Researchers have overcome fundamental challenges in molecular electronics, building reliable single-molecule electronic devices. Advances in fabrication and interface control enable predictable responses to light, electric fields, redox states, or mechanical forces.
Researchers developed a miniature side-viewing fiber probe that breaks the trade-off between image sharpness and depth. The probe achieves extended imaging depth while preserving high lateral resolution, enabling clinicians to see deeper without sacrificing detail.
A review decodes the comprehensive role of GDF15 in prostate cancer metabolism, chemoresistance, and clinical applications, highlighting its involvement in cachexia, bone metastasis, and drug resistance. The study also explores the synergistic power of combining GDF15 with established markers for improved diagnosis and prognosis.
Researchers at Seoul National University have developed an AI-based material redesign technology that transforms hard-to-synthesize materials into synthetically feasible forms. The SynCry model successfully redesigned over 3,400 structures, accelerating the development of next-generation semiconductor and battery materials.
A cohort study of 47,000 adults found that males had a 63% greater risk of all-cause mortality compared to females after adjusting for demographic and behavioral factors. The study suggests intrinsic biological factors, such as sex hormones or immune response, may contribute to these sex differences in mortality.
Non-Hispanic white births now constitute less than half of US births, while Hispanic births exceed one-fourth. These shifts reflect declining fertility across most groups, contrasted with immigration trends and younger ages among Hispanic women that sustain overall birth rates.
A Rutgers Health study reveals increased intentions to purchase firearms and carry them among specific groups following the 2024 presidential election. Liberal beliefs are associated with greater impulses to carry firearms and store them more accessibly.
A recent Nipah virus outbreak in India highlights the importance of surveillance and global collaboration in detecting emerging infectious threats. The Global Virus Network emphasizes that while sporadic cases are not unprecedented, sustained public-good investment is necessary to develop vaccines and treatments.
Biologists have discovered a new mode of communication inside cells that helps bacterial pathogens learn how to evade drugs. The findings, published in Nature Communications, describe how mobile genetic elements transfer DNA sequences, including antimicrobial resistance genes, in Listeria monocytogenes.
Research from Newcastle University suggests that hydrogen-powered ground support equipment (GSE) can slash carbon emissions and support airport decarbonisation. The study gathered views from key stakeholders and highlighted the benefits of zero direct emissions, quieter operation, and faster refuelling.
Researchers found that aged vape plumes in indoor environments contain fine particles with metals and highly reactive compounds, producing radicals that might damage lung tissue if inhaled. Repeated exposure to these plumes could negatively impact lung health, especially for individuals with pre-existing conditions.
Researchers at Boston Children's Hospital have developed a novel mass spectrometry tool called FLEXITau to analyze brain tissue from 203 patients with various tauopathies. The study identified 145 post-translational modifications and 195 cleavage sites across tau, providing a precise molecular roadmap for diagnostics and drug development.
A study of 80 near-Earth asteroids reveals that C/X-complex asteroids are more abundant among smaller NEAs, while X-complex asteroids tend to have sub-kilometer diameters. The research also shows that C/D-complex asteroids dominate NEAs with a Jovian Tisserand parameter T <sub> J </sub> < 3.1, suggesting a potential cometary origin.
Photonic noses leverage light-matter interactions and machine learning to capture detailed chemical fingerprints and interpret them with high accuracy. AI integration enables fast, label-free, and highly sensitive detection of volatile compounds, paving the way for smarter sensing platforms.
Researchers developed an intranasal vaccine that elicited strong immune responses and prevented infections in exposed animals, providing protection against upper respiratory infection and severe disease. The nasal vaccine was effective regardless of prior flu exposure, making it a promising tool in the fight against H5N1 bird flu.
Researchers have developed a dual-additive electrolyte that re-wires the hydrogen-bond network to enhance cryogenic tolerance and lifespan of aqueous zinc-ion batteries. The study demonstrates the potential for high-rate and long-lasting AZIBs deployable in extreme climates.
A recent study highlights the dangers of a compartmentalized medical system and proposes three essential reforms to promote inclusive care. Patients with multiple conditions face difficulties in accessing care due to fragmented services, while interdisciplinary care ultimately leads to positive outcomes.
In a study, participants preferred feedback providers who provided overly optimistic feedback to avoid hurting others, even if it meant telling the truth. This suggests that people strategically adjust their preferences for honesty based on social cues and prioritize the well-being of others.
A new study identified 54 AhPR10 genes in cultivated peanut, showing constitutive and inducible expression patterns. The AhPR10-7, -33, and -41 genes demonstrated potential importance in peanut resistance to Aspergillus flavus, with recombinant AhPR10-33 effectively inhibiting A. flavus mycelial growth.
Marine-derived compounds exhibit potent anti-tumor effects through diverse mechanisms, including apoptosis induction and targeting critical signaling pathways. Challenges remain, but innovative delivery systems and deeper insights into molecular targets hold promise for harnessing the therapeutic potential of these natural compounds.
The IPBES Plenary Session will consider the landmark Business & Biodiversity Assessment Report, which assesses the impact of businesses on nature. The report aims to inform global policy and action on biodiversity and nature, highlighting its significance for economic prosperity, security, and quality of life.
A new 'capping-and-coupling' strategy transforms native sugars into compounds known as C-heteroaryl glycosides in one step through photocatalytic carbon-carbon bond formation. This breakthrough enables simple and efficient coupling of diverse nitrogen-containing aromatics, offering a powerful avenue for late-stage glycosylations.
Leading fashion retailers join forces with the American Heart Association to support Go Red. Shop with Heart., a campaign to raise funds and awareness for cardiovascular disease among women. The initiative aims to drive heart health awareness and support the fight against America's number one killer, heart disease.
A sweeping new study has identified tuberculosis as the predominant cause of deadly sepsis among people with HIV in Africa. Immediate treatment for TB significantly increased survival rates, especially when treatment was started before diagnosis.
Researchers discovered a lesser-known inflammatory signal triggered by proteins TWEAK and Fn14, which amplify inflammation when combined with TNF. Blocking this 'backdoor' pathway could improve RA treatment for up to 80% of patients.
Emerging therapeutic strategies aim to overcome chemoresistance through targeted agents and precision medicine. Key findings highlight the roles of exosomes and metabolic reprogramming in facilitating drug resistance.
Researchers have developed a new material called botanical sandcrete using desert sand with plant-based additives. This innovative solution reduces the need for traditional concrete, which accounts for 8% of global CO₂ emissions. The production process is relatively simple and can be made in many places.
A new species of ladybird beetle, Parastethorus pinicola, was discovered on a pine tree at Kyushu University's Hakozaki Satellite. The beetle measures just over one millimeter in length and is the first major update to Japanese ladybird classification in 50 years.
A new review study led by the University of Maryland School of Medicine identifies genetic ancestry as a key component of assessing head and neck cancerous tumors. The research found that ancestry, rather than self-identified race, was a stronger predictor of genetic differences between tumors.
A global study finds zoantharians, colorful hexacorals, exhibit surprisingly narrow genetic and morphological divergence between oceans. Their ability to disperse via epic larval phases and raft across ocean basins may be key to their success.
The program brought together 31 health professionals from nine Asian and African countries for advanced training in epidemiology, clinical treatment, and research & diagnosis. Participants also conducted on-site field visits to leading institutions, strengthening their response capacities.
A new survey reveals a significant difference between girls' and boys' well-being at school. Girls are found to be happier than boys due to stronger connections with their peers and feeling safe at school. In contrast, boys tend to score lower in academic subjects like reading and science but excel in physical education.
Researchers create novel contactless electricity generation technique leveraging electrostatic charges and viscous force of compressed air. The device generates high ESD-based outputs, powering electronic devices and regulating humidity.
Researchers at Materials Nanoarchitectonics (MANA) propose a novel strategy for controlling tiny droplets on surfaces, reducing friction and enabling precise control. The study demonstrates that particle-coated droplets can move with reduced force, opening new avenues in micro-scale systems and applications.
Researchers developed a solvent-free method to enhance drug bioavailability by transitioning from solid to gas phase. The sealed heating (SH) method increases drug solubility without using organic solvents.
A new study reveals that young sauropods were a key food source for Late Jurassic predators, with adults unable to care for their eggs and offspring. The research team mapped out a 'food web' of the time, finding that sauropods had a significant impact on their ecosystem.
The study reveals that up to 13% of areas allocated to land-based carbon removal could overlap with important biodiversity sites in ambitious emissions reduction scenarios. Effective implementation of reforestation and BECCS can reduce the long-term loss of biodiversity due to climate factors by up to 25%, producing net benefits.
Researchers at HSE Institute for Cognitive Neuroscience found that people tend to trust the current opinion of an authoritative speaker even when new statements contradict their previous position. The study used AI-generated audio recordings of celebrities with opposing views on COVID-19 vaccination and found that participants rated th...
The journal ENGINEERING Energy begins publishing high-quality energy science and engineering research. The new title marks a strategic step to better reflect the journal's growing research community.
Researchers from Tohoku University developed a 3D covalent organic framework (COF) that enables efficient and selective removal of anionic dyes from contaminated water. The COF, TU-123, demonstrates high adsorption capacity and removal efficiency, making it a promising solution for advanced wastewater purification technologies.
Researchers discovered that mycosporine-like amino acids (MAAs) can block a key enzyme involved in blood pressure control and offer antioxidant effects. MAAs are naturally occurring compounds found in algae and cyanobacteria, which also act as natural sunscreens.
The 2024 WHO BPPL prioritizes antibiotic-resistant bacteria, highlighting links to inadequate water and sanitation infrastructure. The list also emphasizes prevention-based strategies, but its human-centric focus overlooks agricultural and environmental drivers of AMR.
Researchers use RHOSTS method to construct dynamic networks capturing risk co-movement among 24 Chinese stock sectors from 2007-2024. This approach reveals how multi-sector co-movements can accelerate contagion and create hidden vulnerabilities.
The absence of exoplanets orbiting tight binary stars is attributed to the effects of general relativity, which causes gravitational tugs from the stars to make a planet's orbit precess. This process makes it difficult for close-in planets to survive, with 75% being destroyed due to tidal disruptions or ejection from the system.
The new centre will support the WHO in estimating disease burden from foodborne diseases and developing integrated risk-benefit approaches, combining nutrition, microbiological risks, and chemical contamination. The centre will contribute scientific expertise to achieve healthy, safe, and sustainable dietary patterns worldwide.
Researchers develop a record-high selective COF membrane for efficient Li+/Mg2+ separation. The gate-lane nanostructure enables high Li+ flux, offering a blueprint for next-generation ion-separation membranes.
Researchers found that intraday high-frequency sentiment, especially from non-trading periods, can capture nuanced market dynamics and improve daily return forecasts. This study demonstrates the potential of using online forum data to enhance stock return predictions in a highly sentiment-driven market.
China has experienced multiple emerging infectious disease events, emphasizing the need for early detection and effective public health responses. A research team outlines an 'environment–animal–human' integrated framework to break down data silos and enable early warning and coordinated responses.
A study found that ocean bacteria SAR11, which thrive in nutrient-poor waters, are more vulnerable to environmental change than thought due to cellular dysregulation. This discovery challenges common assumptions about microbial growth and has broader implications for understanding climate change and marine ecosystems.
A new study shows that microwave-assisted pyrolysis can convert sugarcane bagasse into highly porous biochar with exceptional surface properties. The process produces biochar with a surface area exceeding 1,150 square meters per gram, making it suitable for applications such as pollutant adsorption and energy storage.
A comprehensive review reveals devastating loss of island land snail biodiversity, with extinction rates ranging from 30% to 80%. The Hawaiian Islands, in particular, have lost up to 90% of their unique native snail species due to human arrival and colonization.
Researchers discovered that mannan rich palm handicraft residues, particularly tagua nut and bodhi root powders, can be converted into levomannosan and related furan compounds at moderate temperatures. This process provides a practical guide for using handicraft waste as a controlled chemical feedstock.
A new review proposes a spatial optimization framework to address the slow underground pathways of nitrate nitrogen, which can take decades to show up in river outlets. The framework considers legacy nitrogen, farmer adoption probabilities, and institutional settings to create more realistic and economically viable conservation programs.
A new machine learning tool has identified over 250,000 cancer research papers that may have been produced by 'paper mills', companies selling fake or low-quality scientific studies. The study found suspicious writing patterns in these papers, which can be detected by large language models.
The study found a 12% reduction in interval cancers diagnosed after screening, as well as fewer aggressive sub-type cancers detected. AI-supported mammography also increased cancer detection without an increase in false positives.
Researchers have developed a four-marker panel that can detect early-stage pancreatic cancer with high accuracy, potentially improving survival rates. The new test distinguishes cancer patients from healthy individuals and those with non-cancerous conditions, such as pancreatitis.
A study published in Cell identified a protein complex called CRL5SOCS4 that marks tau for degradation, suggesting strengthening this natural defense mechanism could represent a new therapeutic strategy. Higher expression of CRL5SOCS4 components made neurons more likely to survive despite the accumulation of tau protein.
Researchers found that patients seen by cardiologists had lower mortality rates and fewer serious heart problems, including heart attack, sudden failure, or irregular heartbeat. The study suggests close teamwork between surgical and heart teams can improve outcomes after major surgery.
A new AI tool has been developed to predict the chances of death, major bleeding, or another cardiac event in cancer patients who have had a heart attack. The ONCO-ACS score combines cancer-related factors with standard clinical data to provide individualized treatment recommendations.
Researchers at Science Tokyo discover that a single amino acid deletion in the antibody's lower hinge transforms it into a stable half-IgG1 molecule with altered immune activity. This finding provides a blueprint for engineering next-generation antibody therapies.