Researchers developed a new immunotherapy strategy by pairing next-generation therapy with standard hormone therapy before surgery, reducing Treg levels inside tumors and improving patient outcomes. The study provides clinical evidence for the effectiveness of engineered anti-CTLA-4 therapies in early-stage prostate cancer treatment.
The Society for Brain Health is a new collaborative body dedicated to enhancing cognitive capacity, longevity, and proactive health optimization through cutting-edge research and tools. Its founding members include prominent neuroscientists and experts in the field of brain health.
Researchers have developed new polymer-based materials that can capture short-chain PFAS molecules, which are difficult to remove from drinking water. The polymers use cooperative binding microenvironments to anchor the charged PFAS headgroup and stabilize its fluorinated tail.
The THRIVE team is developing a PROSPR Intrinsic Capacity score to predict 20-year health outcomes, using wearable data, blood-based biomarkers, and health surveys. The score aims to enable accessible, scalable monitoring of aging and improve interventions.
The Alliance for Clinical Trials in Oncology will host a webinar highlighting recent clinical advances in breast cancer, multiple myeloma, and leukemia. Researchers will present key findings from ASH and SABCS meetings, impacting treatment outcomes.
Researchers found that nanoplastics can increase the virulence of Salmonella, causing it to form thicker biofilms. Prolonged exposure slows down stress response, allowing bacteria to persist in the environment. Further research is needed to determine the impact on antibiotic resistance.
Researchers found that sunscreens with the same SPF of 50 and active ingredients can range from $0.04 to $3.79 per application, highlighting huge variations depending on product price and skin exposure.
Dr. Eric Moore, M.D., has been elected as a member of the Mayo Clinic Board of Trustees, bringing his extensive experience in head and neck surgery to guide strategic priorities. He is also a pioneer in less invasive transoral robotic surgery and has improved outcomes for patients with head and neck cancers.
A team of researchers has developed DopFone, an app that uses a smartphone's speaker and microphone to estimate fetal heart rate with high accuracy. The system was tested on 23 pregnant women and showed promising results, with an average error of 2 beats per minute.
A recent study found that more parents are refusing vitamin K shots for their newborns, which can lead to avoidable brain injuries and lifelong brain problems. The study also found that babies who do not receive the vitamin K injection are 81 times more likely to develop a serious condition called vitamin K deficiency bleeding.
A new Simon Fraser University study reveals the full range of emotions kids and teens feel around climate change, including anger, apathy, and feelings of betrayal. The research highlights the need to support young people's emotional well-being and provide them with tools to build resilience and hope.
Researchers from São Paulo State University detected plastic rocks on Trindade Island, Brazil's easternmost territory, where green turtle nests are conducive to plastic accumulation and burial. The study highlights the need for public policies to manage plastic waste and coordinated actions to clean up beaches.
Researchers have identified a master regulator in plants that balances root and shoot growth when nutrients are limited, leading to yield increases of up to 24% in rice plants. This breakthrough could ultimately improve global crop yields while reducing dependence on synthetic fertilisers.
Researchers have developed a new type of cell therapy called HIT cells that can detect and eliminate cancer cells in mice with pancreatic, kidney and ovarian cancers. The treatment shows promise for nearly 20 other types of cancers, including glioblastoma and pancreaticadenocarcinoma.
Early human-Neanderthal interbreeding was primarily between male Neanderthals and female humans, resulting in unevenly distributed Neanderthal ancestry. This pattern can be explained by natural selection eliminating disadvantageous X-chromosome variants or sex-biased mate preference.
Researchers found that agriculture intensity is the main driver of accelerated bird decline in three regions. The study analyzed data from the North American Breeding Bird Survey and estimated a 15% total loss of bird abundance across North America over 35 years.
New CAR T cells engineered to detect low levels of CD70 show promise in eradicating kidney, ovarian, and pancreatic tumors in preclinical models. This breakthrough provides a potential strategy for treating multiple solid tumor types with targeted immunotherapy.
New guidelines recommend strengthening legislative protections against genetic discrimination in insurance, including clearly defining genetic information and regulating its use. State lawmakers should consider carefully wording restrictions on discriminatory practices to ensure the efficacy of current policies.
Researchers at Rockefeller University create comprehensive atlas of cell changes with age, revealing synchronized changes across organs and sex differences. The study identifies vulnerable cell types and molecular hotspots that could be targeted with drugs to slow aging.
Researchers at Rutgers University created a new metric called the Ecological Network Balance Index to track how gut bacterial communities shift between health and disease. The index consistently separated healthy individuals from patients with multiple diseases, including colorectal cancer.
A new study reveals widespread and accelerating declines of North American bird populations, particularly in areas with intensive agriculture. The research found that 47% of species studied show significant population declines, with many hotspots experiencing accelerated loss.
Researchers found that birds adapting to sugar-rich diets evolved both shared and unique genetic changes, affecting genes controlling blood pressure, heart rhythm, and insulin signaling. These findings hold promise for understanding metabolic diseases like diabetes and may lead to new therapeutic targets.
Ancient genetic fragments called L1 elements destabilise the cancer genome years before diagnosis, giving malignant cells more opportunities to grow and adapt. Long-read sequencing technology reveals large-scale structural rearrangements that seed genomic chaos, potentially driving cancer development.
A digital clinical decision support algorithm substantially reduced antibiotic prescribing in pediatric outpatient care in Rwanda, according to a non-randomized controlled trial. The study found no compromise in clinical recovery, suggesting the algorithm's effectiveness in guiding appropriate treatment.
Researchers found that long-standing mating preferences led to sex-biased interbreeding, resulting in the loss of Neanderthal DNA on X chromosomes. The study reveals a complex social history of human evolution, challenging the idea that survival of the fittest drove human migration.
Researchers have discovered that native rice stink bugs have more genetic diversity than invasive species, which could help monitor the spread of insecticide resistance. This study provides valuable insights into pest management for Arkansas rice growers, who face significant costs due to the bug's impact on their crops.
Two NJIT faculty members, Cesar Bandera and Sara Zapico, have been named Senior Members of the National Academy of Inventors for their demonstrated success in producing patented technologies with real-world impact. The class collectively holds over 2,000 US patents, making it the Academy's largest cohort to date.
The institute will focus on technologies required to operate next-generation AI supercomputer systems reliably while accelerating scientific breakthroughs. It aims to drive innovation in making AI data centers more efficient, reliable, secure, and integrated with the nation's energy system.
The American Heart Association brought hypertrophic cardiomyopathy and Hands-Only CPR awareness to Historically Black Colleges and Universities and Hispanic-Serving Institutions across the U.S. Hundreds of students, athletes, and community members received hands-on CPR demonstrations.
A new UCLA study suggests that adding hormone therapy to post-operative radiotherapy may provide little survival benefit for most men with prostate cancer, especially those with low PSA levels. However, men with higher PSA levels before radiation may see modest improvements in survival and metastasis-free survival.
A mobile app has been shown to significantly reduce opioid and non-opioid substance use among adults with unstable housing, as well as improve mental health measures. The uMAT-R app provides free support and resources for people with any substance use disorder, including misuse of opioids, stimulants, and hallucinogens.
Researchers have uncovered a new, exceptionally preserved fossil site in Newfoundland, Canada, dating back to 551 Ma. This find dramatically alters our understanding of the 'Kotlin Crisis,' the first extinction event in animal history, which is now estimated to have resulted in an astonishing 80% loss of biodiversity.
A new USF study challenges long-standing assumptions about the brown recluse spider, finding it's far less common in Florida and exhibits a lower propensity to bite. The research also reveals that bites typically produce shallow wounds with minimal tissue damage.
Researchers argue that AI's limitations and alignment with human values are key to preventing potential threats. They suggest sector-specific policies rather than universal regulations.
Researchers developed a new AI-based SLA forecasting model that outperforms existing approaches and can be widely applied to other prediction tasks. The Multistep-Earthformer model achieves high-accuracy short- and medium-range sea level anomaly forecasting by optimizing training strategies.
A study found that voice AI ordering encourages customers to choose indulgent food options due to mental fatigue. Adding a friendly avatar to the interface can reduce this effect and lead to more balanced decisions.
Researchers at UAlbany are developing a new technique using Raman spectroscopy to ensure mRNA is properly encapsulated in lipid nanoparticles, improving the safety and effectiveness of mRNA vaccines and therapeutics. The technique allows for instantaneous analysis without damaging the sample, enabling optimization of formulations.
A new edge-of-field water-treatment system has been developed to reduce excess nutrients washing into waterways from farm drainage systems. The system, combining woodchip bioreactors with biochar water-treatment modules, demonstrated significant reductions in nitrogen and phosphorus runoff.
A Canadian study of 35,000 Canadians found a significant link between cannabis use and increased rates of anxiety and depression. The study suggests that stronger products, wider availability, and stress relief may be contributing to the observed patterns.
A minimally invasive surgical procedure called lymphovenous anastomosis (LVA) is being explored as a potential treatment for Alzheimer's disease. By improving brain lymphatic flow, LVA may help reduce clearance of neurotoxins and alleviate symptoms.
A new national study assesses the readiness of EMS agencies to care for children, identifying key areas for improvement. Having a pediatric emergency care coordinator is crucial for higher levels of readiness and better outcomes.
A new study analyzing 519 patients with cancer reveals that financial toxicity significantly impacts not only finances but also psychological resources like hope and social support. As these resources weaken, overall life satisfaction declines.
Researchers developed a single-item hoarding screen to quickly identify hoarding behaviors in patients with memory and brain disorders. The tool shows promise in flagging potentially serious hoarding behavior, especially in patients with behavioral variant frontotemporal dementia.
Researchers from Cornell University discovered that fungi can convert low-value agricultural byproducts into nutritious foods through fermentation. The
The preference for feeding on humans among certain mosquito species evolved around 1.8 million years ago in response to the arrival of early hominins in Southeast Asia. This finding provides independent evidence supporting the limited fossil record of early hominin arrival in the region.
A team of researchers successfully enhanced the stability and performance of perovskite solar cells by introducing light-switchable molecules into grain boundaries. The new material design increases operational stability and lifespan while maintaining competitive performance.
Five Lehigh University professors have been recognized for their innovative work, collectively holding over 2,000 U.S. patents. Their research focuses on diverse areas, including orthopaedic device technology, nanocrystalline alloys, and energy storage systems.
Researchers introduce 'tuberculogenic environment' concept, highlighting interplay between social structures and TB risk. Current efforts overlook broader structural factors sustaining TB epidemic.
A new discovery from Lund University reveals that minor changes in moisture levels can promote lipid molecule reorganization, affecting skin, lung, and tear film protection from dehydration. This understanding can inspire smart materials and improve lipid-based drug delivery systems.
Recent studies show that T cells support milk production and have lasting effects on maternal health and infant immunity. The review highlights emerging evidence of the crucial role of immune cells in lactation, which can inform strategies to improve maternal and infant health outcomes.
Researchers shed light on moths & butterflies' evolution, conservation needs, and diverse feeding habits. Discoveries suggest that these insects obtained plant-digesting abilities from fungi, while mandibled moths were once more diverse but largely extinct.
A new study has identified key candidate genes for citronelloid biosynthesis in the Citronella plant, including terpene synthase and dehydrogenase genes. The research also provides a molecular framework explaining species divergence and tissue-specific accumulation of these compounds.
The article summarizes updated recommendations on fertility preservation in people with cancer, considering potential health risks to offspring and treatment side effects. Clinicians should inform patients about available options before treatment initiation.
A study developed a bacterial cellulose-based delivery system loaded with nisin and mandelic acid to target acne treatment. The system exhibited strong antibacterial activity and antioxidant properties, while showing minimal cytotoxicity in fibroblast cells.
Laughter beats embarrassment when making small mistakes, research from the American Psychological Association finds. Laughing at oneself signals social confidence and reduces tension, while acting embarrassed may be perceived as excessive. The study suggests that humor is socially effective in certain situations but risky in others.
A new study from Binghamton University School of Management provides a framework for organizations to anticipate, interpret, and respond to social media backlash. The toolkit identifies four phases of online social disapproval and offers guiding questions and analytical indicators to aid in early detection, response, and recovery.
Contemporary donation after circulatory death (DCD) donors are now at 44% of organ procurement organizations. DCD donations account for half of all deceased donors in the US, leading to increased reliance on these organs to maintain transplant access.
Researchers have identified a novel transcriptional module that governs purple background coloration in flare tree peony. The MYB transcription factor PrMYB75a and its upstream regulator PrFRS2 work together to control anthocyanin accumulation, leading to uniform petal background color.
The GSI Helmholtzzentrum für Schwerionenforschung GmbH has discovered a total of 192 nuclear isomers, more than any other research facility worldwide. Dr. Ivan Kojouharov is responsible for 143 of these discoveries, making him the top co-discoverer globally.
A team of researchers from the University of Oldenburg has discovered a unique genetic pattern, or 'fingerprint', associated with NOTCH1 gene variants that commonly cause congenital heart defects. This breakthrough enables more reliable diagnoses and targeted therapies for patients and their families.