Researchers identified altered gene expression in smokers with periodontitis, leading to weakened gum epithelial integrity and excessive inflammation. A new target molecule, CXCL12, was found to drive immune-cell recruitment and inflammation, making it a potential therapeutic approach.
The EU-funded Trees4Adapt project aims to strengthen Europe's adaptation and resilience to climate change through tree-based solutions. By combining cutting-edge research with practical applications, the project will help policymakers make informed choices and inform EU policies.
The FDA's regulation of mifepristone involves characterizing its decision-making process and rationale for key components. The agency's approach has evolved over time, with notable changes to its regulatory framework.
A new study reveals that childhood exposure to indoor air pollution from solid fuels may impair brain health and cognitive abilities throughout life. The research analysed data from over 7,000 Chinese adults aged 45 and above, showing a significant association between early-life exposure and poorer cognitive performance in adulthood.
Research found that extreme summer heat can overwhelm honey bees' cooling systems, causing significant colony population declines. Larger colonies with more stable internal temperatures were less affected, highlighting the need for effective management strategies to mitigate impacts of high temperatures and maintain colony stability.
The Arabian Gulf's mangroves are vulnerable to development, pollution, and climate change, with a projected 45% decline in coverage over the next 50 years. Conservation efforts have shown promise, but more needs to be done to preserve these salt-tolerant coastal forests.
Research finds that nearly one in four Medicare beneficiaries with dementia are prescribed potentially harmful medications linked to falls, confusion, and hospitalization. Despite declines in prescribing rates, high levels of inappropriate prescribing persist among older adults with cognitive impairment.
Kevin Milner, a research geophysicist at the USGS Geologic Hazards Science Center, has been awarded the Seismological Society of America's Charles F. Richter Early Career Award for his innovative work in seismic hazard analysis modeling and earthquake forecasting.
A new study by CNIO has identified two genes in the complement system that increase the risk of pancreatic ductal adenocarcinoma. These genes, FCN1 and PLAT, may serve as biomarkers for screening high-risk populations.
Scientists create designer enzymes in yeast cells, enabling sustainable production of industrially important fatty acids. The new method reduces environmental issues associated with palm oil extraction.
Adolescents bullied or engaging in bullying face lasting mental, physical and social challenges. The study identified socioeconomic disadvantages, race, physical differences, and pre-existing health conditions as risk factors for bullying.
Researchers discovered a previously unknown interplay between wheat's resistance genes and fungal disease factors. The study found that powdery mildew fungus overcomes resistance by modifying recognized effectors, but a new approach could slow down its development by combining targeted resistance genes.
A cohort study of students in grades 4-12 found that social media use varied by age and sex, with heavy use linked to poorer well-being. The study's findings suggest that abstinence from social media may not always be beneficial for adolescents.
A comprehensive study reveals that urbanization significantly amplifies lake warming, threatening freshwater ecosystems. The research highlights the role of urban heat island effect and altered hydrological processes in driving accelerated warming.
New research from Aalto University clarifies the link between autonomy and well-being, finding it universally important but stronger in wealthier, more individualistic nations. The study suggests that policy-makers should focus on boosting autonomy in richer countries to improve overall well-being.
Researchers at The Lundquist Institute have identified PTRH2 as a critical gene that protects the maternal heart during pregnancy, shedding light on the causes of peripartum cardiomyopathy. Loss of this gene leads to severe postpartum heart failure, highlighting the urgent need for better treatments.
Scientists reveal that slow orbital wobbles, known as precession cycles, generate abrupt millennial-scale climate fluctuations even under ice-free conditions. The study provides a new clue for understanding rapid climate swings and offers insights for future warming scenarios.
A Mass General Brigham study identifies new mutations that emerge in tumor cells following treatment, driving resistance in patients with different types of cancer. The researchers found two main categories of mutations: those impairing p53 function and others disrupting drug binding, highlighting a path forward for overcoming resistance.
Researchers at Cornell University have developed a new technique to create digital images of cloth that more accurately captures the texture of textiles. The method models how light interacts with yarns, both as it passes through and reflects off the fabric, enabling more realistic renderings for the gaming and animation industry.
A joint study by Bar-Ilan University and Sheba Medical Center found that symptoms of post-traumatic stress, anxiety, and depression remain common among childhood cancer survivors and their parents more than a year after treatment completion. The study highlights the need for long-term follow-up care that includes assessment of psycholo...
Researchers analyzed national data and found Black children were more likely to be investigated and placed out-of-home than white children, even when economic profiles were similar. The study suggests racial bias, specifically anti-Black racism, is a key factor driving these outcomes.
Researchers tested large-scale roofing assemblies with mounted PV solar panels, exposing the leading edge to flame and crosswind to understand fire hazards. The study aims to update building codes and fire mitigation protocols for commercial and industrial solar panel installations.
A new consensus classifier for pancreatic cancer has been developed, enabling accurate determination of tumor subtypes and informing treatment choices. The tool also identifies risk factors for the disease, including smoking, which may be more significant in certain subtypes.
Researchers have uncovered the critical function of occludin in regulating cell barriers, particularly in diabetic retinopathy. The study revealed that occludin's alternative splicing produces a form of occludin that controls leaky blood vessels and excessive vessel growth.
Researchers developed a lab-grown model of the prostate gland to study bacterial infections. They found that E. coli targets specific cells and uses a 'lock and key' principle to invade. A sugar molecule called D-mannose blocks this interaction, offering a potential new strategy to prevent and treat prostate infections.
A machine-learning-based approach has been developed to map real-time tumor metabolism in brain cancer patients, helping doctors discover effective treatment strategies. The digital twin uses patient data to calculate metabolic flux, predicting which treatments are likely to work for individual cases of glioma.
Scientists have created a novel form of water that exhibits structural diversity similar to solid ice, revealing new properties under extreme conditions. The discovery provides valuable constraints for improved models of ice giants and their interiors.
Sandia's economic impact reached a record high of $5.2 billion in 2025, more than doubling its economic impact from 12 years ago. The laboratory's workforce of 16,000 people drove this growth through pay raises and high-paying jobs.
Aggressive triple-negative breast cancer fine-tunes its protein production through a previously unknown mechanism discovered by Umea University researchers. The study reveals that fibrillarin collaborates with RPS28 to create specialized ribosomes, leading to imbalance in protein production and driving cancer development.
Researchers discovered genes that regulate fibroblast growth, which builds the scaffolding between cells. Adjusting these factors reversed age-related changes and improved health outcomes in mice. The study offers new opportunities to understand and reverse aging-related diseases.
Researchers have discovered that feline infectious peritonitis virus infects a broader range of immune cells, including B lymphocytes and T lymphocytes. The findings suggest that the virus can persist in these cells even after treatment, potentially leading to long-term immune problems.
Researchers at KAIST developed a new near-planar light outcoupling structure and OLED design method to significantly reduce light loss in OLED devices. This enables brighter displays with the same power consumption, extending battery life and reducing heat generation in mobile devices.
Game theorists propose revising Grand Slam rules to give greater weight to games won, resolving rare but striking fairness problems. In a study of over 50,000 matches, researchers found that game-set discrepancies occur between 3-5% of the time, affecting high-level competition.
A new study demonstrates the effectiveness of a widely-used eye injection in managing hypotony, a rare condition characterized by abnormally low eye pressure. The treatment, which involves injecting HPMC gel, has shown promising results in restoring vision and increasing eye pressure.
University of Florida researchers have identified a new potential target for treating methamphetamine addiction by modulating the immune system. Using immune-modulating medicines, they were able to mitigate the effects of TNF and dopamine release in mouse brain specimens.
Scientists have developed a refined X-ray diffraction technique that allows for the simultaneous analysis of materials on scales from nanometres to millimetres, enabling detailed studies of complex tissue and bone diseases. This method has been successfully applied to reveal the alignment of collagen fibres in a human ossicle, providin...
A study found that older adults are prescribed potentially inappropriate central nervous system-active medications despite guidelines. Patients with cognitive impairment were more likely to receive these medications than those with normal cognition. The study highlights the need for better medication management in older adults.
A new study led by NTU Singapore reveals that El Niño events can persistently slow long-term improvements in mortality rates, leading to enduring reductions in life expectancy. The research estimates that El Niño could reduce life expectancy gains by 2.8 years and cause economic losses of up to US$35 trillion by 2100.
A new study by the University of Stirling has found that introducing parkwalkers to parkrun events has led to a surge in walker participation. The initiative has increased the proportion of new female participants and reversed a decline in the average age of new attendees.
The inaugural JACC Cardiovascular Statistics report examines five major CVD risk factors and conditions, revealing persistent disparities by race, geography and socioeconomic status. The report identifies critical gaps in data and opportunities for innovation to improve US heart health.
A recent study found that people globally perceive themselves as less at risk of climate change than others, with the effect most pronounced among Europeans. This 'self-other' discrepancy may delay necessary action and hinder climate adaptation and mitigation efforts.
Materials and Solidification journal focuses on original research on solidification of various materials, including metals, semiconductors, and polymers. The journal covers topics like solidification processing, non-equilibrium phenomena, and multi-physical fields.
A team led by Prof. Richard Gu has developed an automated robotic nanoprobe that can navigate within living cells, sense metabolic whispers in real time, and pluck individual mitochondria without causing damage or fluorescent labeling. The breakthrough holds great promise for advancing treatment strategies for chronic diseases and cancer.
Dr. Gang Hu, a leading expert in chronic disease epidemiology, has been appointed to the NIH Reproductive, Perinatal and Pediatric Health Review Group. He will evaluate studies on reproductive, perinatal, and pediatric health, with a focus on lifestyle factors and their impact on chronic diseases.
Researchers at KAIST have developed a new OLED technology that more than doubles screen brightness while maintaining the flat structure of OLED displays. The new technology uses a thin, near-planar light outcoupling structure and an OLED design method to significantly reduce light loss inside OLED devices.
A study published in the British Medical Journal identified key criteria for evaluating mobile apps for managing depression, including data safety, clinical efficacy, and intuitive design. The EvalDepApps tool aims to help patients and health professionals choose effective apps by providing clear indications.
The ACET-Estonia project partners to co-design and deliver applied clean energy research, fostering innovative solutions for Estonian island communities. Canadian expertise supports international partners in addressing similar energy challenges.
A new clinical trial, PAGODA, seeks to minimize treatment interruptions and help patients complete their chemotherapy as planned. The trial will test a structured plan to guide doctors in making small, proactive changes to chemotherapy doses to prevent treatment delays.
Lisa Wald, a renowned USGS scientist, has been honored by the Seismological Society of America for creating the Earthquake Hazards Program's information hub. Her groundbreaking work made a wealth of earthquake information accessible to everyone, from the general public to seismologists and governments.
Researchers at QST discovered that controlled gamma-ray mutagenesis can create heat-tolerant nitrogen-fixing bacteria in weeks, shortening development timelines. The method produces robust, climate-ready microbial products for agriculture, food processing, pharmaceuticals, and biofuel production.
Researchers have developed a blood test that can predict Crohn's disease years before symptoms appear. The test measures immune response to flagellin, a protein found on gut bacteria, which is elevated in individuals long before they develop the disease.
A recent study reveals that over 680,000 new cases of hepatocellular carcinoma were estimated worldwide in 2022, with 78.4% attributable to nine modifiable risk factors. The majority of HCC cases are preventable, and the study emphasizes the need for targeted preventive programs.
A new plant-based hydrogel has been developed to tackle the problem of metallic zinc growing needle-like dendrites that short-circuit cells within a few hundred cycles. The cellulose-nanofiber dual network boosts ion flow and mechanical strength, delivering a cheap and biodegradable electrolyte.
Insilico Medicine's Phase IIa clinical trial assesses Garutadustat's safety and efficacy in ulcerative colitis. The novel PHD inhibitor has shown favorable safety and tolerability profiles in completed Phase I studies.
A large-scale population genomic study has shed new light on the evolutionary history of the button mushroom (Agaricus bisporus), one of the most widely cultivated edible fungi in the world. Climate dynamics and a key gene for adaptive evolution and domestication jointly shaped the mushroom's diversity.
Research found that prolonged heavy drinking induces neuroinflammation, promoting negative emotional states lasting for weeks into abstinence. Inhibiting proinflammatory microglia activation during alcohol exposure blocks the development of anxiety and fear memory.
The Berlin Aging Study (BASE) dataset is now publicly accessible, providing detailed longitudinal data on health and well-being. Researchers can explore the connections between physical, psychological, and social factors and aging, shedding light on why people age differently.
Korea University's Institute for Environmental Health trained faculty members from Karakalpakstan Medical Institute to improve environmental health in the region. The training aimed to enhance water quality and waste disposal management, fostering collaboration and joint research.
Abhishek Mishra receives a prestigious $160,000 postdoctoral fellowship from the American Heart Association to explore the molecular mechanisms of heart failure with preserved ejection fraction. The funding will support Dr. Mishra's research on PTP1B inhibition as a potential therapeutic strategy for cardiometabolic diseases.
Georgetown University researchers discovered a method to enhance the function of T cells, making them more effective in killing cancer cells. By inhibiting PARP, an enzyme that detects DNA abnormalities, scientists can boost the body's immune response against tumors.