A new study reveals that endoplasmic reticulum-associated degradation plays a crucial role in controlling hormone levels and systemic water balance. The research found that misfolded proteins can lead to hormone imbalance and diseases such as diabetes insipidus, highlighting the importance of protein folding and quality control.
A new study suggests that nearly 11% of Medicare participants with diabetes have very low blood sugar levels indicating over-treatment. However, only 14% of these patients had a reduction in blood sugar medication refills in the next six months.
A new clinical trial aims to explore the effectiveness of modafinil, cognitive behavioral therapy, and a combination of both in reducing MS fatigue. The study will provide valuable insights to help patients and clinicians make informed decisions about treatment options.
A new study published in JAMA Surgery found that surgeons played a major role in determining whether patients receive aggressive breast cancer surgery. The study revealed that surgeons' attitudes towards breast conservation and CPM had a significant impact on the likelihood of patients receiving this procedure.
Researchers found that 40% of nursing home patients had multiple multidrug-resistant organisms living on their bodies, increasing the risk of urinary tract infections. The study suggests a complex network of interactions among bacteria and antibiotics, highlighting the need for more targeted treatment approaches.
A team of researchers developed a tiny microfluidic device to track the long-term evolution of invasive cancer cells. The device allowed them to cultivate cells for up to three weeks, providing valuable insights into the biology of aggressive cells and potential targets for therapy.
Middle-aged Americans face dental health issues due to lack of care and insurance coverage. Despite the importance of preventive care, many opt for delayed or no care due to cost and fear of the dentist.
A new University of Michigan study found that tired family caregivers are associated with greater ER visits and higher overall health care costs for the person they care for. Patients with fatigued or sad caregivers had 23% higher emergency department visits and $1,900 more in Medicare costs.
A new study reveals that sleep deprivation significantly enhances postoperative pain behaviors and extends recovery time after surgery. Caffeine blocks this effect by blocking adenosine in the brain, suggesting a potential novel intervention for improving postoperative pain management.
A nationally representative survey found that 51% of parents support later school start times to accommodate their teens' natural circadian rhythms. Teens need 8-10 hours of sleep per night, but many parents underestimate their children's sleep needs, with only half agreeing with existing recommendations.
Researchers have discovered that female fruit flies' pheromone signals can reveal the level of energy invested in egg production versus survival. This finding may have implications for understanding human mating and reproduction patterns.
Researchers found that patients of all races receive opioids at similar rates as evidence-based medications, despite concerns about medication overuse and comorbidities. The study suggests that clinicians can improve treating migraine patients by adopting better prescribing practices.
A study found that more than half of heart patients are admitted to the cardiac intensive care unit (CICU) for noncardiac conditions such as sepsis or renal failure. This shift in patient composition requires providers to reassess training and staffing models, with implications for care and outcomes.
A new study published in the Journal of Neurosurgery found that smoking significantly increases the chance of brain aneurysm recurrence. Former and current smokers had a higher rate of recurrence compared to never smokers, emphasizing the importance of quitting smoking after endovascular treatment.
A new study found that women with early-stage breast cancer are more likely to consider double mastectomy due to their decision-making habits and values. Researchers surveyed 2,362 women and discovered that those who were worried about making a bad decision and wanted to make their own choices were more likely to consider the aggressiv...
A recent study published in Pain investigated widespread pain and its relation to the brain. Researchers found that individuals with widespread pain had increased gray matter and brain connectivity in sensory and motor cortical areas, similar to those with fibromyalgia.
Scientists have successfully grown a structure similar to an early stage of human development using pluripotent stem cells. The lab-grown amniotic sac embryoid, or PASE, exhibits key features such as two distinct halves and a hollow center, making it a potential tool for exploring infertility research.
The University of Michigan Injury Center has received $2.5 million from the CDC to continue its research on preventing injuries such as opioid overdoses, concussion, and motor vehicle crashes. The center aims to reduce injury by publishing innovative research and translating it into practice for local communities.
A new study published in Neurology found that most newborns with epilepsy (83%) have identifiable genetic causes, which can help guide treatment and connect families with condition-specific support groups. Genetic testing can provide comfort and closure for families, allow for tailored treatment, and improve diagnostic outcomes.
A new study sequenced DNA and RNA of 500 patients with metastatic cancer, revealing a host of molecular factors driving tumor growth and spread. The analysis identified potential treatment targets and shed light on the underlying mechanisms behind metastatic cancer.
HIV hides in more types of bone marrow cells than previously thought, including hematopoietic progenitor cells that can pass the virus's genetic material to daughter cells. This discovery expands understanding of the type of cells that harbor functional HIV and could aid the search for new drugs to clear it entirely.
Researchers found that Fusobacterium nucleatum in the gut can stop chemotherapy from causing apoptosis, a type of cancer cell death. The bacterium activates autophagy, a cell-survival mechanism that protects cancer cells from destroying themselves.
A large new study shows that only one in three patients who have bariatric surgery succeed in getting their body-mass index below 30 in the first year. Patients with lower BMIs before surgery had higher odds of achieving this goal and better health outcomes, including stopping medication for high blood pressure and cholesterol.
Excess gut calcium plays a crucial role in triggering the germination of Clostridium difficile (C. diff) spores, according to new research published in PLoS Pathogens. This discovery may lead to better treatment for vulnerable patients and help slow or stop the transmission cycle of C. diff infections.
A new poll reveals that many older adults aren't getting help from doctors and pharmacists on drug costs, despite taking multiple prescriptions. Patients who spoke up about cost received recommendations for less expensive drugs, but there's a need for health professionals to engage with patients more routinely.
A new study found that nearly three-quarters of women relied on a support network to discuss their treatment options and attend appointments. Larger support networks were associated with more deliberation about treatment, suggesting patients are thinking through pros and cons.
A new study by Michigan Medicine finds that 60% of patients with acute conjunctivitis are prescribed antibiotic eye drops despite antibiotics rarely being necessary. The study also highlights the socioeconomic factors driving this trend and the potential negative consequences of overprescription.
A survey of newly covered Michigan residents reveals that expanded Medicaid improved their job performance, allowing them to better do their jobs or seek new opportunities. The coverage also had a positive impact on physical and mental health, with nearly half of participants reporting an improvement in health.
Researchers found that zolpidem can have significant effects on patients with disorders of consciousness or movement disorders, including those in comas and vegetative states. The medication's effects were often transient but repeatable, and some patients showed improvement to a minimally conscious state.
A new national poll on healthy aging will release its first results on June 29, tracking key health issues for people between 50 and 80 years old. The poll aims to provide timely insight into current issues affecting older Americans, informing healthcare policy and clinical practice.
Researchers at U-M Medical School discovered that a molecule called cathepsin protease L is crucial to the parasite's ability to survive the cyst phase and cause disease. Interfering with this protein can stop the parasite, offering new hope for treatments. The study suggests that targeting the 'stomach' of the parasite may be key to p...
A new study reveals that US scientific teams still publish more biomedical research discoveries than any other country, but China's rising investment is slowly closing the gap. Chinese teams now rank fourth globally for new discoveries published in top-tier journals.
Researchers have developed a new sequential multiple assignment randomized (SMART) trial method to test two hypotheses at once. This approach allows for the simultaneous evaluation of different treatments, potentially leading to more accurate results and increased efficiency in clinical trials.
A study published in Academic Emergency Medicine found that the level of benefit, risk, and cost significantly influence patients' decisions to receive a diagnostic test. The researchers discovered that participants were more likely to accept a diagnostic test when the cost was lower, highlighting the impact of financial burden on medi...
A new analysis found that nearly three-quarters of patients with advanced cancer could be referred to a targeted treatment based on their tumor's genetic landscape. Genetic sequencing identified anomalies in 11% of patients, including hereditary variations that increase cancer risk.
Researchers found that disease incidence in states with prohibitive EPT legislation grew significantly faster than in states where EPT was allowed. States with EPT laws may see reduced rates of chlamydia infections, with an average increase of 14.1 cases per 100,000 people.
The University of Michigan has received a $58 million grant to support clinical and translational research, partnering with Michiganders of all ages and backgrounds. Over 50,000 volunteers have signed up for the MICHR registry, allowing researchers to reach out when a study needs participants.
A recent study published in The Lancet found that ketamine does not prevent delirium and does not reduce post-surgical pain, contradicting widespread medical practices. However, higher doses of ketamine were associated with increased negative effects such as hallucinations and nightmares.
Researchers have discovered two genetic variants associated with bicuspid aortic valve development, which affects the heart's ability to pump oxygen-rich blood. The study, published in Nature Communications, found that these variants affect a key cardiac transcription factor called GATA4, leading to disruptions in valve formation.
Researchers found that faster administration of care was linked with lower mortality in patients with sepsis and septic shock. The study suggests that hospitals and health care systems should invest in infrastructure to get antibiotics to patients as soon as possible.
A new study found that even low amounts of digital technology interruptions by parents can cause greater child behavior issues such as oversensitivity and hyperactivity. Researchers suggest carving out technology-free times for family bonding and reducing device use during parent-child activities.
Researchers have identified 16 new genetic markers associated with psoriasis, bringing the total to 63 loci linked to the disease. The largest psoriasis meta-analysis to date, involving over 39,000 participants, has shed light on pathways related to the disease and pinpointed potential gene targets.
Researchers from the University of Michigan have discovered how polyomaviruses hijack cellular molecular motors to build a portal for itself, allowing it to reach the nucleus and cause problems. The findings could aid in the development of new treatments or preventive strategies against polyomavirus diseases such as Merkel cell carcinoma.
A recent study found that nearly 1 in 5 patients with lap-band surgery undergo multiple device-related reoperations, and complication rates range greatly. Accredited bariatric centers also vary significantly in their rates of serious complications, with a 17-fold difference between the highest and lowest rates.
Critical care is a constantly evolving field with a huge literature base. EM physicians must stay up-to-date on medical literature to provide the best care for their patients. The recent PEITHO 2 study has sparked debate on pulmonary embolism treatment, and sepsis care requires being mindful of fluid type, pressors, and culture data.
A new COPD National Action Plan was released by the NHLBI, outlining key goals to raise public awareness, advance research, improve patient care, and develop management strategies. The plan aims to empower people with COPD to recognize and reduce its burden, as well as promote education and training for healthcare professionals.
A national patient safety effort led to a significant reduction in urinary tract infections related to catheters in nursing homes. The study shows that implementing a toolkit of training materials and coaching support can lead to improved catheter care and infection prevention.
Michigan Medicine researchers explored best practices in EMS oversight to improve pre-hospital care. They identified seven key factors for high-quality EMS oversight: competition and collaboration, leadership, organizational structure, quality improvement culture and practice, relationships and communication, resources, and community-s...
A large population-based study found that 6.5% of thyroid cancer patients experienced general post-operative complications, while 12% had complications specific to thyroid surgery within a year after their operation. Patients over 65 and those with more advanced thyroid cancer were at higher risk for these complications.
A new study suggests that early solid or tube feeding can lead to fewer symptoms, shorter hospital stays, and similar risk outcomes for patients with mild pancreatitis. However, the evidence for patients with severe disease was weak, but still did not show harm.