Researchers from Kanazawa University create a new, high-performance carbon fiber material by chemically modifying Kraft lignin, reducing its weight while maintaining mechanical strength. The resulting composite exhibits almost 3-fold improvement in mechanical strength compared to unmodified Kraft lignin.
Researchers at Kanazawa University demonstrate the ability to reversibly control the emission of blue-green light from water-soluble tetraphenylethene molecules on artificial cell membrane surfaces. This controlled emission has potential applications in new biological sensors and smart drug delivery platforms.
Researchers at Kanazawa University discovered that thymoquinone selectively kills prostate cancer cells with a SUCLA2 gene deletion. This finding offers a promising therapeutic option for advanced prostate cancer patients who have developed resistance to hormone therapy.
A new potential drug treatment has been discovered for a type of lung-cancer. Researchers have found that combining osimertinib with linsitinib can cure or delay tumor recurrence in EGFR-mutated lung cancer, even in AXL-low expressing tumors.
A new study from Kanazawa University finds that combining antibiotics with antibiotic-laden stem cells effectively treats implant-related bone infections. The researchers used mesenchymal stem cells to deliver ciprofloxacin, which showed strong antimicrobial effects and improved outcomes in animal models of osteomyelitis.
Physicists develop new theory to explain neutrino properties, solving lepton conservation issues and potential dark matter answers. The research provides predictions testable by the Large Hadron Collider.
A study by Makoto Sato and colleagues from Kanazawa University reveals that a gene called Dscam regulates the repulsion between neurons in fly brains, leading to the formation of columnar structures. This finding supports the radial unit hypothesis, which describes the development of the cerebral cortex in mammals.
Researchers from Kanazawa University found that IL-17A triggers cellular changes in the peritoneum, leading to stromal fibrosis in gastric cancer patients. The study suggests that suppressing mast cell degranulation may be a promising treatment strategy for patients with peritoneal dissemination.
Researchers at Kanazawa University used high-speed atomic force microscopy to study the fusogenic transition of Influenza A hemagglutinin, revealing its interaction with exosomes and facilitating viral membrane fusion. This study provides important insights into the mechanism of HA-mediated membrane fusion.
Scientists have developed a novel organocatalyst that can control radical reactions, enabling the synthesis of complex compounds. The catalyst, featuring an N-neopentyl group, promotes coupling reactions while suppressing side reactions, allowing for the synthesis of bulky molecules and pharmaceuticals.
Researchers at Kanazawa University developed a method to overcome constraints in high-sensitivity atomic force microscopy for photosensitive samples. By driving cantilevers with megahertz frequencies, they achieved stable control and imaging of surface topography and composition.
Studies of alpha-synuclein protein aggregates found variations in elongation rates and fibril structures, depending on cross-seeding and pH levels. High-speed atomic force microscopy enabled visualization of growth over time, shedding light on amyloid-related diseases.
Researchers from Kanazawa University developed a new predictor using machine learning to identify patients at risk of sudden arrhythmic cardiac death and heart failure death. The model uses iodine-123 labelled MIBG and standard clinical tests to discriminate between high-risk and low-risk patients.
A recent study published in Communications Biology reveals that osteoblasts use extracellular vesicles to send signaling molecules to immature osteoclasts, triggering their differentiation into mature cells. This process is crucial for bone repair and regeneration after a fracture.
A hemispherical vanadium oxide cluster cavity can stabilize a polarized Br2 molecule, enabling selective bromination of alkanes. The study reveals different product selectivity compared to the radical mechanism.
Scientists study FG-NUPs in normal and colorectal cancer cells, finding altered conformational dynamics in cancer cells. The structure of the central plug is smaller, hindering filamentous features in cancer cells.
Researchers from Kanazawa University purified and characterized Monalysin, a pore-forming bacterial toxin, to study its interaction with the innate immune system. The study revealed that activated Monalysin forms pores in cell membranes, leading to cell death, and that it preferentially inserts into curved parts of membranes.
A simple epithelium modelled as a layer of interconnected polyhedra reveals an inherent mechanical instability that leads to cell extrusion. Small changes in density or topology can trigger extrusion without additional forces, generating forces within the layer that direct further extrusions.
Researchers found high-dose131I-metaiodobenzylguanidine treatment improved outcomes in refractory high-risk neuroblastoma patients. The study discovered a 42% event-free survival rate at 1 year and 16% at 5 years, with overall survival rates of 58% at 1 year and 42% at 5 years.
Researchers from Kanazawa University discovered SLC35B1 as a crucial molecule in the detoxification process, enabling glucuronidation of drugs and toxicants. The study revealed that SLC35B1 significantly affects UGT activity when knocked down, suggesting its vital role in regulating this complex process.
Researchers at Kanazawa University have developed a novel method for generating alkyl radicals under mild conditions using organoboron compounds and visible-light. The new protocol enables the generation of bulky tertiary alkyl radicals and unstable methyl radicals, which are useful carbon sources for chemical reactions.
Mutations in TP53 and concomitant mutant p53 proteins in cancer cells have been found to accelerate tumorigenesis and metastasis. The researchers found that the combination of gain of function mutations and loss of heterozygosity provides protection against cell death, promoting a fibrotic microenvironment and inflammation pathways.
PML bodies are found to physically restrict access to DNA methylation enzymes, suppressing gene activation. The study sheds light on a new role of PML bodies in regulating gene expression by manipulating 3D nuclear organization.
The study evaluates impact response of ultra-high-strength concrete with different steel fiber contents and section heights. Increasing steel fiber content reduces damage by 30-50%, enabling enhanced building safety in high-rise buildings, bridges, and roads.
Researchers identified a novel sublineage of EV-A71-C4 isolates with two recombinants, showing greater virulence than the B5 subgenotype. The study suggests that C4 strains may be more deadly than B5 strains in northern Vietnam.
Researchers discovered a high diversity of physical properties among membrane vesicles (MVs) from different bacteria, with varying adhesion, elasticity and friction. The study used phase imaging atomic force microscopy to analyze MVs from E. coli, P. aeruginosa, P. denitrificans and B. subtilis.
A Kanazawa University researcher proposes a novel cosmological model that extends the concept of black hole thermodynamics. The model satisfies the second law of thermodynamics on the horizon and suggests regions where cosmological models are favored from a thermodynamic viewpoint.
Researchers have identified a gene linked to brain cancer in children that can aid in diagnosis and treatment. Elevated levels of the TPR gene were found in 38% of ependymoma cases, and its deletion led to reduced cancer growth and tumor shrinkage when treated with rapamycin.
A new algorithm has been discovered that can accurately register two point sets consisting of millions of points in a fraction of the time taken by conventional methods. The algorithm's accuracy is not compromised despite using approximations, and it has wide-ranging applications in computer graphics and computer vision.
Scientists at Kanazawa University developed a novel method to detect invisible blood vessels inside tumors, which could help surgeons avoid hemorrhage during tumor resection. The new system uses a master-slave surgical robot with a force sensor that detects pulsation based on gripping force, even in soft and hard tumors.
A new approach to electrostatic layer deposition has been reported, leading to efficient perovskite solar cells. The technique produces uniform electron transport layers without the need for a vacuum environment, enabling the creation of high-efficiency solar cells with improved power-conversion efficiencies.
Researchers discovered that combining alectinib with EGFR-inhibitors prevents CNS metastasis progression in mouse model. This combination treatment overcomes alectinib resistance, offering potential novel therapies for NSCLC and secondary cancers.
Researchers at Kanazawa University developed a method to fill nanopipettes using a temperature gradient, achieving complete filling of a batch with pore diameters below 10 nm. The 'air bubble' that typically remains near the pipette's pore end can be removed by applying the temperature gradient.
A study found that silencing the KPNA4 gene reduces cell proliferation, migration ability and resistance to radiation in HNSCCs. Targeting disease-specifically altered transport systems may serve as promising therapeutic strategies for cancer treatment.
Researchers have developed a nanopipette pH biosensor that can detect changes in extracellular pH with high sensitivity and spatial resolution. The device uses a zwitterionic membrane to enable faster responses and has been tested on live cancer cells, showing its potential for cancer diagnosis, prognosis, and targeted therapies.
Researchers have developed a genetic typing method for Pseudomonas putida, which enables the detection of its virulent strains. The study's findings highlight the bacterium's biotechnological value and its importance in understanding disease-causing pathogens.
Researchers at Kanazawa University develop a scanning electrochemical cell microscopy technique to engineer the catalytic properties of 2D transition metal dichalcogenides. The study reveals changes in catalytic activity at edges, terrace features and heterojunctions, which agrees with previous reports.
A research team at Kanazawa University investigated the molecular mechanisms behind organic solar cell damage from sunlight. They found that UV light causes fragile molecules to degrade, leading to reduced efficiency. This study may lead to the development of more robust and efficient solar cells.
Hematopoietic stem cells can be purified from zebrafish kidneys using a novel purification scheme that allows researchers to collect these elusive cells. The discovery opens up new avenues for studying blood-based diseases and developing medical treatments.
Scientists at Kanazawa University successfully controlled magnetic anisotropy through electric polarization, enabling nonvolatile memory. The researchers applied electricity to a zinc oxide layer, affecting the cobalt-platinum alloy below.
Researchers at Kanazawa University developed a reaction to link three components simultaneously, creating highly functionalized ketones. The method uses free radical chemistry and an N-heterocyclic carbene catalyst, controlling the positions of functional groups with high selectivity.
Scientists controlled host-guest complexes to explore the mechanism of chemical reactions, discovering that modification of guest metal ions could switch between 'recognition first' and 'reaction first' pathways. This finding has potential applications in drug delivery systems.
A study published in Mucosal Immunology reveals that ASC and NLRP3 are key players in maintaining innate immune homeostasis in the airway, independent of caspase-1. This alternative mechanism may provide a new understanding of different possible mechanisms involved in airway protection against microbial infections.
Researchers at Kanazawa University developed a new approach to optimize touch-screen setup for minimal physical workload and optimal screen visibility. The study found that taller users prefer screens installed below shoulder height, while smaller users prefer installation above elbow height.
Researchers investigated melatonin's role in preventing bone loss during space flight using cultured goldfish scales. They found that melatonin suppresses bone resorption by stimulating osteoblasts to produce CALCITONIN. This suggests melatonin could serve as a prophylactic drug to prevent bone loss of astronauts.
Researchers at Kanazawa University have identified catalysts that facilitate the photolysis of cyclopropenones under visible-light conditions. This novel method yields highly reactive alkynes without UV light dependence, making it a valuable alternative for industrial applications.
Researchers from Kanazawa University have developed a three-state switchable chiral stationary phase that can be controlled using metal ions, enabling efficient separation of enantiomers. The phase's stability and separation performance were demonstrated over multiple cycles, opening new doors for drug discovery and other research areas.
Researchers at Kanazawa University developed a robot control system that uses soft fingertips to grasp and release objects, reducing friction under both dry and wet conditions. The system involves injecting a lubricant to reduce friction and enable precise placement of objects.
A recent study by Chiaki Takahashi at Kanazawa University discovered that the cancer gene RB promotes tumor growth by altering the tumor microenvironment (TME). The TME changes enable the accumulation of immunosuppressive cells, which overpower the body's natural defense system.
In the absence of gasdermin D, caspase-1 induces apoptosis, but not pyroptosis, in macrophages. Caspase family members caspase-3 and caspase-9 are involved in this process. The study suggests that caspase-1 activates Bid, a pro-apoptotic protein, which induces cytochrome c release from mitochondria and subsequent apoptosis.