Researchers solved a long-standing climate mystery by combining geological evidence with climate model simulations. They found that speleothem δ18O records reflect precipitation signals from multiple seasons, not just summer monsoon season.
The researchers developed a new imaging technology that enables the creation of high-resolution 3D images of an entire mouse body, including its peripheral nervous system. The technology allows for the mapping of nerve routes at the subcellular level, providing insights into neural regulation and disease mechanisms.
The Chang'e-6 mission has returned samples from the Moon's farside, providing new insights into the lunar geology and thermal evolution. The samples revealed prolonged volcanic activity, a fluctuating magnetic field, asymmetric water distribution, and ultra-depleted mantle signatures.
Researchers at Chinese Academy of Sciences have measured the mass of silicon-22, revealing a new proton magic number. This finding provides deeper insight into exotic nuclear structures and nucleon interactions, shedding light on element formation in the Universe.
A recent study found that forest fragmentation weakens ecosystem resilience in tropical and temperate forests, while enhancing it in boreal forests. The research used satellite data to quantify the effects of edge density on forest resilience worldwide.
Researchers developed an AI-informed method for rapid protein evolution, integrating structural and evolutionary constraints. The approach, AiCE, outperforms traditional methods in predicting high-fitness mutations, enabling efficient protein redesign and applications in precision medicine.
Researchers discovered LAG-3 inhibits T cell activity through spatial proximity to TCR, not ligand binding. This discovery enables precise modulation of autoreactive T cells in autoimmune diseases.
A research team discovered a counter-ion competition mechanism that explains the superiority of negatively charged nanofiltration membranes in separating lithium and magnesium ions. This finding provides critical insights for designing next-generation NF membranes with tailored ion selectivity.
Researchers analyzed Junggar Basin sediments, revealing a previously unrecognized 1.6-million-year cycle in the carbon isotope record, distinct from the current grand eccentricity cycle. This variation provides concrete geological evidence of Solar System chaos and its impact on Earth's climate and carbon cycle.
Researchers have determined high-resolution cryo-electron microscopy (cryo-EM) structures of the GnRHR from two species, revealing a conserved recognition of GnRH and molecular mechanisms underlying receptor activation. The study provides valuable insights for designing more robust peptide drugs.
A study published in Science Advances reveals that VIRMA regulates brain development by modulating ribosome biogenesis. VIRMA depletion impairs key steps in this process, triggering a p53-dependent stress response and disrupting global protein translation.
A recent study has revealed that the diploidization process in plants can be both episodic and gradual, depending on the type of mutation. The researchers used population genomics to uncover a nuanced picture of this process, including gene fractionation, transposable element accumulation, and homoeologous expression bias.
Researchers have discovered that multimodal pain integration in the brain significantly enhances overall pain perception when participants are instructed on how to perceive the pain. The precuneus region of the brain plays a vital role in integrating pain information into a cohesive and intensified pain experience.
Researchers analyzed ancient sedimentary rocks to understand oxygen and CO2 levels during the Late Paleozoic Ice Age, finding rapid drops in carbonate uranium isotopes alongside rising atmospheric CO2. This suggests seafloor anoxia expanded even with high oxygen levels.
A team of researchers has revealed how unique native plant life on the Qinghai-Tibet Plateau evolved over time, with origins dating back to the Early Eocene. The study highlights the Hengduan Mountains as a crucial center of endemism and emphasizes the need for conservation efforts.
Researchers found pyrogenic carbon formed by ancient fires in a 300,000-year-old sediment core, indicating a continental-scale intensification of fire use around 50,000 years ago. This period coincides with the rapid spread of Homo sapiens and their reliance on fire for survival.
Researchers developed a novel amine-functionalized graphene oxide (NGO) membrane reactor for ultrafast synthesis of propranolol, achieving nearly 100% conversion and selectivity in under 4.63 seconds at 23°C. The NGO membrane exhibited higher catalytic flux and turnover frequency compared to the acidic graphene oxide (GO) membrane.
A nearly complete hominin skull discovered near Harbin has been confirmed as part of the Denisovan lineage through advanced proteomic and ancient DNA analysis. The study provides crucial insights into the wide distribution of Denisovans in Asia, shedding light on their morphology and evolutionary history.
Researchers at USTC have developed weakly space-confined all-inorganic perovskite light-emitting diodes (PeLEDs) with a luminous efficiency exceeding 22%. The new PeLEDs achieve a maximum brightness of over 1.16 million nits and can operate for more than 180,000 hours.
A new dual-laser strategy revolutionizes breast cancer photothermal therapy by minimizing damage to surrounding tissues while effectively ablating tumors. The approach uses near-infrared photothermal agents with aggregation-induced emission properties and achieves precise targeting through second NIR-II fluorescence imaging technology.
Researchers identified two novel genetic mechanisms governing disease resistance in wheat, involving pairs of nucleotide-binding leucine-rich repeat immune receptors. The discoveries offer new insights into plant immunity and provide crucial gene resources for breeding resistant wheat varieties.
Researchers from Chinese Academy of Sciences have synthesized a new, highly neutron-deficient isotope of protactinium, protactinium-210. The discovery validates the facility's capability for studying heavy and superheavy nuclei.
Astronomers discover a super-Earth in the habitable zone of Kepler-725, 10 times Earth's mass, using Transit Timing Variation (TTV) technique. The exoplanet receives 1.4 times solar radiation as Earth and has potential for habitability.
Researchers have identified ten hemagglutinin sub-subclades with distinct antigenic variations, explaining why existing vaccines are ineffective against H9N2 AIVs. Key mutations associated with increased infectivity and pathogenicity in mammals have also been found.
The study reveals that the crystallographic characteristics of dinosaur egg SEUs are identical to those of PEUs and modern bird eggshell units, suggesting a biogenic origin. The researchers also discovered grooves and vesicles in SEUs, consistent with organic matrix fiber degradation during fossilization.
Researchers developed an advanced single-cell sorting platform that dramatically shortens the screening process for identifying high-value microbial strains. The technology enabled the isolation of a mutant strain producing 58% more DHA than the wild type in just two days.
Chinese researchers developed a groundbreaking 3D genome mapping technology that reveals how the 3D organization of plant genomes influences gene expression, especially in photosynthesis. The innovation provides a precise tool for understanding long-range chromatin interactions and their role in regulating biological processes.
The Late Ordovician Mass Extinction was caused by the rapid onset of global warming after the Hirnantian glaciation. The extinction lasted approximately 400 kyr with an average species extinction rate of 71.6% per 100 kyr during this period.
A study of ancient genomes from Yunnan, China, has provided new insights into human prehistory in East Asia. The research found that the region is pivotal to understanding the origin of both Tibetan and Austroasiatic population groups, with a previously unobserved Asian ancestry denoted as Xingyi ancestry.
A new study reveals that DNA methylation mediates the transgenerational inheritance of acquired cold tolerance in rice, supporting Lamarck's theory. Researchers developed a novel breeding strategy to develop stress-resilient crops, offering a promising avenue to tackle agricultural challenges posed by global climate change.
A new study reveals that deeply subducted carbonates can cause significant variations in Earth's mantle redox states, influencing diamond formation and craton evolution. This process shapes continent and diamond characteristics, with different mantle environments producing distinct redox signatures.
A new study of diffuse dwarf galaxies has revealed an exceptionally strong clustering pattern, contradicting the established understanding of galaxy clustering. The researchers propose a new model of dark matter based on the Self-Interacting Dark Matter (SIDM) theory.
Researchers find over 500 dense star-forming cores with possible protoplanetary disks in the Milky Way's Central Molecular Zone. Dual-band observations reveal unexpected spectral reddening, suggesting the presence of these early stages of solar system formation.
The study reveals the structure and activation mechanism of the human EP1 receptor, a key player in pain, cardiovascular disease, and certain cancers. The researchers identified unique residues that form a distinct binding motif for prostaglandin E2 and uncovered subtype-specific activation mechanisms.
The study elucidates the molecular mechanism of AUX1/LAX protein family-mediated auxin transport, highlighting the role of His249 residues in substrate recognition. This breakthrough sheds light on plant growth and development processes.
A joint Chinese-American research team has discovered the smallest known Archaeopteryx specimen, acquired by the Field Museum in 2022. The study provides crucial insights into the evolution of the skull and adaptations for flight during the transition from non-avian dinosaurs to birds.
The study provides crucial insights into the evolution of the skull and adaptations for flight in the critical transition from non-avian dinosaurs to birds. The Chicago Archaeopteryx specimen reveals an almost completely preserved skull with a palatal region intermediate between troodontids and more derived Cretaceous birds.
A team of Chinese researchers discovered that the body uses a unique fat molecule called ceramide-1-phosphate (Cer1P) to selectively recognize and manage specific bacteria in the gut. This 'dialogue' helps maintain intestinal health by triggering beneficial immune responses.
A recent study explores how ancient climate behavior can inform our understanding of the South Asian Summer Monsoon's (SASM) dynamics under climate warming. The study identifies similar SASM changes across past warm intervals, suggesting that insights from past warm climates can help predict future changes in monsoon circulation and ra...
A study of oyster fossils from the Early Cretaceous period reveals significant seasonal temperature fluctuations and periodic glacial melt events, overturning the traditional view of greenhouse climates. The findings suggest that elevated greenhouse gas concentrations may amplify seasonal extremes rather than lead to uniform warming.
A study published in Nature Neuroscience has uncovered the neural mechanisms by which social rank influences vulnerability to drug addiction. The research found that low-ranking mice exhibit a stronger reward circuit and weaker control circuit, making them more likely to seek drugs.
Chinese researchers have identified an insect predator using tools to exploit the collective defenses of social insects. The assassin bug, Pahabengkakia piliceps, weaponizes resin from stingless bee nests to lure bees into its optimal hunting position.
The USTC team identified a novel material design that enables record-breaking device performance in pure-red PeLEDs. They introduced a 3D intragrain heterostructure to enhance carrier confinement capacity, suppressing hole leakage and achieving unprecedented efficiency and brightness.
Researchers uncover pivotal role of cyclic dinucleotides in triggering bacterial immune response, leading to rapid and robust activation of defenses. The study provides a unified model for how CDNs trigger membrane-targeting immune responses across diverse immune systems.
Researchers achieve plastic warm metalworking in previously brittle semiconductors, enabling efficient and cost-effective manufacturing of high-performance electronic devices. The new technique unlocks new opportunities for scalable fabrication of thermoelectric devices with improved performance.
A recent study analyzed body size evolution in trilobites, a highly representative group of fossil invertebrates, and found that marine oxygen levels significantly influenced their body size. The research highlights the long-term impact of oxygen on the evolution of early metazoans.
A recent study reveals that a specific genetic variation affects the adherence of an anaerobic bacterium to tumor cells, promoting colorectal cancer progression. The study highlights the complex dynamics between host genetics and intratumoral microbiota in CRC progression.
A research team has uncovered a reciprocal regulatory relationship between extrachromosomal DNA maintenance and the DNA damage response in tumor cells. The study found that ecDNA actively replicates and is stably maintained in ecDNA-positive cells, triggering the ATM-mediated DDR pathway.
Researchers discovered temperature influences plant cell fate by regulating epigenetic marks. Low ambient temperatures can rescue developmental defects by compensating for PRC2 loss, highlighting the importance of H3K27me3 in maintaining cellular identity.
A research team developed a novel strategy to balance high catalytic activity and durability under industrial-level conditions. They constructed a MOF@POM superstructure that undergoes an in-situ transformation into a single-layer CoFe hydroxide catalyst, exhibiting exceptional performance in alkaline electrolytes.