A research team led by Dr Chaogu ZHENG from the University of Hong Kong studies the transcriptome age of C. elegans at the single-cell level, revealing insights into cellular basis of 'hourglass' pattern of animal development and evolutionary relationship among cell types.
A global research team found that long-term methylphenidate treatment does not increase the risk of growth impairments or psychiatric events, but may lead to modest increases in blood pressure. The study suggests potential disparities in ADHD medication access by country-income levels.
A research team at HKUMed has invented a non-invasive technology to effectively reduce methicillin-resistant Staphylococcus aureus (MRSA) infection in bony tissue. The novel antibacterial nano-sheets can release ROS subject to ultrasound stimulation, eliminating MRSA bacteria deeply seated in bony tissue with 99.72% efficacy.
A research team from HKUMed developed thyroid hormone (TH)-encapsulated nanoparticles that selectively target adipose tissues, reducing obesity-related metabolic complications and atherosclerosis. The treatment converts 'bad' white fat to 'good' brown fat, burning calories and alleviating hypercholesterolemia.
A research team led by Dr Lisa Levin assessed the potential risks of OBCIs on deep-sea ecosystems, raising substantial concern about their impacts on biodiversity and biogeochemistry. The study highlights the need for an integrated research framework to carefully consider the cost and benefits of each intervention.
A HKU Mechanical Engineering team has developed a new generation of lithium-ion batteries that are safer, more powerful and have a longer lifespan. The innovative design uses single-ion conducting polymer electrolytes that can conduct electricity faster than traditional liquid electrolytes.
A retrospective cohort study found that sodium-glucose cotransporter 2 inhibitors (SGLT2i) significantly reduced the risk of end-stage renal disease, obstructive airway disease, and pneumonia in patients with type 2 diabetes. SGLT2i may be a better alternative to dipeptidyl peptidase-4 inhibitors for extra-glycaemic protection.
A research team led by Dr Gary Ying Wai Chan has uncovered a new mechanism that ensures correct DNA segregation in cell division, preventing cancer development. RIF1 and protein phosphatase 1 play a crucial role in resolving ultrafine DNA bridges, which can lead to DNA damage and genome instability if not properly resolved.
A research team developed a new dentine analogue material that can substitute extracted human teeth in laboratory-based mechanical and fatigue tests. The materials were tested for their mechanical strength, elastic modulus, indentation hardness, and fatigue behaviour, showing comparable results to those based on extracted human teeth.
Researchers have identified novel host protease determinants that facilitate SARS-CoV-2 entry, including membrane-type matrix metalloproteinases (MT-MMP) and ADAM families. Inhibiting these proteases may provide a new treatment strategy against the Omicron variant.
Researchers at HKU Engineering have developed a new type of continuous Marangoni transport system that generates highly ordered Fermat's spiral patterns. The system utilizes an aqueous two-phase system, inspiring potential biological applications and novel methods for fibre fabrication.
Researchers from HKU identified a protein called menin as the 'reader' of H3K79me2, a histone mark associated with cancer. They used a novel chemical approach to capture menin and visualized its interaction using cryo-electron microscopy.
Researchers estimated that three doses of Comirnaty and CoronaVac vaccines were 48% and 30% effective, respectively, in preventing Omicron infection. Boosters improved efficacy to 69% and 56%, but protection waned over time.
Researchers from HKU School of Biological Sciences reveal the important role of SCT Receptor in regulating drinking behaviour under thirst. The study demonstrates how SCTR participates in SFO to regulate thirst and provides new insights into gut-brain axis regulation.
The international group of clinicians established guidelines on measuring plasma EBV DNA in managing nasopharyngeal carcinoma (NPC) during the COVID-19 pandemic. Plasma EBV DNA can be used in most clinical circumstances with imaging scans, but cannot replace essential procedures like nasoendoscopy and tumour biopsy.
Researchers from HKUMed discovered that somatic deletion of AKTIP promotes luminal breast cancer development and resistance to endocrine therapy. Blocking the alternative escape pathway with a JAK2/STAT3 inhibitor can overcome this resistance, offering new therapeutic possibilities for patients with AKTIP gene deletion.
A research team led by Professor Xiang David LI has developed a novel chemical tool called photo-ANA to investigate bacterial interactions with the host in real-time. This approach enables scientists to comprehensively profile host–bacteria protein interactions during infection, revealing known and newly discovered interactions.
A research team from HKUMed identified chronic Type I Interferon signalling as a driver of CD8+ T cell exhaustion and therapy resistance. The study highlights the harmful effect of IFN-I on tumour-killing CD8+ T cells, providing new insights into immunotherapy improvement.
Coral hosts can punish selfish algae by limiting nutrient supply, promoting more beneficial species. This finding sheds light on coral survival and potential interventions to prevent bleaching due to climate change.
A phase II clinical study has found that nearly 50% of patients with inoperable locally advanced liver cancer can be cured using the tri-modality therapy. The 'Reduce and Remove' approach, which combines TACE, SBRT, and immunotherapy, results in a 90% two-year survival rate with minimal side effects.
The study found that YTT recruits were of high caliber, with many coming from global top-100 PhD programmes. They recorded a noticeably higher post-return productivity compared to their overseas peers, mainly due to access to greater funding and research teams in China.
A new jaw surgery technique, segmental mandibular advancement (SMA), has been shown to effectively treat moderate-to-severe Obstructive Sleep Apnea (OSA) in a pilot study. The procedure resulted in a 50% or more reduction in breathing disturbances at night for 58% of patients, with no signs of sleep apnea.
Researchers uncover new mechanism of human MCM2-7 complex in regulating replication initiation, offering novel anticancer strategy for selective killing of cancer cells. The study provides high-resolution structural and mechanistic information on the human pre-initiation complex.
Researchers at The University of Hong Kong and MIT have developed a new method to produce stronger interactions between photons and electrons, enabling hundredfold increases in light emission. This breakthrough has potential ramifications for commercial applications and fundamental scientific research.
Researchers developed biosensors to measure real-time energy changes in plant cells, revealing the bioenergetics of pollen tube growth. The study found that mitochondrial respiration is a main source of cytosolic ATP, while plastid glycolysis supplies plastid ATP.
Researchers at HKUMed have established a baseline for gene expression profiles of amniotic fluid cells using RNA-sequencing, providing potential clinical utility for prenatal diagnosis. The study identified outliers in genes associated with structural congenital anomalies, offering new evidence for diagnosis.
Researchers at HKUMed identified a new type of nasopharyngeal carcinoma associated with EBV and immunosuppression in the tumor microenvironment. Global DNA hypermethylation was found to be a critical step in NPC pathogenesis, while global DNA hypomethylation may lead to immune evasion.
Researchers at HKU-CAS Joint Laboratory have developed a protonation process to enhance the efficiency of photocatalysts in generating hydrogen using visible solar light. The discovery could lead to more efficient and stable solar energy utilization, paving the way for 'net-zero' green hydrogen production.
A high-precision 3D printing method has been developed to produce polarisation-encoded 3D anticounterfeiting labels with increased data encryption density. The new label can encrypt more digital information than a traditional 2D label.
Researchers discovered the underlying cause of deafness caused by swelling in the inner ear chambers. The study identified two master genes, SOX9 and SOX10, controlling hearing function and providing a new resource for diagnosis and treatment of deafness and balance problems.
Researchers at HKUMed identify Δ42PD-1 as a key player in suppressing killer T cells and promoting tumor growth in HCC. Targeting this protein with an antibody can inhibit tumor growth and increase functional killer T cells, offering new hope for immunotherapy against HCC
Researchers confirmed smoking and obesity increase COVID-19 severity, with ACE2 mediating detrimental effects. Lower socioeconomic position also increases COVID-19 risk, highlighting social inequalities.
A recent study analyzing nearly 22,000 trees across five continents highlights the importance of old-growth trees in withstanding future droughts under climate change. Older hardwood trees exhibit a 21% growth reduction during drought, compared to a 28% reduction experienced by younger hardwood trees.
Researchers identify two southward migration events of Arctic ostracods in the Last Glacial Period, revealing the impact of East Asian winter monsoon on marine ecosystems. The study's findings help understand Asian monsoon dynamics and their effects on polar species distribution, highlighting the risk of extinction under climate change.
A collaborative research team led by Dr Philip Li from HKUMed has pioneered a new nurse-led penicillin allergy triage and testing strategy, which demonstrated its effectiveness and safety compared to traditional allergy testing. The study found that 90% of penicillin allergy labels in Hong Kong are incorrect, leading to potential letha...
Researchers found a reduction of 359,790 hospitalisations, but an increase of 1,873 deaths from cardiovascular diseases due to the COVID-19 pandemic. This suggests that some people may be reluctant to seek medical care even when severely ill.
HKU Marine Scientists found that oyster reef restoration rapidly increases marine biodiversity, with a 35% shortfall in species diversity and ecosystem services. The research suggests that long-term protection is needed to mature restored reefs into complex ecosystems.
Researchers at HKU have developed a novel technique to measure the rotational and translational motion of cell markers with high precision. This breakthrough technology uses single nitrogen-vacancy centers in nanodiamonds to tackle the long-standing challenge in mechanobiology research.
A new anti-virus has been discovered in a medical lecture. The lectin, known as H84T-BanLec, is highly effective against many different types of coronaviruses, including those causing COVID-19 and MERS-CoV. Its unique mechanism makes it difficult for viruses to develop resistance, making it a potential 'pan-coronavirus' antiviral drug ...
Researchers from HKU and Harvard University have developed a new triangular lattice model and sweeping cluster algorithm to simulate Rydberg arrays. Their simulations reveal highly entangled Z2 quantum spin liquids with large parameter regimes, providing valuable insights for future experiments.
A retrospective cohort study of hospitalised patients with COVID-19 found significant reductions in all-cause mortality and disease progression among those receiving oral antivirals like molnupiravir and nirmatrelvir–ritonavir. The study supports the use of these antivirals in this population.
HKU researchers create ultra-strong aerogels by combining aramid nanofibers with polyvinyl alcohol, outperforming traditional aerogels in load-bearing structures. The new material has vast applicational values for diverse functional devices.
A recent study by the University of Hong Kong estimates that there are between 20 x 10^15 and 2 x 10^17 individuals on Earth, weighing more than all wild birds and mammals combined. The study also found that ants are unevenly distributed over the global land surface, with tropical regions harbouring more ants than non-tropical regions.
A recent study by Dr Joseph Michalski from HKU suggests that the number of ancient Martian lakes may have been significantly overestimated. The analysis of satellite data reveals evidence for smaller lakes on Mars, which could contain critical information about past climates.
Researchers from HKU-CAS have created a new material that can produce dual-color spots inspired by nature, leading to innovative applications in message encryption and storage. The breakthrough was achieved through the self-assembly of nanostructures in a one-pot method, enabling programmable binary color information.
New research finds that most tokay geckos sold in Hong Kong's TCM shops originated from Southeast Asia, not locally. The study highlights the need for stricter control of pet trade releases to protect this vulnerable species.
A systematic review and meta-analysis of observational studies found a moderate association between antipsychotic use and an increased risk of breast cancer, estimated at over 30%. The study highlights the importance of risk-benefit assessment of antipsychotic prescription in high-risk patients.
A study by HKU Dentistry found that 'positive stress' can induce good changes in tooth stem cells, making them more resistant to injury and disease. The research team developed a preconditioning protocol that modified the cells genetically to mimic low oxygen conditions, which activated protective mechanisms.
Researchers have found the oldest visible planetary nebula, a rare celestial jewel, hosted by a 500 million-year-old galactic cluster. The team determined that the PN has a 'kinematic age' of 70,000 years and estimates its progenitor star's mass and residual core's mass.
A recent HKU study found that Global South cities experience only one-third of the greenspace exposure level of Global North cities, highlighting the need for prioritizing greening policies and actions. The research reveals a severe disparity in greenspace exposure linked to differences in greenspace provision and landscape design.