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Ann & Robert H. Lurie Children's Hospital of Chicago


Lurie Children’s Hospital performs innovative minimally invasive surgery for severe muscle tone in cerebral palsy

Researchers at Lurie Children's Hospital use computer-guided radiofrequency ablation to decrease excessive muscle tone in children with cerebral palsy, greatly improving quality of life. The procedure is a safe and effective approach that excludes the dysfunctional nervous system, a main driver of pathology.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalOperative Neurosurgery·DateSep 20, 2023

Promising gene-based approaches to repair lethal lung injury in the elderly from COVID-19, pneumonia, flu, sepsis

Researchers discovered a gene called FOXM1 that plays a crucial role in repairing blood vessels and improving survival rates. A low-dose repurposed drug, decitabine, was found to reactivate the gene and promote vascular repair in aged mice. An alternative approach using endothelium-targeted nanoparticle gene delivery also showed promise.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalScience Translational Medicine·DateSep 18, 2023

Prenatal diagnosis matters: Linked to earlier surgery for congenital heart disease

A study by Ann & Robert H. Lurie Children's Hospital of Chicago found that prenatal diagnosis is associated with earlier surgery for babies with congenital heart defects, leading to improved outcomes. Prenatally diagnosed babies had surgery on average one week sooner than those with postnatal diagnosis.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalCirculation Cardiovascular Quality and Outcomes·DateAug 4, 2023

New study findings underscore the importance of timely newborn screenings in early care for cystic fibrosis

A new study by Dr. Stacey Martiniano found that late diagnosis of cystic fibrosis due to delays in evaluation after a positive newborn screen test results in poorer long-term nutritional outcomes, including reduced weight-for-age and height-for-age. Early initiation of CF care is essential to improve health outcomes in infants with CF.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalThe Journal of Pediatrics·DateJul 31, 2023

Multidisciplinary team reduced hypothermia in NICU babies during and after surgery

A multidisciplinary team implemented a quality improvement project to reduce hypothermia in NICU babies before, during, and after surgery. The project resulted in significant decreases in intraoperative and postoperative hypothermia rates, demonstrating the effectiveness of standardized temperature monitoring and thermal support.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalPediatric Quality and Safety·DateJul 13, 2023

Hispanic women still at higher risk for births with neural tube defects after voluntary folic acid fortification of corn masa flour

A new study finds that voluntary folic acid fortification of corn masa flour products has not significantly reduced the rate of births with neural tube defects in Hispanic women. The research suggests that mandatory fortification of cereal grains is more effective in preventing these congenital defects.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalChild s Nervous System·DateJun 2, 2023

Children with drug-resistant epilepsy live longer after cranial surgery

A large retrospective study found that children with drug-resistant epilepsy who underwent cranial surgery lived significantly longer than those treated only with antiseizure medications. The study also highlighted disparities in access to epilepsy surgery, with white, privately insured children more likely to receive surgical treatment.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalThe Lancet Child & Adolescent Health·DateJun 2, 2023

Study identifies messages about vaccinating children against COVID-19 that resonate best with vaccine-hesitant parents

A study from Ann & Robert H Lurie Children's Hospital of Chicago found that the 'trusted parents' and 'safe and tested' message types increased Black parents' intentions to vaccinate their children. Messages emphasizing vaccine safety and efficacy were effective in addressing concerns among hesitant parents.

Paying family members for at-home medical care of their children found to be a viable answer to healthcare worker shortage

A recent study from Ann & Robert H Lurie Children's Hospital of Chicago suggests that paid family caregiving can be a viable answer to the healthcare worker shortage. The study, which compared children with medical complexity cared for by family-CNA caregivers versus traditional non-family CNAs, found no significant difference in hospi...

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalThe Journal of Pediatrics·DateFeb 21, 2023

Study: Gender-affirming hormones improve mental health in transgender and nonbinary youth

A two-year study found that transgender and nonbinary youth experienced improved appearance congruence, reduced depression and anxiety, and increased life satisfaction after starting gender-affirming hormone treatment. The study included 315 participants aged 12-20 and had the longest follow-up reported to date.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalNew England Journal of Medicine·DateJan 18, 2023

New tool predicts risk of hospital readmission for children before discharge

A new tool predicts the risk of hospital readmission for children before discharge, utilizing electronic health record data. This comprehensive prediction model can be implemented in real-time during a hospital stay to tailor discharge planning, potentially reducing readmission rates and freeing up scarce pediatric beds.

Nose swabs may distinguish babies with RSV needing longer intensive care

Researchers used nose swabs from children with RSV in the pediatric intensive care unit (PICU) to examine gene expression. They found that some children had greater damage to nasal cells, correlating to longer PICU stays. This discovery could lead to a diagnostic test to predict which infants will require a longer stay.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalFrontiers in Immunology·DateNov 2, 2022

Differences in state Medicaid programs for children with medical complexity may lead to care inequity

A new study from Ann & Robert H. Lurie Children's Hospital of Chicago highlights the variation in Medicaid programs for children with complex medical needs across states. The research reveals that these disparities can lead to delays in care and impact health outcomes for these vulnerable children.

First ever in pediatrics: World experts set agenda to improve care of acute kidney injury in kids

Acute kidney injury (AKI) affects 25% of hospitalized children and has a high mortality rate. Experts have identified key issues and set a research agenda to improve diagnosis, prevention, and care for AKI in kids. The goal is to develop evidence-based guidelines and quality care for these vulnerable patients.

New research reveals how the heart repairs after a heart attack

Researchers at Ann & Robert H. Lurie Children's Hospital of Chicago discovered that macrophages play a crucial role in cardiac repair after a heart attack by inducing vascular endothelial growth factor C (VEGFC) and promoting healing. This finding offers new hope for developing novel therapeutic approaches to preserve heart function.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalJournal of Clinical Investigation·DateMay 25, 2022

Predictable home environment protects against development of heart disease risk factors after child abuse

A new study published in the Journal of American Heart Association found that well-organized households can help mitigate cardiovascular risk factors in children who have experienced abuse. The study's results suggest that stable home environments may play a crucial role in reducing racial disparities in cardiac disease.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalJournal of the American Heart Association·DateMay 17, 2022

Chicago public schools and Lurie Children’s Hospital expand partnership to support youth mental health

The expanded partnership aims to strengthen the District's response to an escalating national youth mental health crisis. The school-based Behavioral Health Team model provides comprehensive support, including early identification of students with behavioral health needs and connection to evidence-based interventions.

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalPsychology in the Schools·DateApr 28, 2022

COVID-19 vaccine protects kids and teens from severe illness

The study found that vaccination with the Pfizer-BioNTech mRNA COVID-19 vaccine reduced the risk of COVID-19-associated hospitalizations in children ages 5–11 years and adolescents ages 12–18 years by two-thirds during the Omicron period. Protection against critical COVID-19 requiring life-supporting interventions remained high in vacc...

SourceAnn & Robert H. Lurie Children's Hospital of Chicago·JournalNew England Journal of Medicine·DateApr 18, 2022

Vagus nerve stimulation lowers costs of care for children with uncontrolled epilepsy

A new study found that vagus nerve stimulation (VNS) plus anti-seizure medications significantly reduces hospital costs for children with drug-resistant epilepsy. The study showed patients treated with VNS and ASM had lower inpatient healthcare utilization and outpatient care costs compared to those treated with ASM alone.