A study by Columbia University Irving Medical Center reveals that preeclampsia significantly increases stroke risk in pregnant women with infections, chronic high blood pressure, or bleeding/clotting disorders. The risk of stroke after delivery is also a concern for mothers with preeclampsia.
A recent study published in the Journal of Periodontology found that frequent recreational cannabis use increases the risk of gum disease. The study analyzed data from over 1,900 US adults and found that frequent users were twice as likely to have signs of periodontal disease as non-frequent users.
A study in mice suggests that abnormalities in sensory synapses may contribute to the disease, and increasing their activity can alleviate symptoms. The findings also indicate that targeting these synapses could be a new approach for treating spinal muscular atrophy.
Researchers at Columbia University Irving Medical Center have created miniature lung structures, known as organoids, that replicate key features of a full-sized lung. These tiny organs may aid in understanding and treating respiratory diseases such as idiopathic pulmonary fibrosis.
A comprehensive review of clinical and basic research studies found that antipsychotics improve outcomes for patients with schizophrenia and related disorders. The benefits of these medications outweigh potential side effects, and delaying treatment can lead to poorer long-term outcomes.
Researchers discovered that tumor cells in patients with advanced prostate cancer are reprogrammed, reducing response to anti-androgen therapy and creating more aggressive tumors. SOX11 acts as a key regulator in this process, which may be targeted for new treatments.
Researchers at Columbia University have obtained detailed images of AMPA receptor interactions with regulatory proteins, revealing the structural changes that occur during desensitization. This knowledge may aid in designing targeted therapies for conditions like Alzheimer's, Parkinson's, epilepsy, and schizophrenia.
A study of over 100,000 participants found that dietary gluten is not associated with an increased risk of heart disease in people without celiac disease. Limiting whole grains as part of a low-gluten diet may actually increase the risk of heart disease in these individuals.
Researchers found a genetic explanation for how smoking contributes to coronary heart disease, revealing a single gene variant that loses its protective effect in smokers. This discovery opens doors to new therapeutic targets and personalized approaches to preventing CHD.
Researchers created a new tool that analyzes RNA sequencing data using topology, providing insights into cellular differentiation and development. The approach identifies connections between cellular states and genes active during development, offering potential discoveries in understanding cell identity and guiding cellular development.
Researchers developed a personalized algorithm that predicts the impact of particular foods on an individual's blood sugar levels. The Glucoracle app allows users to upload food and blood measurements, providing real-time predictions of post-meal blood sugar levels.
The Obesity Research Initiative aims to study the brain's role in regulating body weight and metabolic disorders like diabetes. The initiative will promote collaborative research across disciplines, including neuroscience, genetics, and metabolism.
A three-year research collaboration aims to create more accurate ways of measuring cancer progression. The project uses digital images from completed clinical trials to develop drug response metrics, with the goal of identifying optimal tumor burden measurement methods.
Christian S. Stohler, Columbia University College of Dental Medicine dean, received the Jack Hein Public Service Award for his leadership in supporting and advancing oral health research. He led a successful transition integrating oral health advocacy operations with the AADR, amplifying voice on Capitol Hill.
Panos N. Papapanou, a Columbia University dental scientist, has received the International Association for Dental Research (IADR) Award for his diverse and prolific contributions to periodontal disease research.
A study found that American adults who survive deliberate self-harm are at increased risk of suicide in the following year. Firearm-related self-harm was associated with the highest suicide risk, with males and older, white adults being disproportionately affected.
A common genetic variant, TMEM106B, accelerates normal brain aging by up to 12 years in people aged 65+, highlighting potential new targets for preventing age-associated brain disorders like Alzheimer's disease. Researchers also identified another variant associated with brain aging within the progranulin gene.
Researchers at Columbia University Medical Center have discovered a bone-derived hormone that regulates food intake and blood sugar. The study found that the hormone, lipocalin 2, turns on brain neurons involved in appetite suppression, potentially leading to new targeted therapies for obesity and type 2 diabetes.
Researchers have identified two genes linked to IgA nephropathy, a common cause of kidney failure. The study found that variations in these genes, C1GALT1 and C1GALT1C1, are significantly more common in patients with high levels of the Gd-IgA1 marker.
A recent study by researchers at Columbia University Medical Center found that only 16 percent of heart attack survivors meet the recommended amount of physical activity in the weeks following hospitalization. Clinician-supervised exercise programs have shown promise in encouraging more physical activity, but participation remains poor.
Researchers found that an initial diagnosis of acute kidney injury may have been inaccurate for many patients, as the current method of assessing kidney function may be misleading during the initial evaluation. The study identified sets of biomarkers in mouse models that could potentially detect kidney damage more reliably.
Researchers found that a single dose of ketamine administered one week before a stressful event can buffer against PTSD symptoms. The study suggests that prophylactic ketamine use might be beneficial for individuals highly likely to experience significant stressors.
A study at Columbia University Medical Center found that a missing CRKL gene causes kidney and urinary tract defects in people with DiGeorge syndrome. The team analyzed genomic data from over 2,600 children with congenital anomalies of the kidney and urinary tract.
Researchers discovered that excess tau protein damages brain's GPS, leading to spatial disorientation and cognitive deficits in Alzheimer's disease. The findings may lead to early diagnostic tests and novel targets for treating this common symptom.
The Chapman Perelman Foundation has awarded a $1 million gift to Columbia Psychiatry to expand on-site clinical psychiatric services at NYC Family Justice Centers. This partnership aims to provide comprehensive care and healing to survivors of domestic violence, helping them rebuild their lives.
Researchers found a significant excess of mutations in five genes previously implicated only in rare forms of epilepsy in individuals with common forms of the disorder. The study identified these genes as contributing to epilepsy risk in approximately 8 percent of people with familial non-acquired focal epilepsy.
Researchers at Columbia University Medical Center found that transfusing older blood (over 5 weeks) can lead to excessive iron release, potentially harming patients. The study suggests reducing the maximum storage limit of red blood cells from 6 weeks to 5 weeks.
Researchers developed iCAGES, a computational tool that integrates whole genome-based approach to identify individual cancer driver genes and select treatment options. The tool was found to be superior in predicting cancer drivers and identifying beneficial treatments compared to other computational tools.
Researchers found that nerve growth factor and tuft cells stimulate gastric tumor growth through aberrant cholinergic signaling, providing a potential therapeutic target for stomach cancer. Blocking nerve growth factor receptor inhibited stomach cancer growth in mice.
Low-income children receive similar amount of dental care as their privately insured peers, yet have higher rates of poor oral health. The study suggests that addressing social determinants such as nutrition and housing is crucial to improving oral health outcomes among low-income populations.
A deficiency of prohormone covertase (PC1) in the brain is linked to most neuro-hormonal abnormalities in Prader-Willi syndrome. The discovery provides insight into molecular mechanisms underlying the syndrome, highlighting a novel target for drug therapy.
A combination therapy of thioguanine and decitabine has shown promising results in a small Phase I clinical trial for patients with relapsed or refractory acute myeloid leukemia. Eight out of 12 patients responded to the treatment, including six who achieved complete remission.
Researchers at Columbia University Irving Medical Center discovered that dysfunctional N-methyl-D-aspartate (NMDA) brain receptors cause hearing deficits in schizophrenia. Patients who received training and administration of an amino acid, D-serine, significantly improved their ability to distinguish subtle differences in pitch.
Peter Arner's research revealed processes that contribute to obesity and diabetes, including the turnover of fat tissue and the production of adipokines. His work also showed that fat cells are renewed relatively rapidly, regardless of weight loss, and that a molecule called TNFα alters leptin levels.
Researchers at Columbia University Irving Medical Center have demonstrated that vision loss associated with retinitis pigmentosa can be slowed dramatically by reprogramming the metabolism of photoreceptors. The treatment aims to correct downstream metabolic aberrations, rather than the underlying genetic defect.
A major international study found that drug-eluting stents are equally effective as bypass surgery for patients with left main coronary artery disease, with fewer complications. The EXCEL trial followed 1,905 patients and showed stents to be safer in the first 30 days after treatment.
Researchers at Columbia University Medical Center discovered that inactivating the TAZ protein in liver cells reverses fibrosis, a primary feature of nonalcoholic fatty liver disease. This finding has potential implications for treating nonalcoholic steatohepatitis, a serious condition that can lead to liver failure and cancer.
A study found that physically active children had reduced airway inflammation but also higher exposure to black carbon and diesel exhaust. Exercise did not counteract the negative effects of high pollutant levels on lung health.
A recent study found that patients who continued with their prescribed medical therapy after stent or bypass surgery had significantly better outcomes than non-adherent patients. Adherence to antiplatelets and statins was a more powerful predictor of adverse event-free survival than the type of revascularization procedure.
A recent study published in JAMA Neurology found that pregnancy significantly increased the risk of stroke in women under 35, but not in those over 45. The researchers analyzed data from over 19,000 women hospitalized for stroke between 2003 and 2012.
Researchers discovered eight pairs of drugs associated with a higher risk of long QT syndrome, which can cause abnormal heart rhythms and sudden death. The study used big data mining to identify the interactions, and found that ceftriaxone and lansoprazole increased the risk by 1.4 times.
Researchers at Columbia University Irving Medical Center have identified stem cells in the temporomandibular joint that can generate cartilage and bone. The discovery suggests a potential new approach to repairing damaged joints, particularly for patients with TMJ disorders.
A clinical trial found that ruxolitinib, a JAK inhibitor, significantly restored hair growth in 75% of patients with moderate to severe alopecia areata. The treatment was well-tolerated and showed promise for treating other forms of hair loss.
Columbia researchers have identified 41 key genes that may contribute to gum disease, offering a promising approach to developing individualized treatments. The study's findings could lead to new compounds that target specific genetic pathways involved in the disease process.
Researchers discovered that fluoxetine, an antidepressant, causes bone loss by increasing epinephrine levels and impairing bone formation. However, co-treating with low-dose beta-blockers may prevent this effect. This finding has significant implications for preventing fractures in peri- and postmenopausal women.
A recent study found that only about a third of American adults with depression received treatment. Among those who did receive treatment, less than half were seen by a mental health specialist for severe psychological distress.
Researchers at Columbia University Medical Center have captured images of the vitamin A transporter protein STRA6 using electron microscopy. The images revealed that STRA6 transports vitamin A through an intermediary protein, providing new insights into cellular function and potentially leading to the development of therapeutic targets.
A new study published in Nature Communications reveals that the Zika virus disrupts the proliferation of radial glial progenitors (RGPs), a type of stem cell essential for brain development. In genetic cases of microcephaly, NDE1 mutations cause RGP cells to fail to divide, resulting in severe brain developmental delays.
Researchers have developed an imaging technique that can accurately diagnose and prognosticate transthyretin-related cardiac amyloidosis (ATTR-CA), a type of heart failure. The test uses technetium 99m pyrophosphate and has been shown to correctly identify ATTR in 91% of patients, ruling out other forms of amyloidosis.
Researchers found that omega-3 fatty acids reduced brain damage in mice with hypoxic-ischemic brain injury. The study suggests that injecting DHA after a stroke-like event can protect brain mitochondria against free radical damage.