A new study analyzing heart attack care and spending in America since the turn of the century shows increased survival rates and growing costs, with variation between hospitals on both scores. Early stenting treatment has been found to be cost-effective, particularly for high-volume hospitals.
A new study by Michigan Medicine finds that babies with spina bifida have early symptoms of sleep-disordered breathing, which can contribute to lifelong issues with neurodevelopment. The research team identified SDB in all 20 newborns with the most serious form of spina bifida.
A new nationwide clinical trial aims to make managing type 1 diabetes easier for patients using the world's first hybrid closed-loop system automated insulin delivery device. The trial, funded by Medtronic, will monitor blood glucose levels and adjust insulin doses continuously to help patients maintain stable blood sugar levels.
A University of Michigan team has identified seven distinct phenotypes in people with bipolar disorder, each with unique biological mechanisms and external influences. These findings have the potential to help patients, clinicians, and researchers better understand the condition.
A team of researchers at the University of Michigan Comprehensive Cancer Center identified a novel gene called THOR that plays a role in cancer development. Knocking out THOR was found to halt tumor growth, while overexpressing it led to increased cell proliferation.
A study from Michigan Medicine found that 20% of young colon cancer patients have an inherited genetic abnormality, highlighting the need for broader genetic testing. The research suggests that even without family history, these alterations can impact care and family members.
A study of over 4,000 Michigan Medicaid enrollees found that nearly half are employed, while 11% are unable to work due to serious health issues. Those who cannot work face significant health challenges and may be more likely to experience worsening conditions without treatment
A study published in Nature Communications reveals a genetic mutation in the C9orf72 gene causes a vicious cycle of toxic protein production, driving neuronal death in ALS. The researchers found that cell stress activates more toxic protein production, creating a loop that potentially drives disease progression.
A new guideline based on patient data and education has been shown to effectively reduce opioid prescribing in surgery patients by up to 66%, while maintaining similar levels of pain control. The study's findings have the potential to significantly impact the national opioid crisis, with estimates suggesting over 13,000 excess pills ha...
A new poll shows that only about one in three older Americans have discussed possible drug interactions with their doctors or pharmacists, putting them at risk of health problems. Patients can reduce risks by being open with their providers and tracking their medications.
A new study suggests that despite the rise in high-deductible health plans (HDHPs), most Americans who have them aren't pursuing consumer-like behaviors such as saving, shopping around, or discussing costs with healthcare providers. Key findings include low savings rates and limited engagement with providers.
A study published in JAMA Ophthalmology found that ambulatory surgery centers performed 73% of cataract surgeries in 2014, up from 43.6% in 2001. The shift is driven by convenience, lower out-of-pocket costs, and decreased cost-per-case for insurers.
A new approach models and predicts the spread of 'superbugs' by analyzing genomic data, identifying key drivers of transmission and enabling early intervention. The method successfully pinpointed the facility origin of every patient's infection in a real-time outbreak simulation.
Researchers at University of Michigan develop new PCR-based approach to study chromosomes' centers, yielding clues about Down syndrome. The technique accelerates analysis of centromere DNA, potentially leading to breakthroughs in birth defects and cancers.
Researchers discovered that tumor metabolism damages naïve T-cells, affecting cancer immunity and immunotherapy. The study suggests targeting lactate pathway to improve immunotherapy effectiveness.
A new study found that 1 in 20 children received codeine after tonsil and adenoid removal surgeries, despite the FDA warning on significant safety risks. The researchers recommend increasing efforts to eliminate inappropriate prescribing and encouraging non-opioid medications.
Women with ER-positive breast cancer still face a substantial risk of cancer returning or spreading even 20 years after diagnosis, according to a new analysis. The risk is directly tied to the original cancer's size and characteristics, as well as the number of lymph nodes involved.
A team of scientists discovered that a non-pathogenic strain of E. coli helps the lining of a newborn's gut prepare for the surge of other bacteria in their lives, leading to better resistance to inflammation and damage.
A new study by Michigan Medicine found that less than 1 in 5 adults believe kids are physically healthier today compared to when they were growing up. Mental health issues are also a dominant factor in children's well-being, with only 15% of respondents believing the chances for good mental health have improved.
A team from Michigan Medicine proposes a data-driven, insurer-funded approach to make surgery safer and less expensive for all; the Value Partnership model has saved lives and dollars at 72 Michigan hospitals, with potential for federal help to accelerate nationwide adoption.
The US Renal Data System report highlights the high burden of kidney disease in the US, with over 30 million adults affected, and a significant cost to healthcare. However, there is low awareness about the condition among patients, especially those with early stages of CKD.
Treg cells suppress immune function, but eliminating them doesn't eliminate their effects. In fact, dying Tregs release metabolites that affect T-cells, making them unhealthy and reducing the cancer-fighting effect of immunotherapy. The study suggests a new approach to limit this function and block the suppressive activity.
A recent poll found that 78% of caregivers experience stress while caring for a loved one with dementia, but 85% also report it as a rewarding experience. The poll suggests that caregivers often neglect their own health and well-being due to caregiving demands.
The Choosing Wisely movement has successfully started conversations about low-value care, but its impact is limited by the difficulty in changing doctor behavior. Researchers recommend prioritizing recommendations, consolidating guidelines, and evaluating efforts to make a greater difference in quality and value in healthcare.
Researchers develop algorithm to transform healthy and diseased cells into desired cell types, leveraging gene expression and transcription factor data. The approach aims to regenerate tissue and fight cancer, offering a shortcut to traditional cell transformation techniques.
A new study found substantial variability across US medical centers in diagnosing and treating disorders of sex development (DSD), with some institutions lacking specialist teams. Families often face difficult decisions about irreversible procedures, highlighting the need for improved guidelines and collaboration among providers.
A new systematic review of evidence suggests that primary care physicians and their teams can provide effective addiction care using anti-opioid medication. The studies found that patients had the highest chance of successful treatment when working with a team of non-physicians, including nurse case managers.
A new tool developed at the University of Michigan provides guidance on prescribing powerful opioid pain medications to surgery patients. The Opioid Prescribing Recommendations for Surgery are based on data and surveys from surgery patients across Michigan, aiming to prevent chronic opioid use and addiction.
A new study from Michigan Medicine found that women who undergo a bilateral mastectomy with reconstruction are 7.8 times more likely to miss work than those who opt for lumpectomy and radiation therapy.
A study suggests that donor organs classified as 'increased risk' due to factors like drug use or incarceration are less likely to be used by transplant patients. Despite low disease transmission risks, these organs account for 1 in every 5 deceased donor organs and could lead to hundreds of additional transplants each year.
A new study reveals that older workers born in 1960 will face more challenges as they continue to work, seek work, or try to retire due to worsening health issues. The research found that younger cohorts have higher rates of poor cognition and limitations in daily living tasks compared to earlier birth cohorts.
A new poll finds that nearly half of older Americans struggle with sleep, but many don't discuss it with their doctors. Prescription sleep medications carry significant health risks for older people, and non-medication-based habits are a more effective solution.
Researchers have discovered a powerful combination treatment that disrupts multiple factors in aggressive triple-negative breast cancer. The novel approach, combining a protein inhibitor with a chemotherapy drug, produced a synergistic effect that was more effective than either drug alone.
A new study reveals that endoplasmic reticulum-associated degradation plays a crucial role in controlling hormone levels and systemic water balance. The research found that misfolded proteins can lead to hormone imbalance and diseases such as diabetes insipidus, highlighting the importance of protein folding and quality control.
A new study suggests that nearly 11% of Medicare participants with diabetes have very low blood sugar levels indicating over-treatment. However, only 14% of these patients had a reduction in blood sugar medication refills in the next six months.
A new clinical trial aims to explore the effectiveness of modafinil, cognitive behavioral therapy, and a combination of both in reducing MS fatigue. The study will provide valuable insights to help patients and clinicians make informed decisions about treatment options.
A new study published in JAMA Surgery found that surgeons played a major role in determining whether patients receive aggressive breast cancer surgery. The study revealed that surgeons' attitudes towards breast conservation and CPM had a significant impact on the likelihood of patients receiving this procedure.
Researchers found that 40% of nursing home patients had multiple multidrug-resistant organisms living on their bodies, increasing the risk of urinary tract infections. The study suggests a complex network of interactions among bacteria and antibiotics, highlighting the need for more targeted treatment approaches.
A team of researchers developed a tiny microfluidic device to track the long-term evolution of invasive cancer cells. The device allowed them to cultivate cells for up to three weeks, providing valuable insights into the biology of aggressive cells and potential targets for therapy.
Middle-aged Americans face dental health issues due to lack of care and insurance coverage. Despite the importance of preventive care, many opt for delayed or no care due to cost and fear of the dentist.
A new University of Michigan study found that tired family caregivers are associated with greater ER visits and higher overall health care costs for the person they care for. Patients with fatigued or sad caregivers had 23% higher emergency department visits and $1,900 more in Medicare costs.
A new study reveals that sleep deprivation significantly enhances postoperative pain behaviors and extends recovery time after surgery. Caffeine blocks this effect by blocking adenosine in the brain, suggesting a potential novel intervention for improving postoperative pain management.
A nationally representative survey found that 51% of parents support later school start times to accommodate their teens' natural circadian rhythms. Teens need 8-10 hours of sleep per night, but many parents underestimate their children's sleep needs, with only half agreeing with existing recommendations.
Researchers have discovered that female fruit flies' pheromone signals can reveal the level of energy invested in egg production versus survival. This finding may have implications for understanding human mating and reproduction patterns.
Researchers found that patients of all races receive opioids at similar rates as evidence-based medications, despite concerns about medication overuse and comorbidities. The study suggests that clinicians can improve treating migraine patients by adopting better prescribing practices.
A study found that more than half of heart patients are admitted to the cardiac intensive care unit (CICU) for noncardiac conditions such as sepsis or renal failure. This shift in patient composition requires providers to reassess training and staffing models, with implications for care and outcomes.
A new study published in the Journal of Neurosurgery found that smoking significantly increases the chance of brain aneurysm recurrence. Former and current smokers had a higher rate of recurrence compared to never smokers, emphasizing the importance of quitting smoking after endovascular treatment.
A new study found that women with early-stage breast cancer are more likely to consider double mastectomy due to their decision-making habits and values. Researchers surveyed 2,362 women and discovered that those who were worried about making a bad decision and wanted to make their own choices were more likely to consider the aggressiv...
A recent study published in Pain investigated widespread pain and its relation to the brain. Researchers found that individuals with widespread pain had increased gray matter and brain connectivity in sensory and motor cortical areas, similar to those with fibromyalgia.
Scientists have successfully grown a structure similar to an early stage of human development using pluripotent stem cells. The lab-grown amniotic sac embryoid, or PASE, exhibits key features such as two distinct halves and a hollow center, making it a potential tool for exploring infertility research.