Researchers used AAV vectors to increase NGF levels in the hearts of diabetic mice, preventing cardiac dysfunction and preserving blood flow. The study suggests NGF gene therapy may have tremendous therapeutic potential for treating diabetic cardiomyopathy.
A study tracking water quality in the Thames River basin over 140 years found significant rises in nitrate concentrations since World War II. The researchers suggest it may take several decades for any reduction in nitrate levels, highlighting the need for long-term sustainable groundwater management practices.
Researchers at the University of Bristol used musical features and machine learning algorithms to predict song hits in the UK singles chart. They found that danceability increased in popularity from the late 1970s and that slower styles, such as ballads, were more likely to become hits in the 1980s.
Researchers from the University of Bristol have discovered a chemical compound in the brain that can weaken synaptic connections between neurons. This finding may provide a potential explanation for memory loss associated with Alzheimer's disease.
Researchers at UWE Bristol and University of Bristol discovered that mutations in one specific cancer gene can control splicing balance, allowing a master switch to be turned on. This enables the growth of cancer cells and blood vessels, but new drugs targeting this process may block tumour growth.
Researchers have developed a multi-purpose photonic chip that generates, manipulates, and measures entanglement and mixture on a tiny silica chip. This device can perform various experiments in a straightforward way using a single reconfigurable chip.
New research reveals that climate change is causing certain species to adapt to new habitats, helping them track ongoing warming. The Brown Argus butterfly has successfully expanded its distribution northwards in the UK, using a range of distinct habitats.
Researchers have identified a crucial part of the nervous system whose malfunction may account for an increased risk of death from heart failure. The cardiac ganglion plays a key role in regulating vagal tone reaching the heart.
Scientists have found that carbon cycling in the terrestrial biosphere was much smaller during the last ice age than in today's warmer climate. The researchers estimate that only about 40 petagrams of carbon were stored in vegetation and soil per year, which is roughly one third of present-day levels.
Researchers have developed a method to design drugs that can target specific areas of the brain by selectively blocking subtype SK channels. This breakthrough could lead to more effective treatments for dementia and depression by enhancing nerve activity in specific nerves.
Researchers used Twitter data to track flu-like illness rates in UK regions and detected emerging epidemics. The study gathered over 50 million geo-located tweets and applied machine learning algorithms to identify keywords associated with elevated flu severity.
Research by University of Bristol neuroscientists found that cannabis disrupts coordinated brain waves, leading to impaired decision-making and memory. The study suggests that 'disorchestrated brains' may contribute to psychiatric diseases like schizophrenia.
A University of Bristol researcher is using £1.3 million to study diatoms' ability to coat themselves in glass, with potential applications in medical imaging tools and novel catalysts.
Researchers at the University of Bristol identified a probiotic strain that can thrive in high-iron environments and reduce inflammation associated with IBD. The discovery offers hope for developing novel treatments for active intestinal disease.
A new study by University of Bristol researchers found that racehorses can adapt rapidly to changes in the daily light-dark cycle, leading to improved physical performance. The horses were able to run at full gallop for an additional 25 seconds before reaching fatigue after experiencing a shift in their 24-hour light-dark cycle.
A University of Bristol study found that omega-3-rich diets reduced disease by 50% compared to a standard diet in guinea pigs with naturally occurring osteoarthritis. Omega-3 influences biochemistry and helps prevent disease progression, potentially controlling established osteoarthritis.
In a cooperative breeding system, cichlid males who sire offspring defend more effectively against predators and stay closer to the breeding shelter. Subordinate males' helping behavior is linked to direct fitness benefits, including paternity and increased safety.
Researchers have developed a method to grow cardiac muscle cells from human cord blood stem cells, which could lead to new treatment options for patients with damaged hearts. The study found that these cells can be expanded and differentiated into cardiomyocyte-like cells, overcoming the technical hurdle of deriving cardiac muscle-type...
Researchers have discovered how cells detect and respond to tissue damage, a process triggered by the molecule syndecan-4. This understanding could lead to improved tissue repair treatments for patients following illness or surgery.
A new study by University of Bristol researchers found that familiarity with snack foods affects children's expectations of fullness, influencing portion sizes. Children who are infrequent consumers rely on food appearance, whereas familiar eaters predict fullness based on product characteristics.
A University of Bristol study examined motivational indicators in public and private sector workers across 51 countries. It found that public sector workers tend to be more intrinsically motivated, but corruption levels can affect motivation.
A major shift in European fish stocks is already underway due to rapidly rising temperatures, with some species' losses being others' gains. The study found that over 72% of common fish species have changed in abundance related to warming trends, with three out of four species increasing in numbers.
Researchers found evidence of oceanic crust in ultra-deep diamonds, suggesting it can be transported from the lower to upper mantle via large-scale upwelling. The discovery provides new insights into the Earth's mantle recycling process.
A new study by the University of Bristol reveals that children from disadvantaged backgrounds are more likely to experience abusive partner relationships. The research found that many young people accept violence as normal and struggle to recognize its impact, highlighting the need for education and support to prevent abuse.
A team of evolutionary biologists found that when mothers control offspring sex ratios, sexual selection collapses, and males lose their elaborate courtship displays to attract females. This twist adds unexpected complexity to Darwin's theory of sexual selection, suggesting that motherly control can override the need for showy males.
Researchers at the University of Bristol analyzed ancient rock samples to determine the origin of Earth's precious metals. They found that the planet's accessible reserves of gold and other precious elements are the result of a catastrophic meteorite shower that hit the Earth after its core formation.
Researchers at the University of Bristol have developed a novel approach for studying molecules within their natural environment, allowing for unprecedented detail on bacterial infection mechanisms. The breakthrough utilizes a lateral molecular force microscope to measure biological phenomena directly on a living cell surface, enabling...
The study discovered that pericytes can stimulate new blood vessels and aid in the recovery of a heart attack by transferring microRNAs to endothelial cells. This novel mechanism could lead to the development of new treatments for cardiovascular disease.
A team of researchers used advanced imaging techniques to study a 400 million-year-old fossilized jawless fish. They found evidence that the brain of early vertebrates was reorganized before the development of jaws, providing new insights into the evolutionary history of vertebrates.
Scientists have identified a natural protection mechanism in some brain nerve cells during stroke, which could be used to develop treatments to protect other nerve cell types. The research found that one type of nerve cell, the CA3 cell, is more resistant to stroke-induced damage and possesses a mechanism for reducing its susceptibility.
Researchers at University of Bristol found that multiple brain regions work together to form memories, particularly in recognizing faces and names. The study's findings have implications for understanding memory disorders like Alzheimer's disease.
Scientists at the University of Bristol develop a new technique to dramatically simplify controlled operations in quantum computing. This breakthrough reduces complexity in quantum circuits, enabling more sophisticated algorithms and applications in precision measurement, simulation, and beyond.
A new study by University of Bristol researchers has identified a mechanism in the brain that explains why people form long-lasting memories of stressful events. The discovery could lead to new treatments for post-traumatic stress disorder (PTSD) and other stress-related psychiatric disorders.
A recent study published in the European Journal of Clinical Nutrition found that 70% of 8-month-old babies have a high salt intake, exceeding the recommended UK maximum level. High salt consumption can damage developing kidneys and establish poor eating practices that continue into adulthood.
Researchers at the University of Bristol have received a major funding boost to continue their research into the pathological processes underpinning Alzheimer's disease. They have found that neuronal excitability is substantially altered in the model of Alzheimer's disease, leading to changes in action potential generation and waveform.
A rainforest vine has evolved a dish-shaped leaf with strong echoes to attract bat pollinators. The researchers found that the leaf reduces search times by 50% when presented above a feeder, indicating its effectiveness as an echo beacon.
A study found that only 47% of parents consulted their GPs about their child's weight, and even fewer were referred to weight-management services. The research highlights the need for healthcare professionals and families to work together to address childhood obesity.
A new study by University of Bristol biologists found that mother foxes determine which cubs stay and which leave their family groups, with dominant females playing a crucial role in dispersal strategy. This unique discovery sheds light on the evolution of social behavior in mammals.
Researchers found a material that conducts heat 100,000 times better than expected, violating the Wiedemann-Franz law. This unusual separation of electron spin and charge has potential technological implications.
Researchers discovered seven new genes linked to Ankylosing Spondylitis, bringing the total to thirteen known predisposing genes. The study also revealed an interaction between genetic mutations HLA-B27 and ERAP1, providing insight into the disease's cause.
A lack of understanding about HPV vaccination and its link to future cervical screening has been found among parents and girls in the UK. Despite being effective against two high-risk HPV types, vaccinated individuals still require regular cervical screenings to protect against other strains that can cause cancer.
A new study suggests that vertebrate jaws evolved relatively early, around 420 million years ago, and that the diversity of feeding mechanisms in these early animals had little impact on jawless fishes. The researchers used physics and engineering concepts to analyze the potential feeding functions of early vertebrate jaw designs.
A new study by Katy Prentice shows that pterosaurs evolved in a unique way, specializing over 160 million years. The research found that pterosaurs remained conservative for 70 million years before experimenting with new modes of life, adapting to feed on different food sources and becoming larger.
Using a dataset of 873 children's heart rate, temperature, and oxygen saturation measurements, researchers developed data fusion models that predicted the severity of their illness with moderate accuracy. The best-performing model had a sensitivity of 79% and specificity of 75.8%, outperforming existing scoring systems.
A recent study of nine-year-old children in Ireland found that overweight youngsters are significantly more prone to being bullied than their slimmer peers. The research also revealed a stark correlation between childhood obesity and an increased risk of chronic illnesses.
The study found that rocky planets, including Earth, are enriched in 17O and 18O by about 6% relative to 16O. This supports the 'isotopic self-shielding' mechanism, where photolysis of carbon monoxide liberates oxygen atoms that are sequestered into water molecules.
Researchers have successfully demonstrated a quantum logic gate acting on four particles of light, enabling new approaches to quantum technologies. The device has the potential to improve secure communication and precision measurement, paving the way for more efficient computers and innovative applications.
Researchers discovered that ancient plants like spikemosses had stomata that could open and close in response to light, carbon dioxide, and abscisic acid, a key plant hormone. This finding suggests that water-conserving innovations occurred early in plant evolution.
Dazzle camouflage, a World War I technique, can affect perception of speed when objects move quickly, potentially reducing losses from attacks on fast-moving vehicles. This effect is due to high contrast geometric patterns, which were found to cause a significant reduction in perceived speed by around 7 percent.
A new study reveals ocean acidification compromises fish hearing, leaving clownfish deaf to predators. Researchers reared larvae in different CO2 environments, showing that increased acidity impacts sensory systems, including those inside the fish's body.