Dr. Christopher Basler receives $100,000 grant to study enzymes critical for SARS-CoV-2 replication and explore small molecule inhibitors as potential COVID-19 treatments. Early data suggests these drugs could be effective in slowing SARS-CoV-2 growth.
Georgia State University researchers have received a $200,000 grant to develop a COVID-19 test tool that detects SARS-CoV-2 using electrochemistry. The technology offers several benefits, including fast turnaround time and decreased false negative outcomes.
Dr. Christopher Basler's five-year grant aims to understand how Ebola and Marburg viruses evade immune responses, leading to new treatment approaches. The study will focus on filovirus-host interactions related to gene expression and translation.
Scientists at Georgia State University have identified a potent and well-tolerated antiviral compound, GHP-88309, that targets paramyxovirus polymerases. The compound is effective against both human parainfluenzaviruses and the measles virus.
Dr. Richard Plemper, a Georgia State University researcher, has received a $3.65 million grant to develop antiviral therapeutics for respiratory syncytial virus (RSV) infections. The goal is to create cost-effective and well-tolerated treatments for RSV, which affects over three million hospitalizations annually.
Researchers at Georgia State University have developed detailed methods for studying SARS-CoV-2, allowing safe analysis of infected cells. The study enables the examination of viral proteins and host responses to infection outside high-containment facilities.
Autoimmune diseases, common in the US after cancer and heart disease, are a mystery due to compromised tolerance. A $1.95M NIH grant will fund research to understand why the immune system attacks its own body.
A new study found that older men are less worried about COVID-19 than women their age or younger people, despite being at higher risk of severe or fatal infections. The study suggests that accurate perception of risk may be more effective in predicting preventive behaviors than worry.
New study finds Paid Sick Leave mandates increase worker absences by 4.5 percentage points, particularly among women and low-wage industries
A study found that US adults with inflammatory bowel disease tend to eat more junk food, such as French fries, cheese, and cookies, which may contribute to their condition. The research also revealed that these foods can increase the risk of inflammatory bowel disease.
Dr. Tim Denning receives a $1.67 million grant to study the IL-36/IL-36 receptor axis in gut immunity and its potential therapeutic value for treating inflammatory bowel disease.
A new biomarker for detecting liver metastases has been identified by a Georgia State University research team. The breakthrough uses a targeted MRI contrast agent that can pinpoint tiny instances of cancer cells, overcoming major barriers in early diagnosis.
Researchers develop new framework to understand changes in brain activity and connections, with implications for modeling brain disease mechanisms. The study identifies three categories of dynamic interaction between neurons involved in cognitive function.
Researchers developed a novel nanoparticle vaccine that combines M2e and NA proteins, providing strong cross-protection against six different influenza virus strains. The vaccine offers potential as a universal flu vaccine or component of such vaccines.
Researchers develop a new approach to alter intestinal microbiota and vaccinate against chronic inflammatory diseases, including inflammatory bowel diseases and obesity. Targeted immunization against bacterial flagellin has been shown to beneficially alter the composition and function of the intestinal microbiota.
A study by Georgia State University found that 43% of US adults consider e-cigarettes to be as harmful as cigarettes, while 8% believe they are more harmful. The increase in perceived harm may reflect growing concerns about the teen vaping epidemic and the recent outbreak of vaping-related illnesses.
Researchers at Georgia State University have made a groundbreaking discovery in catalytic reactions, revealing that nanoconfinement can actually speed up chemical reactions. This finding has major implications for the engineering of new, more energy-efficient catalysts that could save billions of barrels of gasoline every year.
Researchers at Georgia State University have identified the critical protein Z-DNA binding protein 1 (ZBP1), which plays a significant role in triggering an immune response to viral infections. The study found that ZBP1 is essential for restricting West Nile and Zika virus replication, preventing severe disease outcomes.
Researchers at Georgia State University have developed a protein-based contrast agent that can detect early-stage liver diseases, including liver fibrosis, with high accuracy and sensitivity. The new method uses a lower dosage of contrast metal gadolinium, reducing the risk of metal toxicity and enabling earlier diagnosis and treatment.
A new antiviral drug blocks RNA polymerase, inducing mutations in the genetic material of the influenza virus and rendering it nonfunctional. The study found the drug to be highly efficacious against various strains of the flu, including seasonal and pandemic viruses.
A study by Georgia State University researchers found that monkeys were more willing to explore efficient options when solving problems, whereas humans tend to stick with familiar strategies. This cognitive bias can lead to inefficient decisions and missed opportunities.
Researchers at Georgia State University isolated gut bacteria that can prevent and cure rotavirus infection, the leading cause of severe diarrhea in children worldwide. The discovery may lead to possible treatments and preventive measures for rotavirus infection.
A study led by Georgia State University researchers found that early life racial discrimination is linked to elevated depressive symptoms and accelerated aging processes in African American youth. The study, which analyzed data from over 800 African American families, suggests that experiences of racial discrimination may be driving a ...
A study by Georgia State University researchers found that creating mutations in the VP35 protein of the Ebola virus can make it unable to cause disease. The mutated virus was able to induce strong immune responses in non-human primates, protecting them from infection with wildtype Ebola virus.
The study identified a novel protein interface in the polymerase complex that is pivotal for regulating polymerase activity, providing a new objective for target-based antiviral drug discovery. The findings reveal a vulnerability in the viral genome that could be exploited as a target for small-molecule antiviral drugs.
A study by Georgia State University researchers found that blocking the bacterial pathogen's ability to uptake zinc can prevent gonorrhea infection. The study provides insight into how to block growth of this pathogen and could move gonorrhea vaccine development forward.
A recent study published in CANCER found significant disparities in triple-negative breast cancer diagnoses among women of color and younger women. Non-Hispanic black women had a significantly higher incidence of the disease, with over 21% diagnosed compared to under 11% for other ethnic groups.
Researchers found that brain networks are spatially and functionally fluid, with rapid changes in network activity over time. This challenges the long-held assumption that brain regions contribute to each network in a fixed way.
Dr. Baozhong Wang is developing a multivalent layered nanocluster vaccine that can act against multiple influenza virus strains, using conserved antigenic proteins from both A and B viruses. The goal is to induce broadly reactive immune responses providing cross-protection against both influenza A and B viruses.
A study led by Georgia State University researchers found that fecal miRNA can serve as a tool to assess gut microbiota healthiness and provide early clues to intestinal inflammation in mice. The findings offer new hope for diagnosing chronic gut conditions, such as inflammatory bowel disease.
The Georgia Child and Family Policy Lab will improve lifelong well-being for Georgia's children and families by evaluating programs, creating early warning systems, and increasing research capacity. The lab will integrate disparate data sources to examine the impact of social support programs and prevent negative child outcomes.
Research by Georgia State University found that women undergoing radiation therapy for pediatric brain tumors are more likely to experience long-term cognitive issues. Female survivors were more negatively affected in activities of daily living and higher-order skills compared to male counterparts.
A researcher has received funding to develop new models that use brain imaging and genomic data to predict mental health disorders. The goal is to improve diagnosis accuracy by analyzing a patient's genetics and brain activity.
Researchers found that early-season hurricanes result in a 70% increase in disease cases due to stagnant water and disrupted health infrastructure. Mosquito populations boom after heavy rainfall events, putting people at risk of infection.
Researchers at Georgia State University have developed a non-invasive method for detecting liver fibrosis using machine-learning algorithms and ultrasound scans. This technology has the potential to improve early diagnosis and treatment of liver diseases, which affect millions worldwide.
The Urban Studies Institute has been awarded a two-year grant to study the impact of mobility support options on the health behaviors and outcomes of low-income individuals with Type 2 diabetes in metro Atlanta. The research aims to address social barriers to health, reduce healthcare costs and advance health equity.
The program, iQuit Mindfully, combines mobile health technology with mindfulness training to provide round-the-clock support for quitting smoking. A 2019 pilot study showed the technology is effective for diverse, underserved adult populations of low socioeconomic status.
A unique adjuvant has been identified that can prevent vaccine-enhanced respiratory disease in RSV. The study found that combining this adjuvant with RSV vaccination primes the body for protective immune responses and prevents inflammatory RSV disease after infection.
Researchers at Georgia State University discovered that societal expectations around gender roles can alter the human brain at a cellular level. This finding suggests that epigenetic marks in the brain drive differences between males and females, influenced by gender identity rather than just biological sex.
The university will conduct research on the health and well-being of migrant children using an evidence-based parenting program. The goal is to improve parent-child relationships, alleviate stress, and boost children's social-emotional health. The center will work with community partners to design and implement projects.
Researchers found that early-life microbiota play a crucial role in regulating immune responses and preventing colon cancer in adulthood. The absence of microbiota in early life can lead to enhanced pro-inflammatory gene expression and an accumulation of immune cells that suppress tumor growth.
A study led by Georgia State University found that Ugandan youth with both HIV and sexually transmitted infections are more likely to engage in problem drinking. Co-infection rates among youth living in slums of Kampala, Uganda are significantly higher than other areas of sub-Saharan Africa.
A researcher at Georgia State University has received a $3.86 million grant to develop a universal flu vaccine using a microneedle patch that can protect against any strain of the influenza virus. The vaccine aims to induce strong cross-immune protection and overcomes seasonal flu limitations, which have been ineffective in recent years.
A new study predicts that meeting national HIV prevention goals could substantially reduce new HIV infections in the US by 67 percent by 2030. Implementing innovative models for delivering HIV care and prevention interventions, as well as sufficient investments to bring them to scale, are crucial to achieving this goal.
A researcher at Georgia State University is studying how dietary fiber can protect against diabetes and other metabolic disorders. The study aims to develop new strategies to maintain a healthy gut-microbiota relationship, which could enable safe treatment and prevention of type 2 diabetes.
Research at Georgia State University found that Muslim-perpetrated terror attacks receive significantly more media attention, highlighting a serious imbalance in news coverage. The study also identified other factors driving coverage, including arrests and government targets.
A research study led by Georgia State University found that females are more sensitive to the rewarding actions of oxytocin (OT) than males in same-sex social interactions. The study also discovered an inverted U-shape relationship between OT, social reward, and neural activity among females.
A Georgia State researcher has been awarded a $1.2 million grant to develop drone technology for wildfire management, providing real-time data to aid evacuations and fire management decisions. The technology aims to help contain wildfires, predict fire spread, and support human-UAS collaboration.
A study published in eNeuro found that neurons in the hippocampus inhibit future eating behavior by consolidating memories of preceding meals. The findings suggest that techniques promoting hippocampal-dependent memories could be promising strategies for reducing eating and promoting weight loss.
A global carbon tax could reduce greenhouse gas emissions efficiently, according to a survey of people in the US, India, UK, South Africa, and Australia. The majority of respondents supported carbon taxes if revenues were returned to citizens or spent on climate projects.