Researchers developed RNA nanoparticles that selectively bind to HER2-overexpressing breast tumors, eliminating MED1 expression and sensitizing them to tamoxifen treatment. The nanoparticles also reduced cancer stem cell content, a promising strategy for treating advanced metastatic breast cancer.
UC researchers have identified a new drug pathway to combat Pneumocystis pneumonia, which affects immune-compromised individuals and is often fatal. The study found that inhibiting the fungus's inositol transporter could be an effective treatment, offering hope for patients with HIV/AIDS and those on immunosuppressive drugs.
A new study from the University of Cincinnati reveals that former college football players continue to show evidence of neuropathic brain changes several years after graduation. The research found lower cortical thickness in areas critical for attention, memory, and executive abilities.
Scientists have discovered fossils of sulfur-oxidizing bacteria in ancient rocks from South Africa and Western Australia, dating back to the Neoarchean Eon, 2.8 to 2.5 billion years ago. These findings suggest that life existed on Earth before the Great Oxidation Event, which led to a significant increase in oxygen levels.
Researchers found that diabetes patients with all three risk factors (AKI, proteinuria, and poor blood sugar control) lose renal function at nearly 5% annually, accelerating dialysis need to within 12 years. Patients with two or one of these risk factors still face accelerated loss of renal function.
Researchers at the University of Cincinnati have discovered that defective ion channels in T cells may contribute to the inability of the immune system to fight off head and neck cancers. By targeting these channels, patients with these cancers could have better outcomes.
Researchers identified a genetic variant in MYBPC3 that predisposes South Asians to hypertrophic cardiomyopathy, an enlarged heart condition. Early screening of this variant can help reduce the incidence of sudden cardiac death in this population.
Researchers from the University of Cincinnati have joined forces with international efforts to search for a new type of neutrino that may shed light on dark matter. The MINOS and Daya Bay experiments have found no evidence of a sterile neutrino, but their combined results significantly shrink the hiding space for this elusive particle.
David Wendell's technology targets harmful pathogens like E. coli, Listeria, and protozoa while preserving healthy bacteria in public drinking water. It uses light-generated hydrogen peroxide to eliminate outbreaks, without adding contaminants to the environment.
Researchers at University of Cincinnati find non-deleterious sulfate minerals in ancient soil and water, increasing fertility for maize cultivation. The discovery sheds new light on the Ancestral Puebloans' thriving agricultural urban center.
Researchers discovered a well-preserved Bronze Age warrior's tomb in Greece containing over 2,000 objects, including four golden signet rings featuring Minoan iconography. The findings suggest cultural sharing between the ancient civilizations, challenging the theory of mere plunder.
A University of Cincinnati study found that gut bacteria influences intestinal mast cells' activation and fat absorption. The research suggests a novel role for the gut microbiome in promoting lipid absorption.
Research reveals gay men employ tactics like dressing down or toning down behavior to avoid negative consequences in the workplace. They also carefully choose when and how to disclose their sexuality, using strategies like language and body language manipulation to manage their identity.
A University of Cincinnati study finds that high self-esteem can help individuals recognize and respond to envy in the workplace. Researchers suggest that when envied employees attribute negative behaviors to envy, they are more likely to respond positively. In contrast, low self-esteem may lead to acceptance or suspicion. The study ai...
Research found that employees experiencing envy tend to ruminate on social injustice, leading to ego depletion and decreased productivity. High epistemic motivation can contribute to creative output but also exacerbate negative emotions.
The University of Cincinnati has received a five-year, $4.3 million NIH grant to continue work at its Mouse Metabolic Phenotyping Center in Reading, Ohio. The center provides experimental testing services for scientists studying diabetes and metabolic diseases in mice.
A new study from the University of Cincinnati found that 66.9% of college-aged women engaged in unprotected sex during their last encounter involving alcohol. The study suggests that stronger beliefs about alcohol promoting sexual risk-taking and motivation for sex to satisfy personal needs contribute to decreased condom use.
Researchers found that mindfulness-based cognitive therapy increases activity in brain regions controlling emotional processing, leading to reduced anxiety in youth at risk of bipolar disorder. The study's pilot trial showed significant improvements in clinician-rated and youth-rated anxiety following 12 weeks of treatment.
A new artificial intelligence system called ALPHA has been developed by Psibernetix, Inc., which consistently outperforms human experts in simulated air combat. ALPHA's ability to process vast amounts of sensor data and make tactical decisions in milliseconds makes it a formidable opponent, even when its aircraft are handicapped.
Early findings suggest carfilzomib may provide improved reduction of antibodies in potential kidney transplant candidates with reduced side effects. The study's preliminary data show antibody reductions between 31 to 100 percent in the first group of six patients.
Researchers at the University of Cincinnati found that a pre-procedure medication regimen can significantly reduce hospital stays and readmission rates for liver cancer patients undergoing DEB TACE treatment. The study involved 113 procedures in 71 patients, with only 5% requiring hospital admission due to post-procedural syndrome.
Researchers found that adding metformin to a chemotherapy and radiation treatment regimen for head and neck cancer patients showed improved outcomes, including better overall survival, compared to those not on metformin. However, faster escalation of metformin was poorly tolerated due to nausea, vomiting, and other side effects.
Researchers found that female atrial fibrillation patients are less likely than men to receive blood thinning therapies. The study used a computerized decision support tool to review medical therapies for over 1,500 patients and found significant sex differences in treatment.
The study, published in the American Society of Neuroradiology's annual meeting, found that younger patients, African-Americans, and those seen by a stroke team received more advanced imaging, including MRI and MR angiogram. The findings highlight disparities in neuroimaging use for different patient groups.
Researchers analyzed untreated acute stroke patients and found no correlation between salvageable penumbra and time. However, they discovered a significant association between salvaged penumbra and collateral blood flow rerouting of the blocked arteries.
Researchers from University of Cincinnati identified sources of methane in three US states using isotopic composition analysis. Methane levels came from organic matter decay and biological processes in coal formations, with fracking contributing to high emissions in some areas.
Researchers are investigating the protein HuR and its role in cardiovascular disease, with a goal of translating this research to improve human health. By deleting HuR in animal models, they found that mice lacking the protein were protected from hypertrophy and heart failure.
A computerized decision support tool helps physicians and patients make informed decisions about blood thinning treatment to prevent strokes in individuals with atrial fibrillation. The tool, which takes into account patient characteristics and medical therapies, resulted in a significant reduction in deviations from recommended treatm...
Researchers at the University of Cincinnati developed a simple in-home screening device to monitor blood-clotting levels, reducing frequent lab tests and costs. The paper-based test stick can quickly reveal changes in coagulation properties, allowing patients to detect potential issues early.
A study by the University of Cincinnati's James L. Winkle College of Pharmacy uses mathematical modeling to predict chemical compound behavior in biological tissues, such as skin. This approach enables researchers to test cosmetic or consumer products virtually, reducing the need for animal testing.
Acute myeloid leukemia researchers have identified a microRNA pathway that could lead to new targets for treatment. The study found that miR-22 is down-regulated in AML, leading to the development of cancer-causing genes and pathways. This discovery offers hope for developing effective therapies against this deadly disease.
Researchers successfully killed and removed invasive plants using specific herbicides during late winter, allowing native plant species to regrow in southwestern Ohio. This approach has shown positive results in controlling aggressive invasive species such as Wintercreeper, English ivy, and lesser periwinkle.
A study by University of Cincinnati researchers found that trauma patients receiving blood quickly after severe injuries have a decreased death risk. The delay in blood transfusion increased the chances of death, with each 10-minute delay resulting in higher mortality rates.
Researchers at the University of Cincinnati have made new discoveries about how ancient Maya commoners conserved water for drinking and irrigation. The study, using LiDAR technology, found evidence of over 100 small reservoirs in a Maya site, with three confirmed as water features.
Researchers at the University of Cincinnati have developed quantum nanowire structures that can detect infrared light and measure electrical processes in thin-strand nanowires. The technology has potential applications in medical devices, environmental sensors, and night-vision imaging for military applications.
A UC team created a new nanostructure that shows significantly higher properties for detecting and destroying cancerous cells, enabling targeted drug delivery. The discovery was made possible by complex calculations conducted by PhD student Zohre Gorunmez.
Researchers Nayana Shah and Carlos Bolech found a discrepancy in the conventional approach to bosonization-debosonization, contradicting past work on quantum computers and electronic devices. Their new consistent formalism offers a general recipe for solving problems involving strong particle interactions.
A University of Cincinnati researcher is studying nearly 3,000 patients to see if a genetic variant that protects against HIV also prevents injury from Hepatitis C. The study aims to understand how inhibition of the CCR5 receptor may influence liver injury and disease progression in individuals co-infected with HIV and hepatitis C.
Researchers at the University of Cincinnati have discovered that a human cancer-causing gene called DEK can be detected in the plasma of head and neck cancer patients. High levels of DEK may indicate better outcomes for patients, while low levels are associated with advanced cancers.
Researchers at the University of Cincinnati are studying the interacting roles of the sympathetic nervous system, sensory nervous system, and immune system in preclinical models of back pain and neuropathic pain. The goal is to understand how timing of a nerve block treatment affects chronic pain relief.
A new study published in The Lancet Neurology confirmed that different generic antiepileptic products are equally effective in treating epilepsy, with no measurable difference found between them. This finding provides reassurance for patients and clinicians about the safety of substituting generics.
The University of Cincinnati's Arlitt Center has received a three-year, $1.6 million grant from the National Science Foundation to support teacher development and research into early childhood science learning through outdoor play environments. The grant will fund four initiatives: web-based professional development programs, research ...
Researchers found that exposure to structured environments increases thoughtful decision-making, leading to better choices. This effect is particularly pronounced in chaotic environments where people invest less thought into their decisions.
A global research collaboration sequenced the bed bug genome, identifying genes linked to pesticide resistance, mating traits, and blood digestion. The study provides a comprehensive understanding of the biology of human ectoparasites and offers new avenues for controlling bed bug populations.
A new study from the University of Cincinnati suggests that prenatal exposure to flame retardants and PFASs may have a lasting impact on executive function in children, characterized by impairments in focus, working memory, delegation of tasks, and emotional control. The research evaluated levels of PBDEs and PFASs in mothers during pr...
A new study by the University of Cincinnati reveals that migraine headaches increase in frequency and severity for women approaching menopause. Hormonal fluctuations during this time may trigger increased headaches, but researchers also suggest that medication overuse could be a contributing factor.
Recent University of Cincinnati research on ancient burial practices in pre-Roman Italy sheds light on economic and social mobility, military service, and drinking customs. The study found strong social stratification and hierarchy, as well as commonality of military service among men's tombs.
A University of Cincinnati researcher has identified PI5P4Kβ, an enzyme that senses GTP levels in cells, as a potential therapeutic target for cancer drugs. The discovery could help slow or halt the growth of aggressive brain cancers and other types of cancer.
The discovery suggests that Knossos rapidly grew and thrived after the collapse of the socio-political system around 1200 BC. The site was found to have a range of imports from mainland Greece, Cyprus, Egypt, Italy, Sardinia, and the western Mediterranean.
A University of Cincinnati study using RNA-sequencing analysis on a pregnant cockroach has identified 11,000 possible genes, with unique expressed genes corresponding to each developmental stage. The research holds potential for understanding how stress during pregnancy affects both mother and offspring in mammals.