH2-related neurodevelopmental disorder. The study provides vital mechanistic data to support advancement of this promising therapy.
A study at University at Buffalo found that L-arginine enhances protein droplet stability, preventing fibril conversion and preserving microtubule assembly. This naturally occurring small molecule may help guide therapies targeting fibril formation in Alzheimer's disease.
Research by Virginia Tech researcher Phil Thompson and his colleagues found that when managers frame work problems as potential losses, employees are more likely to take action. Framing something as a loss yields employees to voice a work suggestion more than framing them as gains. This approach can influence employees' motivation to s...
The Yolo County basic income program provided a monthly stipend of $1,289 per month to 76 mostly single-parent families, helping them gain housing, food, and general wellbeing. Participants reported reduced stress levels and improved parenting skills, but faced challenges in achieving long-term financial stability.
A new PET biomarker outperforms established risk scores in predicting survival for large B-cell lymphoma patients. Metabolic tumor volume, derived from PET imaging, was found to be an important predictor of progression-free survival.
A USF study found that easy-to-use QR codes significantly reduce frustration and cognitive load among older adults, leading to higher satisfaction and customer loyalty. The research emphasizes the importance of businesses incorporating user-friendly technologies to cater to seniors' needs.
A recent study investigated microplastic movement in freshwater ecosystems across Pennsylvania, finding that watersheds with higher population densities and adjacent wastewater treatment plants had higher concentrations of microplastics. The research also revealed local features, such as forests and rural areas, play a critical role in...
Researchers will build connections with Detroit's digital equity ecosystem and promote digital inclusion to link cancer patients, survivors, and caregivers with resources. The Digital Engagement and Cancer Outcomes (DECO) Center aims to advance interventions that improve outcomes at the individual level.
Climate change is already reshaping health, work, and food security in Europe, with rising temperatures reducing working hours and economic output. Climate extremes are increasing food insecurity primarily through higher prices and diet quality, according to Shouro Dasgupta, a leading expert on the economic impacts of climate change.
The experimental drug DH20931 targets triple-negative breast cancer by triggering a surge in fat-like molecules called ceramides, overwhelming cancer cells with toxic fats. In lab experiments, the drug made standard chemotherapy more effective, reducing the dose needed to kill cancer cells by about fivefold.
Researchers found that electron spin interacts differently with mirror-image molecules, causing small but meaningful differences in behavior during dynamic processes. This asymmetry could lead to the dominance of a single 'hand' in biology, offering a possible route toward understanding how one molecular form came to dominate.
The study found that Methana volcano's magma chambers held steady amounts of magma for over 100,000 years, with intense activity peaking during zircon growth. This challenges the assumption that a prolonged period of volcanic silence means a volcano is extinct.
A study by University of Innsbruck researchers found that removing secondary product displays in crowded supermarket aisles increases sales by 11.5% due to increased browsing and interactions. Shopping carts amplify the negative effects, making narrow aisles feel tighter and reducing perceived control.
A new scoping review reveals silicone toothbrushes as a promising tool in global oral health, yet their effectiveness and environmental impact remain understudied. The study suggests that switching to silicone toothbrushes could be a viable alternative to traditional toothbrushes.
tACS modulates brain oscillations, induces synaptic plasticity, and regulates neurotransmitter release to alleviate symptoms of various neuropsychiatric conditions. Personalized approaches are essential for treatment efficacy.
A new study found that in-aisle displays can increase spatial crowding, leading to reduced sales and purchase-related behaviors. For cart users, this effect is stronger, with increased crowding and reduced control while shopping.
A study found that higher midlife cardiorespiratory fitness is strongly associated with later onset of chronic disease, lower overall disease burden, and longer life expectancy. Adults with higher fitness levels developed fewer chronic diseases and spent more years free from serious illness.
Researchers have shown that extracts from bioengineered chewing gum reduce levels of three microbes linked to worse outcomes in oral cancers, including HPV and bacteria Pg and Fn. The findings support the value of advancing these therapies to clinical trials as adjuvants or prophylaxis.
Researchers found that malaria significantly influenced habitat choice, pushing groups away from high-risk environments and separating populations. This led to the fragmentation of human societies, shaping their population structure for the past 74,000 years.
Researchers aim to accelerate public spinach breeding by identifying genetic variation and developing genomic tools for Pythium tolerance. They are evaluating 480 diverse spinach genotypes to identify over 30 Pythium-tolerant lines.
Researchers analyzed 505 ME/CFS memorial records, highlighting common themes of neglect, dismissal, and misdiagnosis. The study suggests that ME/CFS patients face widespread systemic, clinical, and social challenges, which contribute to their early deaths.
A Chinese-German research team has reconstructed the genetic processes of re-diploidization in snow carps, revealing the fusion of chromosomes as the first stage. This process, which occurred relatively recently in evolutionary terms, led to an initial fourfold set of chromosomes that eventually reduced to two through asynchronous fusi...
Researchers analyzed a Virginia colony of wild gray bats, finding they modify their echolocation calls based on the size of their flying group and environmental obstacles. The study reveals how these adjustments help the bats navigate safely during flight.
A new study finds that blood protein levels change markedly over the course of a lifetime, rendering adult reference values inadequate for children and adolescents. Gender differences also emerge, particularly after puberty.
Internationally recognized pediatric hand surgeon Dr. Scott H. Kozin takes the helm as Shriners Children's Chief Medical Officer, bringing decades of clinical expertise to expand access to high-quality pediatric care nationwide. The appointment comes at a pivotal moment, with the upcoming opening of the new Shriners Children's Research...