A four-year grant will explore nanoparticle-mediated manipulation of pro- and anti-inflammatory factors to limit intestinal inflammation and promote wound healing in IBD patients.
Dr. Sang-Moo Kang's project aims to improve the efficacy and extent of cross protection against new influenza virus strains by incorporating M2e epitopes into HA molecules. The research will test novel approaches to boost cross protective properties of licensed seasonal influenza vaccines, with results expected to impact public health.
Inlighta Biosciences is developing a novel, protein-based MRI contrast agent called ProCA32 to detect early stages of liver cancers and other metastatic tumors. The agent has shown improved imaging contrast compared to conventional agents, enabling earlier detection and characterization of cancerous lesions.
A microneedle patch vaccination with an influenza fusion protein improves the effectiveness of conventional flu vaccines by boosting humoral immunity and cellular immune responses in mice. The study offers a new perspective for universal influenza vaccines.
A Georgia State University study found that early-life inflammatory pain increases sucrose intake and decreases memory-related protein expression in adult rats, with female rats showing more pronounced effects. The study suggests that preventing pain in premature infants may reduce the risk of obesity.
Researchers at Georgia State University have discovered a link between male sexual behavior and elevated male sex hormone receptors in the muscles of sex-changing fish. The study found that males express more androgen receptors in the supracarinalis muscle, which is associated with increased rates of courtship and aggressive displays.
A Georgia State University researcher has received a $7.7 million federal grant to develop three-dimensional human brain models called organoids for studying West Nile and Zika virus infections. The study aims to understand the differences between these two neurotropic viruses, which have distinct disease effects in humans.
Georgia State neuroscientists rewired the brain of one species to have the connections of another, finding distinct neural circuits underlying swimming behavior in two closely related sea slugs. The study's results suggest that behaviors can be conserved while their neural basis shifts over evolution.
Researchers found a link between isolated white communities and late-stage breast cancer diagnoses, with one-third of new patients diagnosed at a late stage in the US. Concerted public health efforts may explain lower risk disparities in black and Hispanic neighborhoods.
Researchers found that people with type 2 diabetes have bacteria that penetrate the mucus lining of their colon, leading to insulin resistance and abnormal blood glucose levels. The study's results provide a new understanding of how metabolic diseases like diabetes develop.
Researchers at Georgia State University are studying the role of an enzyme in causing diabetic vascular diseases and exploring its potential as a new treatment. The study aims to understand the molecular mechanisms behind the disease and identify a strategy to protect against its development.
A Georgia State University researcher is studying how to reduce tumor growth in lung cancer using a $2.3 million grant. The goal is to identify novel targets for treatment, as tumors become resistant to current therapies and promote new blood vessel formation.
Researchers at Georgia State University are testing a new mobile phone application that combines two existing programs to decrease maternal depression and build parenting skills. The project aims to promote infant social-emotional health and development, with the potential to reach larger numbers of mothers than traditional programs.
Researchers from Georgia State University are investigating the role of mitochondrial dysfunction in developing diabetic cardiomyopathy, a leading cause of heart failure and death in diabetic patients. They aim to understand how increased FUNDC1 expression impairs mitochondrial function, leading to cardiac damage and dysfunction.
A study led by Georgia State University found that cytokine IL-36γ promotes the development of pro-inflammatory T helper cells and inhibits regulatory T cells in humans. This discovery could lead to new therapeutic approaches for inflammatory bowel disease, particularly ulcerative colitis.
A Georgia State University study found that high school dropout rates are influenced by both student-level and school-level factors. Socioeconomic status plays a significant role in determining dropout rates, regardless of race or ethnicity. Schools can make a difference by offering extracurricular activities and limiting retention pol...
A Georgia State University researcher has received a five-year grant to develop a new drug targeting the Ebola virus. The goal is to find compounds that block the growth of Ebola virus by inhibiting its viral machinery.
A recent study by Georgia State University researchers found that female brains have more active immune cells in pain processing regions. This leads to improved response to opioid pain medication, often less effective in females.
A study published in PLOS ONE found that marathon performance decline begins at around 35 years old, with top runners experiencing a slowdown of two minutes per year. Average runners start to experience a decline at age 50, with women having a slightly faster rate of decline.
A new study finds that high levels of a biomarker called nuclear KIFC1 are linked to poor prognosis in African-American patients with triple-negative breast cancer. In contrast, the same biomarker does not affect disease outcomes in white patients, highlighting racial disparities in breast cancer treatment.
Dr. Anne Murphy's research aims to improve pain management strategies for people aged 65 or older, who experience severe under-treatment of chronic pain. She will use a systems-level approach to investigate the impact of age on central opioidergic circuits.
Researchers found that African-American breast cancer patients who receive chemotherapy prior to surgery exhibit reduced regional and distant tumor recurrence rates. Early-stage patients with African-American ancestry display higher tumor recurrence rates compared to European-Americans.
Researchers used social media and internet reports to analyze exposure patterns during the 2014-2015 Ebola epidemic and 2015 Middle East Respiratory Syndrome outbreak. The study found that alternative data streams can provide reliable information on disease dynamics in the early stages of an outbreak.
A recent study led by Georgia State University researcher found that living in segregated communities can affect colorectal cancer diagnosis timing. Residents of highly segregated Asian communities are more likely to receive late diagnoses, while those in African American communities are less likely.
Researchers identified MMP9 as a tumor suppressor role in colitis-associated cancer (CAC), which is driven by chronic inflammation. The study found that MMP9 suppresses tumors by activating the MMP9-Notch1-ARF-p53 axis pathway.
A study examining late-life couplehood in assisted living found benefits of companionship, support, and affection. Fellow residents can play an important role in shielding against negative health outcomes associated with marital transitions.
Researchers found that amphetamine slows down body temperature rise and masks fatigue in rats, allowing them to run longer. However, this mechanism can lead to dangerous overheating of muscles, posing a significant health risk.
The new observatory will record high-resolution images of the Sun every five seconds, measuring internal gravity waves and their role in transporting energy and momentum. The data will aid in understanding space weather events, solar coronal heating, and the structure of the Sun's atmosphere.
A survey of primary care physicians reveals most would provide only partial disclosure of medical errors, falling short of patient expectations and national guidelines. The strongest predictors of disclosure were perceived personal responsibility, seriousness of the event, and value of patient-centered communication.
Researchers used fruit flies to investigate the genetic and neural bases of detecting painful or harmful cold stimuli. The study found that cold-sensing neurons activate specific aversive behaviors and are linked to a gene implicated in autosomal dominant polycystic kidney disease.
A recent study published in Cancer Research found that emulsifiers in processed foods can alter the gut microbiota in mice, leading to increased tumor development and inflammation. The study suggests that dietary emulsifiers may be partially responsible for the increasing incidence of colorectal cancer worldwide.
Researchers at Georgia State University discovered serotonin and arginine-vasopressin act in opposite ways to influence aggression and dominance in males and females. The findings may lead to more effective gender-specific treatment strategies for stress-related neuropsychiatric disorders.
A study found that elderly Chinese immigrants in the US feel at home due to favorable social policies like Medicare and Medicaid, as well as affordable cost of living. However, language barriers continue to be a significant issue, with many unable to speak fluent English and relying on family members for translation.
A study by Georgia State University found that the perception of e-cigarette harm among US adults has tripled over the last few years. Adult smokers now believe e-cigarettes are equally or more harmful than traditional cigarettes, a significant increase from nearly 12% in 2012.
A study published in the American Journal of Agricultural Economics found that federal school lunch guidelines led to improved health outcomes for students. The research showed a reduction in calories from fat and sodium, but varying responses across socioeconomic and demographic groups.
A team from Georgia State University has won a $2 million federal grant to improve mental health services for child victims of commercial sex trafficking. The project will expand therapy programs and train therapists working in juvenile justice and foster care systems.
The CHARA Array, a world-leading optical interferometer, has been upgraded with a $3.9 million grant from the NSF. This new funding will enable scientists worldwide to access the Array's powerful telescopes and explore stars and planets in unprecedented detail.
A study by Georgia State University researchers found that yoga can reduce worry, the main symptom of Generalized Anxiety Disorder. The findings suggest that yoga has promise in helping people with this condition reduce their symptoms and improve quality of life.
The Center for Behavioral Neuroscience has received a grant from NIMH to develop transgenic and gene-targeted Syrian hamsters for understanding complex social behavior. The technology will enable molecular interrogation of genes regulating social behavior, leading to progress toward better understanding of psychiatric disorders.
A study led by Georgia State University found that incorporating laughter into a physical activity program can improve the mental health, aerobic endurance, and confidence of older adults. The LaughActive program, which includes playful simulated laughter exercises, also increases motivation to participate in exercise.
Resveratrol, a compound found in red wine and grapes, has been shown to reduce inflammation induced by bacterial pathogens that cause respiratory diseases such as asthma and COPD. The study identified a novel mechanism by which resveratrol suppresses inflammation by upregulating a negative regulator called MyD88 short.
A study by Georgia State University found that college-educated smokers are more likely to use e-cigarettes as a tool to quit smoking. The survey of over 1,200 smokers revealed that those with higher education levels were more intent on quitting and attempting to stop smoking in the past year.
Researchers at Georgia State University have developed edible ginger-derived nano-lipids that effectively target and deliver chemotherapeutic drugs to colon cancer cells. These nanovectors, modified with folic acid, show high-affinity binding to tumor tissues and inhibit tumor growth while reducing side effects.
The collaboration will improve the sensitivity of the interferometric telescopes and enable the observation of smaller objects in the sky. The new system will allow astronomers to study high-interest targets such as dusty debris disks and accretion disks around newborn stars.
Researchers at Georgia State University are investigating how the human brain has evolved to support technological learning. The study aims to identify unique aspects of the human brain and understand the factors that cause individuals to acquire technological skills differently.
Researchers at Georgia State University identified a brain mechanism that prevents morphine tolerance and addiction. Blocking a particular cytokine eliminated morphine tolerance, reducing the dose required for pain relief by half.
A Georgia State University researcher is investigating how changes in intestinal bacteria may lead to obesity and metabolic syndrome. He aims to understand the role of dietary fiber in altering gut bacteria and promoting inflammation.
Older adults in assisted-living facilities face limits to their sexual freedom due to inadequate policies and an environment of surveillance. The study found that staff and administrators often prioritize residents' health and safety over autonomy, leading to restrictions on intimate behavior.
The Center for Leadership in Disability at Georgia State University is conducting a three-year study on the impact of tree canopy on symptoms of children with autism. The research aims to investigate the relationship between nature walks, memory, and stress responses in children with autism.
The university has grown its research funding by nearly $40 million over the past two years, with federal agency funding increasing by 30 percent. Georgia State now ranks among the nation's premier urban public research universities, with a 'very high research activity' designation from the Carnegie Foundation.