Researchers found metreleptin treatment improved liver function and reduced fatty liver disease progression in patients with partial lipodystrophy. Patients with lower baseline leptin levels showed higher response rates to the treatment.
Researchers compiled a list of over 40 online programs with evidence from randomized controlled trials, finding nearly 80% were unavailable to the public. The sites address various health issues, including depression, weight loss, and chronic pain, and offer interactive modules and assignments to complete.
A new study finds that hospitals' self-reported safety protocols can greatly impact their Leapfrog Hospital Safety Grades. Hospitals that report perfect compliance on these measures receive little grade advantage, while those with imperfect scores risk lower grades.
A study found that midazolam was more effective in treating seizures than other benzodiazepines and was adopted by ambulances across the country, increasing from 26.1% to 61.7% between 2010 and 2014. The rate of adoption accelerated after a clinical trial's publication, with EMS agencies adopting midazolam at a rate of 8.9% per year.
Researchers from Michigan Medicine have identified a novel strategy to target the genetic anomaly that occurs in half of all prostate cancers. They developed large molecule peptides that can effectively target and degrade the ERG fusion with little impact on regular cell function.
A recent study by Asheesh Bedi at the AAOS Annual Meeting highlights that ACL reconstruction surgery can fail in up to 20% of cases, requiring repeat surgery. The surgeon is working on identifying correctable factors to reduce failure rates and improve outcomes for young active athletes.
A new study published in PLOS ONE found that pre-pregnancy body mass index (BMI) is directly linked to excess weight gain during pregnancy, especially among young mothers. The research also showed that Hispanic women are less likely to experience excessive weight gain compared to non-Hispanic women.
New research reveals a significant gap in statin eligibility for African Americans under different guidelines, highlighting the need for personalized treatment. The study found that stricter USPSTF guidelines may miss some individuals with vascular calcification and low or moderate risk.
A new study finds that patients with hypertrophic cardiomyopathy (HCM) who undergo moderate-intensity exercise training experience a small but statistically significant increase in peak VO2 max. This improvement is associated with reduced mortality risk and improved self-reported physical functioning.
A new study finds that veterans with substance use disorders, especially those who also have mental health conditions, are at a higher risk of suicide. Women veterans with opioid misuses have a particularly high rate of suicide, more than five times that of their peers.
A new study suggests that ER visits can be effective 'teachable moments' for reducing drug use, with brief chats with counselors or virtual therapists showing promise. Participants who received the intervention had 21% fewer days of drug use compared to those in the control group.
A new study suggests that pre-surgery opioid use is a significant risk factor for post-operative problems, including longer hospital stays and higher medical costs. Researchers recommend considering pre-op opioid use as a modifiable risk factor to improve patient outcomes and surgical experience.
A new framework uses math to understand how genetic information and cell interactions give rise to tissue function, potentially aiding in understanding diseases like cancer. Researchers aim to apply this approach to real-world genome and cell biology experiments to inform future work on cancer and cell reprogramming.
Researchers recommend that doctors exclude common liver issues before testing for rare conditions. Directed testing means ordering tests for the most common causes of sudden severe liver issues first, followed by tests for rare, dangerous autoimmune or genetic disorders that attack livers.
A study found that fewer than three out of five women with locally advanced cervical cancer received guideline-based care, with black and Hispanic women receiving lower rates. Despite an increase in guideline-based care over time, disparities persist, highlighting the need for further investigation into barriers to treatment.
A new study by Michigan Medicine researchers found that cells from lung transplant patients with bronchiolitis obliterans syndrome (BOS) can become activated and promote scarring. The team identified a chain of upstream signals starting with autotaxin, an enzyme that generates lysophosphatidic acid, which stimulates collagen production.
Researchers from U-M Medical School and VA Ann Arbor Healthcare System studied the DNA of bacteria in healthy volunteers' lungs, finding most bacteria arrived through microaspiration. The study confirms that bronchoscope-based techniques can be used to study the lung microbiome in both healthy and sick individuals.
A recent survey found that more than two-thirds of non-foot-specialist clinicians are unaware of Charcot neuroarthropathy, a rare form of foot damage. The condition can lead to significant disability and morbidity if not diagnosed early. Improving education on this topic is crucial for better patient outcomes.
Researchers discovered that disruption in Schwann cells, which make myelin, leads to hidden hearing loss. This finding may help diagnose and treat the condition, which affects individuals exposed to high levels of noise. The discovery could lead to new treatments for hidden hearing loss.
A new study from Michigan Medicine identifies a protein in the microenvironment of metastatic breast cancer cells that promotes their spread. The researchers found that this protein, DDR2, plays a key role in fueling the growth and migration of cancer cells, and that inhibiting it may prevent metastasis.
A new study reveals that nearly one in four people who seek emergency care for eye problems have mild conditions, such as conjunctivitis or blepharitis, that don't require emergency treatment. The researchers recommend ways to reduce inappropriate ER visits, including telemedicine and after-hours appointments.
A team of researchers has identified a common regulatory grammar in islet cells that affects the activity of Regulatory Factor X, a master regulator involved in gene expression. Many Type 2 diabetes-linked DNA changes disrupt this grammar, leading to a range of health problems.
A study found that seniors taking three or more brain-affecting medications increased by over 100% between 2004 and 2013, with falls and driving problems being major concerns. The combination of opioids, antidepressants, tranquilizers, and antipsychotics carries special risks for older adults.
A new laser-based camera has been developed to improve the view of the carotid artery, allowing physicians to detect potential problem areas and monitor atherosclerosis. The technology uses high-resolution imaging to identify lesions and biological markers associated with increased stroke risk.
Experts suggest taking social risk factors into account to deliver high-quality care to vulnerable populations. The Medicare system can start using existing data on factors like dual eligibility, rural/urban residence, and birthplace to adjust payments and quality measurements.
A new approach to surgical pathology in brain tumor patients uses stimulated Raman histology, improving speed and diagnostic efficiency. The method, tested in an operating room, produces accurate results faster than conventional methods.
A new study found that people with higher BMIs are less likely to receive hospice care, die at home, or receive high-quality end-of-life care. Those who did use hospice services spent fewer days in hospice due to differences in home hospice usage.
A new treatment approach uses a single dose of chemotherapy to select patients for chemo-radiation or surgery, resulting in near-80% survival rates. This method tailors treatments to individual tumor biology and patient characteristics, improving quality of life and reducing complications.
The American Diabetes Association and Michigan Medicine have released updated guidelines for the prevention, treatment, and management of diabetic neuropathy. The guidelines provide recommendations for primary care physicians on preventing this complication and suggest guidelines to manage and treat each form of diabetic neuropathy. Th...
Researchers identified distinct changes in bone mineral content and area among midlife women transitioning through menopause, contradicting previous assumptions about bone expansion. The findings suggest that individual variability in bone structure can be used to identify women at risk of fractures far in advance.
A study from Michigan Medicine reveals significant disparities between patients' self-reported eye symptoms and their electronic medical records. The study analyzed 162 Kellogg patients and found that only 38 had exact agreement between their survey responses and medical records, with symptom reporting driving the inconsistencies.
A study found that nearly half of women treated for early stage breast cancer experienced at least one severe or very severe side effect from their treatment. The most common side effects were pain, skin irritation, and constipation, with Latina women being 30% more likely to report a severe side effect.
A multicenter study found that therapeutic hypothermia and active temperature control have similar outcomes in young patients after in-hospital cardiac arrest. The study included 329 children between two days and 18 years old, who experienced cardiac arrest in the hospital setting.
Researchers found that brief conversations in waiting rooms increased fruit and vegetable consumption among low-income families, with a nearly four-fold increase in program use. The Double Up Food Bucks program matches SNAP funds spent on healthy foods, supporting local growers.
Researchers found PDX1 plays a complex role in pancreatic cancer, maintaining cell identity in normal cells but contributing to growth once tumor forms. Blocking PDX1 may actually make the cancer more aggressive by selecting for MYC-expressing cells.
A new study finds that the Veterans Health Administration's Opioid Safety Initiative reduced high-dose opioid prescribing by 24% and very-high-dose prescribing by 21%, resulting in 331 fewer patients per month receiving prescriptions above 100 MEQ. The initiative also led to a 21% decrease in patients receiving both opioids and sedatives.
Researchers propose a high-value health plan that combines consumer-driven HDHPs with exemptions for clinical services proven to benefit patients. The concept has already gained bipartisan appeal in the US House bill.
A new study finds that prostate cancer treatment rates dropped by 42% due to changes in screening recommendations, but treatment rates among those diagnosed remained high. Low-risk patients with limited life expectancy can now opt for surveillance instead of treatment.
A new study finds that even low-deductible plans can result in high out-of-pocket costs for individuals with chronic health conditions. The researchers analyzed data from over 17,000 people and found that those with high-deductible plans spent more than 10% of their total income on healthcare costs.
A new study by Michigan Medicine found that hospitals' decisions on sending surgery patients to healing destinations greatly impact healthcare spending. The choice between inpatient, home, or outpatient care drives post-acute spending, with inpatient rehabilitation being a key driver of total 90-day costs.
A new mouse model has revealed the role of CCN6 protein in developing metaplastic breast cancer, a rare and aggressive subtype of triple-negative breast cancer. The study identified potential genes to target with therapeutics, offering hope for better treatment options for patients.
A new study found that Michigan's Medicaid expansion has boosted the state's economy and budget, generating over $2.3 billion in personal spending power each year. The program is expected to continue having a self-paying effect for at least five years, with the state ending up with more money than it spends.
A new research from Michigan Medicine supports combining immune checkpoint blockade with gene therapy to fight gliomas. The approach showed stronger results when used in combination with either depletion of immunosuppressive cells or immune checkpoint blockade.
Researchers found that atrial fibrillation patients are more likely to discontinue warfarin therapy if they've had a recent procedure. The study analyzed 734 patients and found that over half were off warfarin within a year of starting it, with procedures being the most common reason for discontinuation.
A new study found that nearly half of early-stage breast cancer patients considered having a double mastectomy, despite knowing it offers little benefit. Patients were unaware of the surgery's risks and benefits, with many choosing it for peace of mind.
Researchers found that complex reaction time accuracy, or 'brain speed,' is a key factor in determining an older person's ability to recover from a trip or stumble. This measure was shown to be more predictive of fall-related injuries than lower limb strength and perception of motion.
Women are more susceptible to autoimmune diseases due to a new regulatory mechanism identified by researchers. The study found that the master regulator gene VGLL3 promotes autoimmunity in women, regardless of sex hormone involvement.
A new study found that urinary epidermal growth factor levels provided improved ability to distinguish between patients with kidney involvement and those without. The biomarker was also associated with overall lupus damage, suggesting its potential role in monitoring disease progression.
A study found that patients with oropharyngeal cancer who recur have higher levels of antibodies for proteins E6 and E7, which can detect recurrence before it's diagnosed. This biomarker could provide an early window for treatment.
A survey of 393 hospital neonatal intensive care units found only 56% believe there are enough ophthalmologists to screen and treat retinopathy of prematurity. Screening can be done with telemedicine, but only 21% of respondents used retinal imaging devices, with half being unsure about its safety.