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The University of Hong Kong


HKU study shows bad sleep harms old-age memory by disrupting the brain’s ‘waste removal system’

A recent study published in Molecular Psychiatry suggests that poor sleep quality among older adults disrupts the brain's glymphatic system, leading to memory decline. The research team found that deactivation of the restorative glymphatic system negatively impacts normal brain function and cognitive health.

SourceThe University of Hong Kong·JournalMolecular Psychiatry·TypeExperimental study·DateMar 9, 2025

HKU researchers unveil neuromorphic exposure control system to improve machine vision in extreme lighting environments

Researchers at HKU have developed a neuromorphic exposure control system that mimics human peripheral vision to achieve unprecedented speed and robustness in dynamic perception environments. The system operates at 130 million events/sec, enabling edge deployment and addressing limitations of traditional exposure control.

SourceThe University of Hong Kong·JournalNature Communications·TypeComputational simulation/modeling·DateMar 3, 2025

HKUMed reveals genetic evidence that diabetes drug GLP-1 receptor agonists achieve weight loss primarily by reducing fat mass more than muscle

Researchers found that GLP-1 receptor agonists decrease whole-body fat mass by about 7.9 kg for every unit reduction in BMI, while muscle mass decreases by 6.4 kg. This suggests that GLP-1 receptor agonists are more effective at reducing overall body fat than muscle mass.

SourceThe University of Hong Kong·JournalDiabetes Obesity and Metabolism·TypeExperimental study·DateFeb 23, 2025

Breakthrough discovery: HKUMed identifies novel gene behind neurodevelopmental syndrome for enhanced clinical treatment

A clinical research team from HKUMed discovered a novel gene DDX39B linked to a rare neurodevelopmental syndrome, causing developmental delay and hypotonia. The study used multi-omics analysis and identified six patients worldwide with variations in the gene, providing crucial information for targeted diagnostic and treatment plans.

SourceThe University of Hong Kong·JournalBrain·TypeExperimental study·DateFeb 20, 2025

HKU physicists pioneer entanglement microscopy algorithm to explore how matter entangles in quantum many-body systems

Researchers develop 'entanglement microscopy' to map quantum entanglement in small regions of quantum systems, revealing intricate interactions and structures. The study reveals short-range entanglement at critical points and more gradual decline in entanglement with increasing separation.

SourceThe University of Hong Kong·JournalNature Communications·TypeExperimental study·DateJan 23, 2025

HKUMed study finds 80% mislabelled NSAID allergies among stroke patients leads to poorer treatment outcomes and urges evaluation to identify mislabelling

A recent study found that 80% of NSAID allergy labels for stroke patients are inaccurate, leading to the use of less-effective medications and potentially dangerous consequences. The research highlights the need for thorough evaluation and management of drug allergies in Hong Kong.

SourceThe University of Hong Kong·JournalStroke·TypeCase study·DateJan 22, 2025

HKU ecologists uncover significant ecological impact of hybrid grouper release through religious practices

A study by HKU ecologists highlights the ecological impact of releasing hybrid groupers into Hong Kong's coastal waters, disrupting local food webs and potentially becoming dominant predators. The research underscores the need for public education and conservation measures to mitigate unintended ecological impacts.

SourceThe University of Hong Kong·JournalReviews in Fish Biology and Fisheries·TypeObservational study·DateJan 19, 2025

HKU ecologist highlights critical gaps in global wildlife trade monitoring

A recent study by HKU ecologist Professor Alice C. Hughes reveals that almost 30,000 wild species were traded globally between 2000 and 2022, with over 50% sourced directly from the wild. This highlights the critical need for systematic monitoring of wildlife trade to assess its sustainability.

SourceThe University of Hong Kong·JournalProceedings of the National Academy of Sciences·TypeObservational study·DateJan 14, 2025

HKUMed scientists culture previously uncultivable human rhinovirus C with innovative respiratory organoids after a 20-year effort, accelerating vaccine and drug development

A research team at HKUMed successfully cultured human rhinovirus C using respiratory organoids, overcoming a 20-year challenge in virus cultivation. This breakthrough enables the study of HRV-C and expedites the development of vaccines and antiviral drugs.

SourceThe University of Hong Kong·JournalNature Communications·TypeExperimental study·DateJan 13, 2025

HKU ecologists reveal key genetic insights for the conservation of iconic cockatoo species

Researchers have made valuable discoveries that could transform the conservation of two iconic cockatoo species. The studies uncovered new genetic insights, reshaping our understanding of these species and offering fresh hope for their survival amid severe threats from habitat loss and illegal trapping.

SourceThe University of Hong Kong·JournalMolecular Biology and Evolution·TypeExperimental study·DateJan 12, 2025

HKU paleobiologists unlock 500,000 years of fossil records revealing climate change impacts on Southern Ocean ecosystems and risks of marine carbon removal

A 500,000-year fossil record study by HKU paleobiologists sheds light on temperature changes and food input shaping deep-sea ecosystems in the Southern Ocean. The research warns that human-induced warming may harm delicate deep-sea ecosystems with potential impacts of marine carbon removal.

SourceThe University of Hong Kong·JournalCurrent Biology·TypeExperimental study·DateDec 22, 2024

HKUMed innovates photocurrent-responsive coating: Cuts bone-to-implant integration time in half to just two weeks

Researchers developed a near-infrared light-responsive implant surface that accelerates bone-to-implant integration by reducing acute inflammation and promoting mesenchymal stem cell recruitment. Bone-to-implant integration was accelerated from 28 days to just 14 days, doubling the speed in animal experiments.

SourceThe University of Hong Kong·JournalAdvanced Functional Materials·TypeCase study·DateDec 15, 2024

Enhancing solar energy harvesting: HKU Engineering researchers unlock the key to efficient organic photovoltaics

Researchers from HKU Engineering discover how structure of Y-type acceptors impacts OPV performance, providing critical insights for future material development. The breakthrough could lead to the creation of flexible, affordable, and high-performance solar devices that can power a greener future.

SourceThe University of Hong Kong·JournalEnergy & Environmental Science·TypeExperimental study·DateNov 27, 2024

HKUMed meta-analysis links high-risk Epstein-Barr virus lineage to nasopharyngeal cancer in southern China

A HKUMed research team discovered a significant association between specific EBV variants and nasopharyngeal carcinoma (NPC), which is prevalent in southern China. The study identified high-risk EBV haplotype present in about 70% of NPC cases, suggesting potential new avenues for screening and diagnosis.

SourceThe University of Hong Kong·JournalPLOS Pathogens·TypeMeta-analysis·DateNov 15, 2024

HKU remote sensing, landscape and economic scholars jointly reveal cloud cover and urban structures drastically reduce sunlight in cities

Research reveals a substantial reduction in available sunlight due to cloud cover and urban structures, with cloud cover accounting for 55% of the decrease. The study emphasizes the pressing need for interdisciplinary urban planning strategies prioritizing access to natural sunlight.

SourceThe University of Hong Kong·JournalNature Cities·TypeImaging analysis·DateSep 25, 2024

HKU chemists develop organic supramolecular crystals with high hydrogen storage performance - promising to enhance the efficiency of fuel cell vehicles

Researchers developed a controlled 'point-contact catenation strategy' to guide catenation in supramolecular crystals, achieving record-high gravimetric and balanced volumetric surface areas. This design strategy unlocks the potential of organic supramolecular crystals for onboard hydrogen storage.

SourceThe University of Hong Kong·JournalNature Chemistry·TypeExperimental study·DateSep 23, 2024

HKU geologists discover hidden magmatism at the chang'e-6 lunar landing site, shedding light on solving fundamental scientific questions relating early evolution of the moon

Researchers have discovered widespread intrusive magmatism in the South Pole-Aitken basin on the farside of the Moon. The study suggests that these magmatic activities played a crucial role in shaping the lunar crust, providing valuable insights into the Moon's early evolution and internal structure.

SourceThe University of Hong Kong·JournalThe Astrophysical Journal Letters·TypeExperimental study·DateAug 27, 2024

HKU scientists develop AI-driven method to enhance electron microscopy imaging capabilities of complex biological systems

Researchers from HKU have developed a diffusion model-based algorithm called EMDiffuse to enhance imaging capabilities of complex biological systems using electron microscopy. The method addresses trade-offs between imaging speed, quality, and sample size, and improves the accuracy of ultrastructural details.

SourceThe University of Hong Kong·JournalNature Communications·DateAug 26, 2024

HKU researchers shed light on overcoming cancer drug resistance unlocking potential to expand use of PARP inhibitors across cancer types

A research team from the University of Hong Kong has discovered that the protein FANCM promotes resistance to cancer drugs called PARP inhibitors. This discovery could lead to new treatment strategies and broaden the application of PARP inhibitors across various cancer types.

SourceThe University of Hong Kong·JournalCell Reports·TypeMeta-analysis·DateAug 7, 2024

HKU chemists develop a clickable tryptophan modification strategy for late-stage diversification of native peptides

A team of researchers from HKU developed a new approach to modify peptides at the late stage of development, allowing for precise targeting and improved drug properties. This method enables the installation of various functional groups onto tryptophan residues within native peptide structures.

SourceThe University of Hong Kong·JournalScience Advances·TypeExperimental study·DateJul 24, 2024

HKU ecologists discover rare fiddler crab species on Hong Kong coast highlighting the impact of climate change and coastal development

Two rare fiddler crab species, Tubuca dussumieri and T. coarctata, have been confirmed in Hong Kong, with the potential impact of climate change and coastal development on their distribution explored. The study highlights the importance of environmental conservation for these species.

SourceThe University of Hong Kong·JournalZootaxa·TypeExperimental study·DateJul 22, 2024

HKU Engineering researchers develop new method for achieving controllable tuning and assessing instability in 2D materials for engineering applications

Researchers at HKU have developed a new method to assess the stability of 2D materials, enabling controllable tuning of their mechanical properties. The study provides opportunities for modulating nano-scale instability morphology and physical properties of atomically thin films.

SourceThe University of Hong Kong·JournalNature Communications·TypeExperimental study·DateJul 21, 2024

HKU ecologists reconstruct the history of biodiversity in the indo-australian archipelago and its rise as a hotspot

Researchers reconstructing the history of biodiversity in the Indo-Australian Archipelago found that marine diversity increased since the early Miocene, driven by habitat factors. The findings suggest that the region's thermal stress moderated around 14 million years ago, allowing for favorable conditions for biodiversity to flourish.

SourceThe University of Hong Kong·JournalNature·DateJun 27, 2024

HKUMed and Harvard world-first study finds statins reduce the relative risk of cardiovascular diseases by over 20% in adults aged 75+ with high cholesterol in Hong Kong

A world-first study from HKUMed and Harvard found that continuous statin therapy reduces the relative risk of cardiovascular diseases by 21-35% in adults aged 75+, without increased safety concerns. The study used real-world data to inform decision-making on statin initiation for this large population.

SourceThe University of Hong Kong·JournalAnnals of Internal Medicine·TypeExperimental study·DateJun 26, 2024

HKU chemists develop a concise approach to access L-cyclodextrins, setting the stage to explore the mirror-image world of the century-old naturally occurring cyclodextrins

Researchers at HKU have developed a concise approach to synthesize L-cyclodextrins, enabling the investigation of their chiral self-sorting and recognition properties. The availability of L-CDs opens up new opportunities for biomedical applications, including drug delivery systems and active pharmaceutical ingredients.

SourceThe University of Hong Kong·JournalNature Synthesis·TypeExperimental study·DateJun 24, 2024