A recent clinical trial has shown that switching part of the standard chemotherapy protocol for a targeted immunotherapy significantly improves outcomes for young people living with acute lymphoblastic leukaemia (ALL). Nearly 89% of patients are still alive and cancer-free after three years of follow-up.
Prof. Benjamin Weiss, a renowned mathematician, has been awarded the Israel Prize for his pioneering contributions to mathematics and computer science. His groundbreaking research has earned him international recognition and accolades from prominent institutions like the American Academy of Arts and Sciences.
Researchers have developed new CXCR4-targeting radiolabeled peptides for cancer imaging and therapy, producing clear tumor images and extending survival in preclinical testing studies. Additionally, PET scans are being used to predict prostate cancer outcomes, identify primary aldosteronism, and guide treatment decisions.
Researchers drilled up to 7,906 meters below the sea surface to investigate what caused the Tōhoku-oki fault to rupture and trigger the earthquake. The clay layer was found to be soft, slippery, and exceptionally weak, allowing it to act like a natural 'tear line' that caused the fault to form.
Researchers have developed a new memory principle that enables electrical information storage and retrieval through simple stacking of materials. The 'graphene memory' mechanism, discovered by stacking graphene with α-RuCl₃, retains stored information even when power is turned off.
Researchers have successfully classified new quantum phases using duality, revealing insights into non-invertible symmetries. The study's findings offer important theoretical contributions for applications in quantum technology.
A 230-million-year-old footprint discovered in Brisbane is now recognized as Australia's oldest dinosaur fossil. The small, two-legged dinosaur, likely an early sauropodomorph, stood about 75-80 cm tall and weighed around 140 kg.
A new platform developed by VIB and UGent researchers allows for more accurate prediction of antibody drug effects in humans. The platform uses a next-generation mouse model that closely reflects human immune biology, enabling better decisions early in drug development.
Key cytokines in tumor microenvironment exhibit both protumor and antitumor effects, influencing immune response and tumor progression. Current research focuses on reducing toxicity while enhancing efficacy of cytokine therapies.
The conference brought together researchers, policymakers, and community leaders to discuss evidence-based strategies for ageing in place. Duke-NUS studies found that programmes aligned with older persons' routines and interests are more effective at reducing loneliness and fostering meaningful relationships.
A Sydney PhD student has recreated a tiny piece of the Universe inside a bottle in her laboratory, producing cosmic dust from scratch. The results shed new light on how the chemical building blocks of life may have formed long before Earth existed.
A new perspective argues that European steel's green industrialisation pathway and Africa's steel development are intertwined solutions. Hydrogen-based direct reduced iron (H2-DRI) production in Africa can provide a lower-cost alternative for European steelmakers, while supporting developing countries' economic growth.
Researchers at Adelaide University have discovered a new way to optimize barley seed dormancy, allowing growers to improve crop growth and efficiency. The breakthrough, published in the International Journal of Molecular Sciences, sheds light on the genetic underpinnings of seed dormancy in barley.
The NUS-IHME Global Burden of Disease Research Centre aims to bridge the gap between longevity and healthy ageing by examining the impact of extreme heat, antimicrobial resistance, and other environmental shifts. The centre will provide critical data and insights to inform health strategies across Southeast Asia.
Researchers have demonstrated an angstrom-scale electroplasmonic platform enabling giant modulation (2000% V⁻¹ ) of near-field nonlinear optical effects across a broad spectral range. The discovery provides a novel scheme for highly efficient electro-optical conversion in an infinitesimal spatial scale.
The study found that students with physical disabilities reported higher overall quality of life scores compared to those with visual and hearing impairments. The research team recommends expanding inclusive sports programs and social activities tailored to sensory impairments.
Researchers have identified MDGA2 as a causative gene for developmental and epileptic encephalopathy (DEE), a rare neurological disorder. The study highlights the potential for early diagnosis and new therapies to modulate MDGA2 function or reduce excessive excitatory signaling in the brain.
Researchers developed a phase multiplication technique harnessing laser feedback and cavity dynamics to enhance ranging resolution. Higher-order harmonics exhibit higher phase sensitivity, allowing for improved measurement accuracy.
Researchers have discovered a crucial pattern of gene evolution that appears significant for the origin and diversification of vertebrates. The study found diverse protein variations in sea squirts, lampreys, and frogs, which shed light on how animals with backbones evolved.
Vinay Badhwar, MD, was elected President of The Society of Thoracic Surgeons with a three-part framework emphasizing daily practice excellence, data-driven science, and measurable impact. He aims to advance collaboration across surgical disciplines and integrate the specialty into the broader healthcare ecosystem.
A systematic nuclear data evaluation of the five-nucleon 5^He system was performed using the Generalized Reduced R-matrix framework. The study provides reliable cross-sections with improved uncertainties, covering energy ranges up to 46 MeV for neutron-induced reactions and 30 MeV for deuteron-induced reactions.
Researchers measured energy correlations between two 252Cf prompt fission neutrons, finding a positive correlation at 180° and a negative correlation at 90°. These findings are crucial for developing and verifying fission physics theories, and should be considered in neutron coincidence and multiplication measurement techniques.
Ascending aortic hemiarch replacement is comparable to extended arch reconstruction for patients over 65 with acute type A aortic dissection. The study found no significant difference in long-term survival or surgical reintervention rates between the two procedures.
The European Commission and ECMWF have signed an agreement for the third implementation phase of DestinE, a digital twin project aiming to improve AI climate and weather predictions. The project will start in June 2026 and focus on operating and interlinking digital twins, as well as developing AI capabilities further.
A late-breaking study analyzing over 2.1 million patients found that bilateral internal thoracic artery (BITA) and single internal thoracic artery plus radial artery (SITA+RA) strategies offer comparable long-term survival overall. The study suggests that patient age may play a crucial role in selecting the optimal conduit strategy.
Researchers analyzed cases in the STS Adult Cardiac Surgery Database to identify factors predicting postoperative risk. The study found that 16.7% of adults nationwide with CHD were considered high-risk for operative mortality and serious complications after redo cardiac surgery.
Breakthrough research recommends that more than one N1 node be removed and evaluated during surgery for non-small cell lung cancer (NSCLC). The study found that many cancers were identified in N1 nodes adjacent to the bronchi, highlighting the need for expanded lymph node evaluation.
A novel radiation therapy QA method has been developed by combining Monte Carlo simulation with deep learning to generate patient-specific dose verification. This integrated technology accelerates quality assurance and paves the way for efficient online adaptive radiation therapy.
Researchers developed an AI tool called ONCO-ACS to predict the risk of secondary heart attacks in cancer patients after a heart attack. The tool combines cancer-related factors with standard clinical data to provide reliable information for doctors to balance treatment benefits and harms.
The Muonium-to-Antimuonium Conversion Experiment (MACE) aims to detect the rare conversion of muonium into antimuonium, a process that could reveal new physics. The experiment seeks to improve upon the last experimental limit by more than two orders of magnitude and target a conversion probability as low as 10^-13.
Researchers introduce a framework linking biochar's internal structure to its performance in various applications. The physical genome framework unifies scattered findings and encourages future studies measuring multiple properties.
Researchers at Tsinghua University developed a novel method for synthesizing chiral alpha-amino acids using a photo-driven nitrogen heterocyclic carbene catalyst. The reaction achieves good to excellent enantioselectivity and substrate versatility, enabling the rapid preparation of structurally diverse chiral alpha-amino acid derivatives.
Cells move in groups during biological processes, but researchers have made a surprising discovery that upends understanding of how cells move. Negative viscosity, which propels cells forward, has been found to increase metabolic activity in affected regions.
A comprehensive review evaluates the global race to track urban carbon emissions, highlighting the importance of high-precision atmospheric observations. The study reveals a stark geographical divide between monitored and unmonitored cities, emphasizing the need for a transparent framework for carbon neutrality.
Iakovos Toumazis leads IDSO's focus area on decision analytics for health to optimize patient outcomes and resource allocation. His research informs data-driven approaches to cancer prevention and policy decisions.
Researchers develop biochar-based phase change material that captures, stores, and releases heat with high efficiency while locking carbon away. The resulting material stores nearly twice as much latent heat as lower-temperature versions.
A study tracking nearly 1,000 emerging adults found that reports of childhood adversity remained stable but fluctuated over time, influenced by relationship quality. Fluctuations were more pronounced when people reported less support from their parents.
A mobile endoscopy team performed over 500 procedures in rural hospitals across Western Cape, South Africa, revealing a high burden of treatable gastrointestinal diseases. The program substantially reduced patient travel, improving continuity of care and early cancer detection.
The Gerdt Lab at Indiana University Bloomington has found a chemical solution to weaken bacteria's defenses against viruses, providing an alternative to antibiotics. The discovery could apply to hard-to-treat infections in humans and agriculture, where antibiotic overuse can worsen the spread of resistance.
Researchers identified a crucial factor that may help improve treatment for glioblastoma, one of the most aggressive and common forms of adult brain cancer. They discovered a small molecule called miR-181d acts like a master switch that controls how much MGMT is produced by each glioblastoma cell.
The University of East London has launched its first South Asia Careers Hub in Chennai, combining international academic practice with regional perspectives. The hub will focus on areas such as Health and Behavioural Sciences, Engineering, Business Management, and Psychology, aligning with Tamil Nadu's priorities.
Researchers develop a new design strategy for MEMS electrothermal actuators, correcting nonlinearity mechanically by integrating machine learning-optimized metastructures. This approach simplifies system architecture while preserving precision and enabling robust motion in compact environments.
The portable optical sensor uses machine learning to analyze spectral patterns and estimate grape ripeness directly on the vine. This technology promises significant business benefits for winemakers by providing non-destructive, real-time insight into grape ripeness, reducing labor and time required for sampling and analysis.
A new analysis by UC Berkeley researchers found that 'red flag' laws significantly reduced firearm suicides in four states that implemented the laws. The study estimates that these laws prevented over 675 suicides between 2023 and 2024. Non-firearm suicide rates remained unchanged.
Researchers develop a dissolving microneedle patch with embedded bubble structures to co-deliver multiple therapeutics for enhanced local drug availability and therapeutic efficacy in acne vulgaris. The system achieves rapid symptom relief and sustained antibacterial action, overcoming long-standing delivery limitations.
A team of researchers has developed a novel single-photon source that combines on-demand operation with record-high photon quality in the telecommunications C-band. This achievement brings deterministic quantum dot sources into the same performance regime as probabilistic SPDC sources, enabling applications such as measurement-based qu...
A new study by University of Cincinnati economics professor David Brasington found that local business benefits from city services, particularly tax renewals, in Ohio. The research compared communities with renewed taxes and those with cut taxes, revealing a significant difference in commercial property redevelopment.
Researchers have developed a miniaturized microoptical system for continuous, real-time fluorescence monitoring of three-dimensional microtissues directly on chip-based platforms. This technology tracks functional changes in living tissues over extended periods with high accuracy.
The Swiss National Science Foundation has awarded funding to the Paul Scherrer Institute's Muoniverse project, a large-scale collaboration in muon research. The project aims to improve muon beam quality and precision, enabling new research opportunities in materials science, energy, and archaeology.
Researchers developed a chemiresistive gas sensor that dramatically improves ethanol detection by integrating ultrathin catalytic nanosheets onto a conventional metal-oxide sensing film. The resulting device responds strongly to ethanol concentrations spanning from parts per million down to a few parts per billion.
Researchers found that bacteria exposed to perchlorate produce stronger calcium carbonate crystals, leading to better biocementation skills. The presence of guar gum and nickel chloride enhances the process, paving the way for alternative building strategies on Earth and Mars.
A new metasurface approach transforms uneven laser beams into uniform pumping fields, reducing spin decoherence and enhancing signal stability. This innovation improves magnetic measurement performance, enabling more precise and robust quantum sensors.
Researchers developed an EEG-based system to decode pleasure from listener's brain activity and suggest personalized playlists. The system outperformed 'acoustics-only' methods, capturing neural markers of pleasure with high accuracy.
Researchers develop optoelectrowetting-based system for ultra-precise microdroplets, achieving high volume consistency and reproducibility. The system uses programmable light patterns to control droplet formation, eliminating random pinch-off and improving accuracy.
Researchers developed a high-performance electrochemical vector hydrophone with micron-scale control of electrode spacing, achieving higher sensitivity and broader frequency coverage. The device enables the detection of weak and broadband underwater signals in complex marine environments.
Researchers found that eosinophils suppress chordoma growth and induce cell death in tumor cells, suggesting them as a novel immunotherapeutic target. The study's findings provide new insight into the immune mechanisms underlying chordoma progression.
Researchers developed a novel microfluidic strategy for separating flexible microalgae based on size differences. The approach achieves precise separation while preserving cell viability, offering a scalable and energy-efficient alternative to existing technologies.
A Goethe University-led study reveals how mutations in the SPRTN enzyme cause chronic inflammation and premature ageing. The research team found that damaged DNA in the cell nucleus leaks into the cytoplasm, activating defense mechanisms and leading to chronic inflammation.
Researchers introduce a new single-cell sorting strategy operating directly in air to overcome constraints of fixed microfluidic channels. The system achieves exceptionally high accuracy and survival rates, enabling flexible sorting of multiple cell subpopulations from complex samples.
A team from the University of Illinois developed a photobiocatalytic platform that enables Escherichia coli to produce complex molecules through light-driven enzymatic reactions. This breakthrough broadens the capabilities of biomanufacturing, offering a promising avenue for sustainable production of chemicals and materials.