The UCI system uses lab-on-a-chip technology to detect COVID-19 antibodies in a low-cost, portable imaging platform. The device can process hundreds of antibody responses simultaneously, enabling accurate testing and potentially informing public health strategies.
Researchers at UCI are learning about resilience from the mantis shrimp, which has a uniquely designed nanoparticle coating that absorbs and dissipates energy. This finding has significant implications for engineered materials in various industries.
Researchers from UCI School of Medicine evaluate anterograde and retrograde viral tracers for neural circuit analysis, providing guidance on experimental uses. The primer aims to advance the study of neural circuits using animal models to define mechanisms underlying neurodevelopmental and neuropsychiatric disorders.
A recent study found alarming levels of human bacterial pathogens and microdebris materials, including plastics and milk supplement powders, in oysters from the eastern Andaman Sea. The research suggests that coastal urbanization increases contamination in seafood, posing significant health risks to humans and threatening global food s...
Researchers found distinct responses to ultraviolet and other colors of light between day- and night-biting mosquito species. The study's findings have important implications for using light to control harmful insects.
A study published in Neuron reveals how normal brain network function of hippocampus cells, which works to discriminate a distinct spatial environment, is disrupted in Alzheimer's disease. The disruption is likely caused by the activity impairment of the entorhinal cortex.
UCI researchers received the most funding in campus history, with a 20% increase over last year, thanks to strong support from federal and state agencies, leading foundations, and companies. This milestone accelerates UCI's ascent as a world-class research university, with notable boosts in biomedical research and data privacy.
A new clinical trial suggests that vaporized cannabis is safe and potentially effective in mitigating chronic pain caused by sickle cell disease. The study found that patients experienced reduced pain levels and improved mood over time, paving the way for further research on medical cannabis as a treatment option.
Researchers at the University of California, Irvine have discovered a key mechanism in breaking down nitrogen gas, a crucial step towards developing more efficient and sustainable methods. The breakthrough could lead to cheaper and more energy-efficient ways to produce fertilizers and alternative fuels.
Researchers discovered that quercetin in pickled capers regulates proteins controlling bodily processes like heartbeat, thought, and muscular contraction. The study may lead to future therapies for epilepsy and abnormal heart rhythms.
A new study has identified a key signaling pathway in the development of Paget's disease, a rare and debilitating skin cancer. Researchers found that using a topical cream containing an FDA-approved drug can alleviate clinical symptoms in patients with Paget's disease.
UCI researchers have discovered a protein responsible for genetic changes in various cancers and identified potential targets for effective therapy. By monitoring RNA hotspots, the team found that targeting the APOBEC3A protein's activity could disrupt cancer cell vulnerabilities.
Oncology pharmacy practitioners worldwide are struggling with limited and restricted PPE supply, making it difficult for them to provide high-quality cancer care. In a study, half of the surveyed countries reported impaired access to essential medications, including anti-infective agents and anticancer medications.
Researchers at UCI have engineered human cells to mimic squid skin, allowing them to change their transparency and scattering of light. The study's findings offer a potential method for tuning light-scattering properties in human cells and may lead to new biomolecular markers for medical applications.
A research team at the University of California, Irvine has been awarded $3.8 million to investigate epigenomic changes in the brain caused by Alzheimer's disease. The team aims to identify new therapeutic targets and biomarkers for early detection and treatment.
Researchers discovered that microorganisms change the rock's nature by extracting water, causing a phase transformation from gypsum to anhydrite. The organisms use organic acids to penetrate the rock and access water, revealing an innovative survival strategy.
Researchers at the University of California, Irvine have discovered a key receptor for dopamine called D2R that intervenes in cocaine's modifying functions in the striatum. Disrupting D2R signaling may lead to new therapeutic strategies for treating cocaine addiction.
Researchers at UCI developed TrackCOVID, a free, open-source app for anonymous contact tracing. The app logs interactions and notifies users at risk of exposure through an anonymous graph.
Researchers at UCI have successfully designed a novel plate-cell architecture for nanometer-sized carbon structures that are stronger than diamonds. The design has been shown to improve on the average performance of cylindrical beam-based architectures by up to 639% in strength and 522% in rigidity.
A new UCI-led study suggests that metabolic alterations, rather than just amyloid accumulation, contribute to the development of Alzheimer's disease in people with Down Syndrome. The study found similar energy metabolism deficits in adults with Down Syndrome and Alzheimer's disease, opening up new avenues for prevention.
Researchers at UCI found that depriving colon cancer cells of glutamine causes them to adapt and become more invasive, but a modified version of the metabolite alpha-ketoglutarate inhibits key signaling pathways and curbs tumor growth
A statistical analysis predicts that a highly purified fish oil therapy could prevent thousands of cardiovascular events each year. The study used data from the National Health and Nutrition Examination Survey and showed a 25% reduction in cardiovascular events for patients with elevated triglyceride levels.
Researchers have assessed East Antarctica's Denman Glacier, which has retreated 5 kilometers, and found alarming clues about its condition. The glacier's potential impact on long-term sea level rise is significant due to its sheer size.
UCI researchers successfully transplanted healthy mitochondria into cardiomyocytes, boosting cellular energy and improving bioenergetics indices. The study's findings suggest a potential method to mitigate cardiovascular, metabolic, and neurodegenerative disorders.
Researchers at University of California, Irvine have published a comprehensive overview of skin cell changes before wound healing. The study provides insights into the underlying mechanisms driving poor wound healing in diabetic patients.
Scientists track unprecedented rate of Greenland's ice melting and continued Antarctic loss in a new study. The research used data from NASA's GRACE Follow-On satellites to monitor changes in Earth's gravity and water reserves, revealing striking results.
A study by UCI researchers found that reductions in ground ozone resulted in $600 million in increased production annually, with yields projected to rise by 5-20% for certain crops like wine grapes and table grapes. The study highlights the benefits of air quality standards for California's high-value crops.
Researchers have discovered that breast cancer cells change their metabolism to move to other parts of the body, a finding that could lead to new strategies for preventing the spread of cancer. This shift in metabolism may be targeted with drugs to prevent metastasis and improve survival rates.
Researchers developed a new technique called zombie scanning to study peptide-receptor interactions on the cell surface. This method hijacks cell machinery to simplify the creation of peptides, allowing for rapid studies and lower production costs.
Researchers at University of California, Irvine discovered that cancer cells use a process called macropinocytosis to obtain nutrients from dead cell material within tumors. This mechanism enables tumor cells to resist chemotherapy and other treatments, making it a promising target for new therapies.
A new study reveals that the overlying skin and a layer of non-adhesive cells are required for digit separation during mammalian development. The research identifies epidermal developmental processes beyond connective tissue removal, which may be implicated in other complex syndromes.
Researchers developed bifunctional nanobodies that neutralize multiple types of botulinum neurotoxins, including Botox, with greater potency than single-nanobody approaches. The findings address urgent need for antitoxins against Tier 1 select agents.
A recent study found that the monkeyface prickleback, a unique fish species, has an efficient digestive system capable of breaking down plant material. This discovery holds promise for developing new, sustainable sources of protein for human consumption and could be an important alternative to traditional livestock farming.
Researchers found that low oxygen levels cause abnormal sodium currents that lead to dangerous cardiac rhythms. The discovery offers new targets for therapeutics to prevent late current and arrhythmia associated with heart attacks, chronic heart failure and other life-threatening conditions.
A new study using a neural network-driven Earth system model predicts an increase in phytoplankton biomass in low-latitude regions by 2100. The team found that the traditional assumption of declining biomass due to climate change is not supported, and instead, phytoplankton may actually thrive in warmer waters.
A new UCI-led study reveals that early life adversity is directly linked to opioid addiction vulnerability by affecting brain development and function. The research highlights the importance of attention to sex differences in future studies and prevention strategies, which could help address the growing opioid crisis.
Researchers found that adolescents who viewed their family as having a higher social status had better mental health and transitioned to adulthood more easily. The study controlled for factors like poverty and environmental influences.
A UCI-led team has unveiled the most accurate portrait yet of Antarctica's ice sheet bed topography, revealing stabilizing ridges and deep land canyons. The new map will help scientists predict the continent's vulnerability to future climate warming.
Researchers at the University of California, Irvine developed a cell therapy that transplants inhibitory neurons to improve memory precision after traumatic brain injury. The treatment prevented seizures in mice with traumatic brain injuries, showing promising results for potential human treatment.
Researchers discovered a sustained light response in central brain neurons to blue and ultra violet light, informing internal circadian processes about the time of day. The study sheds light on non-image-forming vision and its role in regulating circadian rhythms.
UCI researchers found that as trees and plants conserve water due to high CO2 levels, soil moisture builds up underground, leading to increased rain runoff. This 'forest effect' can significantly impact river dynamics, particularly in regions like the Mississippi River basin.
Researchers at UCI have developed a new scanning transmission electron microscopy method that enables visualization of the electric charge density of materials at sub-angstrom resolution. The technique revealed the mechanism of charge transfer between two materials and uncovered clues to the origins of ferroelectricity.
Researchers aim to develop treatments for behavioral symptoms of chronic stress and depression by understanding and controlling memory. Beier's project explores neuronal plasticity and synaptic protein interactions to engineer molecular reagents for selective modulation of memories.
Scientists have identified a key role for the brain protein TOM-1 in regulating inflammatory responses, which are linked to Alzheimer's disease. By restoring TOM-1 levels, the study found improved pathology and cognitive problems associated with the disease.
The University of California, Irvine will conduct a major multi-site health study on the relationship between PFAS-contaminated drinking water and health outcomes. The study aims to advance scientific evidence on human health effects of PFAS and provide answers to communities exposed to contaminated water.
Researchers discovered a shared molecular mechanism among botanical folk medicines that lower blood pressure by activating the KCNQ5 potassium channel in blood vessels. This finding could lead to targeted therapies for diseases like hypertension and KCNQ5 loss-of-function encephalopathy.
A team of US and Chinese scientists, led by UCI Professors Xiangmin Xu and Rozanne Sandri-Goldin, will develop a new brain mapping tool using genetically engineered herpesviruses. The tool aims to enhance signal outputs and generate variants carrying different functional payloads.
Researchers discovered novel brain circuits in the hippocampal formation play a critical role in object-location learning and memory. The study provides new insights into Alzheimer's disease, offering potential targets for treatment.
A UCI team developed a new technique for predicting wildfires' final size, focusing on specific ignitions that pose the greatest risk of getting out of control. The model can forecast whether a blaze will be small, medium or large by its end, helping allocate scarce firefighting resources.
Scientists at University of California, Irvine predict that Valley fever will double in size this century due to climate change. The fungal infection is expected to become widespread in previously unaffected areas across the western U.S., including Montana, Nebraska, and Wyoming.