Researchers developed a new method to quickly screen large numbers of molecules for activity against the nsp13 protein, which is essential for viral replication. The approach identified six promising compounds as potential starting points for antiviral drug development.
Researchers have successfully used lasers to control neutrophils, a type of white blood cell, as natural microrobots in living fish. The 'neutrobots' can perform multiple tasks, including delivering drugs to precise locations in the body, and show promise for targeted drug delivery and disease treatment.
Researchers have developed microsupercapacitors that can be integrated onto stone tiles, enabling high-performance and customizable power from natural building materials. The devices maintain a high energy storage capacity even after multiple charge-discharge cycles.
The use of computational tools and new strategies is transforming drug discovery, enabling researchers to navigate the vast chemical space more efficiently. Companies are leveraging virtual libraries of compounds and advanced technologies like artificial intelligence and machine learning to optimize screens and identify promising leads.
Researchers report that apratoxin S4, an anticancer drug candidate, can interfere with viral replication in human cells. The compound was effective against multiple viruses, including SARS-CoV-2, influenza A, and Zika virus. Further studies are needed to confirm its potential as a broadly acting antiviral.
The ACS Fall 2022 meeting is a hybrid event with nearly 11,000 presentations on topics like lab safety, sustainable chemicals, and energy. Press registration is open for journalists and public info officers, offering access to embargoed press releases and a virtual media briefing schedule.
A new study published in ACS' Journal of Agricultural and Food Chemistry found that plant-based meat substitutes contain proteins that are not as easily absorbed by human cells. The researchers used a model meat alternative made from soy and wheat gluten, which was found to have lower peptide uptake than chicken meat.
Researchers created a light-activated fish robot that rapidly swims around and removes microplastics from waterways. The robot's unique material allows it to heal itself and maintain its ability to adsorb pollutants.
Researchers created a new gel that can protect fragile objects like eggs by adding starch to gelatin, reducing impact force up to 15%. The gel's flexibility and impact absorption make it suitable for sports equipment, defense materials, and packaging.
Herbicide companies are shifting their research focus to address growing resistance, using AI, X-ray crystallography, and computer simulations to predict target enzymes and inhibit herbicides. This could lead to new commercial products, but experts caution farmers to moderate use and consider additional crop protection tools.
Scientists identified proline-modified dipeptides and larger proteins that enhance umami and salty flavors in soy sauce. This discovery could help producers optimize fermentation conditions to boost desirable compounds and tailor the taste of soy sauce.
Researchers have developed a novel fusion protein that enables the detection of SARS-CoV-2 antibodies using widely available glucose meters. The test was validated on various patient samples and found to be as accurate as four different ELISAs.
A pilot study found that drinking either alcoholic or non-alcoholic lager daily increased the diversity of gut microbes in healthy men, potentially reducing chronic disease risk. The researchers suggest that non-alcoholic beer may be a healthier choice due to its lower alcohol content.
Researchers developed a nanocomposite coating method using Langmuir-Blodgett technology to improve wig durability, reducing UV damage, breakage, and static electricity. The new coating provides better coverage than previous methods and can be scaled up for mass production.
Research reveals Paradise, California's water contained VOCs at levels exceeding EPA standards due to degraded plastic pipes near or above ground. To protect communities, experts recommend burying service lines deeper, using isolation valves, and monitoring temperature thresholds.
Researchers developed a bumpy carbon-based material that maintains rechargeable storage capacity down to -31 F, improving lithium-ion batteries' performance in freezing temperatures. The new material enables electric cars to drive longer and reduces the risk of battery failure in extreme cold.
Researchers have developed an electric nose using porous metal-organic framework films to distinguish between xylene isomers in mixtures. The MOF-based e-nose achieved 86% and 96% accuracy for detecting xylene at low concentrations, paving the way for improved environmental monitoring and diagnostic health testing.
Scientists construct figure-eight-shaped machines with rotary motors and polymer chains to enable measurement of mechanical work and forces. The machines twist and untwist like whirligig toys, exerting similar torque to the enzyme that produces ATP.
Recent papers in ACS Environmental Au explore the impact of aerosol acidity in the southeastern U.S. and the effects of environmental films on native ecosystems. The journal also investigates electrospun nanofibrous membranes for controlling airborne viruses.
A new study presents a self-powering smart pillow that tracks head movement during sleep using triboelectric nanogenerators. This system could improve the accuracy of sleep monitoring and have uses beyond tracking sleep, such as monitoring patients with cervical spondylosis or detecting early warning signs for falls.
Researchers investigate microplastic risks using nanotoxicology lessons, standardizing particles for reproducible studies. Scientists aim to replicate real-world situations in lab simulations to understand human gut and lung cell effects.
Scientists have developed a sustainable method to create valuable aroma compound mixtures from limonene, the main compound in orange peel oil. The process generates an amber-colored liquid with a pleasant odor and 17 different compounds with fruity, herbal, citrus, and resinous notes.
Researchers present a 'green' process for tie-dyeing cotton with renewable resources and wastes, linking science, art, and sustainability. The natural dyes used produce designs of white, brown, orange, and bluish-black colors on fabrics.
Racial gaps in NIH grant funding are attributed to the subjective review process and lack of diversity among reviewers. The NIH has proposed initiatives to address these disparities, including appointing diversity officers and allocating funding for research on health equity and health disparities.
Scientists create a bendable organic LED with a mica backing that produces soft, warm light similar to candlelight, with minimal blue wavelength emissions. This device offers a potential solution for sleep-friendly lighting alternatives.
Environmental advocates argue that chemical recycling doesn't eliminate single-use plastics, which remain a significant pollution concern. The Biden administration is seeking comment on exempting industry processes from Clean Air Act regulations, amid growing state legislation encouraging advanced recycling.
Researchers have designed a lightweight wood-based foam that reflects sunlight, emits absorbed heat, and is thermally insulating. The material could reduce buildings' cooling energy needs by an average of 35.4% depending on weather conditions, making it a promising solution for hot climates.
A recent study reveals that nearly half of SARS-CoV-2 variants contain the same three mutations, which together improve the virus's ability to infect human cells and evade the immune system. The combination of K417, E484, and N501 mutations enhances viral fitness by balancing positive and negative selection pressures.
Researchers developed a strong, water-resistant wood glue using glucose and citric acid for plywood. The adhesive meets China's standard requirement and is more energy-efficient than traditional adhesives.
A flexible sensor embedded in a diaper measures multiple components in urine, sharing results over Bluetooth for fast bedside analyses. The technology has potential to provide quick and painless urinalysis for incontinent, elderly or infant patients.
Companies are turning to biobased surfactants and renewable biomass feedstocks to make their products greener. These alternatives can have a lower carbon footprint than traditional surfactants, but may also be more expensive.
A study by American Chemical Society researchers reveals that 54 of the 93 surveyed items contained fluorine, an indicator of PFAS. The team found that 19 products had precursor compounds that can be transformed into highly stable perfluoroalkyl acids, which are linked to various health issues.
Researchers tested two valved N95 masks and found one to be substantially better at filtering out respiratory particles than the other. The study suggests that valved masks should be avoided in public health settings.
Researchers have created a wearable sensor for plant leaves that wirelessly transmits data to a smartphone app, allowing for early detection of water loss and remote monitoring of drought stress. The device has the potential to save resources and increase yields by providing reliable data on plant health.
A new cocoa processing method called moist incubation has been found to produce a fruitier and more flowery-tasting dark chocolate compared to traditional fermentation. The method involves rehydrating dried, unfermented cocoa nibs in an acidic solution and heating them for 72 hours before re-drying.
Researchers have developed a new silver-ion releasing coating that effectively prevents bacteria from adhering to implants and killing them. The coating, dubbed "SAFE", was tested on rats and showed promising results, with no signs of toxicity or wear and tear.
Researchers are developing innovative ways to reuse automotive glass, crushing it into small pieces and purifying the polyvinyl butyral (PVB) for industrial use. This approach aims to reduce waste and conserve resources as the demand for automotive glass continues to grow.
A new study found that nylon cooking bags and plastic-lined cups can release trillions of nanometer-sized particles into each liter of water they come into contact with. The levels of these particles are below regulatory limits for consumption, but still pose a potential health risk.
Researchers are developing radioconjugate drugs that combine radiation with a tumor-targeting agent to selectively kill cancer cells. Two approved drugs, Lutathera and Pluvicto, demonstrate the potential of this therapy, which could change the future of cancer treatment.
Researchers found that non-biting midge larvae accumulate pesticides from polluted water and retain them into adulthood. Adult female midges have higher pesticide concentrations than males, which are transferred to their offspring. The study suggests that midges can be a source of pesticides in terrestrial ecosystems.
Researchers at ACS Sustainable Chemistry & Engineering have identified a less toxic dye called pigment red 254 (PR254) as a greener alternative to current anthraquinone dyes used in signal smokes. PR254 forms a red-colored smoke cloud more effectively and is thermally stable, making it suitable for use in heat-generating systems.
Researchers have developed a rapid COVID-19 test that uses molecularly imprinted polymer nanoparticles to detect SARS-CoV-2. The new test is more sensitive and works under extreme conditions than existing antibody-based tests, with preliminary results indicating it can detect a 6,000-times lower amount of the virus.
Researchers characterized viral protein binding to sialic acids on animal and human coronaviruses, revealing host-specific patterns. This adaptation enables coronaviruses to quickly jump species, driving cross-species transmission.
Researchers created edible tags with fluorescent silk proteins to track medications, providing a new way for consumers to verify authenticity. The codes are readable by a smartphone app and can be ingested without causing harm.
A recent study published in ACS Omega analyzed protein levels in semen of men who recovered from COVID-19 and found significant reductions in sperm count, motility, and normally shaped sperm. The researchers also detected changes in fertility-related proteins such as semenogelin 1 and prosaposin.
Researchers have developed a new implant that reduces ghrelin levels and body weight gain by half when exposed to laser light, offering a minimally invasive treatment option for obese patients. The implant uses a laser-activated dye to kill cells producing the 'hunger hormone'.
Researchers found that earthworms prefer soils with bioplastic particles and digest them differently than petroleum-derived plastics. The worms can break down bioplastics like polylactic acid into smaller fragments, which are then excreted slowly.
Researchers discover that common herbicides can kill the Toxoplasma gondii parasite without harming human cells. The compounds work by inhibiting heme biosynthesis, a promising approach for treating toxoplasmosis.
A study found that most face masks tested contained low or negligible levels of PFAS, except for a firefighter mask with potentially hazardous levels. Researchers estimate that regular wear of surgical and N95 masks does not pose a risk, but extended use of the firefighter mask could cause health problems.
Researchers found that prior infection with common human coronaviruses does not provide immunity against SARS-CoV-2 due to limited cross-reactive antibodies. This suggests no significant adverse effects from antibody-dependent enhancement, reducing the risk of COVID-19 complications.