Five fellows will receive funding for four years to study hard-to-treat pediatric cancers, reduce treatment toxicity, and develop innovative therapies. Their research focuses on Ewing sarcoma, leukemia, kidney cancer, and immune system vulnerabilities.
Professor Radmila Matijevic received the IOF CNS Medal for her outstanding work in advancing bone health awareness, diagnosis, and management. Her contributions to osteoporosis research and clinical practice have improved patient care in Serbia and the wider Balkan region.
A new treatment using low-dose nivolumab injections into precancerous oral lesions significantly reduced lesion size and risk of cancer progression. The study showed a 60% average reduction in lesion size and complete pathologic response in six patients, with no dose-limiting side effects.
The study reveals that Chinese characters exhibit unique mechanical properties due to their geometric structures. The researchers found that curves, crossbeams, and gradation in the characters improve the material's stiffness and flexibility.
A retrospective cross-sectional study found significant associations between unsecured firearm storage and heightened suicide risk in US Army service members. Carrying a weapon other than a firearm also linked to elevated suicide risk, suggesting that any type of weapon carrying behavior may indicate increased vulnerability.
A cohort study found that bullying and restrictive legislation were associated with higher rates of psychotic-like experiences in gender-diverse youths. The study suggests that supportive environments and policies can help alleviate mental health concerns among this population.
A Japanese study examines the long-term effects of COVID-19 lockdowns on individuals with glucose intolerance, revealing a clear divergence in clinical trajectories among those who worsened and improved. Flexible lifestyle adaptation is crucial for restoring metabolic health, suggesting personalized support may improve glycemic control.
Guideline recommendations for immune checkpoint inhibitor-induced liver injury (ICILI) vary, with corticosteroids and biopsy indications differing among organizations. Rechallenge after ICILI is feasible in selected patients, with low recurrence rates, but standardized algorithms are needed.
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
Researchers developed a novel adhesive conduit inspired by pinecones that can adapt to natural nerve geometries without suturing. The conduit achieved robust nerve regeneration, functional recovery, and minimized secondary complications in animal models.
A study of 371 patients with autoimmune hepatitis (AIH) found that extrahepatic autoimmune diseases (EADs) are common, particularly Sjogren's syndrome and autoimmune thyroid disease. Patients with EADs had a poorer early treatment response but achieved comparable outcomes after six months.
The American Kidney Fund has awarded over $6 million in grants to researchers Dr. Sophie Claudel and Dr. Liz Kiernan, exploring the connection between kidney disease and cardiovascular health. Their studies aim to develop new treatments and improve diagnostics for patients with chronic kidney disease.
Researchers have developed a new microscopy method that uses polarized light and a magnetic field to detect malaria parasites in blood. The method provides quantitative information and can be used for faster and more objective detection of malaria.
A new study by the University of Technology Sydney and Massachusetts General Hospital/Harvard Medical School found that dietary patterns and a history of appendix removal are strongly associated with Alzheimer's risk. The research suggests that a healthy gut microbiome plays a crucial role in protecting the brain from neurodegeneration.
A study by Griffith University found microplastics and nanoplastics reduced plant growth and entered plant tissues through soil, raising concerns about food safety. Fibre-shaped plastics had the most effects on plant growth, with nanoparticles transported within plants.
Researchers at Kyoto University found that chaotic component of heartbeat variability is sensitive to cognitive brain activity, providing a new indicator of brain-heart interaction. Chaos-based measures revealed clear and reproducible changes associated with task engagement, contrasting with conventional HRV indices.
A Tohoku University research group developed an AI model that estimates retinal age from a fundus photograph, reflecting biological aging and potential disease risk. The model is non-invasive and can be used as a screening aid, identifying patients who may need further health assessments.
The new centres will focus on studying the complex relationship between culture, biology, and technology, aiming to accelerate discovery of new medicines and materials. Researchers from NTU, MPG, and Singapore institutions will collaborate on interdisciplinary projects.
A study by the University of Vienna reveals that European colonialism has left a lasting impact on the threat to languages and species. Island regions, such as Oceania and East Asia, are disproportionately affected due to their small size and vulnerable ecosystems.
Researchers found that polyploid cells activate a stress signaling pathway causing increased mobility and engulfing neighboring cells. This behavior can promote tumor growth and therapy resistance in aggressive cancers.
Researchers have created a novel sorbent made from chitosan/cellulose acetate and bentonite composites that show promise for cleaning up oil spills. The beads are floatable, biodegradable, and environmentally compatible, making them an efficient and cost-effective solution.
The article highlights how advances in remote monitoring and portable medical technology are dismantling traditional hospital walls. Hospital-at-Home programs offer a scalable solution to acute care delivery, resulting in lower costs, reduced readmission rates, and improved patient outcomes.
A new study by the University of Sydney found that toddlers' pretend play ability is significantly associated with fewer emotional and behavioral difficulties at primary school. The researchers analyzed data from over 1400 Australian children and found that stronger pretend play ability among two- to three-year-olds was linked to bette...
Researchers developed two heart failure risk assessment models using large international health databases, enabling early detection of the disease. The SCORE2-HF model estimates up to 30-year risk of heart failure in the general population, while the SMART2-HF model assesses risk for people with a history of cardiovascular disease.
Researchers at DZNE discovered complex, situation-dependent interactions between glioblastoma cells and microglia in the brain. The study found that microglial activity changes as tumors spread, influencing containment and spread of the disease.
A new analysis found that prescriptions for curable hepatitis C drugs have declined sharply in recent years, leaving millions without treatment. The researchers urge swift actions to deliver the drugs to those who need them, including increased screening and system-level changes.
Researchers found that pill bugs do not simply incorporate ingested CaCO3 minerals as building blocks. Instead, they actively restructure CaCO3 within their bodies to form their tergite cuticles. This study highlights the biological control underlying mineral formation and provides new insights into biomineralization mechanisms.
A ketogenic diet has been shown to improve beta-cell function in patients with type 2 diabetes by decreasing proinsulin secretion and reducing pancreas stress. This improvement is associated with changes in the proinsulin-C-peptide ratio, a biomarker of pancreas stress.
The Pediatric Academic Societies (PAS) recognizes 46 outstanding trainees and early career professionals for their contributions to pediatric research. The recipients will receive complimentary registration and a travel stipend to attend the PAS 2026 Meeting in Boston, Massachusetts.
A new method for treating sewage sludge efficiently creates renewable natural gas while reducing treatment costs by nearly 50%. The process produces pipeline-quality renewable natural gas with minimal CO2 content.
Pediatric low-grade gliomas require distinct treatment strategies, with a focus on molecular diagnosis and age-appropriate treatment. The new Chinese guidelines cover imaging, pathology, surgery, radiotherapy, and systemic therapy, aiming to maximize tumor control while protecting neurodevelopment.
Researchers have developed cyborg animals that integrate machine and biological intelligence, enabling them to execute human commands while retaining natural advantages. Key findings include advancements in control paradigms, miniaturized electronic backpacks, and self-sustaining energy harvesting technologies.
Researchers created a video to educate journalists on key elements of reporting scientific studies, resulting in more accurate headlines. The study found that journalists who watched the video were 64% more likely to write accurate headlines than those who did not.
New findings render antibiotic-resistant bacteria vulnerable by disabling individual resistance and cross-protection. This approach offers new possibilities for treating resistant infections associated with cystic fibrosis and may inform the treatment of a broad range of antibiotic-resistant infections.
A large multiethnic study identifies genetic factors associated with developmental dysplasia of the hip (DDH) and its progression to osteoarthritis of the hip. Variations in COL11A2, CALN1, and TRPM7 genes were found to be common to both DDH and hip OA.
A new study found that an elevated NLR is significantly associated with both long-term and short-term risk of Alzheimer's and dementia. High NLRs were more prevalent among Hispanic patients and women, suggesting potential genetic or social factors at play.
Researchers found a distinct pattern of immune activation early in infection among individuals who later developed broadly neutralizing antibodies, suggesting interactions between the immune system and other infections may be linked to HIV response.
A study published in the Journal of Aggression, Maltreatment & Trauma found that feeling safe with a trusted adult during childhood reduces the risk of depression, chronic disease, and poor health. The presence of protective adults significantly mitigates the long-term impact of abuse.
Astronomers have identified the edge of the Milky Way's star-forming disc for the first time, finding that most star formation happens within 40,000 light-years of the Galactic Center. This discovery uses a new approach combining star ages with galaxy simulations to pinpoint the boundary.
NASA's Curiosity Mars rover has discovered diverse organic molecules on Mars, including chemicals that could be signs of ancient life. The findings suggest the Martian surface can preserve molecules that could serve as building blocks for life.
Researchers discovered that coffee consumption affects the microbiota-gut-brain axis, influencing mood and stress levels. Decaffeinated coffee improved learning and memory, while caffeinated coffee reduced anxiety and inflammation.
Researchers at John Innes Centre develop rapid seed germination protocol, reducing Ash dieback's impact. This new method has already produced over 2,000 seedlings for trials and research.
The US is not prepared for a mass disaster with multiple burn casualties, experts say. Gaps in everyday burn care for children must be addressed before it will be considered ready.
Colorectal cancer incidence is rising among young individuals in Switzerland, with cancers occurring before age 50 accounting for 6.1% of all cases. The study highlights the importance of awareness and earlier screening to address this trend.
A tiny binding site in the TRPM3 ion channel is found to be crucial for pain signaling, with even small changes affecting its behavior. The study also reveals that patient-derived mutations can alter drug responses, highlighting the need for personalized pain therapies.
A new study reveals a strong link between extreme climate events and the incidence of heart disease among middle-aged and older adults in 157 Chinese cities. Exposure to extreme heat, cold, and precipitation increases the risk of cardiovascular disease, with higher BMI-related risks associated with temperature intensity and cold-induce...
A research group developed an optimized signal transmission system for implantable medical devices, improving accuracy and strength of wireless signals. The approach uses ultra-wideband communication to coordinate multiple implants and reduce signal distortion, enabling more effective healthcare applications.
A new study reveals that over 90% of lead paints sold in Mexico contain hazardous lead chromate pigments, which dominate the market. The widespread use of these pigments poses serious health consequences for children and workers, with alarming levels of blood lead found in Mexican children.
A study by the Alliance Foundation Trials shows that combining immunotherapy and chemotherapy before surgery can help more patients with locally advanced non-small cell lung cancer undergo complete cancer resection, improving their long-term health. The treatment also led to high rates of lymph node clearance and successful surgical re...
A multidisciplinary research team has discovered a novel antimicrobial material with impressive potency against various fungal and bacterial pathogens. The sulfur-rich polymer material overcomes previous limitations and shows promise as a low-cost, effective medicine and agrichemical solution.
Researchers used genome editing to inactivate a gene involved in anthocyanin production, resulting in increased accumulation of other flavonoids. This modification did not affect lettuce growth, suggesting a promising strategy for developing cultivars with tailored functional components.
A study by DGIST researchers reveals that the olfactory system is the first to be damaged in Alzheimer's disease due to distinct immune responses in different brain regions. The findings provide new insights into the early warning signs of dementia and potential diagnostic markers.
Artificial synapses are built from soft, bio-friendly materials that operate like human brain synapses, merging data storage and computing into a single unit. Laboratory prototypes demonstrate immense capabilities, consuming energy on the scale of femtojoules.
A research team at DGIST has developed a wearable sweat sensor using semiconductor fibers that can collect and analyze sweat automatically. The sensor detects various biosignals, including electrolytes and metabolites, without the need for external power sources.
Researchers have developed a new method to detect single micro/nanoparticles and protein binding events using non-linear resonance in a commercial quartz crystal microbalance. The system achieves femtogram-level sensitivity without requiring surface functionalization or nanomaterial integration.
A research team at DGIST has developed a next-generation near-infrared image sensor technology combining quantum dots with two-dimensional semiconductors. The new sensor exhibits high responsivity and detectivity, enabling rapid detection of weak infrared signals in fog or smoke.
Researchers developed bioinspired auxetic triboelectric nanogenerators that resolve mechanical mismatch challenges in flexible sensors. The devices achieve high energy conversion efficiencies and conform to biological tissues with minimal energy loss.
Researchers discovered a way to tune the quantum properties of tiny defects in diamond by stretching or compressing the crystal, enabling next-generation sensors with unprecedented precision. The silicon-vacancy center, a promising building block for quantum devices, responds predictably to mechanical deformation.
An international analysis found that intrauterine administration of human chorionic gonadotropin (hCG) before embryo transfer does not increase pregnancy or live birth rates. The study urges patients and clinicians to rethink the commonly offered IVF add-on, citing concerns about unreliable trial data.
Researchers have developed a simple yet effective ocean-based model that can predict El Niño and La Niña 15 months in advance using only surface temperature and height observations. The model leverages two core climate memories, Wyrtki memory and Hasselmann memory, to achieve forecast skill comparable to more complex models.